FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9568, 398 aa 1>>>pF1KE9568 398 - 398 aa - 398 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9674+/-0.000567; mu= 19.2438+/- 0.035 mean_var=127.9883+/-37.556, 0's: 0 Z-trim(107.6): 580 B-trim: 878 in 1/50 Lambda= 0.113368 statistics sampled from 14976 (15712) to 14976 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.519), E-opt: 0.2 (0.184), width: 16 Scan time: 6.760 The best scores are: opt bits E(85289) NP_003292 (OMIM: 188545) thyrotropin-releasing hor ( 398) 2615 440.2 4.1e-123 XP_011515565 (OMIM: 188545) PREDICTED: thyrotropin ( 398) 2615 440.2 4.1e-123 XP_011508789 (OMIM: 604153) PREDICTED: neuromedin- ( 403) 448 85.8 2e-16 NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [ ( 426) 448 85.9 2.1e-16 NP_002522 (OMIM: 162651) neurotensin receptor type ( 418) 393 76.8 1e-13 NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 368 72.7 1.7e-12 NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 364 72.0 2.6e-12 NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 364 72.0 2.6e-12 XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 364 72.0 2.6e-12 NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 364 72.0 2.6e-12 XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 364 72.1 2.7e-12 XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 364 72.1 2.7e-12 XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 364 72.1 2.7e-12 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 364 72.2 3.2e-12 NP_444264 (OMIM: 607449) neuropeptide FF receptor ( 420) 361 71.6 3.9e-12 NP_001138228 (OMIM: 607449) neuropeptide FF recept ( 423) 361 71.6 4e-12 NP_004876 (OMIM: 607449) neuropeptide FF receptor ( 522) 361 71.7 4.5e-12 NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 353 70.3 9.9e-12 XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 353 70.3 9.9e-12 NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 353 70.4 1e-11 NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 353 70.4 1e-11 NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 353 70.4 1e-11 XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 353 70.4 1e-11 XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 353 70.4 1e-11 XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 353 70.4 1e-11 NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 341 68.4 3.9e-11 NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 341 68.4 3.9e-11 NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 341 68.4 4.1e-11 XP_011535972 (OMIM: 605108) PREDICTED: neuromedin- ( 321) 339 67.8 4.1e-11 NP_064552 (OMIM: 605108) neuromedin-U receptor 2 [ ( 415) 339 68.0 4.8e-11 XP_016883344 (OMIM: 602548) PREDICTED: nociceptin ( 365) 336 67.4 6.2e-11 NP_001305783 (OMIM: 602548) nociceptin receptor is ( 365) 336 67.4 6.2e-11 NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 336 67.5 6.7e-11 NP_795344 (OMIM: 118445) gastrin/cholecystokinin t ( 447) 335 67.4 7.8e-11 NP_001517 (OMIM: 602393) orexin receptor type 2 [H ( 444) 334 67.2 8.7e-11 XP_016866287 (OMIM: 602393) PREDICTED: orexin rece ( 461) 334 67.3 8.9e-11 XP_016856596 (OMIM: 602392) PREDICTED: orexin rece ( 389) 328 66.2 1.6e-10 XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cho ( 516) 329 66.5 1.7e-10 NP_001516 (OMIM: 602392) orexin receptor type 1 [H ( 425) 328 66.2 1.7e-10 XP_016856594 (OMIM: 602392) PREDICTED: orexin rece ( 425) 328 66.2 1.7e-10 XP_016856595 (OMIM: 602392) PREDICTED: orexin rece ( 425) 328 66.2 1.7e-10 NP_000721 (OMIM: 118444) cholecystokinin receptor ( 428) 326 65.9 2.1e-10 XP_016874005 (OMIM: 118445) PREDICTED: gastrin/cho ( 381) 322 65.2 3.1e-10 NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 320 64.8 3.9e-10 NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 320 64.9 4.1e-10 NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 316 64.2 6.1e-10 NP_620414 (OMIM: 607122) prokineticin receptor 1 [ ( 393) 314 63.9 7.8e-10 XP_011508791 (OMIM: 604153) PREDICTED: neuromedin- ( 313) 312 63.4 8.7e-10 XP_006712259 (OMIM: 604153) PREDICTED: neuromedin- ( 333) 312 63.5 9e-10 XP_006712258 (OMIM: 604153) PREDICTED: neuromedin- ( 370) 312 63.5 9.5e-10 >>NP_003292 (OMIM: 188545) thyrotropin-releasing hormone (398 aa) initn: 2615 init1: 2615 opt: 2615 Z-score: 2331.4 bits: 440.2 E(85289): 4.1e-123 Smith-Waterman score: 2615; 100.0% identity (100.0% similar) in 398 aa