FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6457, 476 aa 1>>>pF1KE6457 476 - 476 aa - 476 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2660+/-0.000383; mu= 18.6902+/- 0.024 mean_var=88.5066+/-16.924, 0's: 0 Z-trim(114.4): 96 B-trim: 0 in 0/54 Lambda= 0.136328 statistics sampled from 24099 (24200) to 24099 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.284), width: 16 Scan time: 7.530 The best scores are: opt bits E(85289) NP_055279 (OMIM: 606749) tubulointerstitial nephri ( 476) 3395 678.1 1.4e-194 XP_006715125 (OMIM: 606749) PREDICTED: tubulointer ( 458) 3269 653.3 4e-187 XP_016866234 (OMIM: 606749) PREDICTED: tubulointer ( 438) 2982 596.8 3.8e-170 XP_016866235 (OMIM: 606749) PREDICTED: tubulointer ( 401) 2511 504.2 2.8e-142 XP_016866237 (OMIM: 606749) PREDICTED: tubulointer ( 309) 2121 427.4 2.8e-119 XP_016866236 (OMIM: 606749) PREDICTED: tubulointer ( 351) 2121 427.4 3.1e-119 XP_011512799 (OMIM: 606749) PREDICTED: tubulointer ( 426) 2121 427.5 3.5e-119 NP_071447 (OMIM: 616064) tubulointerstitial nephri ( 467) 1533 311.9 2.5e-84 XP_005271164 (OMIM: 616064) PREDICTED: tubulointer ( 362) 1324 270.7 4.9e-72 NP_001191344 (OMIM: 616064) tubulointerstitial nep ( 362) 1324 270.7 4.9e-72 XP_011540248 (OMIM: 616064) PREDICTED: tubulointer ( 408) 1283 262.7 1.4e-69 NP_001191343 (OMIM: 616064) tubulointerstitial nep ( 436) 1165 239.5 1.4e-62 XP_005271163 (OMIM: 616064) PREDICTED: tubulointer ( 440) 1145 235.5 2.2e-61 NP_001805 (OMIM: 170650,245000,245010,602365) dipe ( 463) 300 69.4 2.5e-11 XP_006716307 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06 XP_016868589 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06 NP_001899 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06 NP_680093 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06 XP_016868587 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06 XP_016868586 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06 NP_680091 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06 NP_680092 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06 XP_006716308 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06 XP_016868588 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06 XP_011542114 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06 NP_680090 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06 NP_001324 (OMIM: 603308) cathepsin L2 preproprotei ( 334) 205 50.6 8.2e-06 NP_001188504 (OMIM: 603308) cathepsin L2 prepropro ( 334) 205 50.6 8.2e-06 NP_001304166 (OMIM: 116810) cathepsin B isoform 2 ( 215) 192 47.8 3.5e-05 XP_016868590 (OMIM: 116810) PREDICTED: cathepsin B ( 245) 192 47.9 3.9e-05 NP_001244902 (OMIM: 116880) cathepsin L1 isoform 2 ( 151) 188 46.9 4.7e-05 NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 188 47.2 8.3e-05 NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 188 47.2 8.3e-05 NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 188 47.2 8.3e-05 XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L ( 333) 188 47.2 8.3e-05 NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 188 47.2 8.3e-05 XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 164 42.4 0.0019 XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 164 42.4 0.0019 >>NP_055279 (OMIM: 606749) tubulointerstitial nephritis (476 aa) initn: 3395 init1: 3395 opt: 3395 Z-score: 3614.2 bits: 678.1 E(85289): 1.4e-194 Smith-Waterman score: 3395; 99.4% identity (99.8% similar) in 476 aa overlap (1-476:1-476) 10 20 30 40 50 60 pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: NP_055 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: NP_055 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: NP_055 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP 430 440 450 460 470 >>XP_006715125 (OMIM: 606749) PREDICTED: tubulointerstit (458 aa) initn: 3269 init1: 3269 opt: 3269 Z-score: 3480.4 bits: 653.3 E(85289): 4e-187 Smith-Waterman score: 3269; 99.3% identity (99.8% similar) in 458 aa overlap (19-476:1-458) 10 20 30 40 50 60 pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF :::.:::::::::::::::::::::::::::::::::::::: XP_006 MEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF 10 20 30 40 70 80 90 100 110 120 pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_006 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN 290 300 310 320 330 340 370 380 390 400 410 420 pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_006 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT 350 360 370 380 390 400 430 440 450 460 470 pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP 410 420 430 440 450 >>XP_016866234 (OMIM: 606749) PREDICTED: tubulointerstit (438 aa) initn: 2979 init1: 2979 opt: 2982 Z-score: 3175.6 bits: 596.8 E(85289): 3.8e-170 Smith-Waterman score: 2982; 97.0% identity (98.6% similar) in 429 aa overlap (1-428:1-429) 10 20 30 40 50 60 pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: XP_016 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT ::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: XP_016 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGLLP 370 380 390 400 410 420 430 440 450 460 470 pF1KE6 LRG-AQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP . : ..:.. XP_016 IPGESHGERMAISGFFEE 430 >>XP_016866235 (OMIM: 606749) PREDICTED: tubulointerstit (401 aa) initn: 2511 init1: 