Result of FASTA (omim) for
pFN21AE5056
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5056, 224 aa
1>>>pF1KE5056 224 - 224 aa - 224 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1131+/-0.00032; mu= 14.5670+/- 0.020
mean_var=55.3934+/-11.111, 0's: 0 Z-trim(114.5): 31 B-trim: 1273 in 1/52
Lambda= 0.172324
statistics sampled from 24291 (24322) to 24291 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.285), width: 16
Scan time: 6.550
The best scores are: opt bits E(85289)
NP_006780 (OMIM: 604797) C->U-editing enzyme APOBE ( 224) 1489 377.9 7.3e-105
NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme ( 373) 403 108.0 2.1e-23
XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 442) 403 108.1 2.5e-23
NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme ( 190) 383 102.9 3.7e-22
XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 455) 367 99.1 1.3e-20
NP_065712 (OMIM: 605257,605258) single-stranded DN ( 198) 358 96.7 2.9e-20
XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU- ( 227) 349 94.5 1.5e-19
NP_001257340 (OMIM: 607110) DNA dC->dU-editing enz ( 357) 330 89.9 6e-18
NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme ( 382) 330 89.9 6.4e-18
NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme ( 384) 294 80.9 3.2e-15
XP_016884392 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 524) 294 81.0 4.2e-15
XP_005261394 (OMIM: 609900) PREDICTED: DNA dC->dU- ( 202) 285 78.6 8.5e-15
NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme ( 386) 272 75.5 1.4e-13
XP_011519075 (OMIM: 605257,605258) PREDICTED: sing ( 145) 265 73.6 2e-13
NP_001317272 (OMIM: 605257,605258) single-stranded ( 188) 265 73.6 2.5e-13
NP_663745 (OMIM: 607109) DNA dC->dU-editing enzyme ( 199) 254 70.9 1.7e-12
NP_001257335 (OMIM: 607109) DNA dC->dU-editing enz ( 181) 251 70.1 2.7e-12
NP_001159474 (OMIM: 610976) DNA dC->dU-editing enz ( 182) 243 68.1 1.1e-11
NP_861438 (OMIM: 610976) DNA dC->dU-editing enzyme ( 183) 243 68.1 1.1e-11
XP_011528294 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 200) 243 68.1 1.2e-11
NP_001159475 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 243 68.1 1.2e-11
XP_011528292 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 243 68.2 1.2e-11
XP_011528293 (OMIM: 610976) PREDICTED: DNA dC->dU- ( 203) 243 68.2 1.2e-11
XP_006724353 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 317) 228 64.5 2.3e-10
XP_016884393 (OMIM: 607113) PREDICTED: DNA dC->dU- ( 457) 228 64.6 3.2e-10
NP_001291495 (OMIM: 600130) C->U-editing enzyme AP ( 236) 217 61.7 1.2e-09
NP_001635 (OMIM: 600130) C->U-editing enzyme APOBE ( 236) 217 61.7 1.2e-09
NP_005880 (OMIM: 600130) C->U-editing enzyme APOBE ( 191) 209 59.7 3.9e-09
NP_001159476 (OMIM: 610976) DNA dC->dU-editing enz ( 154) 186 53.9 1.7e-07
>>NP_006780 (OMIM: 604797) C->U-editing enzyme APOBEC-2 (224 aa)
initn: 1489 init1: 1489 opt: 1489 Z-score: 2003.7 bits: 377.9 E(85289): 7.3e-105
Smith-Waterman score: 1489; 100.0% identity (100.0% similar) in 224 aa overlap (1-224:1-224)
10 20 30 40 50 60
pF1KE5 MAQKEEAAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAQKEEAAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 YSSGRNKTFLCYVVEAQGKGGQVQASRGYLEDEHAAAHAEEAFFNTILPAFDPALRYNVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YSSGRNKTFLCYVVEAQGKGGQVQASRGYLEDEHAAAHAEEAFFNTILPAFDPALRYNVT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 WYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMK
130 140 150 160 170 180
190 200 210 220
pF1KE5 PQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
::::::::::::::::::::::::::::::::::::::::::::
NP_006 PQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
190 200 210 220
>>NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme APO (373 aa)
initn: 541 init1: 219 opt: 403 Z-score: 541.0 bits: 108.0 E(85289): 2.1e-23
Smith-Waterman score: 403; 32.2% identity (68.3% similar) in 199 aa overlap (30-224:184-373)
10 20 30 40 50
pF1KE5 MAQKEEAAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNV
:::... : : . ..: :.:.:.
