FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6615, 289 aa 1>>>pF1KE6615 289 - 289 aa - 289 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0548+/-0.000366; mu= 12.0843+/- 0.023 mean_var=82.8249+/-16.070, 0's: 0 Z-trim(114.7): 6 B-trim: 31 in 1/52 Lambda= 0.140927 statistics sampled from 24641 (24647) to 24641 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.289), width: 16 Scan time: 5.440 The best scores are: opt bits E(85289) NP_981932 (OMIM: 274800,612025) iodotyrosine deiod ( 289) 1917 399.3 4.5e-111 NP_001158167 (OMIM: 274800,612025) iodotyrosine de ( 247) 1537 322.0 7.1e-88 NP_001158166 (OMIM: 274800,612025) iodotyrosine de ( 293) 1537 322.0 8.2e-88 XP_006715541 (OMIM: 274800,612025) PREDICTED: iodo ( 294) 1535 321.6 1.1e-87 XP_006715542 (OMIM: 274800,612025) PREDICTED: iodo ( 239) 1138 240.9 1.8e-63 NP_001305424 (OMIM: 274800,612025) iodotyrosine de ( 207) 1103 233.7 2.2e-61 >>NP_981932 (OMIM: 274800,612025) iodotyrosine deiodinas (289 aa) initn: 1917 init1: 1917 opt: 1917 Z-score: 2115.1 bits: 399.3 E(85289): 4.5e-111 Smith-Waterman score: 1917; 99.7% identity (99.7% similar) in 289 aa overlap (1-289:1-289) 10 20 30 40 50 60 pF1KE6 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_981 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_981 ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_981 RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_981 IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTP 190 200 210 220 230 240 250 260 270 280 pF1KE6 LNCGPRLRVLLGRPAHEKLPMLLPVGYPSKEATVPDLKRKPLDQIMVTV ::::::::::::::::::: ::::::::::::::::::::::::::::: NP_981 LNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV 250 260 270 280 >>NP_001158167 (OMIM: 274800,612025) iodotyrosine deiodi (247 aa) initn: 1533 init1: 1533 opt: 1537 Z-score: 1698.6 bits: 322.0 E(85289): 7.1e-88 Smith-Waterman score: 1537; 95.9% identity (96.7% similar) in 241 aa overlap (1-241:1-241) 10 20 30 40 50 60 pF1KE6 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTP ::::::::::::::::::::::::::::::::::::::::::::::::: : . . NP_001 IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQVFGKIILKELA 190 200 210 220 230 240 250 260 270 280 pF1KE6 LNCGPRLRVLLGRPAHEKLPMLLPVGYPSKEATVPDLKRKPLDQIMVTV : NP_001 LISFLNL >>NP_001158166 (OMIM: 274800,612025) iodotyrosine deiodi (293 aa) initn: 1533 init1: 1533 opt: 1537 Z-score: 1697.5 bits: 322.0 E(85289): 8.2e-88 Smith-Waterman score: 1537; 98.7% identity (99.1% similar) in 234 aa overlap (1-233:1-234) 10 20 30 40 50 60 pF1KE6 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQ-NAGLVTVTTT ::::::::::::::::::::::::::::::::::::::::::::::::: : :. NP_001 IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQVNNGITMRHQT 190 200 210 220 230 240 240 250 260 270 280 pF1KE6 PLNCGPRLRVLLGRPAHEKLPMLLPVGYPSKEATVPDLKRKPLDQIMVTV NP_001 ARHRHLIEGPGRSSEACSKLSSQGCPECRSGDCHYHSSQLWPSTEGAPGPPRT 250 260 270 280 290 >>XP_006715541 (OMIM: 274800,612025) PREDICTED: iodotyro (294 aa) initn: 1533 init1: 1533 opt: 1535 Z-score: 1695.2 bits: 321.6 E(85289): 1.1e-87 Smith-Waterman score: 1535; 98.3% identity (98.7% similar) in 235 aa overlap (1-233:1-235) 10 20 30 40 50 60 pF1KE6 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQ--NAGLVTVTT ::::::::::::::::::::::::::::::::::::::::::::::::: : :. XP_006 IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQQVNNGITMRHQ 190 200 210 220 230 240 240 250 260 270 280 pF1KE6 TPLNCGPRLRVLLGRPAHEKLPMLLPVGYPSKEATVPDLKRKPLDQIMVTV XP_006 TARHRHLIEGPGRSSEACSKLSSQGCPECRSGDCHYHSSQLWPSTEGAPGPPRT 250 260 270 280 290 >>XP_006715542 (OMIM: 274800,612025) PREDICTED: iodotyro (239 aa) initn: 1136 init1: 1136 opt: 1138 Z-score: 1260.4 bits: 240.9 E(85289): 1.8e-63 Smith-Waterman score: 1138; 97.7% identity (98.3% similar) in 176 aa overlap (60-233:5-180) 30 40 50 60 70 80 pF1KE6 KKGEPRTRAEARPWVDEDLKDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKR :::::::::::::::::::::::::::::: XP_006 MVCADADEWQESEENVEHIPFSHNHYPEKEMVKR 10 20 30 90 100 110 120 130 140 pF1KE6 SQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SQEFYELLNKRRSVRFISNEQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKI 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE6 RKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RKIIEEEEEINYMKRMGHRWVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKV 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE6 HYYNEISVSIACGILLAALQ--NAGLVTVTTTPLNCGPRLRVLLGRPAHEKLPMLLPVGY :::::::::::::::::::: : :. XP_006 HYYNEISVSIACGILLAALQQVNNGITMRHQTARHRHLIEGPGRSSEACSKLSSQGCPEC 160 170 180 190 200 210 >>NP_001305424 (OMIM: 274800,612025) iodotyrosine deiodi (207 aa) initn: 1092 init1: 1092 opt: 1103 Z-score: 1222.9 bits: 233.7 E(85289): 2.2e-61 Smith-Waterman score: 1103; 82.5% identity (88.2% similar) in 211 aa overlap (79-289:4-207) 50 60 70 80 90 100 pF1KE6 KDSSDLHQAEEDADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISN : .:.:.. : . . .:. .: . : NP_001 MLMNGKNQKKMLNTSPSLITTILRRKWLRGLRN 10 20 30 110 120 130 140 150 160 pF1KE6 EQVPMEVIDNVIRTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHR .. :: ::::::::::::::::::::::::::::::::::::::::::::: NP_001 ------FMNFSIRD-GTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHR 40 50 60 70 80 170 180 190 200 210 220 pF1KE6 WVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WVTDLKKLRTNWIKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAAL 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE6 QNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLPMLLPVGYPSKEATVPDLKRKPLDQIMVT ::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::: NP_001 QNAGLVTVTTTPLNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVT 150 160 170 180 190 200 pF1KE6 V : NP_001 V 289 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 14:47:48 2016 done: Tue Nov 8 14:47:49 2016 Total Scan time: 5.440 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]