FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4122, 505 aa 1>>>pF1KE4122 505 - 505 aa - 505 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2461+/-0.000402; mu= 13.5134+/- 0.025 mean_var=85.7467+/-17.939, 0's: 0 Z-trim(113.6): 157 B-trim: 581 in 1/51 Lambda= 0.138505 statistics sampled from 22838 (23000) to 22838 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.27), width: 16 Scan time: 9.450 The best scores are: opt bits E(85289) NP_060242 (OMIM: 616880) TBC1 domain family member ( 505) 3406 690.8 2.4e-198 XP_011513040 (OMIM: 616880) PREDICTED: TBC1 domain ( 504) 3129 635.5 1.1e-181 XP_011513041 (OMIM: 616880) PREDICTED: TBC1 domain ( 389) 2581 525.9 8.2e-149 XP_016884233 (OMIM: 616879) PREDICTED: TBC1 domain ( 470) 1805 370.9 4.6e-102 NP_001271234 (OMIM: 616879) TBC1 domain family mem ( 470) 1805 370.9 4.6e-102 NP_001271233 (OMIM: 616879) TBC1 domain family mem ( 487) 1805 370.9 4.7e-102 NP_055161 (OMIM: 616879) TBC1 domain family member ( 517) 1805 370.9 5e-102 NP_001271232 (OMIM: 616879) TBC1 domain family mem ( 439) 1655 340.9 4.6e-93 XP_016884234 (OMIM: 616879) PREDICTED: TBC1 domain ( 458) 1655 340.9 4.7e-93 XP_011528401 (OMIM: 616879) PREDICTED: TBC1 domain ( 491) 1590 327.9 4.1e-89 XP_016884232 (OMIM: 616879) PREDICTED: TBC1 domain ( 530) 1590 327.9 4.4e-89 XP_011528402 (OMIM: 616879) PREDICTED: TBC1 domain ( 401) 1116 233.2 1.1e-60 XP_011528403 (OMIM: 616879) PREDICTED: TBC1 domain ( 376) 974 204.8 3.7e-52 XP_016884235 (OMIM: 616879) PREDICTED: TBC1 domain ( 388) 972 204.4 5e-52 XP_011528404 (OMIM: 616879) PREDICTED: TBC1 domain ( 362) 838 177.6 5.4e-44 XP_016884236 (OMIM: 616879) PREDICTED: TBC1 domain ( 364) 833 176.6 1.1e-43 XP_005261553 (OMIM: 616879) PREDICTED: TBC1 domain ( 371) 831 176.2 1.4e-43 XP_016884231 (OMIM: 616879) PREDICTED: TBC1 domain ( 549) 833 176.7 1.5e-43 XP_005252117 (OMIM: 616218) PREDICTED: TBC1 domain ( 324) 225 55.1 3.6e-07 NP_060671 (OMIM: 616218) TBC1 domain family member ( 400) 225 55.1 4.4e-07 XP_011536984 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 220 54.2 9.6e-07 XP_006719630 (OMIM: 612662) PREDICTED: TBC1 domain ( 445) 220 54.2 9.6e-07 XP_016875317 (OMIM: 612662) PREDICTED: TBC1 domain ( 530) 220 54.2 1.1e-06 XP_016875316 (OMIM: 612662) PREDICTED: TBC1 domain ( 547) 220 54.2 1.1e-06 XP_016875314 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 220 54.2 1.2e-06 XP_016875315 (OMIM: 612662) PREDICTED: TBC1 domain ( 575) 220 54.2 1.2e-06 XP_006719629 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 220 54.2 1.2e-06 XP_011536982 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 220 54.2 1.2e-06 XP_011536981 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 220 54.2 1.2e-06 XP_016875313 (OMIM: 612662) PREDICTED: TBC1 domain ( 592) 220 54.2 1.2e-06 NP_001139685 (OMIM: 612662) TBC1 domain family mem ( 674) 220 54.2 1.4e-06 XP_006719628 (OMIM: 612662) PREDICTED: TBC1 domain ( 682) 220 54.2 1.4e-06 NP_001139686 (OMIM: 612662) TBC1 domain family mem ( 682) 220 54.2 1.4e-06 NP_073608 (OMIM: 612662) TBC1 domain family member ( 691) 220 54.2 1.4e-06 XP_006719627 (OMIM: 612662) PREDICTED: TBC1 domain ( 699) 220 54.2 1.4e-06 XP_011522624 (OMIM: 616637) PREDICTED: TBC1 domain ( 753) 190 48.3 9.6e-05 NP_001161694 (OMIM: 616659) TBC1 domain family mem ( 615) 186 47.4 0.00014 NP_078958 (OMIM: 616659) TBC1 domain family member ( 648) 186 47.4 0.00015 NP_001258775 (OMIM: 616637) TBC1 domain family mem ( 278) 179 45.9 0.00019 NP_001273701 (OMIM: 616218) TBC1 domain family mem ( 275) 177 45.5 0.00024 NP_001258773 (OMIM: 616637) TBC1 domain family mem ( 392) 179 45.9 0.00025 XP_011522626 (OMIM: 616637) PREDICTED: TBC1 domain ( 396) 179 45.9 0.00025 NP_001258774 (OMIM: 616637) TBC1 domain family mem ( 405) 179 45.9 0.00026 XP_016879677 (OMIM: 616637) PREDICTED: TBC1 domain ( 462) 179 46.0 0.00029 XP_011522625 (OMIM: 616637) PREDICTED: TBC1 domain ( 521) 179 46.0 0.00032 XP_016879676 (OMIM: 616637) PREDICTED: TBC1 domain ( 543) 179 46.0 0.00033 XP_016879675 (OMIM: 616637) PREDICTED: TBC1 domain ( 599) 179 46.0 0.00036 XP_006721758 (OMIM: 616637) PREDICTED: TBC1 domain ( 634) 179 46.0 0.00038 XP_016879674 (OMIM: 616637) PREDICTED: TBC1 domain ( 639) 179 46.0 0.00038 XP_005257109 (OMIM: 616637) PREDICTED: TBC1 domain ( 640) 179 46.0 0.00038 >>NP_060242 (OMIM: 616880) TBC1 domain family member 22B (505 aa) initn: 3406 init1: 3406 opt: 3406 Z-score: 3681.8 bits: 690.8 E(85289): 2.4e-198 Smith-Waterman score: 3406; 100.0% identity (100.0% similar) in 505 aa overlap (1-505:1-505) 10 20 30 40 50 60 pF1KE4 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE 430 440 450 460 470 480 490 500 pF1KE4 EIGLLLAEAYRLKYMFADAPNHYRR ::::::::::::::::::::::::: NP_060 EIGLLLAEAYRLKYMFADAPNHYRR 490 500 >>XP_011513040 (OMIM: 616880) PREDICTED: TBC1 domain fam (504 aa) initn: 3128 init1: 3128 opt: 3129 Z-score: 3382.7 bits: 635.5 E(85289): 1.1e-181 Smith-Waterman score: 3129; 97.7% identity (98.7% similar) in 478 aa overlap (1-477:1-478) 10 20 30 40 50 60 pF1KE4 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL 370 380 390 400 410 420 430 440 450 460 470 pF1KE4 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLML-LQNLPTIHWGN ::::::::::::::::::::::::::::::::::::::::::: ::. ...: . : XP_011 RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQPLLQSKISQLLVTSWVT 430 440 450 460 470 480 480 490 500 pF1KE4 EEIGLLLAEAYRLKYMFADAPNHYRR XP_011 LVAGKDQEEAEEEVAPMIKIHSRI 490 500 >>XP_011513041 (OMIM: 616880) PREDICTED: TBC1 domain fam (389 aa) initn: 2581 init1: 2581 opt: 2581 Z-score: 2792.7 bits: 525.9 E(85289): 8.2e-149 Smith-Waterman score: 2581; 100.0% identity (100.0% similar) in 388 aa overlap (1-388:1-388) 10 20 30 40 50 60 pF1KE4 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL :::::::::::::::::::::::::::: XP_011 GIQDNYTFAQPGIQKKVKALEELVSRIDV 370 380 >>XP_016884233 (OMIM: 616879) PREDICTED: TBC1 domain fam (470 aa) initn: 1912 init1: 1454 opt: 1805 Z-score: 1953.4 bits: 370.9 E(85289): 4.6e-102 Smith-Waterman score: 1964; 62.0% identity (82.2% similar) in 471 aa overlap (48-505:3-470) 20 30 40 50 60 70 pF1KE4 GSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTSDAWDIGDDEE :.:.: :..:.:.:: ::::::: :.:.. XP_016 MPTTPVKAKRVSTFQEFESNTSDAWDAGEDDD 10 20 30 80 90 100 110 120 pF1KE4 EDFSSPSFQTLNSKVALATAAQVLENHSK------------LRVKPERSQSTTSDVPANY : .. . ..:::.:.. :: .::.:::. :. ::. : .. XP_016 ELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 KVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTR ...:: :... : . .. ::...:::: . : . :: .. .. .. :: .: XP_016 RLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GGTSDPSTLSSSALSEREASR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 LEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEY :.::.:::.. ::::.:::. :: :.:. :::.::.:::::::::..:: :::::..:: XP_016 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 FGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPAS :.:::.::::::.: :::::::::::::: .: :. :: : ::::::::::::::::: XP_016 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIWAIRHPAS 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 GYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQD :::::::::::::::::. ::.: :.:.. ::... ..: .::::..:::::::::::: XP_016 GYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQD 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE4 NYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTI :::::::::: ::: ::::::::::::: :. ..::.::::::::::::::::.:::::: XP_016 NYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTI 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE4 RLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGL ::::::::::.::::::::::::::..::::::.:.::: ::..:::::: :: .:.:.: XP_016 RLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISL 390 400 410 420 430 440 490 500 pF1KE4 LLAEAYRLKYMFADAPNHYRR :::::::::. ::::::::.. XP_016 LLAEAYRLKFAFADAPNHYKK 450 460 470 >>NP_001271234 (OMIM: 616879) TBC1 domain family member (470 aa) initn: 1912 init1: 1454 opt: 1805 Z-score: 1953.4 bits: 370.9 E(85289): 4.6e-102 Smith-Waterman score: 1964; 62.0% identity (82.2% similar) in 471 aa overlap (48-505:3-470) 20 30 40 50 60 70 pF1KE4 GSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTSDAWDIGDDEE :.:.: :..:.:.:: ::::::: :.:.. NP_001 MPTTPVKAKRVSTFQEFESNTSDAWDAGEDDD 10 20 30 80 90 100 110 120 pF1KE4 EDFSSPSFQTLNSKVALATAAQVLENHSK------------LRVKPERSQSTTSDVPANY : .. . ..:::.:.. :: .::.:::. :. ::. : .. NP_001 ELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEAEPPSPPSGDL 40 50 60 70 80 90 130 140 150 160 170 180 pF1KE4 KVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTR ...:: :... : . .. ::...:::: . : . :: .. .. .. :: .: NP_001 RLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GGTSDPSTLSSSALSEREASR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KE4 LEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEY :.::.:::.. ::::.:::. :: :.:. :::.::.:::::::::..:: :::::..:: NP_001 LDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKEY 160 170 180 190 200 210 250 260 270 280 290 300 pF1KE4 FGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPAS :.:::.::::::.: :::::::::::::: .: :. :: : ::::::::::::::::: NP_001 FAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIWAIRHPAS 220 230 240 250 260 310 320 330 340 350 360 pF1KE4 GYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQD :::::::::::::::::. ::.: :.:.. ::... ..: .::::..:::::::::::: NP_001 GYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQD 270 280 290 300 310 320 370 380 390 400 410 420 pF1KE4 NYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTI :::::::::: ::: ::::::::::::: :. ..::.::::::::::::::::.:::::: NP_001 NYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTI 330 340 350 360 370 380 430 440 450 460 470 480 pF1KE4 RLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGL ::::::::::.::::::::::::::..::::::.:.::: ::..:::::: :: .:.:.: NP_001 RLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISL 390 400 410 420 430 440 490 500 pF1KE4 LLAEAYRLKYMFADAPNHYRR :::::::::. ::::::::.. NP_001 LLAEAYRLKFAFADAPNHYKK 450 460 470 >>NP_001271233 (OMIM: 616879) TBC1 domain family member (487 aa) initn: 1912 init1: 1454 opt: 1805 Z-score: 1953.1 bits: 370.9 E(85289): 4.7e-102 Smith-Waterman score: 1975; 60.9% identity (81.9% similar) in 481 aa overlap (38-505:10-487) 10 20 30 40 50 60 pF1KE4 QFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTS .... .:. :.:.: :..:.:.:: ::: NP_001 MWEPQPDVGSLLRSTAKMPTTPVKAKRVSTFQEFESNTS 10 20 30 70 80 90 100 110 pF1KE4 DAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------LRVKPERSQ :::: :.:..: .. . ..:::.:.. :: .::.:::. :. ::. NP_001 DAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPGLQQKPRPEA 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE4 STTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGA : .. ...:: :... : . .. ::...:::: . : . :: .. .. NP_001 EPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GGTSDPSTLSS 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE4 PPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRK .. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.:::::::::..:: NP_001 SALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRP 160 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 LTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERIL :::::..:::.:::.::::::.: :::::::::::::: .: :. :: : ::::::: NP_001 ATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERIL 220 230 240 250 260 270 300 310 320 330 340 350 pF1KE4 FIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWC :::::::::::::::::::::::::::. ::.: :.:.. ::... ..: .::::..:: NP_001 FIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWC 280 290 300 310 320 330 360 370 380 390 400 410 pF1KE4 MSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLL :::::::::::::::::::: ::: ::::::::::::: :. ..::.::::::::::::: NP_001 MSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLL 340 350 360 370 380 390 420 430 440 450 460 470 pF1KE4 MRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPT :::.::::::::::::::::.::::::::::::::..::::::.:.::: ::..:::::: NP_001 MREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPT 400 410 420 430 440 450 480 490 500 pF1KE4 IHWGNEEIGLLLAEAYRLKYMFADAPNHYRR :: .:.:.::::::::::. ::::::::.. NP_001 AHWDDEDISLLLAEAYRLKFAFADAPNHYKK 460 470 480 >>NP_055161 (OMIM: 616879) TBC1 domain family member 22A (517 aa) initn: 2100 init1: 1454 opt: 1805 Z-score: 1952.7 bits: 370.9 E(85289): 5e-102 Smith-Waterman score: 2145; 61.5% identity (82.1% similar) in 520 aa overlap (1-505:1-517) 10 20 30 40 50 pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS ::.... ::::::: .::::::: ::::::::.:: : .... .:. :.:.: :..:. NP_055 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST 10 20 30 40 50 60 60 70 80 90 100 pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------ :.