FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1759, 263 aa 1>>>pF1KE1759 263 - 263 aa - 263 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7318+/-0.000307; mu= 17.9607+/- 0.019 mean_var=63.2616+/-12.279, 0's: 0 Z-trim(116.4): 5 B-trim: 90 in 1/53 Lambda= 0.161252 statistics sampled from 27603 (27608) to 27603 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.716), E-opt: 0.2 (0.324), width: 16 Scan time: 6.950 The best scores are: opt bits E(85289) NP_006765 (OMIM: 604854) indolethylamine N-methylt ( 263) 1778 421.9 6e-118 NP_001186148 (OMIM: 604854) indolethylamine N-meth ( 262) 1758 417.2 1.5e-116 NP_006160 (OMIM: 600008) nicotinamide N-methyltran ( 264) 887 214.6 1.5e-55 NP_002677 (OMIM: 171190) phenylethanolamine N-meth ( 282) 590 145.5 1e-34 XP_011523211 (OMIM: 171190) PREDICTED: phenylethan ( 184) 388 98.4 1e-20 >>NP_006765 (OMIM: 604854) indolethylamine N-methyltrans (263 aa) initn: 1778 init1: 1778 opt: 1778 Z-score: 2238.5 bits: 421.9 E(85289): 6e-118 Smith-Waterman score: 1778; 99.2% identity (99.2% similar) in 263 aa overlap (1-263:1-263) 10 20 30 40 50 60 pF1KE1 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGEVEQAVLDAGFDIEQLLHSPQ :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: NP_006 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ 190 200 210 220 230 240 250 260 pF1KE1 SYSVTNAANNGVCCIVARKKPGP ::::::::::::: ::::::::: NP_006 SYSVTNAANNGVCFIVARKKPGP 250 260 >>NP_001186148 (OMIM: 604854) indolethylamine N-methyltr (262 aa) initn: 1405 init1: 1405 opt: 1758 Z-score: 2213.4 bits: 417.2 E(85289): 1.5e-116 Smith-Waterman score: 1758; 98.9% identity (98.9% similar) in 263 aa overlap (1-263:1-262) 10 20 30 40 50 60 pF1KE1 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::: NP_001 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPG-LQGDTLI 10 20 30 40 50 70 80 90 100 110 120 pF1KE1 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE1 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE1 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGEVEQAVLDAGFDIEQLLHSPQ :::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::: NP_001 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQ 180 190 200 210 220 230 250 260 pF1KE1 SYSVTNAANNGVCCIVARKKPGP ::::::::::::: ::::::::: NP_001 SYSVTNAANNGVCFIVARKKPGP 240 250 260 >>NP_006160 (OMIM: 600008) nicotinamide N-methyltransfer (264 aa) initn: 884 init1: 884 opt: 887 Z-score: 1118.2 bits: 214.6 E(85289): 1.5e-55 Smith-Waterman score: 887; 52.9% identity (74.1% similar) in 263 aa overlap (1-263:1-263) 10 20 30 40 50 60 pF1KE1 MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLI :..:::. : : .:: ::::: ::.: . : :...:: :. : : : :..:: :: NP_006 MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 DIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGN ::::::::::.:.::.::..:...:..:.: .:::::::::: :.::.:.: ..:.:::: NP_006 DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 SGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAAL . ::::::: :::.:::::: ..::. . :: :::::. : .. :: .: .: :: NP_006 RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 CNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGEVEQAVLDAGFDIEQLLHSPQ ::.::::::: :: .:. ::.:...:: . : . :: :: .::. :: . : NP_006 RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ 190 200 210 220 230 240 250 260 pF1KE1 SYSVTNAANNGVCCIVARKKPGP ::: : : :.:. .:::: : NP_006 SYSSTMANNEGLFSLVARKLSRPL 250 260 >>NP_002677 (OMIM: 171190) phenylethanolamine N-methyltr (282 aa) initn: 576 init1: 429 opt: 590 Z-score: 744.4 bits: 145.5 E(85289): 1e-34 Smith-Waterman score: 590; 41.0% identity (72.5% similar) in 229 aa overlap (11-235:27-253) 10 20 30 40 pF1KE1 MKGGFTGGDEYQKHFLPRDYLATYYSFD-GSPSPEAEMLKFNLE ::. : :: :: . :. :. . ..:. NP_002 MSGADRSPNAGAAPDSAPGQAAVASAYQR-FEPRAYLRNNYAPPRGDLCNPNGVGPWKLR 10 20 30 40 50 50 60 70 80 90 100 pF1KE1 CLHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPG :: .::. : ..: ::::::::::.::.:.::. :.:::..:: . ::.:: .::..::: NP_002 CLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPG 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 AYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPL---APAVLPLADCV :..:. . :: .::.. :..::..::: ::::: ::: .:: .:: :: :: . NP_002 AFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLP-ADAL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE1 LTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGE .. . .: . .: ... :: ....::.:::::. .:. :..:. ... : . . : NP_002 VSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEE 180 190 200 210 220 230 230 240 250 260 pF1KE1 VEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCCIVARKKPGP :..:.. .:. ...: NP_002 VREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL 240 250 260 270 280 >>XP_011523211 (OMIM: 171190) PREDICTED: phenylethanolam (184 aa) initn: 374 init1: 246 opt: 388 Z-score: 493.0 bits: 98.4 E(85289): 1e-20 Smith-Waterman score: 388; 37.8% identity (73.1% similar) in 156 aa overlap (83-235:1-155) 60 70 80 90 100 110 pF1KE1 GLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVK ..:: . ::.:: .::..::::..:. . XP_011 MTDFLEVNRQELGRWLQEEPGAFNWSMYSQ 10 20 30 120 130 140 150 160 pF1KE1 FACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPL---APAVLPLADCVLTLLAMECA :: .::.. :..::..::: ::::: ::: .:: .:: :: :: ... . .: . XP_011 HACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLP-ADALVSAFCLEAV 40 50 60 70 80 170 180 190 200 210 220 pF1KE1 CCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKGEVEQAVLDAG .: ... :: ....::.:::::. .:. :..:. ... : . . ::..:.. .: XP_011 SPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSG 90 100 110 120 130 140 230 240 250 260 pF1KE1 FDIEQLLHSPQSYSVTNAANNGVCCIVARKKPGP . ...: XP_011 YKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL 150 160 170 180 263 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 16:25:15 2016 done: Sun Nov 6 16:25:17 2016 Total Scan time: 6.950 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]