NP_660 YCWENFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPM------EAMYPHIFYFHFKNL
160 170 180 190 200
60 70 80 90 100 110
pF1KE5 EYSSGRNKTFLCYVVEAQGKGGQVQASRGYLE---DEHAAAHAEEAFFNTILP-AFDPAL
. . :::...::...:. . . :. .:: .. : .. :::. :.. . ..:
NP_660 RKAYGRNESWLCFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNT
210 220 230 240 250 260
120 130 140 150 160 170
pF1KE5 RYNVTWYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCK
:.::::.: ::: :: .. . :.. .:. : :...::... . . : .:..:.. : .
NP_660 NYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGAS
270 280 290 300 310 320
180 190 200 210 220
pF1KE5 LRIMKPQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
..:: .::.: :.::: ... . :.::. .. :::. . :: .::.
NP_660 VEIMGYKDFKYCWENFVYNDD---EPFKPWKGLKYNFLFLDSKLQEILE
330 340 350 360 370
>--
initn: 337 init1: 206 opt: 332 Z-score: 445.6 bits: 90.4 E(85289): 4.4e-18
Smith-Waterman score: 332; 32.6% identity (64.1% similar) in 184 aa overlap (37-214:3-179)
10 20 30 40 50 60
pF1KE5 AAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRN
: :. : ::. . :...: : : ::
NP_660 MKPHFRN-TVERMYRDTFSYNFYNRPILSRRN
10 20 30
70 80 90 100 110 120
pF1KE5 KTFLCYVVEAQGKG-GQVQAS--RG--YLEDEHAAAHAEEAFFNTILPAFDPALR-YNVT
..::: :...: . ...:. :: : . :: ::: :.. . :: . ...:
NP_660 TVWLCYEVKTKGPSRPRLDAKIFRGQVYSQPEH---HAEMCFLSWFCGNQLPAYKCFQIT
40 50 60 70 80
130 140 150 160 170 180
pF1KE5 WYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMK
:.:: .:: :. .. . :.. :. : : ..::... : . . :: .:..:: ...::
NP_660 WFVSWTPCPDCVAKLAEFLAEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMD
90 100 110 120 130 140
190 200 210 220
pF1KE5 PQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
..: : :.::: .:.. :.:: ...:. .
NP_660 DEEFAYCWENFVY---SEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFK
150 160 170 180 190 200
NP_660 NLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSP
210 220 230 240 250 260
>>XP_011528296 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (442 aa)
initn: 492 init1: 219 opt: 403 Z-score: 539.8 bits: 108.1 E(85289): 2.5e-23
Smith-Waterman score: 403; 32.2% identity (68.3% similar) in 199 aa overlap (30-224:253-442)
10 20 30 40 50
pF1KE5 MAQKEEAAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNV
:::... : : . ..: :.:.:.
XP_011 YCWENFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPM------EAMYPHIFYFHFKNL
230 240 250 260 270
60 70 80 90 100 110
pF1KE5 EYSSGRNKTFLCYVVEAQGKGGQVQASRGYLE---DEHAAAHAEEAFFNTILP-AFDPAL
. . :::...::...:. . . :. .:: .. : .. :::. :.. . ..:
XP_011 RKAYGRNESWLCFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNT
280 290 300 310 320 330
120 130 140 150 160 170
pF1KE5 RYNVTWYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCK
:.::::.: ::: :: .. . :.. .:. : :...::... . . : .:..:.. : .
XP_011 NYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGAS
340 350 360 370 380 390
180 190 200 210 220
pF1KE5 LRIMKPQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
..:: .::.: :.::: ... . :.::. .. :::. . :: .::.
