Result of FASTA (omim) for
pFN21AE5815
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE5815, 865 aa
1>>>pF1KE5815 865 - 865 aa - 865 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4559+/-0.00049; mu= 16.5510+/- 0.031
mean_var=120.1078+/-24.246, 0's: 0 Z-trim(111.3): 71 B-trim: 194 in 1/52
Lambda= 0.117028
statistics sampled from 19749 (19818) to 19749 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.585), E-opt: 0.2 (0.232), width: 16
Scan time: 11.470
The best scores are: opt bits E(85289)
NP_619732 (OMIM: 606766,608480) testis anion trans ( 865) 5660 967.9 0
NP_443193 (OMIM: 606766,608480) testis anion trans ( 970) 4292 737.0 1e-211
NP_001180405 (OMIM: 606766,608480) testis anion tr ( 970) 4292 737.0 1e-211
XP_016865724 (OMIM: 606766,608480) PREDICTED: test ( 970) 4292 737.0 1e-211
XP_011512596 (OMIM: 606766,608480) PREDICTED: test ( 944) 3398 586.0 2.7e-166
NP_001035544 (OMIM: 610068) solute carrier family ( 738) 648 121.6 1.3e-26
NP_602298 (OMIM: 610068) solute carrier family 26 ( 740) 648 121.6 1.3e-26
NP_599025 (OMIM: 610068) solute carrier family 26 ( 758) 648 121.6 1.3e-26
NP_075062 (OMIM: 610068) solute carrier family 26 ( 759) 648 121.6 1.3e-26
NP_001268662 (OMIM: 610068) solute carrier family ( 651) 631 118.7 8.8e-26
NP_001268661 (OMIM: 610068) solute carrier family ( 723) 624 117.6 2.2e-25
NP_996766 (OMIM: 604943,613865) prestin isoform b ( 685) 605 114.3 1.9e-24
XP_011514472 (OMIM: 604943,613865) PREDICTED: pres ( 744) 605 114.4 2e-24
NP_945350 (OMIM: 604943,613865) prestin isoform a ( 744) 605 114.4 2e-24
NP_000432 (OMIM: 274600,600791,605646) pendrin [Ho ( 780) 559 106.6 4.6e-22
XP_005250482 (OMIM: 274600,600791,605646) PREDICTE ( 780) 559 106.6 4.6e-22
NP_000102 (OMIM: 126650,214700) chloride anion exc ( 764) 554 105.8 8.1e-22
XP_011514169 (OMIM: 126650,214700) PREDICTED: chlo ( 764) 554 105.8 8.1e-22
XP_016864680 (OMIM: 222600,226900,256050,600972,60 ( 739) 533 102.2 9.2e-21
NP_000103 (OMIM: 222600,226900,256050,600972,60671 ( 739) 533 102.2 9.2e-21
XP_011507424 (OMIM: 608481) PREDICTED: solute carr ( 627) 520 100.0 3.7e-20
XP_011507423 (OMIM: 608481) PREDICTED: solute carr ( 702) 520 100.0 4.1e-20
NP_443166 (OMIM: 608481) solute carrier family 26 ( 791) 520 100.0 4.5e-20
NP_599152 (OMIM: 608481) solute carrier family 26 ( 887) 520 100.1 4.9e-20
NP_996767 (OMIM: 604943,613865) prestin isoform c ( 516) 486 94.2 1.7e-18
NP_071325 (OMIM: 167030,610130) sulfate anion tran ( 701) 464 90.6 2.9e-17
NP_998778 (OMIM: 167030,610130) sulfate anion tran ( 701) 464 90.6 2.9e-17
XP_011507426 (OMIM: 608481) PREDICTED: solute carr ( 466) 358 72.5 5.1e-12
NP_001269285 (OMIM: 608479) anion exchange transpo ( 656) 342 69.9 4.3e-11
NP_439897 (OMIM: 608479) anion exchange transporte ( 656) 342 69.9 4.3e-11
NP_599028 (OMIM: 608479) anion exchange transporte ( 663) 342 69.9 4.3e-11
NP_001269286 (OMIM: 608479) anion exchange transpo ( 355) 311 64.5 1e-09
NP_001308716 (OMIM: 604943,613865) prestin isoform ( 653) 310 64.5 1.8e-09
NP_001161434 (OMIM: 604943,613865) prestin isoform ( 712) 310 64.6 1.9e-09
NP_996768 (OMIM: 604943,613865) prestin isoform d ( 335) 259 55.7 4.3e-07
XP_016867807 (OMIM: 274600,600791,605646) PREDICTE ( 754) 262 56.5 5.6e-07
XP_006716088 (OMIM: 274600,600791,605646) PREDICTE ( 423) 258 55.6 5.7e-07
XP_011522955 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 231 51.0 1.4e-05
XP_011522956 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 231 51.0 1.4e-05
XP_011522954 (OMIM: 610117) PREDICTED: sodium-inde ( 465) 231 51.1 1.5e-05
NP_001159819 (OMIM: 610117) sodium-independent sul ( 606) 231 51.2 1.8e-05
NP_001159821 (OMIM: 610117) sodium-independent sul ( 606) 231 51.2 1.8e-05
NP_775897 (OMIM: 610117) sodium-independent sulfat ( 606) 231 51.2 1.8e-05
NP_001159820 (OMIM: 610117) sodium-independent sul ( 606) 231 51.2 1.8e-05
XP_016879996 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 231 51.2 1.8e-05
XP_006721896 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 231 51.2 1.8e-05
XP_016879995 (OMIM: 610117) PREDICTED: sodium-inde ( 677) 231 51.2 1.9e-05
XP_016879994 (OMIM: 610117) PREDICTED: sodium-inde ( 696) 231 51.2 2e-05
NP_602297 (OMIM: 167030,610130) sulfate anion tran ( 224) 209 47.1 0.00011
>>NP_619732 (OMIM: 606766,608480) testis anion transport (865 aa)
initn: 5660 init1: 5660 opt: 5660 Z-score: 5171.0 bits: 967.9 E(85289): 0
Smith-Waterman score: 5660; 99.8% identity (100.0% similar) in 865 aa overlap (1-865:1-865)
10 20 30 40 50 60
pF1KE5 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
