FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2197, 378 aa 1>>>pF1KE2197 378 - 378 aa - 378 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4243+/-0.000815; mu= 16.1773+/- 0.049 mean_var=67.6175+/-13.630, 0's: 0 Z-trim(106.6): 22 B-trim: 10 in 1/49 Lambda= 0.155971 statistics sampled from 9068 (9082) to 9068 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.279), width: 16 Scan time: 2.610 The best scores are: opt bits E(32554) CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 ( 378) 2606 595.3 2.9e-170 CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 ( 378) 2565 586.1 1.7e-167 CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 ( 407) 1329 308.0 9.7e-84 CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 ( 291) 823 194.0 1.4e-49 CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 ( 241) 716 169.9 2.1e-42 CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 ( 284) 601 144.1 1.5e-34 CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 ( 239) 429 105.3 5.7e-23 >>CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 (378 aa) initn: 2606 init1: 2606 opt: 2606 Z-score: 3170.3 bits: 595.3 E(32554): 2.9e-170 Smith-Waterman score: 2606; 99.7% identity (100.0% similar) in 378 aa overlap (1-378:1-378) 10 20 30 40 50 60 pF1KE2 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ :::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::: CCDS58 CDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS58 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM 310 320 330 340 350 360 370 pF1KE2 YRVWIQCKYCKPLLSSTS :::::::::::::::::: CCDS58 YRVWIQCKYCKPLLSSTS 370 >>CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 (378 aa) initn: 2565 init1: 2565 opt: 2565 Z-score: 3120.4 bits: 586.1 E(32554): 1.7e-167 Smith-Waterman score: 2565; 98.7% identity (99.2% similar) in 378 aa overlap (1-378:1-378) 10 20 30 40 50 60 pF1KE2 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ :::::::::::.::::::::::::: :::::::::::::::::::::::::::::::::: CCDS45 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 RVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSA ::: :::::::::::::::::::::::::::::: ::::::::::::::::::::::::: CCDS45 SEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 TYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE2 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQ :::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::: CCDS45 CDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE2 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 LRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTM 310 320 330 340 350 360 370 pF1KE2 YRVWIQCKYCKPLLSSTS :::::::::::::::::: CCDS45 YRVWIQCKYCKPLLSSTS 370 >>CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 (407 aa) initn: 1318 init1: 795 opt: 1329 Z-score: 1616.8 bits: 308.0 E(32554): 9.7e-84 Smith-Waterman score: 1329; 55.4% identity (78.4% similar) in 361 aa overlap (20-373:31-390) 10 20 30 40 pF1KE2 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAA .:::.:.:::.::.:: ::...::.:. :: CCDS22 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ :..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ... CCDS22 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 NHLK----DWFLENKSEVCECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQ . : .: . :. . . . : . :..: . :: : : ...: :. .. CCDS22 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV : . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.::: CCDS22 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE2 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLL ...: : ..:::::::.::. :: : : ::.:.:.::::.: ::.:: ..::::.:: CCDS22 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE2 KPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV :::::.:.::::::: .:::::::.::: ::::::::::.::::. :. ..: :.:.. CCDS22 KPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEK 300 310 320 330 340 350 350 360 370 pF1KE2 QNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS :::::::::::: ::. :.::::: :. ::: CCDS22 QNLVDRRLQVNRKKQVKMHRVWIQGKFQKPLHQTQNSSNMVSTLLSQD 360 370 380 390 400 >>CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 (291 aa) initn: 803 init1: 393 opt: 823 Z-score: 1003.7 bits: 194.0 E(32554): 1.4e-49 Smith-Waterman score: 823; 49.2% identity (74.4% similar) in 258 aa overlap (20-270:31-287) 10 20 30 40 pF1KE2 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAA .:::.:.:::.::.:: ::...::.:. :: CCDS82 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE2 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ :..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ... CCDS82 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE2 NHLK----DWFLENKSEVCECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQ . : .: . :. . . . : . :..: . :: : : ...: :. .. CCDS82 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV : . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.::: CCDS82 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE2 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLL ...: : ..:::::::.::. :: : : ::.:.:.::::.: ::. CCDS82 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLFI 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE2 KPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV >>CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 (241 aa) initn: 694 init1: 284 opt: 716 Z-score: 874.8 bits: 169.9 E(32554): 2.1e-42 Smith-Waterman score: 716; 47.9% identity (72.7% similar) in 238 aa overlap (40-270:1-237) 10 20 30 40 50 60 pF1KE2 PAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVD ..::.:. :::..::.::: :: :.:: CCDS82 MQWSKEEEAAARKKVKENSAVRVLLEEQVK 10 20 30 70 80 90 100 110 120 pF1KE2 YEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLK----DWFLENKSEVCE :: .: :::. :::::.: :::::.::. ::::. : ... . : .: . :. . . CCDS82 YEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSW-DHVKTSATN 40 50 60 70 80 130 140 150 160 170 180 pF1KE2 CRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQKISDLEICADEFPGSSATYR . : . :..: . :: : : ...: :. ..: . . . ::::.::.: CCDS82 RFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFR 90 100 110 120 130 140 190 200 210 220 230 240 pF1KE2 ILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCD :::::::.::.:::::.: .:.: :.:::::.: :.:::...: : ..:::::::.:: CCDS82 ILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCD 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE2 EEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLR . :: : : ::.:.:.::::.: ::. CCDS82 DGLPYPFPDGILDVILLVFVLSSIHPDRTLFI 210 220 230 240 >>CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 (284 aa) initn: 711 init1: 516 opt: 601 Z-score: 733.9 bits: 144.1 E(32554): 1.5e-34 Smith-Waterman score: 607; 38.5% identity (56.2% similar) in 322 aa overlap (51-372:19-269) 30 40 50 60 70 80 pF1KE2 GSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWND :.:..... : . :: : .:.: :. CCDS43 MASLQRKGLQARILTSEEEEKLKRDQTL-VSDFKQQKLEQEAQKNWDL 10 20 30 40 90 100 110 120 130 140 pF1KE2 FYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGLIMEEQ ::: . ..::::::: :: :: .: ::. :: CCDS43 FYKRNSTNFFKDRHWTTREFEEL----------------RS----CREFED--------- 50 60 70 150 160 170 180 190 200 pF1KE2 HKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQ ::.. .::.:::::: .::.:. CCDS43 ----------------------QKLT-----------------MLEAGCGVGNCLFPLLE 80 90 210 220 230 240 250 260 pF1KE2 TNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILI .::..:.: :::: ::: :. : :: :: .: :: .. :: :.:...:: CCDS43 --EDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLI 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE2 FVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGT :::::. ::::. ... . ..:::: ::.:::: :: :.:::: .. :. ::::: ::: CCDS43 FVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGT 160 170 180 190 200 210 330 340 350 360 370 pF1KE2 RVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS : ::::.. : :: .: :.: : : ::. . : . ::..: :. :: CCDS43 RSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVV 220 230 240 250 260 270 CCDS43 LGLDPKS 280 >>CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 (239 aa) initn: 429 init1: 429 opt: 429 Z-score: 525.9 bits: 105.3 E(32554): 5.7e-23 Smith-Waterman score: 429; 47.3% identity (68.0% similar) in 150 aa overlap (223-372:75-224) 200 210 220 230 240 250 pF1KE2 NTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKG . : :: :: .: :: .. :: CCDS77 WDLFYKRNSTNFFKDRHWTTREFEELRSCREQNPLYDTERCKVFQCDLTKDDLLDHVPPE 50 60 70 80 90 100 260 270 280 290 300 310 pF1KE2 SLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGN :.:...:::::::. ::::. ... . ..:::: ::.:::: :: :.:::: .. :. : CCDS77 SVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGEN 110 120 130 140 150 160 320 330 340 350 360 370 pF1KE2 FYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKP :::: :::: ::::.. : :: .: :.: : : ::. . : . ::..: :. :: CCDS77 FYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKP 170 180 190 200 210 220 pF1KE2 LLSSTS CCDS77 PKNPSPVVLGLDPKS 230 378 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 16:17:30 2016 done: Sun Nov 6 16:17:31 2016 Total Scan time: 2.610 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]