XP_011 VEIMGYKDFKYCWENFVYNDD---EPFKPWKGLKYNFLFLDSKLQEILE
400 410 420 430 440
>--
initn: 288 init1: 157 opt: 246 Z-score: 328.9 bits: 69.0 E(85289): 1.4e-11
Smith-Waterman score: 246; 31.5% identity (62.3% similar) in 162 aa overlap (37-192:3-160)
10 20 30 40 50 60
pF1KE5 AAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRN
: :. : ::. . :...: : : ::
XP_011 MKPHFRN-TVERMYRDTFSYNFYNRPILSRRN
10 20 30
70 80 90 100 110 120
pF1KE5 KTFLCYVVEAQGKG-GQVQAS--RG--YLEDEHAAAHAEEAFFNTILPAFDPALR-YNVT
..::: :...: . ...:. :: : . :: ::: :.. . :: . ...:
XP_011 TVWLCYEVKTKGPSRPRLDAKIFRGQVYSQPEH---HAEMCFLSWFCGNQLPAYKCFQIT
40 50 60 70 80
130 140 150 160 170 180
pF1KE5 WYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMK
:.:: .:: :. .. . :.. :. : : ..::... : . . :: .:..:: ...::
XP_011 WFVSWTPCPDCVAKLAEFLAEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMD
90 100 110 120 130 140
190 200 210 220
pF1KE5 PQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
. .. :. :
XP_011 DEGERWRGQGSVSGRNSMKDGWICNAMAGGVPGQPAGAGPALTATDSQETRPGSAGPGSG
150 160 170 180 190 200
>>NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme APO (190 aa)
initn: 361 init1: 243 opt: 383 Z-score: 518.8 bits: 102.9 E(85289): 3.7e-22
Smith-Waterman score: 383; 32.6% identity (69.1% similar) in 181 aa overlap (48-224:14-190)
20 30 40 50 60 70
pF1KE5 GEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVVEAQ
:..:. :::.:. .. ::.:.::..::.
NP_055 MNPQIRNPMKAMYPGTFY-FQFKNLWEANDRNETWLCFTVEGI
10 20 30 40
80 90 100 110 120 130
pF1KE5 GKGGQVQASRGYLE---DEHAAAHAEEAFFNTILP-AFDPALRYNVTWYVSSSPCAACAD
. . :. . : .. : .. :::. :.. . ..: .:.::::.: ::: ::
NP_055 KRRSVVSWKTGVFRNQVDSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAG
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE5 RIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQDFEYVWQNFVE
.. . :.. .:. : :...::.... : : .:..:.. : ..:: .::.: :.:::
NP_055 EVAEFLARHSNVNLTIFTARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVY
110 120 130 140 150 160
200 210 220
pF1KE5 QEEGESKAFQPWEDIQENFLYYEEKLADILK
.. .. :.::. .. :: ...: . :.
NP_055 ND---NEPFKPWKGLKTNFRLLKRRLRESLQ
170 180 190
>>XP_016884085 (OMIM: 609900) PREDICTED: DNA dC->dU-edit (455 aa)
initn: 491 init1: 196 opt: 367 Z-score: 491.3 bits: 99.1 E(85289): 1.3e-20
Smith-Waterman score: 367; 31.2% identity (64.8% similar) in 199 aa overlap (30-224:266-455)
10 20 30 40 50
pF1KE5 MAQKEEAAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNV
:::... : : . ..: :.:.:.
XP_016 YCWENFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPM------EAMYPHIFYFHFKNL
240 250 260 270 280
60 70 80 90 100 110
pF1KE5 EYSSGRNKTFLCYVVEAQGKGGQVQASRGYLE---DEHAAAHAEEAFFNTILP-AFDPAL
. :::...::...:. . . : .:: .. : .. :::. :.. . ..:
XP_016 LKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNT
290 300 310 320 330 340
120 130 140 150 160 170
pF1KE5 RYNVTWYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCK
:.::::.: ::: :: .. . :.. .:. : :...:: .. . . : .: .:.. : .
XP_016 NYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGAS
350 360 370 380 390 400
180 190 200 210 220
pF1KE5 LRIMKPQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
..:: .:: :.::: ... . :.::. .: :: ...: .::.
XP_016 VKIMGYKDFVSCWKNFVYSDD---EPFKPWKGLQTNFRLLKRRLREILQ
410 420 430 440 450
>--
initn: 294 init1: 158 opt: 206 Z-score: 274.9 bits: 59.1 E(85289): 1.4e-08
Smith-Waterman score: 206; 28.7% identity (59.9% similar) in 157 aa overlap (45-185:10-163)
20 30 40 50 60 70
pF1KE5 SQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVV
::. . : .:.: ::. :.::: :
XP_016 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEV
10 20 30
80 90 100 110
pF1KE5 EAQ-GKGGQVQAS---RGYLEDEHAAAHAEEAFFN-------TILPAFD----PA-LRYN
. . :... . . :: . .. . : .:..: .: : :: :..
