FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2452, 529 aa 1>>>pF1KE2452 529 - 529 aa - 529 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.5485+/-0.0003; mu= 13.1909+/- 0.019 mean_var=91.8232+/-18.300, 0's: 0 Z-trim(119.2): 173 B-trim: 0 in 0/51 Lambda= 0.133844 statistics sampled from 32881 (33066) to 32881 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.388), width: 16 Scan time: 10.720 The best scores are: opt bits E(85289) XP_011542690 (OMIM: 118502,610353) PREDICTED: neur ( 529) 3658 716.2 6.2e-206 XP_006716345 (OMIM: 118502,610353) PREDICTED: neur ( 529) 3658 716.2 6.2e-206 NP_000733 (OMIM: 118502,610353) neuronal acetylcho ( 529) 3658 716.2 6.2e-206 NP_001269384 (OMIM: 118502,610353) neuronal acetyl ( 514) 2986 586.4 7e-167 XP_005273454 (OMIM: 118502,610353) PREDICTED: neur ( 370) 2539 500.0 5e-141 XP_016868492 (OMIM: 118502,610353) PREDICTED: neur ( 370) 2539 500.0 5e-141 XP_016868493 (OMIM: 118502,610353) PREDICTED: neur ( 331) 2258 445.7 9.8e-125 XP_011542691 (OMIM: 118502,610353) PREDICTED: neur ( 331) 2258 445.7 9.8e-125 NP_000735 (OMIM: 118504,188890,600513) neuronal ac ( 627) 1919 380.4 8.7e-105 NP_000734 (OMIM: 118503,612052) neuronal acetylcho ( 505) 1841 365.3 2.5e-100 XP_006720445 (OMIM: 118503,612052) PREDICTED: neur ( 438) 1720 341.9 2.4e-93 XP_016883113 (OMIM: 118504,188890,600513) PREDICTE ( 546) 1654 329.2 2e-89 NP_001160166 (OMIM: 118503,612052) neuronal acetyl ( 489) 1639 326.3 1.3e-88 NP_004189 (OMIM: 606888) neuronal acetylcholine re ( 494) 1522 303.7 8.4e-82 NP_000740 (OMIM: 118508) neuronal acetylcholine re ( 458) 1423 284.6 4.5e-76 NP_000736 (OMIM: 118505,612052) neuronal acetylcho ( 468) 1397 279.6 1.5e-74 XP_011526826 (OMIM: 118504,188890,600513) PREDICTE ( 556) 1370 274.4 6.4e-73 NP_001186208 (OMIM: 606888) neuronal acetylcholine ( 479) 1318 264.3 5.9e-70 NP_000739 (OMIM: 118507,605375) neuronal acetylcho ( 502) 1314 263.5 1.1e-69 XP_011519489 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 1289 258.7 3e-68 XP_011519488 (OMIM: 118509) PREDICTED: neuronal ac ( 495) 1289 258.7 3e-68 NP_001177384 (OMIM: 118511,612001) neuronal acetyl ( 531) 1285 257.9 5.4e-68 XP_016858746 (OMIM: 100690,253290,601462,608930) P ( 464) 1283 257.5 6.2e-68 XP_016877378 (OMIM: 118509) PREDICTED: neuronal ac ( 449) 1281 257.1 7.9e-68 NP_000070 (OMIM: 100690,253290,601462,608930) acet ( 457) 1281 257.1 8e-68 XP_016877377 (OMIM: 118509) PREDICTED: neuronal ac ( 462) 1281 257.1 8.1e-68 XP_016877376 (OMIM: 118509) PREDICTED: neuronal ac ( 463) 1281 257.1 8.1e-68 NP_000741 (OMIM: 118509) neuronal acetylcholine re ( 498) 1281 257.2 8.7e-68 XP_016877374 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 1278 256.6 1.2e-67 XP_016877375 (OMIM: 118509) PREDICTED: neuronal ac ( 468) 1278 256.6 1.2e-67 NP_000737 (OMIM: 118511,612001) neuronal acetylcho ( 502) 1232 247.7 6.2e-65 XP_011519492 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1176 236.9 9.6e-62 XP_011519493 (OMIM: 118509) PREDICTED: neuronal ac ( 424) 1176 236.9 9.6e-62 XP_011519478 (OMIM: 118511,612001) PREDICTED: neur ( 486) 1119 225.9 2.2e-58 NP_001034612 (OMIM: 100690,253290,601462,608930) a ( 482) 1113 224.7 4.9e-58 XP_016858745 (OMIM: 100690,253290,601462,608930) P ( 489) 1113 224.7 5e-58 NP_001243502 (OMIM: 118504,188890,600513) neuronal ( 451) 1076 217.6 6.6e-56 XP_016883114 (OMIM: 118504,188890,600513) PREDICTE ( 451) 1076 217.6 6.6e-56 NP_065135 (OMIM: 606372) neuronal acetylcholine re ( 450) 989 200.8 7.5e-51 NP_060051 (OMIM: 605116) neuronal acetylcholine re ( 479) 971 197.3 8.8e-50 XP_011519480 (OMIM: 118511,612001) PREDICTED: neur ( 380) 965 196.1 1.6e-49 XP_011542692 (OMIM: 118508) PREDICTED: neuronal ac ( 329) 917 186.8 8.7e-47 XP_011519479 (OMIM: 118511,612001) PREDICTED: neur ( 401) 907 184.9 3.9e-46 NP_647536 (OMIM: 609756) CHRNA7-FAM7A fusion prote ( 412) 903 184.1 6.9e-46 XP_011520455 (OMIM: 609756) PREDICTED: CHRNA7-FAM7 ( 412) 903 184.1 6.9e-46 XP_016877372 (OMIM: 118511,612001) PREDICTED: neur ( 440) 903 184.1 7.3e-46 XP_016877371 (OMIM: 118511,612001) PREDICTED: neur ( 