NP_619 QCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE5 IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE5 EFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 EFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE5 PVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 PVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE5 FRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 FRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE5 VIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 VIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE5 ILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 ILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE5 KEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSVNLIHCS
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_619 KEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE5 HFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 HFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE5 RRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 RRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE5 VRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 VRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKN
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE5 DNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 DNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPE
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE5 MEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_619 MEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQT
790 800 810 820 830 840
850 860
pF1KE5 RTWSVERRRHPMDSYSPEGNSNEDV
:::::::::::::::::::::::::
NP_619 RTWSVERRRHPMDSYSPEGNSNEDV
850 860
>>NP_443193 (OMIM: 606766,608480) testis anion transport (970 aa)
initn: 4282 init1: 4282 opt: 4292 Z-score: 3922.0 bits: 737.0 E(85289): 1e-211
Smith-Waterman score: 4946; 88.2% identity (88.3% similar) in 897 aa overlap (74-865:74-970)
50 60 70 80 90 100
pF1KE5 SSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVG
::::::::::::::::::::::::::::::
NP_443 SSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVG
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE5 LVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK
110 120 130 140 150 160
170 180 190 200
pF1KE5 VSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQ--------------
::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATY
170 180 190 200 210 220
pF1KE5 ------------------------------------------------------------
NP_443 LPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILV
230 240 250 260 270 280
210 220 230
pF1KE5 -------------------------------IIGFTVIANKISMATETSQTLIDMIPYSF
:::::::::::::::::::::::::::::
NP_443 FLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSF
290 300 310 320 330 340
240 250 260 270 280 290
pF1KE5 LLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVS
350 360 370 380 390 400
300 310 320 330 340 350
pF1KE5 SFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL
410 420 430 440 450 460
360 370 380 390 400 410
pF1KE5 SNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHR
470 480 490 500 510 520
420 430 440 450 460 470
pF1KE5 AKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 AKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKV
530 540 550 560 570 580
480 490 500 510 520 530
pF1KE5 PLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSVNLIH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_443 PLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIH
590 600 610 620 630 640
540 550 560 570 580 590
pF1KE5 CSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 CSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAES
650 660 670 680 690 700
600 610 620 630 640 650
pF1KE5 QGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 QGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHS
710 720 730 740 750 760
660 670 680 690 700 710
pF1KE5 SIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETD
770 780 790 800 810 820
720 730 740 750 760 770
pF1KE5 KNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 KNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELE
830 840 850 860 870 880
780 790 800 810 820 830
pF1KE5 PEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQT
890 900 910 920 930 940
840 850 860
pF1KE5 QTRTWSVERRRHPMDSYSPEGNSNEDV
:::::::::::::::::::::::::::
NP_443 QTRTWSVERRRHPMDSYSPEGNSNEDV
950 960 970
>--
initn: 500 init1: 494 opt: 494 Z-score: 456.5 bits: 95.7 E(85289): 1.1e-18
Smith-Waterman score: 494; 98.6% identity (100.0% similar) in 73 aa overlap (1-73:1-73)
10 20 30 40 50 60
pF1KE5 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
::::::::::::.
