FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6459, 453 aa 1>>>pF1KE6459 453 - 453 aa - 453 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1997+/-0.000307; mu= 15.0130+/- 0.019 mean_var=104.1788+/-20.837, 0's: 0 Z-trim(118.9): 42 B-trim: 21 in 1/55 Lambda= 0.125656 statistics sampled from 32318 (32364) to 32318 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.379), width: 16 Scan time: 6.590 The best scores are: opt bits E(85289) NP_004713 (OMIM: 602296,612936) AP-4 complex subun ( 453) 2996 553.4 4.5e-157 XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 2972 549.1 9.2e-156 XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 2972 549.1 9.2e-156 XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 ( 419) 2441 452.8 8.2e-127 XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 ( 385) 2237 415.8 1e-115 XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 ( 284) 1628 305.3 1.4e-82 XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 ( 228) 1568 294.3 2.2e-79 NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 559 111.6 4.3e-24 NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 515 103.6 1.1e-21 NP_001298127 (OMIM: 601024) AP-2 complex subunit m ( 460) 515 103.6 1.1e-21 NP_001123996 (OMIM: 603535) AP-1 complex subunit m ( 435) 409 84.4 6.5e-16 XP_016882909 (OMIM: 603535) PREDICTED: AP-1 comple ( 409) 371 77.5 7.4e-14 NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 ( 423) 273 59.8 1.7e-08 NP_001287816 (OMIM: 607309) AP-1 complex subunit m ( 425) 273 59.8 1.7e-08 NP_001307193 (OMIM: 610366) AP-3 complex subunit m ( 418) 271 59.4 2.1e-08 NP_001307192 (OMIM: 610366) AP-3 complex subunit m ( 418) 271 59.4 2.1e-08 NP_036227 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 271 59.4 2.1e-08 NP_996895 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 271 59.4 2.1e-08 NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 ( 423) 258 57.0 1.1e-07 XP_016882910 (OMIM: 603535) PREDICTED: AP-1 comple ( 397) 220 50.1 1.3e-05 NP_001307194 (OMIM: 610366) AP-3 complex subunit m ( 364) 182 43.2 0.0014 >>NP_004713 (OMIM: 602296,612936) AP-4 complex subunit m (453 aa) initn: 2996 init1: 2996 opt: 2996 Z-score: 2941.0 bits: 553.4 E(85289): 4.5e-157 Smith-Waterman score: 2996; 100.0% identity (100.0% similar) in 453 aa overlap (1-453:1-453) 10 20 30 40 50 60 pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ 370 380 390 400 410 420 430 440 450 pF1KE6 VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI ::::::::::::::::::::::::::::::::: NP_004 VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI 430 440 450 >>XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 com (460 aa) initn: 2668 init1: 2668 opt: 2972 Z-score: 2917.4 bits: 549.1 E(85289): 9.2e-156 Smith-Waterman score: 2972; 98.5% identity (98.5% similar) in 460 aa overlap (1-453:1-460) 10 20 30 40 50 pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVM-------HHHG ::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_005 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTSGGRRHHHG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR 370 380 390 400 410 420 420 430 440 450 pF1KE6 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI :::::::::::::::::::::::::::::::::::::::: XP_005 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI 430 440 450 460 >>XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 com (460 aa) initn: 2668 init1: 2668 opt: 2972 Z-score: 2917.4 bits: 549.1 E(85289): 9.2e-156 Smith-Waterman score: 2972; 98.5% identity (98.5% similar) in 460 aa overlap (1-453:1-460) 10 20 30 40 50 pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVM-------HHHG ::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_011 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTSGGRRHHHG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR 370 380 390 400 410 420 420 430 440 450 pF1KE6 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI :::::::::::::::::::::::::::::::::::::::: XP_011 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI 430 440 450 460 >>XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 com (419 aa) initn: 2478 init1: 2137 opt: 2441 Z-score: 2397.7 bits: 452.8 E(85289): 8.2e-127 Smith-Waterman score: 2586; 89.6% identity (89.6% similar) in 460 aa overlap (1-453:1-419) 10 20 30 40 50 pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVM-------HHHG ::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_006 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTSGGRRHHHG 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR :::::::::::::::::::::::::: XP_006 AELAEGALRWDLPRVQGGSQLSGLFQ---------------------------------- 370 380 420 430 440 450 pF1KE6 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI ::::::::::::::::::::::::::::::::: XP_006 -------VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI 390 400 410 >>XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 com (385 aa) initn: 2237 init1: 2237 opt: 2237 Z-score: 2198.4 bits: 415.8 E(85289): 1e-115 Smith-Waterman score: 2411; 85.0% identity (85.0% similar) in 453 aa overlap (1-453:1-385) 10 20 30 40 50 60 pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR ::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVM----------- 10 20 30 40 70 80 90 100 110 120 pF1KE6 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG ::: XP_005 ---------------------------------------------------------DYG 50 130 140 150 160 170 180 pF1KE6 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD 60 70 80 90 100 110 190 200 210 220 230 240 pF1KE6 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE 120 130 140 150 160 170 250 260 270 280 290 300 pF1KE6 LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP 180 190 200 210 220 230 310 320 330 340 350 360 pF1KE6 SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA 240 250 260 270 280 290 370 380 390 400 410 420 pF1KE6 LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ 300 310 320 330 340 350 430 440 450 pF1KE6 VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI ::::::::::::::::::::::::::::::::: XP_005 VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI 360 370 380 >>XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 com (284 aa) initn: 1678 init1: 1628 opt: 1628 Z-score: 1603.5 bits: 305.3 E(85289): 1.4e-82 Smith-Waterman score: 1773; 87.4% identity (87.4% similar) in 325 aa overlap (129-453:1-284) 100 110 120 130 140 150 pF1KE6 EGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAE :::::::::::::::::::::::::::::: XP_016 MLRNFIQTEAVVSKPFSLFDLSSVGLFGAE 10 20 30 160 170 180 190 200 210 pF1KE6 TQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKS 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE6 FLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGE 100 110 120 130 140 150 280 290 300 310 320 330 pF1KE6 LTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPR 160 170 180 190 200 210 340 350 360 370 380 390 pF1KE6 GVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSAS ::::::::::::::::::::::::::::::::::::::::: XP_016 GVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQ------------------- 220 230 240 250 400 410 420 430 440 450 pF1KE6 PLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI ::::::::::::::::::::::::::::::::: XP_016 ----------------------VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI 260 270 280 >>XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 com (228 aa) initn: 1568 init1: 1568 opt: 1568 Z-score: 1546.1 bits: 294.3 E(85289): 2.2e-79 Smith-Waterman score: 1568; 100.0% identity (100.0% similar) in 228 aa overlap (226-453:1-228) 200 210 220 230 240 250 pF1KE6 SVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSF :::::::::::::::::::::::::::::: XP_016 MRIGLTEEFCVGKSELRGYGPGIRVDEVSF 10 20 30 260 270 280 290 300 310 pF1KE6 HSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYL 40 50 60 70 80 90 320 330 340 350 360 370 pF1KE6 KLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLS 100 110 120 130 140 150 380 390 400 410 420 430 pF1KE6 GLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNAN 160 170 180 190 200 210 440 450 pF1KE6 PHKWVRHLSHSDAYVIRI :::::::::::::::::: XP_016 PHKWVRHLSHSDAYVIRI 220 >>NP_004059 (OMIM: 601024) AP-2 complex subunit mu isofo (435 aa) initn: 474 init1: 136 opt: 559 Z-score: 553.6 bits: 111.6 E(85289): 4.3e-24 Smith-Waterman score: 643; 28.9% identity (63.4% similar) in 464 aa overlap (1-452:1-434) 10 20 30 40 50 60 pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR ::. .:: . ::. :: . .: : : :.... : .. . : . :.:.. NP_004 MIGGLFIYNHKGEVLISRVYRDDIG-RNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVK 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG .:...:...:..::. ..:.: .. ... : :...: .:. : .:.::::::.::.: NP_004 RSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD : :.. : :..:: ... :. . . :.. :.:. . . : .. : NP_004 YPQNSETGALKTFITQQGIKSQHQTKEEQSQI--------TSQVTGQIGWRREGIKYR-- 120 130 140 150 160 190 200 210 220 230 pF1KE6 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCV---G .::.::::.: ...:.. .:..:.. :.:.. .::.: . : ..:..... . : NP_004 ---RNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQG 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 KS---ELRGYGP-GIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP :. : : .: .:. .::. : :..:.:.: . . ::.::. .:::. . :. NP_004 KGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDI--I 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK ::::..: :. . : .:.: . .. .. . : ......: : .. ... . . : NP_004 LPFRVIPLVR-EVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAK 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE6 AELAEGALRWDLPRVQGG--SQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFEL . .:.:. : . :. : ::.:. ... :.. . : : : :..::. NP_004 YKASENAIVWKIKRMAGMKESQISAEIELL-------PTNDKKKWARP----PISMNFEV 350 360 370 380 390 420 430 440 450 pF1KE6 PRHTCSGLQVRFLRLAFRPCGNANPH---KWVRHLSHSDAYVIRI : . :::.::.:.. :.: : . : ::::....: : : NP_004 P-FAPSGLKVRYLKV-FEPKLNYSDHDVIKWVRYIGRSGIYETRC 400 410 420 430 >>NP_001020376 (OMIM: 601024) AP-2 complex subunit mu is (433 aa) initn: 474 init1: 136 opt: 515 Z-score: 510.5 bits: 103.6 E(85289): 1.1e-21 Smith-Waterman score: 641; 28.4% identity (64.0% similar) in 464 aa overlap (1-452:1-432) 10 20 30 40 50 60 pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR ::. .:: . ::. :: . .: : : :.... : .. . : . :.:.. NP_001 MIGGLFIYNHKGEVLISRVYRDDIG-RNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVK 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG .:...:...:..::. ..:.: .. ... : :...: .:. : .:.::::::.::.: NP_001 RSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD : :.. : :..:: ... :. .. .::... :..... .. NP_001 YPQNSETGALKTFITQQGIKSQ--------------TKEEQSQIT-SQVTGQIGWRREGI 120 130 140 150 160 190 200 210 220 230 pF1KE6 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCV---G . ..::.::::.: ...:.. .:..:.. :.:.. .::.: . : ..:..... . : NP_001 KYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQG 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 KS---ELRGYGP-GIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP :. : : .: .:. .::. : :..:.:.: . . ::.::. .:::. . :. NP_001 KGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDI--I 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK ::::..: :. . : .:.: . .. .. . : ......: : .. ... . . : NP_001 LPFRVIPLVR-EVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAK 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE6 AELAEGALRWDLPRVQGG--SQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFEL . .:.:. : . :. : ::.:. ... :.. . : : : :..::. NP_001 YKASENAIVWKIKRMAGMKESQISAEIELL-------PTNDKKKWARP----PISMNFEV 350 360 370 380 390 420 430 440 450 pF1KE6 PRHTCSGLQVRFLRLAFRPCGNANPH---KWVRHLSHSDAYVIRI : . :::.::.:.. :.: : . : ::::....: : : NP_001 P-FAPSGLKVRYLKV-FEPKLNYSDHDVIKWVRYIGRSGIYETRC 400 410 420 430 >>NP_001298127 (OMIM: 601024) AP-2 complex subunit mu is (460 aa) initn: 488 init1: 136 opt: 515 Z-score: 510.2 bits: 103.6 E(85289): 1.1e-21 Smith-Waterman score: 628; 28.5% identity (62.1% similar) in 488 aa overlap (1-452:1-459) 10 20 30 40 pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTG-LPGD----------ESPVVM ::. .:: . ::. :: . .: : :.:..:. . .: .::. .. : NP_001 MIGGLFIYNHKGEVLISRVYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVN 10 20 30 40 50 60 50 60 70 80 90 pF1KE6 HHHGRH-------------FIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGS :.:. :.:...:...:...:..::. ..:.: .. ... : :. NP_001 VIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE6 LGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFG ..: .:. : .:.::::::.::.:: :.. : :..:: ... :. . . :.. NP_001 ISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQI---- 130 140 150 160 170 160 170 180 190 200 210 pF1KE6 AETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRL :.:. . . : .. : .::.::::.: ...:.. .:..:.. :.:.. . NP_001 ----TSQVTGQIGWRREGIKYR-----RNELFLDVLESVNLLMSPQGQVLSAHVSGRVVM 180 190 200 210 220 220 230 240 250 260 pF1KE6 KSFLPSGSEMRIGLTEEFCV---GKS---ELRGYGP-GIRVDEVSFHSSVNLDEFESHRI ::.: . : ..:..... . ::. : : .: .:. .::. : :..:.:.: NP_001 KSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERS 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE6 LRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALN . . ::.::. .:::. . :. ::::..: :. . : .:.: . .. .. . : . NP_001 ISFIPPDGEFELMRYRTTKDI--ILPFRVIPLVR-EVGRTKLEVKVVIKSNFKPSLLAQK 290 300 310 320 330 340 330 340 350 360 370 380 pF1KE6 VRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGG--SQLSGLFQMDVPGPPG .....: : .. ... . . : . .:.:. : . :. : ::.:. ... NP_001 IEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELL------ 350 360 370 380 390 390 400 410 420 430 440 pF1KE6 PPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPH---KWVRHLS :.. . : : : :..::.: . :::.::.:.. :.: : . : ::::... NP_001 -PTNDKKKWARP----PISMNFEVP-FAPSGLKVRYLKV-FEPKLNYSDHDVIKWVRYIG 400 410 420 430 440 450 450 pF1KE6 HSDAYVIRI .: : : NP_001 RSGIYETRC 460 453 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:29:58 2016 done: Tue Nov 8 13:29:59 2016 Total Scan time: 6.590 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]