441) 903 184.2 7.3e-46 XP_016877370 (OMIM: 118505,612052) PREDICTED: neur ( 245) 851 174.0 4.6e-43 XP_005254199 (OMIM: 118505,612052) PREDICTED: neur ( 243) 850 173.8 5.2e-43 XP_016855669 (OMIM: 118507,605375) PREDICTED: neur ( 332) 746 153.8 7.6e-37 >>XP_011542690 (OMIM: 118502,610353) PREDICTED: neuronal (529 aa) initn: 3658 init1: 3658 opt: 3658 Z-score: 3818.2 bits: 716.2 E(85289): 6.2e-206 Smith-Waterman score: 3658; 100.0% identity (100.0% similar) in 529 aa overlap (1-529:1-529) 10 20 30 40 50 60 pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL 430 440 450 460 470 480 490 500 510 520 pF1KE2 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI ::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 490 500 510 520 >>XP_006716345 (OMIM: 118502,610353) PREDICTED: neuronal (529 aa) initn: 3658 init1: 3658 opt: 3658 Z-score: 3818.2 bits: 716.2 E(85289): 6.2e-206 Smith-Waterman score: 3658; 100.0% identity (100.0% similar) in 529 aa overlap (1-529:1-529) 10 20 30 40 50 60 pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL 430 440 450 460 470 480 490 500 510 520 pF1KE2 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI ::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 490 500 510 520 >>NP_000733 (OMIM: 118502,610353) neuronal acetylcholine (529 aa) initn: 3658 init1: 3658 opt: 3658 Z-score: 3818.2 bits: 716.2 E(85289): 6.2e-206 Smith-Waterman score: 3658; 100.0% identity (100.0% similar) in 529 aa overlap (1-529:1-529) 10 20 30 40 50 60 pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE2 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE2 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL 430 440 450 460 470 480 490 500 510 520 pF1KE2 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI ::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 490 500 510 520 >>NP_001269384 (OMIM: 118502,610353) neuronal acetylchol (514 aa) initn: 2983 init1: 2983 opt: 2986 Z-score: 3117.1 bits: 586.4 E(85289): 7e-167 Smith-Waterman score: 3530; 97.2% identity (97.2% similar) in 529 aa overlap (1-529:1-514) 10 20 30 40 50 60 pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKL ::::::::::::::::::::::: :::::::::::::::::::::: NP_001 RLFKHLFRGYNRWARPVPNTSDV---------------DEKNQMMTTNVWLKQEWSDYKL 70 80 90 100 130 140 150 160 170 180 pF1KE2 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYK 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE2 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTY 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE2 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLC 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE2 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTH 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE2 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEE 350 360 370 380 390 400 430 440 450 460 470 480 pF1KE2 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHL 410 420 430 440 450 460 490 500 510 520 pF1KE2 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 470 480 490 500 510 >>XP_005273454 (OMIM: 118502,610353) PREDICTED: neuronal (370 aa) initn: 2539 init1: 2539 opt: 2539 Z-score: 2652.8 bits: 500.0 E(85289): 5e-141 Smith-Waterman score: 2539; 100.0% identity (100.0% similar) in 370 aa overlap (160-529:1-370) 130 140 150 160 170 180 pF1KE2 ITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTF :::::::::::::::::::::::::::::: XP_005 MTKAHLFSTGTVHWVPPAIYKSSCSIDVTF 10 20 30 190 200 210 220 230 240 pF1KE2 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE2 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE2 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE2 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE2 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV 280 290 300 310 320 330 490 500 510 520 pF1KE2 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI :::::::::::::::::::::::::::::::::::::::: XP_005 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 340 350 360 370 >>XP_016868492 (OMIM: 118502,610353) PREDICTED: neuronal (370 aa) initn: 2539 init1: 2539 