FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5642, 503 aa 1>>>pF1KE5642 503 - 503 aa - 503 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2203+/-0.000371; mu= 18.1538+/- 0.023 mean_var=64.1807+/-13.224, 0's: 0 Z-trim(112.3): 192 B-trim: 1098 in 1/52 Lambda= 0.160093 statistics sampled from 20904 (21116) to 20904 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.248), width: 16 Scan time: 7.230 The best scores are: opt bits E(85289) NP_059488 (OMIM: 124010) cytochrome P450 3A4 isofo ( 503) 3343 781.2 0 NP_001189784 (OMIM: 124010) cytochrome P450 3A4 is ( 502) 3325 777.1 0 NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo ( 503) 2982 697.8 1.8e-200 NP_000768 (OMIM: 145500,605325) cytochrome P450 3A ( 502) 2878 673.8 3.1e-193 XP_016867269 (OMIM: 124010) PREDICTED: cytochrome ( 449) 2788 653.0 5.1e-187 NP_001278759 (OMIM: 145500,605325) cytochrome P450 ( 492) 2770 648.9 9.9e-186 NP_476436 (OMIM: 606534) cytochrome P450 3A43 isof ( 503) 2627 615.8 8.8e-176 NP_073731 (OMIM: 606534) cytochrome P450 3A43 isof ( 504) 2615 613.1 6e-175 XP_016867270 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 2244 527.3 3e-149 NP_001278758 (OMIM: 145500,605325) cytochrome P450 ( 389) 2244 527.3 3e-149 XP_011514145 (OMIM: 145500,605325) PREDICTED: cyto ( 389) 2244 527.3 3e-149 NP_476437 (OMIM: 606534) cytochrome P450 3A43 isof ( 420) 2189 514.6 2.2e-145 XP_016868032 (OMIM: 606534) PREDICTED: cytochrome ( 394) 2029 477.7 2.7e-134 XP_016868031 (OMIM: 606534) PREDICTED: cytochrome ( 394) 2029 477.7 2.7e-134 XP_006715922 (OMIM: 145500,605325) PREDICTED: cyto ( 381) 1918 452.0 1.4e-126 XP_016868034 (OMIM: 606534) PREDICTED: cytochrome ( 360) 1858 438.2 2e-122 XP_016868033 (OMIM: 606534) PREDICTED: cytochrome ( 360) 1858 438.2 2e-122 XP_016867271 (OMIM: 145500,605325) PREDICTED: cyto ( 322) 1840 434.0 3.2e-121 NP_001265850 (OMIM: 606534) cytochrome P450 3A43 i ( 393) 1482 351.3 2.9e-96 NP_001159726 (OMIM: 231095,274180,614158) thrombox ( 466) 627 153.9 9.4e-37 XP_016868058 (OMIM: 231095,274180,614158) PREDICTE ( 472) 627 153.9 9.5e-37 NP_001300957 (OMIM: 231095,274180,614158) thrombox ( 514) 627 153.9 1e-36 NP_001052 (OMIM: 231095,274180,614158) thromboxane ( 534) 627 153.9 1.1e-36 NP_001124438 (OMIM: 231095,274180,614158) thrombox ( 534) 627 153.9 1.1e-36 NP_001159725 (OMIM: 231095,274180,614158) thrombox ( 580) 627 154.0 1.1e-36 NP_001177413 (OMIM: 145500,605325) cytochrome P450 ( 140) 595 146.2 5.8e-35 NP_828847 (OMIM: 614999) cytochrome P450 4X1 isofo ( 509) 593 146.1 2.3e-34 NP_001307219 (OMIM: 614999) cytochrome P450 4X1 is ( 444) 585 144.2 7.5e-34 NP_001307218 (OMIM: 614999) cytochrome P450 4X1 is ( 508) 585 144.2 8.4e-34 XP_005262992 (OMIM: 210370,608614) PREDICTED: cyto ( 524) 575 141.9 4.3e-33 NP_076433 (OMIM: 611485) cytochrome P450 4F12 [Hom ( 524) 573 141.5 5.9e-33 NP_000769 (OMIM: 601310) cytochrome P450 4A11 isof ( 519) 571 141.0 8e-33 XP_011525995 (OMIM: 611495) PREDICTED: cytochrome ( 531) 569 140.5 1.1e-32 XP_011525994 (OMIM: 611495) PREDICTED: cytochrome ( 531) 569 140.5 1.1e-32 NP_775754 (OMIM: 611495) cytochrome P450 4F22 [Hom ( 531) 569 140.5 1.1e-32 XP_016856462 (OMIM: 614999) PREDICTED: cytochrome ( 470) 563 139.1 2.7e-32 NP_001010969 (OMIM: 615341) cytochrome P450 4A22 i ( 519) 561 138.7 4e-32 NP_009184 (OMIM: 611545) cytochrome P450 4F8 precu ( 520) 555 137.3 1e-31 XP_016868061 (OMIM: 231095,274180,614158) PREDICTE ( 411) 551 136.3 1.6e-31 XP_016868060 (OMIM: 