XP_016 KIKRGRSNLLWDTGVFRGPVLPKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQ
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE5 VTWYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRI
.::.:: .:: :. .. : :.. :. : : ..::..... . . .: .:..:: ...:
XP_016 ITWFVSWNPCLPCVVKVTKFLAEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKI
100 110 120 130 140 150
180 190 200 210 220
pF1KE5 MKPQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
: :.:
XP_016 M---DYEGERCRGQGSMTGRNSLRDGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRA
160 170 180 190 200 210
>>NP_065712 (OMIM: 605257,605258) single-stranded DNA cy (198 aa)
initn: 271 init1: 199 opt: 358 Z-score: 484.9 bits: 96.7 E(85289): 2.9e-20
Smith-Waterman score: 358; 35.1% identity (68.4% similar) in 174 aa overlap (52-223:11-180)
30 40 50 60 70 80
pF1KE5 ENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVVEAQGKGG
: .::.::....:: .:.:::::. . ..
NP_065 MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSAT
10 20 30 40
90 100 110 120 130 140
pF1KE5 QVQASRGYLEDEHAAAHAEEAFFNTILP-AFDPALRYNVTWYVSSSPCAACADRIIKTLS
. . . :::..... :.: :. : .::. : :::..: ::: :: .. :
NP_065 SFSLDFGYLRNKNGC-HVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVADFLR
50 60 70 80 90
150 160 170 180 190
pF1KE5 KTKNLRLLILVGRLFMWEEPEIQA-ALKKLKEAGCKLRIMKPQDFEYVWQNFVEQEEGES
. :: : :...::.. :. . . .:..:..:: .. :: .:. : :..:::..:
NP_065 GNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIAIMTFKDYFYCWNTFVENHE---
100 110 120 130 140 150
200 210 220
pF1KE5 KAFQPWEDIQENFLYYEEKLADILK
..:. :: ..:: . ..: ::
NP_065 RTFKAWEGLHENSVRLSRQLRRILLPLYEVDDLRDAFRTLGL
160 170 180 190
>>XP_016884131 (OMIM: 608993) PREDICTED: DNA dC->dU-edit (227 aa)
initn: 341 init1: 206 opt: 349 Z-score: 471.9 bits: 94.5 E(85289): 1.5e-19
Smith-Waterman score: 349; 32.5% identity (64.4% similar) in 194 aa overlap (37-224:3-189)
10 20 30 40 50 60
pF1KE5 AAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRN
: :. : ::. . :...: : : ::
XP_016 MKPHFRN-TVERMYRDTFSYNFYNRPILSRRN
10 20 30
70 80 90 100 110 120
pF1KE5 KTFLCYVVEAQGKG-GQVQAS--RG--YLEDEHAAAHAEEAFFNTILPAFDPALR-YNVT
..::: :...: . ...:. :: : . :: ::: :.. . :: . ...:
XP_016 TVWLCYEVKTKGPSRPRLDAKIFRGQVYSQPEH---HAEMCFLSWFCGNQLPAYKCFQIT
40 50 60 70 80
130 140 150 160 170 180
pF1KE5 WYVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMK
:.:: .:: :. .. . :.. :. : : ..::... : . . :: .:..:: ...::
XP_016 WFVSWTPCPDCVAKLAEFLAEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMD
90 100 110 120 130 140
190 200 210 220
pF1KE5 PQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
..: : :.::: . :.. :.:: ...:. . .. : .::.