NP_443 QCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
70 80 90 100 110 120
>>NP_001180405 (OMIM: 606766,608480) testis anion transp (970 aa)
initn: 4282 init1: 4282 opt: 4292 Z-score: 3922.0 bits: 737.0 E(85289): 1e-211
Smith-Waterman score: 4946; 88.2% identity (88.3% similar) in 897 aa overlap (74-865:74-970)
50 60 70 80 90 100
pF1KE5 SSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVG
::::::::::::::::::::::::::::::
NP_001 SSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVG
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE5 LVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK
110 120 130 140 150 160
170 180 190 200
pF1KE5 VSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQ--------------
::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATY
170 180 190 200 210 220
pF1KE5 ------------------------------------------------------------
NP_001 LPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILV
230 240 250 260 270 280
210 220 230
pF1KE5 -------------------------------IIGFTVIANKISMATETSQTLIDMIPYSF
:::::::::::::::::::::::::::::
NP_001 FLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSF
290 300 310 320 330 340
240 250 260 270 280 290
pF1KE5 LLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVS
350 360 370 380 390 400
300 310 320 330 340 350
pF1KE5 SFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL
410 420 430 440 450 460
360 370 380 390 400 410
pF1KE5 SNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHR
470 480 490 500 510 520
420 430 440 450 460 470
pF1KE5 AKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKV
530 540 550 560 570 580
480 490 500 510 520 530
pF1KE5 PLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSVNLIH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
NP_001 PLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIH
590 600 610 620 630 640
540 550 560 570 580 590
pF1KE5 CSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAES
650 660 670 680 690 700
600 610 620 630 640 650
pF1KE5 QGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHS
710 720 730 740 750 760
660 670 680 690 700 710
pF1KE5 SIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETD
770 780 790 800 810 820
720 730 740 750 760 770
pF1KE5 KNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELE
830 840 850 860 870 880
780 790 800 810 820 830
pF1KE5 PEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQT
890 900 910 920 930 940
840 850 860
pF1KE5 QTRTWSVERRRHPMDSYSPEGNSNEDV
:::::::::::::::::::::::::::
NP_001 QTRTWSVERRRHPMDSYSPEGNSNEDV
950 960 970
>--
initn: 500 init1: 494 opt: 494 Z-score: 456.5 bits: 95.7 E(85289): 1.1e-18
Smith-Waterman score: 494; 98.6% identity (100.0% similar) in 73 aa overlap (1-73:1-73)
10 20 30 40 50 60
pF1KE5 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
::::::::::::.