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::. NP_055 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPG 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 LRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVAR :. ::. : .. ...:: :... : . .. ::...:::: . : . NP_055 LQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGY :: .. .. .. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.::::: NP_055 TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGY 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 LPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPL ::::..:: :::::..:::.:::.::::::.: :::::::::::::: .: :. :: NP_055 LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPK 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLR : ::::::::::::::::::::::::::::::::::. ::.: :.:.. ::... ..: NP_055 VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLC 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 SIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQF .::::..:::::::::::::::::::::: ::: ::::::::::::: :. ..::.:::: NP_055 NIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQF 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE4 AFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGL ::::::::::::.::::::::::::::::.::::::::::::::..::::::.:.::: : NP_055 AFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQEL 420 430 440 450 460 470 470 480 490 500 pF1KE4 LMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR :..:::::: :: .:.:.::::::::::. ::::::::.. NP_055 LLFLQNLPTAHWDDEDISLLLAEAYRLKFAFADAPNHYKK 480 490 500 510 >>NP_001271232 (OMIM: 616879) TBC1 domain family member (439 aa) initn: 1792 init1: 1354 opt: 1655 Z-score: 1791.8 bits: 340.9 E(85289): 4.6e-93 Smith-Waterman score: 1799; 57.1% identity (73.8% similar) in 508 aa overlap (1-505:1-439) 10 20 30 40 50 pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS ::.... ::::::: .:::::. .. .:. :.:.: :..:. NP_001 MASDGARKQFWKRSNSKLPGSL-------------------LRSTAKMPTTPVKAKRVST 10 20 30 40 60 70 80 90 100 110 pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTT :.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::. . .: NP_001 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRP------- 50 60 70 80 90 120 130 140 150 160 170 pF1KE4 SDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPM : ..: .:. : :: . :: NP_001 ------------------------TLQEGPGLQQK--P-RP-------------EAEPPS 100 110 180 190 200 210 220 230 pF1KE4 TVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTL :: : . : . .:::. :: :.:. :::.::.:::::::::..:: :: NP_001 PPSGDLRLVKSVSE-SHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATL 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE4 QRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIW :::..:::.:::.::::::.: :::::::::::::: .: :. :: : :::::::::: NP_001 QRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIW 180 190 200 210 220 230 300 310 320 330 340 350 pF1KE4 AIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSK ::::::::::::::::::::::::. ::.: :.:.. ::... ..: .::::..::::: NP_001 AIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSK 240 250 260 270 280 290 360 370 380 390 400 410 pF1KE4 LLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRE ::::::::::::::::: ::: ::::::::::::: :. ..::.:::::::::::::::: NP_001 LLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMRE 300 310 320 330 340 350 420 430 440 450 460 470 pF1KE4 LPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHW .::::::::::::::::.::::::::::::::..::::::.:.::: ::..:::::: :: NP_001 VPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHW 360 370 380 390 400 410 480 490 500 pF1KE4 GNEEIGLLLAEAYRLKYMFADAPNHYRR .:.:.::::::::::. ::::::::.. NP_001 DDEDISLLLAEAYRLKFAFADAPNHYKK 420 430 >>XP_016884234 (OMIM: 616879) PREDICTED: TBC1 domain fam (458 aa) initn: 1940 init1: 1354 opt: 1655 Z-score: 1791.6 bits: 340.9 E(85289): 4.7e-93 Smith-Waterman score: 1936; 59.6% identity (76.8% similar) in 508 aa overlap (1-505:1-458) 10 20 30 40 50 pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS ::.... ::::::: .::::::: ::::::::.:: : .... .:. :.:.: :..:. XP_016 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTT :.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::. . .: XP_016 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRP------- 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 SDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPM : ..: .:. : :: . :: XP_016 ------------------------TLQEGPGLQQK--P-RP-------------EAEPPS 120 130 180 190 200 210 220 230 pF1KE4 TVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTL :: : . : . .:::. :: :.:. :::.::.:::::::::..:: :: XP_016 PPSGDLRLVKSVSE-SHTSCPAEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATL 140 150 160 170 180 190 240 250 260 270 280 290 pF1KE4 QRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIW :::..:::.:::.::::::.: :::::::::::::: .: :. :: : :::::::::: XP_016 QRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPKVTEIFERILFIW 200 210 220 230 240 250 300 310 320 330 340 350 pF1KE4 AIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLRSIEADSFWCMSK ::::::::::::::::::::::::. ::.: :.:.. ::... ..: .::::..::::: XP_016 AIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSK 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE4 LLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRE ::::::::::::::::: ::: ::::::::::::: :. ..::.:::::::::::::::: XP_016 LLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLMRE 320 330 340 350 360 370 420 430 440 450 460 470 pF1KE4 LPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHW .::::::::::::::::.::::::::::::::..::::::.:.::: ::..:::::: :: XP_016 VPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHW 380 390 400 410 420 430 480 490 500 pF1KE4 GNEEIGLLLAEAYRLKYMFADAPNHYRR .:.:.::::::::::. ::::::::.. XP_016 DDEDISLLLAEAYRLKFAFADAPNHYKK 440 450 >>XP_011528401 (OMIM: 616879) PREDICTED: TBC1 domain fam (491 aa) initn: 1620 init1: 1239 opt: 1590 Z-score: 1720.9 bits: 327.9 E(85289): 4.1e-89 Smith-Waterman score: 1930; 60.7% identity (81.4% similar) in 478 aa overlap (1-463:1-475) 10 20 30 40 50 pF1KE4 MAAENS-KQFWKRS-AKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASS ::.... ::::::: .::::::: ::::::::.:: : .... .:. :.:.: :..:. XP_011 MASDGARKQFWKRSNSKLPGSIQHVYGAQHPPFDPLLHGTLLRSTAKMPTTPVKAKRVST 10 20 30 40 50 60 60 70 80 90 100 pF1KE4 FHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSK------------ :.:: ::::::: :.:..: .. . ..:::.:.. :: .::.:::. XP_011 FQEFESNTSDAWDAGEDDDELLAMAA-ESLNSEVVMETANRVLRNHSQRQGRPTLQEGPG 70 80 90 100 110 110 120 130 140 150 160 pF1KE4 LRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVAR :. ::. : .. ...:: :... : . .. ::...:::: . : . XP_011 LQQKPRPEAEPPSPPSGDLRLVKSVSESHTSCPAESASDAAPLQRSQSLPHSATVTL-GG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE4 ISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGY :: .. .. .. :: .::.::.:::.. ::::.:::. :: :.:. :::.::.::::: XP_011 TSDPSTLSSSALSEREASRLDKFKQLLAGPNTDLEELRRLSWSGIPKPVRPMTWKLLSGY 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE4 LPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPL ::::..:: :::::..:::.:::.::::::.: :::::::::::::: .: :. :: XP_011 LPANVDRRPATLQRKQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEA-LILQPK 240 250 260 270 280 290 290 300 310 320 330 340 pF1KE4 VQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVE-EDVENFDVTNLSQDMLR : ::::::::::::::::::::::::::::::::::. ::.: :.:.. ::... ..: XP_011 VTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLC 300 310 320 330 340 350 350 360 370 380 390 400 pF1KE4 SIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQF .::::..:::::::::::::::::::::: ::: ::::::::::::: :. ..::.:::: XP_011 NIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQF 360 370 380 390 400 410 410 420 430 440 450 460 pF1KE4 AFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGL ::::::::::::.::::::::::::::::.::::::::::::::..::::::.:.::: XP_011 AFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQHC 420 430 440 450 460 470 470 480 490 500 pF1KE4 LMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR XP_011 RLRRTGHFYSPSIQ 480 490 505 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:10:30 2016 done: Sun Nov 6 04:10:31 2016 Total Scan time: 9.450 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]