XP_016 DEEFAYCWENFVYS---EGQPFMPWYKFDDNYAFLHRTLKEILRATSIHLRGRPPHSLGS
150 160 170 180 190 200
XP_016 PTWLLPSPWHNRICHKTGRKWA
210 220
>>NP_001257340 (OMIM: 607110) DNA dC->dU-editing enzyme (357 aa)
initn: 383 init1: 208 opt: 330 Z-score: 443.2 bits: 89.9 E(85289): 6e-18
Smith-Waterman score: 330; 31.6% identity (63.6% similar) in 187 aa overlap (45-224:10-190)
20 30 40 50 60 70
pF1KE5 SQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVV
::. . : .:.: ::. :.::: :
NP_001 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEV
10 20 30
80 90 100 110 120
pF1KE5 EAQ-GKGGQVQAS---RG--YLEDEHAAAHAEEAFFNTILPAFDPALR-YNVTWYVSSSP
. . :... . . :: :.. .. ::: :.. . :: . ...::.:: .:
NP_001 KIKRGRSNLLWDTGVFRGQVYFKPQY---HAEMCFLSWFCGNQLPAYKCFQITWFVSWTP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE5 CAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQDFEYV
: :. .. . ::. :. : : ..::... : . . :: .:..:: ...:: ..: :
NP_001 CPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYC
100 110 120 130 140 150
190 200 210 220
pF1KE5 WQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
:.::: .: .. :.:: ..::. . .. : .::.
NP_001 WENFVYNE---GQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQ
160 170 180 190 200 210
NP_001 TYLCYEVERLDNGTWVLMDQHMGFLCNELDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQ
220 230 240 250 260 270
>--
initn: 287 init1: 94 opt: 288 Z-score: 386.8 bits: 79.4 E(85289): 8.3e-15
Smith-Waterman score: 288; 31.7% identity (57.2% similar) in 180 aa overlap (47-224:193-353)
20 30 40 50 60 70
pF1KE5 NGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVVEA
. . : :.: : : .:.::: ::
NP_001 NEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVER
170 180 190 200 210 220
80 90 100 110 120 130
pF1KE5 QGKGGQVQASRGYLEDEHAAAHAEEAFFNTILPAFDPALRYNVTWYVSSSPCAA--CADR
.: : : :.: . .: .::: : :::..: ::: . :: .
NP_001 LDNGTWV------LMDQHMGFLCNE---------LDPAQIYRVTWFISWSPCFSWGCAGE
230 240 250 260
140 150 160 170 180 190
pF1KE5 IIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQDFEYVWQNFVEQ
. :... ..:: :...:.. .. : . ::. :..:: .. :: ..::: :..:: .
NP_001 VRAFLQENTHVRLRIFAARIYDYD-PLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYR
270 280 290 300 310 320
200 210 220
pF1KE5 EEGESKAFQPWEDIQENFLYYEEKLADILK
. . ::::. ..:. .: ::.
NP_001 Q---GCPFQPWDGLEEHSQALSGRLRAILQNQGN
330 340 350
>>NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme APO (382 aa)
initn: 383 init1: 208 opt: 330 Z-score: 442.8 bits: 89.9 E(85289): 6.4e-18
Smith-Waterman score: 330; 31.6% identity (63.6% similar) in 187 aa overlap (45-224:10-190)
20 30 40 50 60 70
pF1KE5 SQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVV
::. . : .:.: ::. :.::: :
NP_004 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEV
10 20 30
80 90 100 110 120
pF1KE5 EAQ-GKGGQVQAS---RG--YLEDEHAAAHAEEAFFNTILPAFDPALR-YNVTWYVSSSP
. . :... . . :: :.. .. ::: :.. . :: . ...::.:: .:
NP_004 KIKRGRSNLLWDTGVFRGQVYFKPQY---HAEMCFLSWFCGNQLPAYKCFQITWFVSWTP
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE5 CAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQDFEYV
: :. .. . ::. :. : : ..::... : . . :: .:..:: ...:: ..: :
NP_004 CPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYC
100 110 120 130 140 150
190 200 210 220
pF1KE5 WQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
:.::: .: .. :.:: ..::. . .. : .::.