NP_001 QCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
70 80 90 100 110 120
>>XP_016865724 (OMIM: 606766,608480) PREDICTED: testis a (970 aa)
initn: 4282 init1: 4282 opt: 4292 Z-score: 3922.0 bits: 737.0 E(85289): 1e-211
Smith-Waterman score: 4946; 88.2% identity (88.3% similar) in 897 aa overlap (74-865:74-970)
50 60 70 80 90 100
pF1KE5 SSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVG
::::::::::::::::::::::::::::::
XP_016 SSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVG
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE5 LVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK
110 120 130 140 150 160
170 180 190 200
pF1KE5 VSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQ--------------
::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQLIMGVLGLGFIATY
170 180 190 200 210 220
pF1KE5 ------------------------------------------------------------
XP_016 LPESAMSAYLAAVALHIMLSQLTFIFGIMISFHAGPISFFYDIINYCVALPKANSTSILV
230 240 250 260 270 280
210 220 230
pF1KE5 -------------------------------IIGFTVIANKISMATETSQTLIDMIPYSF
:::::::::::::::::::::::::::::
XP_016 FLTVVVALRINKCIRISFNQYPIEFPMELFLIIGFTVIANKISMATETSQTLIDMIPYSF
290 300 310 320 330 340
240 250 260 270 280 290
pF1KE5 LLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVS
350 360 370 380 390 400
300 310 320 330 340 350
pF1KE5 SFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL
410 420 430 440 450 460
360 370 380 390 400 410
pF1KE5 SNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHR
470 480 490 500 510 520
420 430 440 450 460 470
pF1KE5 AKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKV
530 540 550 560 570 580
480 490 500 510 520 530
pF1KE5 PLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSVNLIH
:::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::
XP_016 PLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIH
590 600 610 620 630 640
540 550 560 570 580 590
pF1KE5 CSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAES
650 660 670 680 690 700
600 610 620 630 640 650
pF1KE5 QGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHS
710 720 730 740 750 760
660 670 680 690 700 710
pF1KE5 SIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETD
770 780 790 800 810 820
720 730 740 750 760 770
pF1KE5 KNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELE
830 840 850 860 870 880
780 790 800 810 820 830
pF1KE5 PEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQT
890 900 910 920 930 940
840 850 860
pF1KE5 QTRTWSVERRRHPMDSYSPEGNSNEDV
:::::::::::::::::::::::::::
XP_016 QTRTWSVERRRHPMDSYSPEGNSNEDV
950 960 970
>--
initn: 500 init1: 494 opt: 494 Z-score: 456.5 bits: 95.7 E(85289): 1.1e-18
Smith-Waterman score: 494; 98.6% identity (100.0% similar) in 73 aa overlap (1-73:1-73)
10 20 30 40 50 60
pF1KE5 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
::::::::::::.
XP_016 QCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
70 80 90 100 110 120
>>XP_011512596 (OMIM: 606766,608480) PREDICTED: testis a (944 aa)
initn: 4766 init1: 3395 opt: 3398 Z-score: 3106.5 bits: 586.0 E(85289): 2.7e-166
Smith-Waterman score: 4913; 85.6% identity (85.8% similar) in 923 aa overlap (48-865:48-944)
20 30 40 50 60 70
pF1KE5 RNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIF
:::::::::::::::::::::::::.::::
XP_011 RNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCVLTIF
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE5 PFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIY
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE5 VIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSV
140 150 160 170 180 190
200
pF1KE5 VATTTFLTGIIQ------------------------------------------------
::::::::::::
XP_011 VATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHA
200 210 220 230 240 250
210
pF1KE5 ---------------------------------------------------------IIG
:::
XP_011 GPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQYPIEFPMELFLIIG
260 270 280 290 300 310
220 230 240 250 260 270
pF1KE5 FTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGK
320 330 340 350 360 370
280 290 300 310 320 330
pF1KE5 KIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAG
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQ--------
380 390 400 410 420
340 350 360 370 380 390
pF1KE5 VMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSS
::::::::::::::::::::::::::::::::::::::::::
XP_011 ------------------AVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSS
430 440 450 460 470