231095,274180,614158) PREDICTE ( 418) 551 136.3 1.6e-31 XP_016868059 (OMIM: 231095,274180,614158) PREDICTE ( 451) 551 136.3 1.8e-31 NP_112246 (OMIM: 231095,274180,614158) thromboxane ( 460) 551 136.3 1.8e-31 XP_011514846 (OMIM: 231095,274180,614158) PREDICTE ( 463) 551 136.3 1.8e-31 NP_001186137 (OMIM: 601270) docosahexaenoic acid o ( 520) 551 136.4 2e-31 NP_000887 (OMIM: 601270) docosahexaenoic acid omeg ( 520) 551 136.4 2e-31 NP_001186138 (OMIM: 601270) docosahexaenoic acid o ( 520) 551 136.4 2e-31 XP_016882303 (OMIM: 601270) PREDICTED: docosahexae ( 520) 551 136.4 2e-31 XP_006722913 (OMIM: 611485) PREDICTED: cytochrome ( 375) 543 134.4 5.4e-31 XP_011526504 (OMIM: 611485) PREDICTED: cytochrome ( 375) 543 134.4 5.4e-31 XP_011526510 (OMIM: 611485) PREDICTED: cytochrome ( 375) 543 134.4 5.4e-31 >>NP_059488 (OMIM: 124010) cytochrome P450 3A4 isoform 1 (503 aa) initn: 3343 init1: 3343 opt: 3343 Z-score: 4170.6 bits: 781.2 E(85289): 0 Smith-Waterman score: 3343; 100.0% identity (100.0% similar) in 503 aa overlap (1-503:1-503) 10 20 30 40 50 60 pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_059 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 430 440 450 460 470 480 490 500 pF1KE5 GLLQPEKPVVLKVESRDGTVSGA ::::::::::::::::::::::: NP_059 GLLQPEKPVVLKVESRDGTVSGA 490 500 >>NP_001189784 (OMIM: 124010) cytochrome P450 3A4 isofor (502 aa) initn: 3323 init1: 1834 opt: 3325 Z-score: 4148.1 bits: 777.1 E(85289): 0 Smith-Waterman score: 3325; 99.6% identity (99.8% similar) in 503 aa overlap (1-503:1-502) 10 20 30 40 50 60 pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV ::::::::::::::::::::::::::::::::::::::::::: .::::::::::::::: NP_001 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSI-IFPFLIPILEVLNICV 190 200 210 220 230 250 260 270 280 290 300 pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 420 430 440 450 460 470 490 500 pF1KE5 GLLQPEKPVVLKVESRDGTVSGA ::::::::::::::::::::::: NP_001 GLLQPEKPVVLKVESRDGTVSGA 480 490 500 >>NP_000756 (OMIM: 605340) cytochrome P450 3A7 [Homo sap (503 aa) initn: 2982 init1: 2982 opt: 2982 Z-score: 3719.9 bits: 697.8 E(85289): 1.8e-200 Smith-Waterman score: 2982; 88.5% identity (96.4% similar) in 503 aa overlap (1-503:1-503) 10 20 30 40 50 60 pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF : :::.::.::::::::::.:::::::..:::::::::::::::::::: ::..::. : NP_000 MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI ::::.::: ::::.:: :::.::::::::::::::::::::::::::::::::::.:::: NP_000 DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS ::::::::.:::::::::::::::::::::::::::::::::::::::::::: :::::: NP_000 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV :::::::::::.:::::::::::::::::::::. :::: ::: ::::: ::::.::: : NP_000 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI :::.: .:: ::::..::.::..:::::::::::::::::::..:.:::::::::.:::: NP_000 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV :::::::::::::::::.::::::::::::.:.:::.:::::::::::::::.::::::: NP_000 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS ::::::::.::::::::::::::::::::::::::::::.::.::::::::::::::::: NP_000 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG :::::::::::::::::::::::::::::.::::::.:::::::::::::::::::: .: NP_000 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 430 440 450 460 470 480 490 500 pF1KE5 GLLQPEKPVVLKVESRDGTVSGA ::: :::.:::.:::: ::::: NP_000 GLLLTEKPIVLKAESRDETVSGA 490 500 >>NP_000768 (OMIM: 145500,605325) cytochrome P450 3A5 is (502 aa) initn: 2397 