overlap (1-398:1-398) 10 20 30 40 50 60 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES 310 320 330 340 350 360 370 380 390 pF1KE9 DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS :::::::::::::::::::::::::::::::::::::: NP_003 DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS 370 380 390 >>XP_011515565 (OMIM: 188545) PREDICTED: thyrotropin-rel (398 aa) initn: 2615 init1: 2615 opt: 2615 Z-score: 2331.4 bits: 440.2 E(85289): 4.1e-123 Smith-Waterman score: 2615; 100.0% identity (100.0% similar) in 398 aa overlap (1-398:1-398) 10 20 30 40 50 60 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKES 310 320 330 340 350 360 370 380 390 pF1KE9 DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS :::::::::::::::::::::::::::::::::::::: XP_011 DHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS 370 380 390 >>XP_011508789 (OMIM: 604153) PREDICTED: neuromedin-U re (403 aa) initn: 367 init1: 150 opt: 448 Z-score: 415.8 bits: 85.8 E(85289): 2e-16 Smith-Waterman score: 449; 29.5% identity (57.4% similar) in 376 aa overlap (3-351:18-367) 10 20 30 40 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIM : : : : :. . . .: ::.... : ::: . XP_011 MACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVV---GAVGNGL 10 20 30 40 50 50 60 70 80 90 100 pF1KE9 VVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSW-----VYGYVGCLC . ::..: : :::::: :: ::::.::.::.. ::: .: : . : :: XP_011 TCLVILRHKAMRTPTNYYLFSLAVSDLLVLLV-GLPL---ELYEMWHNYPFLLGVGGCYF 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE9 ITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLW : : . :: ..::...:::.:. ::..:. . : ....... ::.. .. : : XP_011 RTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGL-AMLCSLP 120 130 140 150 160 170 170 180 190 200 210 pF1KE9 FFLL----DLNI---STYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGF : .:.. . :. : : : :. . .:. .:: . .::: . XP_011 NTSLHGIRQLHVPCRGPVPDSAV--CMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLL 180 190 200 210 220 230 220 230 240 250 260 pF1KE9 IA------RILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKM :. :.:.. ...: . .... . .. .: .:.::::: XP_011 IGLRLRRERLLLM--------QEAKGRGSAAARSRYTCRLQQHDR-------GRRQVTKM 240 250 260 270 270 280 290 300 310 320 pF1KE9 LAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICI------YLNSAINPVIYN : :.:..:.. : :... :. : .:. . .. : : .. . ::.:: :::.:. XP_011 LFVLVVVFGICWAPFHADRVMWSVVSQ-WTDGLHLAFQHVHVISGIFFYLGSAANPVLYS 280 290 300 310 320 330 330 340 350 360 370 pF1KE9 LMSQKFRAAFRK-LC--NCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLS :::..:: .:.. :: : .. . ...:.. XP_011 LMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGP 340 350 360 370 380 390 380 390 pF1KE9 ATKVSFDDTCLASEVSFSQS XP_011 EAQQETDPS 400 >>NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [Homo (426 aa) initn: 367 init1: 150 opt: 448 Z-score: 415.6 bits: 85.9 E(85289): 2.1e-16 Smith-Waterman score: 449; 29.5% identity (57.4% similar) in 376 aa overlap (3-351:41-390) 10 20 30 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLV : : : : :. . . .: ::. NP_006 LPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE9 LIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSW- ... : ::: .. ::..: : :::::: :: ::::.::.::.. ::: .: : NP_006 FVV---GAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLV-GLPL---ELYEMWH 80 90 100 110 120 100 110 120 130 140 pF1KE9 ----VYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIII . : :: : : . :: ..::...:::.:. ::..:. . : ....... NP_006 NYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLG 130 140 150 160 170 180 150 160 170 180 190 200 pF1KE9 FVWAFTSLYCMLWFFLL----DLNI---STYKDAIVISCGYKISRNYYSPIYLMDFGVFY ::.. .. : : : .:.. . :. : : : :. . .:. NP_006 AVWGL-AMLCSLPNTSLHGIRQLHVPCRGPVPDSAV--CMLVRPRALYNMVVQTTALLFF 190 200 210 220 230 240 210 220 230 240 250 pF1KE9 VVPMILATVLYGFIA------RILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCF .:: . .::: .:. :.:.. ...: . .... . .. .: NP_006 CLPMAIMSVLYLLIGLRLRRERLLLM--------QEAKGRGSAAARSRYTCRLQQHDR-- 250 260 270 280 290 260 270 280 290 300 pF1KE9 NSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICI----- .:.:::::: :.:..:.. : :... :. : .:. . .. : : .. . NP_006 -----GRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQ-WTDGLHLAFQHVHVISGIF 300 310 320 330 340 310 320 330 340 350 360 pF1KE9 -YLNSAINPVIYNLMSQKFRAAFRK-LC--NCKQKPTEKPANYSVALNYSVIKESDHFST ::.:: :::.:.:::..:: .:.. :: : .. . ...:.. NP_006 FYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSL 350 360 370 380 390 400 370 380 390 pF1KE9 ELDDITVTDTYLSATKVSFDDTCLASEVSFSQS NP_006 GSWVHPLAGNDGPEAQQETDPS 410 420 >>NP_002522 (OMIM: 162651) neurotensin receptor type 1 [ (418 aa) initn: 323 init1: 186 opt: 393 Z-score: 367.1 bits: 76.8 E(85289): 1e-13 Smith-Waterman score: 393; 24.6% identity (59.4% similar) in 362 aa overlap (3-346:43-394) 10 20 30 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLV .: : ...:. . . . :... :. NP_002 TPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLA 20 30 40 50 60 70 40 50 60 70 80 pF1KE9 LIICGLGIVGNIMVVLVVMRTKHMRT---PTNCYLVSLAVADLMVLVAAGLPNITDSIY- :.. .: ::: ...... : : ... .. .: :::..::..:. : .. . :. NP_002 LFV--VGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWV 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE9 -GSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIII :..: .:: .:. :.. .......:::.:::::.::. : . ::.::.: NP_002 HHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFIS 140 150 160 170 180 190 150 160 170 180 190 200 pF1KE9 FVWAFTSLYCMLWFFLL-DLNISTY-KDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMI .: ..: . .: . . : :. . : . : : . . .. . .. ::. NP_002 AIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMV 200 210 220 230 240 250 210 220 230 240 250 260 pF1KE9 LATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVT . .:: .:: : . . . :.... . :.. .. .. . :.. .. . NP_002 VISVLNTIIANKLTV--MVRQAAEQGQVCTVGGEHSTFSMAIEPGR------VQALRHGV 260 270 280 290 300 270 280 290 300 310 pF1KE9 KMLAVVVILFALLWMPYRTLVVVNSFLS----SPFQENWFLLFCRIC---IYLNSAINPV ..: .::: :.. :.::.. .. ..: .:: ... : . .:..:.:::. NP_002 RVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPI 310 320 330 340 350 360 320 330 340 350 360 370 pF1KE9 IYNLMSQKFRAAFRK----LCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTD .:::.: .:: : :: .. ..:: NP_002 LYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY 370 380 390 400 410 380 390 pF1KE9 TYLSATKVSFDDTCLASEVSFSQS >>NP_001305782 (OMIM: 602548) nociceptin receptor isofor (399 aa) initn: 335 init1: 132 opt: 368 Z-score: 345.2 bits: 72.7 E(85289): 1.7e-12 Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335) 10 20 30 40 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV : . : .:. . : : .: :..:: .:. NP_001 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY :..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..: NP_001 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL .. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. . NP_001 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI .. . : : .: ..:..:.. . . .: ..::... .: :... : : . NP_001 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR : .:... :: ...:... ::: .:. : : . NP_001 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ 250 260 270 280 290 300 310 320 330 340 pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP ..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: : NP_001 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL 290 300 310 320 330 350 360 370 380 390 pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS NP_001 RRDVQVSDRVRSIAKDVALACKTSETVPRPAXLGVDLPMVPVSPQSPSTPNTELTQVTAL 340 350 360 370 380 390 >>NP_001186948 (OMIM: 602548) nociceptin receptor isofor (370 aa) initn: 368 init1: 132 opt: 364 Z-score: 342.0 bits: 72.0 E(85289): 2.6e-12 Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335) 10 20 30 40 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV : . : .:. . : : .: :..:: .:. NP_001 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY :..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..: NP_001 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL .. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. . NP_001 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI .. . : : .: ..:..:.. . . .: ..::... .: :... : : . NP_001 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR : .:... :: ...:... ::: .:. : : . NP_001 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ 250 260 270 280 290 300 310 320 330 340 pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP ..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: : NP_001 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL 290 300 310 320 330 350 360 370 380 390 pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS NP_001 RRDVQVSDRVRSIAKDVALACKTSETVPRPA 340 350 360 370 >>NP_000904 (OMIM: 602548) nociceptin receptor isoform 1 (370 aa) initn: 368 init1: 132 opt: 364 Z-score: 342.0 bits: 72.0 E(85289): 2.6e-12 Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335) 10 20 30 40 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV : . : .:. . : : .: :..:: .:. NP_000 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY :..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..: NP_000 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL .. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. . NP_000 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI .. . : : .: ..:..:.. . . .: ..::... .: :... : : . NP_000 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR : .:... :: ...:... ::: .:. : : . NP_000 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ 250 260 270 280 290 300 310 320 330 340 pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP ..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: : NP_000 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL 290 300 310 320 330 350 360 370 380 390 pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS NP_000 RRDVQVSDRVRSIAKDVALACKTSETVPRPA 340 350 360 370 >>XP_016883343 (OMIM: 602548) PREDICTED: nociceptin rece (370 aa) initn: 368 init1: 132 opt: 364 Z-score: 342.0 bits: 72.0 E(85289): 2.6e-12 Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335) 10 20 30 40 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV : . : .:. . : : .: :..:: .:. XP_016 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY :..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..: XP_016 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL .. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. . XP_016 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI .. . : : .: ..:..:.. . . .: ..::... .: :... : : . XP_016 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR : .:... :: ...:... ::: .:. : : . XP_016 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ 250 260 270 280 290 300 310 320 330 340 pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP ..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: : XP_016 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL 290 300 310 320 330 350 360 370 380 390 pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS XP_016 RRDVQVSDRVRSIAKDVALACKTSETVPRPA 340 350 360 370 >>NP_872588 (OMIM: 602548) nociceptin receptor isoform 1 (370 aa) initn: 368 init1: 132 opt: 364 Z-score: 342.0 bits: 72.0 E(85289): 2.6e-12 Smith-Waterman score: 482; 28.2% identity (61.7% similar) in 326 aa overlap (18-337:44-335) 10 20 30 40 pF1KE9 MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVV : . : .:. . : : .: :..:: .:. NP_872 YGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVM 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE9 LVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLP-NITDSIYGSWVYGYVGCLCITYLQY :..: .:.: :: :. .::.:: .::.. :: . :: . : : .: . : . ..: NP_872 YVILRHTKMKTATNIYIFNLALADTLVLLT--LPFQGTDILLGFWPFGNALCKTVIAIDY 80 90 100 110 120 130 110 120 130 140 150 160 pF1KE9 LGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDL .. .:. ..::....::.::::::.: . : :.:. . . .::..:. . .. . NP_872 YNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSA 140 150 160 170 180 190 170 180 190 200 210 220 pF1KE9 NISTYKDAIVISCGYKIS--RNYYSPIYLMDFGVF-YVVPMILATVLYGFIARILFLNPI .. . : : .: ..:..:.. . . .: ..::... .: :... : : . NP_872 QVEDEE----IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRL 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 PSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYR : .:... :: ...:... ::: .:. : : . NP_872 LSGSREKDR-----------NL----------------RRITRLVLVVVAVFVGCWTPVQ 250 260 270 280 290 300 310 320 330 340 pF1KE9 TLVVVNSFLSSPFQENW--FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKP ..:..... .: .:. .: :: :.:: .::..: .....:.: :::.: : NP_872 VFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFC-CASAL 290 300 310 320 330 350 360 370 380 390 pF1KE9 TEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS NP_872 RRDVQVSDRVRSIAKDVALACKTSETVPRPA 340 350 360 370 398 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 16:04:22 2016 done: Sun Nov 6 16:04:23 2016 Total Scan time: 6.760 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]