400 410 420 430 440 450
pF1KE5 IFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQ
480 490 500 510 520 530
460 470 480 490 500 510
pF1KE5 CCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLE
540 550 560 570 580 590
520 530 540 550 560 570
pF1KE5 PLPRILYTERFENKLDPEASSVNLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQY
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_011 PLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQY
600 610 620 630 640 650
580 590 600 610 620 630
pF1KE5 EEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSR
660 670 680 690 700 710
640 650 660 670 680 690
pF1KE5 GLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALS
720 730 740 750 760 770
700 710 720 730 740 750
pF1KE5 RKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEE
780 790 800 810 820 830
760 770 780 790 800 810
pF1KE5 SELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSR
840 850 860 870 880 890
820 830 840 850 860
pF1KE5 PRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
900 910 920 930 940
>--
initn: 295 init1: 295 opt: 295 Z-score: 275.1 bits: 62.1 E(85289): 1.4e-08
Smith-Waterman score: 295; 100.0% identity (100.0% similar) in 47 aa overlap (1-47:1-47)
10 20 30 40 50 60
pF1KE5 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE5 QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
XP_011 QCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
70 80 90 100 110 120
>>NP_001035544 (OMIM: 610068) solute carrier family 26 m (738 aa)
initn: 1081 init1: 613 opt: 648 Z-score: 598.6 bits: 121.6 E(85289): 1.3e-26
Smith-Waterman score: 904; 27.2% identity (59.4% similar) in 739 aa overlap (63-703:40-735)
40 50 60 70 80 90
pF1KE5 ETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWL
.:: : .: .: : :. : ..:::
NP_001 MERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWL
10 20 30 40 50 60
100 110 120 130 140 150
pF1KE5 LGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFF
:::::.:.::...:.::::. .::: .::. :..: :: .::. ...:.:.:
NP_001 LGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFLFGTSRHISVGTFA
70 80 90 100 110 120
160 170 180
pF1KE5 LVSALLINVLK-VSP--FNNG-------------------------QLVMG----SFVKN
..:... .: . ..: .:.. :. .: .:: .
NP_001 VMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVT
130 140 150 160 170 180
190 200
pF1KE5 EFSAP------------------SYLMGYNKS-----LSVVAT-----------------
.: : .:..: . : ::.. :
NP_001 YLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVV
190 200 210 220 230 240
210 220 230
pF1KE5 TTFLTGIIQI------------------------IGFTVIANKISMATETSQTLIDMIPY
:. ..:.. . :: : :. ... . .. ::
NP_001 TAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPA
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE5 SFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNV
... ::.:. .:. :.. .::....:. . : ::: .: :.: :.:::.:.:.:: :.
NP_001 GLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNL
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE5 VSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGI
....:. . ...:...:...:: .: :. ... .::..::.:..:. ::.::::.:
NP_001 IGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAI
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE5 ILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRS
:. :. .:. .:.. :::. .. : .:..::...:.:.::.::...:. ......::.
NP_001 IIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRT
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE5 HRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMV
. . .:::.:.:.:::.. .: : . :::.:. ... :.:. . . : .. .
NP_001 QMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGV-
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE5 KVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKL-DPEASSVN
:... .. . . . ..:. : .. :..... .:...::.
NP_001 ----------------DVDFLISQKKKLLKKQEQLK-LKQLQKEEKLRKQAASPKGASVS
550 560 570 580
540 550 560 570 580 590
pF1KE5 LIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDV
. . .:.: .... :: . ::: ..: . . :. :..:. .. :::.
NP_001 INVNTSLEDMRSNNV--EDCKMMQVSS-GDKMEDATANGQEDSKAPDGSTLKAL-GLPQ-
590 600 610 620 630 640
600 610 620 630 640 650
pF1KE5 AESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAG
:. :..:::.. . .::. : :..: . :.. .. . .:.
NP_001 ------------------PDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAA
650 660 670 680
660 670 680 690 700 710
pF1KE5 CHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSR-KVIGSSELSIDESETVIRETY
::: .: .: . ::::.::: .:: :::::: :::.. . . .: .:.