init1: 2397 opt: 2878 Z-score: 3590.1 bits: 673.8 E(85289): 3.1e-193 Smith-Waterman score: 2878; 84.3% identity (95.6% similar) in 502 aa overlap (1-502:1-501) 10 20 30 40 50 60 pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF : :::.::.::::::::::::::::::..:::::.::::::::::.:::.:::..:. : NP_000 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI : ::.:::::.:: :.:: :::::::::.:.::::::::::::::: .:::::::::::. NP_000 DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS ::::::::.:::::::::::::::: ::::::::::::::::::: ::::::::.::::: NP_000 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV :::::.:::::::::::::::::::.:::.:.: ::::.:::: .:::: :..:.::. . NP_000 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI ::... ::: :::.:::.:::.: ::::.::::::::::::::::::::::::::.:::: NP_000 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV :::::::::::::::: .::::::::::::::.:::::::::::::::.:.::::::::: NP_000 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS ::::::::.:.::::.:::::::::.::::: .:.::.::::.:::::::::.: ::::: NP_000 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG :: ::.::::::::::.::::::::::::::::::::::::::::::::::::::::. NP_000 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ 430 440 450 460 470 490 500 pF1KE5 GLLQPEKPVVLKVESRDGTVSGA ::::::::.::::.:::::.:: NP_000 GLLQPEKPIVLKVDSRDGTLSGE 480 490 500 >>XP_016867269 (OMIM: 124010) PREDICTED: cytochrome P450 (449 aa) initn: 2783 init1: 2783 opt: 2788 Z-score: 3478.5 bits: 653.0 E(85289): 5.1e-187 Smith-Waterman score: 2788; 95.7% identity (97.3% similar) in 442 aa overlap (1-442:1-440) 10 20 30 40 50 60 pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::. XP_016 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERLE 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG :.. .. : : . : . : XP_016 KRKLQS--STIPTTYDEGHQLCPYGSSVSKM 430 440 >>NP_001278759 (OMIM: 145500,605325) cytochrome P450 3A5 (492 aa) initn: 2287 init1: 2287 opt: 2770 Z-score: 3455.5 bits: 648.9 E(85289): 9.9e-186 Smith-Waterman score: 2770; 83.1% identity (95.1% similar) in 490 aa overlap (14-502:3-491) 10 20 30 40 50 pF1KE5 MALIPDLAMETWLLLAVSLVLLYL-YGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCM :: . :.::.. :::..:::::.::::::::::.:::.:::..:. NP_001 MQLLMLELLLLFIVYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWK 10 20 30 40 60 70 80 90 100 110 pF1KE5 FDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAIS :: ::.:::::.:: :.:: :::::::::.:.::::::::::::::: .::::::::::: NP_001 FDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAIS 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE5 IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY .::::::::.:::::::::::::::: ::::::::::::::::::: ::::::::.:::: NP_001 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE5 SMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNIC ::::::.:::::::::::::::::::.:::.:.: ::::.:::: .:::: :..:.::. NP_001 SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVS 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE5 VFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQS .::... ::: :::.:::.:::.: ::::.::::::::::::::::::::::::::.::: NP_001 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE5 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV ::::::::::::::::: .::::::::::::::.:::::::::::::::.:.:::::::: NP_001 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE5 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF :::::::::.:.::::.:::::::::.::::: .:.::.::::.:::::::::.: :::: NP_001 VNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE5 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSL ::: ::.::::::::::.::::::::::::::::::::::::::::::::::::::::. NP_001 SKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 410 420 430 440 450 460 480 490 500 pF1KE5 GGLLQPEKPVVLKVESRDGTVSGA ::::::::.::::.:::::.:: NP_001 QGLLQPEKPIVLKVDSRDGTLSGE 470 480 490 >>NP_476436 (OMIM: 606534) cytochrome P450 3A43 isoform (503 aa) initn: 2627 init1: 2627 opt: 2627 Z-score: 3276.8 bits: 615.8 E(85289): 8.8e-176 Smith-Waterman score: 2627; 75.9% identity (93.0% similar) in 502 aa overlap (1-502:1-502) 10 20 30 40 50 60 pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF : :::..:::::.:.:.::::::.:::::: :::::::::::::::::.:: : .:. : NP_476 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI : ::..:::..::.:.::::.:.: :::::::::::::::::::. :.::.::.:::.:. NP_476 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS ::::::::.:.::::.::: :.:::::::.: ::.:::.::.:::..: ..::: ::::. NP_476 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV :::::.: ::::.::::::::::..: ::::..::::::.: :..:::: :..:.::: . NP_476 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI ::..::.::..:..:::::::.: :::::::.: ::::::::::.::::::::::::::: NP_476 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV :.:::.:.:::..: ::::::::::::::::::::::::::::: :::...::::::::: NP_476 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS ::::::::.. :. ::::::.::::.:::::..::.: ::::.::::::::::: ::::: NP_476 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG :::::.:: : : :::.:::::::::::: :.:::.::.::::::::::::::::::. NP_476 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 430 440 450 460 470 480 490 500 pF1KE5 GLLQPEKPVVLKVESRDGTVSGA .::::::.::::. ::: .:: NP_476 PILQPEKPIVLKVHLRDGITSGP 490 500 >>NP_073731 (OMIM: 606534) cytochrome P450 3A43 isoform (504 aa) initn: 2613 init1: 2182 opt: 2615 Z-score: 3261.8 bits: 613.1 E(85289): 6e-175 Smith-Waterman score: 2615; 75.7% identity (92.8% similar) in 503 aa overlap (1-502:1-503) 10 20 30 40 50 60 pF1KE5 MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF : :::..:::::.:.:.::::::.:::::: :::::::::::::::::.:: : .:. : NP_073 MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI : ::..:::..::.:.::::.:.: :::::::::::::::::::. :.::.::.:::.:. NP_073 DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS ::::::::.:.::::.::: :.:::::::.: ::.:::.::.:::..: ..::: ::::. NP_073 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV :::::.: ::::.::::::::::..: ::::..::::::.: :..:::: :..:.::: . NP_073 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI ::..::.::..:..:::::::.: :::::::.: ::::::::::.::::::::::::::: NP_073 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV :.:::.:.:::..: ::::::::::::::::::::::::::::: :::...::::::::: NP_073 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPE-RF ::::::::.. :. ::::::.::::.:::::..::.: ::::.::::::::::: :: :: NP_073 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 370 380 390 400 410 420 420 430 440 450 460 470 pF1KE5 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSL ::::::.:: : : :::.:::::::::::: :.:::.::.::::::::::::::::::. NP_073 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 430 440 450 460 470 480 480 490 500 pF1KE5 GGLLQPEKPVVLKVESRDGTVSGA .::::::.::::. ::: .:: NP_073 LPILQPEKPIVLKVHLRDGITSGP 490 500 >>XP_016867270 (OMIM: 145500,605325) PREDICTED: cytochro (389 aa) initn: 1763 init1: 1763 