opt: 2539 Z-score: 2652.8 bits: 500.0 E(85289): 5e-141 Smith-Waterman score: 2539; 100.0% identity (100.0% similar) in 370 aa overlap (160-529:1-370) 130 140 150 160 170 180 pF1KE2 ITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTF :::::::::::::::::::::::::::::: XP_016 MTKAHLFSTGTVHWVPPAIYKSSCSIDVTF 10 20 30 190 200 210 220 230 240 pF1KE2 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCA 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE2 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTV 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE2 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGA 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE2 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHV 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE2 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV 280 290 300 310 320 330 490 500 510 520 pF1KE2 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI :::::::::::::::::::::::::::::::::::::::: XP_016 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI 340 350 360 370 >>XP_016868493 (OMIM: 118502,610353) PREDICTED: neuronal (331 aa) initn: 2258 init1: 2258 opt: 2258 Z-score: 2360.4 bits: 445.7 E(85289): 9.8e-125 Smith-Waterman score: 2258; 100.0% identity (100.0% similar) in 331 aa overlap (199-529:1-331) 170 180 190 200 210 220 pF1KE2 GTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWES :::::::::::::::::::::::::::::: XP_016 MKFGSWTYDKAKIDLEQMEQTVDLKDYWES 10 20 30 230 240 250 260 270 280 pF1KE2 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE2 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE2 VLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNV 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE2 DAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQK 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE2 ALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGM 280 290 300 310 320 330 pF1KE2 I : XP_016 I >>XP_011542691 (OMIM: 118502,610353) PREDICTED: neuronal (331 aa) initn: 2258 init1: 2258 opt: 2258 Z-score: 2360.4 bits: 445.7 E(85289): 9.8e-125 Smith-Waterman score: 2258; 100.0% identity (100.0% similar) in 331 aa overlap (199-529:1-331) 170 180 190 200 210 220 pF1KE2 GTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWES :::::::::::::::::::::::::::::: XP_011 MKFGSWTYDKAKIDLEQMEQTVDLKDYWES 10 20 30 230 240 250 260 270 280 pF1KE2 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFY 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE2 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVF 100 110 120 130 140 150 350 360 370 380 390 400 pF1KE2 VLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLNVHHRSPSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNV 160 170 180 190 200 210 410 420 430 440 450 460 pF1KE2 DAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQK 220 230 240 250 260 270 470 480 490 500 510 520 pF1KE2 ALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGM 280 290 300 310 320 330 pF1KE2 I : XP_011 I >>NP_000735 (OMIM: 118504,188890,600513) neuronal acetyl (627 aa) initn: 2271 init1: 1898 opt: 1919 Z-score: 2002.2 bits: 380.4 E(85289): 8.7e-105 Smith-Waterman score: 1919; 75.1% identity (86.3% similar) in 386 aa overlap (25-406:4-380) 10 20 30 40 50 pF1KE2 MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTET-- :: : : : :: :.: ...::.:: NP_000 MELGGPGAPRLLP-----PLLLLLGTGLLRASSHVETRA 10 20 30 60 70 80 90 100 110 pF1KE2 --EDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWS :.::.:.:: :::.:.::: : ::::.:::::::::::::::::::::::::.:::: NP_000 HAEERLLKKLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWH 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE2 DYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPP ::::::.:.:. :.::.:.:::.:: :::::::::::.:::::.:::::: : :.:.:: NP_000 DYKLRWDPADYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPP 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE2 AIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNA ::::::::::::::::::::: ::::::::::::::: .:.. :: :.::::::.::.: NP_000 AIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDA 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE2 TGTYNSKKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEK .::::..::.::::::::.::::::::::::::::::::::::::::::::::::.:::: NP_000 VGTYNTRKYECCAEIYPDITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEK 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE2 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRS 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE2 PSTHTMPHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVV : ::::: ::: ..: ::: :::.:: . :. .: :.: . : NP_000 PRTHTMPTWVRRVFLDIVPRLLLMKRPSVVKDNCR----RLIESMHKMASAPRFWPEPEG 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE2 VEEEDRWACAGHVAPSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYI NP_000 EPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQPLEAEKASPHPSPGPCR 400 410 420 430 440 450 >-- initn: 480 init1: 387 opt: 387 Z-score: 403.5 bits: 84.6 E(85289): 9.8e-16 Smith-Waterman score: 387; 78.6% identity (94.3% similar) in 70 aa overlap (460-529:558-627) 430 440 450 460 470 480 pF1KE2 APSVGTLCSHGHLHSGASGPKAEALLQEGELLLSPHMQKALEGVHYIADHLRSEDADSSV : ::: . .:.:::.::::::..::.: :: NP_000 PCKCTCKKEPSSVSPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSV 530 540 550 560 570 580 490 500 510 520 pF1KE2 KEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI :::::::::::::::::.:::::.:::.::::::.::::: NP_000 KEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAGMI 590 600 610 620 >>NP_000734 (OMIM: 118503,612052) neuronal acetylcholine (505 aa) initn: 1864 init1: 1602 opt: 1841 Z-score: 1922.3 bits: 365.3 E(85289): 2.5e-100 Smith-Waterman score: 1842; 56.7% identity (76.1% similar) in 506 aa overlap (33-526:14-501) 10 20 30 40 50 60 pF1KE2 PSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPPRAPGDPLSSPSPTALPQGGSHTETEDRL ::: : : :.: .:.: :: NP_000 MGSGPLSLPLALSPPRLLLLLLLSLLPVA-----RASEAEHRL 10 20 30 70 80 90 100 110 120 pF1KE2 FKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRW :..::. ::. ::: :.:: ::..: .:..::. ::: ::.: ::.:::: :.::::.: NP_000 FERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKW 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE2 NPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSS ::.:.:. .:::.. :: ::::::::: :.: : ::: : :: : :.::::.::: NP_000 NPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSS 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE2 CSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMEQTVDLKDYWESGEWAIVNATGTYNS :.::::.:::: ::: ::::::.:::::::: . ....::::::::::::..: : .. NP_000 CKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHD 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE2 KKYDCCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCIS ::.:: :::::.::.. :::::::::::::::::::: :::::::::::::::.::::: NP_000 IKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCIS 220 230 240 250 260 270 310 320 330 340 350 360 pF1KE2 VLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTM ::::::::::.::: ::::::::::::::::::::::::::::::::::::.:.:.:::: NP_000 VLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTM 280 290 300 310 320 330 370 380 390 400 410 420 pF1KE2 PHWVRGALLGCVPRWLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDR : ::. ..:. .:: ..:.:: . : : : ::.. : :.. NP_000 PSWVKTVFLNLLPRVMFMTRPTSNEGNAQKPR----PLYGAELSNLNCFSRA-----ESK 340 350 360 370 380 430 440 450 460 470 pF1KE2 WACAGHVAPSVGTLCSHGH------------LHSGASGPKAEALLQEGELLLSPHMQKAL :. : .:.. : : ..:. ...:.:. . : ::....:. NP_000 GCKEGY--PCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSAL--SPEIKEAI 390 400 410 420 430 440 480 490 500 510 520 pF1KE2 EGVHYIADHLRSEDADSSVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFLPPFLAGMI ..:.:::....... . ...:::::::::::::::.: .::.::: :::: :..: NP_000 QSVKYIAENMKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQPLMAREDA 450 460 470 480 490 500 529 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:15:18 2016 done: Sat Nov 5 04:15:19 2016 Total Scan time: 10.720 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]