2511 opt: 2511 Z-score: 2675.5 bits: 504.2 E(85289): 2.8e-142 Smith-Waterman score: 2629; 83.6% identity (84.0% similar) in 476 aa overlap (1-476:1-401) 10 20 30 40 50 60 pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF :::::::::::::::::::::.:::::::::::::::::::::: XP_016 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQG---------------- 10 20 30 40 70 80 90 100 110 120 pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC : XP_016 -----------------------------------------------------------C 130 140 150 160 170 180 pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW 50 60 70 80 90 100 190 200 210 220 230 240 pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC 110 120 130 140 150 160 250 260 270 280 290 300 pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG 170 180 190 200 210 220 310 320 330 340 350 360 pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_016 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT 290 300 310 320 330 340 430 440 450 460 470 pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP 350 360 370 380 390 400 >>XP_016866237 (OMIM: 606749) PREDICTED: tubulointerstit (309 aa) initn: 2121 init1: 2121 opt: 2121 Z-score: 2262.4 bits: 427.4 E(85289): 2.8e-119 Smith-Waterman score: 2121; 99.3% identity (99.7% similar) in 306 aa overlap (171-476:4-309) 150 160 170 180 190 200 pF1KE6 TCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSLM :::::::::::::::::::::::::::: : XP_016 MGRWTAQNYSQFWGMTLEDGFKFRLGTLPPSPM 10 20 30 210 220 230 240 250 260 pF1KE6 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS 40 50 60 70 80 90 270 280 290 300 310 320 pF1KE6 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLFKDQNATNNGC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLFKDQNATNNGC 100 110 120 130 140 150 330 340 350 360 370 380 pF1KE6 AMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQV 160 170 180 190 200 210 390 400 410 420 430 440 pF1KE6 HEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGK .::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 REDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGK 220 230 240 250 260 270 450 460 470 pF1KE6 SWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP :::::::::::::::::::::::::::::::::::: XP_016 SWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP 280 290 300 >>XP_016866236 (OMIM: 606749) PREDICTED: tubulointerstit (351 aa) initn: 2395 init1: 2121 opt: 2121 Z-score: 2261.7 bits: 427.4 E(85289): 3.1e-119 Smith-Waterman score: 2148; 72.9% identity (73.3% similar) in 476 aa overlap (1-476:1-351) 10 20 30 40 50 60 pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF :::::::::::::::::::::.:::::::::::::::::::::: XP_016 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGR--------------- 10 20 30 40 70 80 90 100 110 120 pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC XP_016 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW :::::::::: XP_016 --------------------------------------------------WTAQNYSQFW 50 190 200 210 220 230 240 pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_016 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC 60 70 80 90 100 110 250 260 270 280 290 300 pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG 120 130 140 150 160 170 310 320 330 340 350 360 pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN 180 190 200 210 220 230 370 380 390 400 410 420 pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_016 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT 240 250 260 270 280 290 430 440 450 460 470 pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP 300 310 320 330 340 350 >>XP_011512799 (OMIM: 606749) PREDICTED: tubulointerstit (426 aa) initn: 3001 init1: 2121 opt: 2121 Z-score: 2260.6 bits: 427.5 E(85289): 3.5e-119 Smith-Waterman score: 2902; 88.9% identity (89.3% similar) in 476 aa overlap (1-476:1-426) 10 20 30 40 50 60 pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: XP_011 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEG- 70 80 90 100 110 130 140 150 160 170 180 pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW : :::::::::: XP_011 ------------------------------------R-------------WTAQNYSQFW 120 130 190 200 210 220 230 240 pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: XP_011 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC 140 150 160 170 180 190 250 260 270 280 290 300 pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG 200 210 220 230 240 250 310 320 330 340 350 360 pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN 260 270 280 290 300 310 370 380 390 400 410 420 pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT ::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::: XP_011 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT 320 330 340 350 360 370 430 440 450 460 470 pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP 380 390 400 410 420 >>NP_071447 (OMIM: 616064) tubulointerstitial nephritis (467 aa) initn: 1459 init1: 662 opt: 1533 Z-score: 1635.1 bits: 311.9 E(85289): 2.5e-84 Smith-Waterman score: 1533; 49.6% identity (73.5% similar) in 427 aa overlap (54-474:45-463) 30 40 50 60 70 80 pF1KE6 LSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNFG-CCEDRDDGCVTEFYAANALCY :.::.. ::. : : :. . .: .:: NP_071 AGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGA--ICY 20 30 40 50 60 70 90 100 