NP_004 WENFVYNE---GQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQ
160 170 180 190 200 210
NP_004 TYLCYEVERLDNGTWVLMDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIY
220 230 240 250 260 270
>--
initn: 287 init1: 94 opt: 309 Z-score: 414.5 bits: 84.7 E(85289): 2.4e-16
Smith-Waterman score: 309; 31.9% identity (59.7% similar) in 191 aa overlap (47-224:193-378)
20 30 40 50 60 70
pF1KE5 NGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVVEA
. . : :.: : : .:.::: ::
NP_004 NEGQQFMPWYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVER
170 180 190 200 210 220
80 90 100 110 120
pF1KE5 QGKGGQVQASR--GYLEDEHA-------AAHAEEAFFNTILPAF--DPALRYNVTWYVSS
.: : .. :.: .: . ::: :.. ..:.. ::: : :::..:
NP_004 LDNGTWVLMDQHMGFLCNEAKNLLCGFYGRHAELRFLD-LVPSLQLDPAQIYRVTWFISW
230 240 250 260 270 280
130 140 150 160 170 180
pF1KE5 SPCAA--CADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQD
::: . :: .. :... ..:: :...:.. .. : . ::. :..:: .. :: ..
NP_004 SPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYD-PLYKEALQMLRDAGAQVSIMTYDE
290 300 310 320 330 340
190 200 210 220
pF1KE5 FEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
::: :..:: .. . ::::. ..:. .: ::.
NP_004 FEYCWDTFVYRQ---GCPFQPWDGLEEHSQALSGRLRAILQNQGN
350 360 370 380
>>NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme APO (384 aa)
initn: 316 init1: 143 opt: 294 Z-score: 394.3 bits: 80.9 E(85289): 3.2e-15
Smith-Waterman score: 300; 32.6% identity (62.5% similar) in 184 aa overlap (52-224:202-380)
30 40 50 60 70 80
pF1KE5 ENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRNKTFLCYVVEAQGKGG
: :.: : . ::..:.::: :: . .
NP_068 FEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDT
180 190 200 210 220 230
90 100 110 120 130
pF1KE5 QV--QASRGYLEDE----HA---AAHAEEAFFNTILP--AFDPALRYNVTWYVSSSPCAA
: . ::.: .. :. . ::: :.. ..: .: : :: ..: ::: .
NP_068 WVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLD-VIPFWKLDLDQDYRVTCFTSWSPCFS
240 250 260 270 280 290
140 150 160 170 180 190
pF1KE5 CADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKLKEAGCKLRIMKPQDFEYVWQN
::... : .::.:.. : :...:.. .. . : .:. : ::: :. :: ..:.. :..
NP_068 CAQEMAKFISKNKHVSLCIFTARIYD-DQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDT
300 310 320 330 340
200 210 220
pF1KE5 FVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
::... . ::::. ..:. .: ::.
NP_068 FVDHQ---GCPFQPWDGLDEHSQDLSGRLRAILQNQEN
350 360 370 380
>--
initn: 316 init1: 143 opt: 294 Z-score: 394.3 bits: 80.9 E(85289): 3.2e-15
Smith-Waterman score: 294; 29.4% identity (62.4% similar) in 197 aa overlap (37-224:3-194)
10 20 30 40 50 60
pF1KE5 AAVATEAASQNGEDLENLDDPEKLKELIELPPFEIVTGERLPANFFKFQFRNVEYSSGRN
: :. : ::. . :...: : : ::
NP_068 MKPHFRN-TVERMYRDTFSYNFYNRPILSRRN
10 20 30
70 80 90 100 110 120
pF1KE5 KTFLCYVVEAQGKGG---QVQASRGYLEDEHAAAHAEEAFFN--TILPAFDPALRYNVTW
..::: :...: . ... :: . .: : : ::. . . .:.:::
NP_068 TVWLCYEVKTKGPSRPPLDAKIFRGQVYSE-LKYHPEMRFFHWFSKWRKLHRDQEYEVTW
40 50 60 70 80 90
130 140 150 160 170
pF1KE5 YVSSSPCAACADRIIKTLSKTKNLRLLILVGRLFMWEEPEIQAALKKL--KEAGCK--LR
:.: :::. :. . :.. .. : :.:.::... .:. : ::..: :. : . ..
NP_068 YISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMK
100 110 120 130 140 150
180 190 200 210 220
pF1KE5 IMKPQDFEYVWQNFVEQEEGESKAFQPWEDIQENFLYYEEKLADILK
::. ..:.. :..:: ... . :.::... . .. . :..::.
NP_068 IMNYDEFQHCWSKFVYSQR---ELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFN
160 170 180 190 200
NP_068 NEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIP
210 220 230 240 250 260
224 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 04:36:00 2016 done: Tue Nov 8 04:36:01 2016
Total Scan time: 6.550 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]