Result of FASTA (omim) for
pFN21AE3419
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3419, 475 aa
1>>>pF1KE3419 475 - 475 aa - 475 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.5583+/-0.000424; mu= 23.1416+/- 0.027
mean_var=173.8082+/-41.830, 0's: 0 Z-trim(113.4): 662 B-trim: 2285 in 2/51
Lambda= 0.097283
statistics sampled from 21809 (22765) to 21809 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.267), width: 16
Scan time: 9.010
The best scores are: opt bits E(85289)
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 3183 460.1 6.2e-129
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 3183 460.1 6.2e-129
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 3183 460.1 6.2e-129
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 3183 460.1 6.2e-129
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 2860 414.7 2.7e-115
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 2846 412.7 1e-114
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 2834 411.0 3.3e-114
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 2834 411.0 3.3e-114
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 1983 291.4 2.8e-78
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 1980 290.9 3.5e-78
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 1962 288.4 2e-77
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 1953 287.1 4.7e-77
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 1953 287.2 4.9e-77
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 1953 287.2 5.1e-77
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 1527 227.7 5.9e-59
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 1470 219.8 1.6e-56
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 1296 195.1 3e-49
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 1294 194.8 3.7e-49
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 1272 192.0 3.6e-48
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 1256 189.3 1.4e-47
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 1255 189.2 1.5e-47
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 1254 189.1 1.7e-47
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 784 123.4 1.4e-27
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 770 121.3 5.3e-27
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 768 121.0 6.4e-27
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 705 112.2 2.9e-24
NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 675 107.8 5e-23
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 652 104.8 5.2e-22
NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 611 99.0 2.8e-20
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 568 93.0 1.8e-18
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 558 91.6 4.8e-18
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 550 90.4 9.9e-18
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 545 89.6 1.6e-17
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 545 89.6 1.6e-17
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 545 89.7 1.6e-17
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 545 89.7 1.6e-17
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 545 89.7 1.7e-17
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 542 89.4 2.3e-17
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 524 86.9 1.3e-16
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 520 86.3 2e-16
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 511 84.8 4.2e-16
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 511 84.8 4.3e-16
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 511 84.9 4.4e-16
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 511 85.0 4.6e-16
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 511 85.0 4.6e-16
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 511 85.0 4.6e-16
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 511 85.0 4.6e-16
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 511 85.0 4.6e-16
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 508 84.4 5.7e-16
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 508 84.4 5.7e-16
>>XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 3183 init1: 3183 opt: 3183 Z-score: 2435.8 bits: 460.1 E(85289): 6.2e-129
Smith-Waterman score: 3183; 99.8% identity (99.8% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_016 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
430 440 450 460 470
>>NP_150646 (OMIM: 104221) alpha-1A adrenergic receptor (475 aa)
initn: 3183 init1: 3183 opt: 3183 Z-score: 2435.8 bits: 460.1 E(85289): 6.2e-129
Smith-Waterman score: 3183; 99.8% identity (99.8% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_150 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
430 440 450 460 470
>>XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 3183 init1: 3183 opt: 3183 Z-score: 2435.8 bits: 460.1 E(85289): 6.2e-129
Smith-Waterman score: 3183; 99.8% identity (99.8% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_016 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
430 440 450 460 470
>>XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A adrene (475 aa)
initn: 3183 init1: 3183 opt: 3183 Z-score: 2435.8 bits: 460.1 E(85289): 6.2e-129
Smith-Waterman score: 3183; 99.8% identity (99.8% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_006 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
430 440 450 460 470
>>NP_000671 (OMIM: 104221) alpha-1A adrenergic receptor (466 aa)
initn: 2911 init1: 2860 opt: 2860 Z-score: 2190.9 bits: 414.7 E(85289): 2.7e-115
Smith-Waterman score: 2860; 97.9% identity (99.1% similar) in 434 aa overlap (1-434:1-434)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_000 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
:::..:.: .. :
NP_000 TARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
430 440 450 460
>>NP_150647 (OMIM: 104221) alpha-1A adrenergic receptor (455 aa)
initn: 2834 init1: 2834 opt: 2846 Z-score: 2180.3 bits: 412.7 E(85289): 1e-114
Smith-Waterman score: 2846; 95.1% identity (96.0% similar) in 452 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_150 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 TART--KSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
::: : :. .: : : :. .: :
NP_150 TARRGMDCRYFTK-NCREHI-KHVNFMMPPWRKGSEC
430 440 450
>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa)
initn: 2834 init1: 2834 opt: 2834 Z-score: 2171.4 bits: 411.0 E(85289): 3.3e-114
Smith-Waterman score: 2834; 99.8% identity (99.8% similar) in 423 aa overlap (1-423:1-423)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
NP_150 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_150 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
:::
NP_150 TARGHTPMT
>>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa)
initn: 2834 init1: 2834 opt: 2834 Z-score: 2171.4 bits: 411.0 E(85289): 3.3e-114
Smith-Waterman score: 2834; 99.8% identity (99.8% similar) in 423 aa overlap (1-423:1-423)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
:::::::::::::::::::::::::::::::::::::::::::::: :::::::::::::
XP_006 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCT
370 380 390 400 410 420
430 440 450 460 470
pF1KE3 TARTKSRSVTRLECSGMILAHCNLRLPGSRDSPASASQAAGTTGMCHQADATRPS
:::
XP_006 TARGHTPMT
>>NP_001309431 (OMIM: 104221) alpha-1A adrenergic recept (372 aa)
initn: 2011 init1: 1983 opt: 1983 Z-score: 1526.4 bits: 291.4 E(85289): 2.8e-78
Smith-Waterman score: 1983; 98.0% identity (99.0% similar) in 304 aa overlap (1-304:1-304)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::. :
NP_001 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGTHTHD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
.::.
NP_001 MKPASRPRLLSLLPKEGEHETHHWSCDPLSLESTPGAQEPCLTLGFTSLSSIHLTKAQIQ
310 320 330 340 350 360
>>XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A adrene (324 aa)
initn: 1995 init1: 1967 opt: 1980 Z-score: 1524.6 bits: 290.9 E(85289): 3.5e-78
Smith-Waterman score: 1980; 93.8% identity (96.2% similar) in 320 aa overlap (1-320:1-313)
10 20 30 40 50 60
pF1KE3 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 THYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
:::::::::::::::::::::::::::::::::::::::::::::::::::::::...
XP_011 APAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGTYI--
250 260 270 280 290
310 320 330 340 350 360
pF1KE3 FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHALGYTL
.: . ..:: :. :
XP_011 LK-----YDVLFWRKGLSVCTRLRERKEIKN
300 310 320
475 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 02:11:28 2016 done: Tue Nov 8 02:11:29 2016
Total Scan time: 9.010 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]