opt: 2244 Z-score: 2800.4 bits: 527.3 E(85289): 3e-149 Smith-Waterman score: 2244; 85.6% identity (96.1% similar) in 389 aa overlap (114-502:1-388) 90 100 110 120 130 140 pF1KE5 ITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLK ::::::.::::::::.:::::::::::::: XP_016 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK 10 20 30 150 160 170 180 190 200 pF1KE5 EMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPF :: ::::::::::::::::::: ::::::::.::::::::::.::::::::::::::::: XP_016 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE5 VENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLED ::.:::.:.: ::::.:::: .:::: :..:.::. .::... ::: :::.:::.:::.: XP_016 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE5 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT ::::.::::::::::::::::::::::::::.:::::::::::::::::::: .::::: XP_016 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE5 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI :::::::::.:::::::::::::::.:.:::::::::::::::::.:.::::.::::::: XP_016 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE5 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI ::.::::: .:.::.::::.:::::::::.: ::::::: ::.::::::::::.:::::: XP_016 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCI 280 290 300 310 320 450 460 470 480 490 500 pF1KE5 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA ::::::::::::::::::::::::::::::::::. ::::::::.::::.:::::.:: XP_016 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE 330 340 350 360 370 380 >>NP_001278758 (OMIM: 145500,605325) cytochrome P450 3A5 (389 aa) initn: 1763 init1: 1763 opt: 2244 Z-score: 2800.4 bits: 527.3 E(85289): 3e-149 Smith-Waterman score: 2244; 85.6% identity (96.1% similar) in 389 aa overlap (114-502:1-388) 90 100 110 120 130 140 pF1KE5 ITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLK ::::::.::::::::.:::::::::::::: NP_001 MKSAISLAEDEEWKRIRSLLSPTFTSGKLK 10 20 30 150 160 170 180 190 200 pF1KE5 EMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPF :: ::::::::::::::::::: ::::::::.::::::::::.::::::::::::::::: NP_001 EMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPF 40 50 60 70 80 90 210 220 230 240 250 260 pF1KE5 VENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLED ::.:::.:.: ::::.:::: .:::: :..:.::. .::... ::: :::.:::.:::.: NP_001 VESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLND 100 110 120 130 140 150 270 280 290 300 310 320 pF1KE5 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT ::::.::::::::::::::::::::::::::.:::::::::::::::::::: .::::: NP_001 KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELAT 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE5 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI :::::::::.:::::::::::::::.:.:::::::::::::::::.:.::::.::::::: NP_001 HPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE5 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI ::.::::: .:.::.::::.:::::::::.: ::::::: ::.::::::::::.:::::: NP_001 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCI 280 290 300 310 320 450 460 470 480 490 500 pF1KE5 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA ::::::::::::::::::::::::::::::::::. ::::::::.::::.:::::.:: NP_001 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE 330 340 350 360 370 380 503 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 05:28:25 2016 done: Tue Nov 8 05:28:26 2016 Total Scan time: 7.230 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]