110 120 130 140 pF1KE6 CDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYP-EGCFKDGQHYEEGSVIKENCNSCT :: ::.: ::::::. .:: :: :. : .::.. :. : .. .::: :: NP_071 CDLFCNRTVSDCCPDFWDFCLGV---PP---PFPPIQGCMHGGRIYPVLGTYWDNCNRCT 80 90 100 110 120 150 160 170 180 190 200 pF1KE6 CS-GQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSLM :. ..::.:.:. ::: ..:. .:.:.::: : :.: ::::::..:...::::. :: NP_071 CQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSS 130 140 150 160 170 180 210 220 230 240 250 260 pF1KE6 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS ...:.:. . : :: : :: :::. : :::: :::.:::::::.::.::..:.: NP_071 VMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHS 190 200 210 220 230 240 270 280 290 300 310 pF1KE6 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLF---KDQNATN :..: ::::::.:: .....:: .: .: :::.::.::.:: :::. .:. . NP_071 LGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPA 250 260 270 280 290 300 320 330 340 350 360 370 pF1KE6 NGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAI : : ::. :::::.:: :::. ..: ::: .: ::..::. :::::.:.::::::. NP_071 PPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQAL 310 320 330 340 350 360 380 390 400 410 420 430 pF1KE6 MQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANS :.:::::: :: ::: :. . . :.::. ::.::.:::: .:. :.: :::: NP_071 MEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANS 370 380 390 400 410 420 440 450 460 470 pF1KE6 WGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP :: .::: :.:::.::::: :::......::.. : NP_071 WGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH 430 440 450 460 >>XP_005271164 (OMIM: 616064) PREDICTED: tubulointerstit (362 aa) initn: 1299 init1: 662 opt: 1324 Z-score: 1414.3 bits: 270.7 E(85289): 4.9e-72 Smith-Waterman score: 1324; 51.3% identity (75.8% similar) in 355 aa overlap (124-474:4-358) 100 110 120 130 140 150 pF1KE6 CCPDYKSFCREEKEWPPHTQPWYPEGCFKDGQHYEEGSVIKENCNSCTCS-GQQWKCSQH :. : .. .::: :::. ..::.:.:. XP_005 MHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQE 10 20 30 160 170 180 190 200 210 pF1KE6 VCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSLMLLSMNEMTASLP ::: ..:. .:.:.::: : :.: ::::::..:...::::. :: ...:.:. . : XP_005 PCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLN 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE6 ATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQN :: : :: :::. : :::: :::.:::::::.::.::..:.: :..: ::::: XP_005 PGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQN 100 110 120 130 140 150 280 290 300 310 320 pF1KE6 LISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLF---KDQNATNNGCAMASRSDGR :.:: .....:: .: .: :::.::.::.:: :::. .:. . : : ::. :: XP_005 LLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGR 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE6 GKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVHEDFFHYKT :::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.:.:::::: :: XP_005 GKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKG 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE6 GIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFR ::: :. . . :.::. ::.::.:::: .:. :.: :::::: .::: :.:: XP_005 GIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFR 280 290 300 310 320 330 450 460 470 pF1KE6 ILRGVNESDIEKLIIAAWGQLTSSDEP :.::::: :::......::.. : XP_005 IVRGVNECDIESFVLGVWGRVGMEDMGHH 340 350 360 >>NP_001191344 (OMIM: 616064) tubulointerstitial nephrit (362 aa) initn: 1299 init1: 662 opt: 1324 Z-score: 1414.3 bits: 270.7 E(85289): 4.9e-72 Smith-Waterman score: 1324; 51.3% identity (75.8% similar) in 355 aa overlap (124-474:4-358) 100 110 120 130 140 150 pF1KE6 CCPDYKSFCREEKEWPPHTQPWYPEGCFKDGQHYEEGSVIKENCNSCTCS-GQQWKCSQH :. : .. .::: :::. ..::.:.:. NP_001 MHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQE 10 20 30 160 170 180 190 200 210 pF1KE6 VCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSLMLLSMNEMTASLP ::: ..:. .:.:.::: : :.: ::::::..:...::::. :: ...:.:. . : NP_001 PCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLN 40 50 60 70 80 90 220 230 240 250 260 270 pF1KE6 ATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQN :: : :: :::. : :::: :::.:::::::.::.::..:.: :..: ::::: NP_001 PGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQN 100 110 120 130 140 150 280 290 300 310 320 pF1KE6 LISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLF---KDQNATNNGCAMASRSDGR :.:: .....:: .: .: :::.::.::.:: :::. .:. . : : ::. :: NP_001 LLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGR 160 170 180 190 200 210 330 340 350 360 370 380 pF1KE6 GKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVHEDFFHYKT :::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.:.:::::: :: NP_001 GKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKG 220 230 240 250 260 270 390 400 410 420 430 440 pF1KE6 GIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFR ::: :. . . :.::. ::.::.:::: .:. :.: :::::: .::: :.:: NP_001 GIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFR 280 290 300 310 320 330 450 460 470 pF1KE6 ILRGVNESDIEKLIIAAWGQLTSSDEP :.::::: :::......::.. : NP_001 IVRGVNECDIESFVLGVWGRVGMEDMGHH 340 350 360 476 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 13:28:51 2016 done: Tue Nov 8 13:28:53 2016 Total Scan time: 7.530 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]