NP_001 CHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
690 700 710 720 730
720 730 740 750 760 770
pF1KE5 SETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLD
>>NP_602298 (OMIM: 610068) solute carrier family 26 memb (740 aa)
initn: 1081 init1: 613 opt: 648 Z-score: 598.6 bits: 121.6 E(85289): 1.3e-26
Smith-Waterman score: 871; 26.8% identity (58.1% similar) in 738 aa overlap (63-703:61-737)
40 50 60 70 80 90
pF1KE5 ETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWL
.:: : .: .: : :. : ..:::
NP_602 MERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWL
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE5 LGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFF
:::::.:.::...:.::::. .::: .::. :..: :: .::. ...:.:.:
NP_602 LGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFLFGTSRHISVGTFA
100 110 120 130 140
160 170 180
pF1KE5 LVSALLINVLK-VSP--FNNG-------------------------QLVMG----SFVKN
..:... .: . ..: .:.. :. .: .:: .
NP_602 VMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVT
150 160 170 180 190 200
190 200
pF1KE5 EFSAP------------------SYLMGYNKS-----LSVVAT-----------------
.: : .:..: . : ::.. :
NP_602 YLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVV
210 220 230 240 250 260
210 220 230
pF1KE5 TTFLTGIIQI------------------------IGFTVIANKISMATETSQTLIDMIPY
:. ..:.. . :: : :. ... . .. ::
NP_602 TAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPA
270 280 290 300 310 320
240 250 260 270 280 290
pF1KE5 SFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNV
... ::.:. .:. :.. .::....:. . : ::: .: :.: :.:::.:.:.:: :.
NP_602 GLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNL
330 340 350 360 370 380
300 310 320 330 340 350
pF1KE5 VSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGI
....:. . ...:...:...:: .: :. ... .::..::.:..:. ::.::::.:
NP_602 IGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAI
390 400 410 420 430 440
360 370 380 390 400 410
pF1KE5 ILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRS
:. :. .:. .:.. :::. .. : .:..::...:.:.::.::...:. ......::.
NP_602 IIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRT
450 460 470 480 490 500
420 430 440 450 460 470
pF1KE5 HRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMV
. . .:::.:.:.:::.. .: : . :::.:. ... :.:. . . : .. .
NP_602 QMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGV-
510 520 530 540 550 560
480 490 500 510 520 530
pF1KE5 KVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSVNL
:... .. . . . ..:. : .. :..... : :.
NP_602 ----------------DVDFLISQKKKLLKKQEQLK-LKQLQKEEKLRKQAGPLLSA---
570 580 590 600
540 550 560 570 580 590
pF1KE5 IHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVA
: . .:..: :.. .... :: :. :..:. .. :::.
NP_602 --C-----LAPQQVSSGDKMEDATAN------GQ-----EDSKAPDGSTLKAL-GLPQ--
610 620 630 640
600 610 620 630 640 650
pF1KE5 ESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGC
:. :..:::.. . .::. : :..: . :.. .. . .:.:
NP_602 -----------------PDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAAC
650 660 670 680
660 670 680 690 700 710
pF1KE5 HSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSR-KVIGSSELSIDESETVIRETYS
:: .: .: . ::::.::: .:: :::::: :::.. . . .: .:.
NP_602 HSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
690 700 710 720 730 740
720 730 740 750 760 770
pF1KE5 ETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDR
>>NP_599025 (OMIM: 610068) solute carrier family 26 memb (758 aa)
initn: 1086 init1: 618 opt: 648 Z-score: 598.5 bits: 121.6 E(85289): 1.3e-26
Smith-Waterman score: 899; 27.2% identity (59.4% similar) in 739 aa overlap (63-703:61-755)
40 50 60 70 80 90
pF1KE5 ETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWL
.:: : .: .: : :. : ..:::
NP_599 MERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWL
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE5 LGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFF
:::::.:.::...:.::::. .::: .::. :..: :: .::. ...:.:.:
NP_599 LGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFLFGTSRHISVGTFA
100 110 120 130 140
160 170 180
pF1KE5 LVSALLINVLK-VSP--FNNG-------------------------QLVMG----SFVKN
..:... .: . ..: .:.. :. .: .:: .
NP_599 VMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVT
150 160 170 180 190 200
190 200
pF1KE5 EFSAP------------------SYLMGYNKS-----LSVVAT-----------------
.: : .:..: . : ::.. :
NP_599 YLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVV
210 220 230 240 250 260
210 220 230
pF1KE5 TTFLTGIIQI------------------------IGFTVIANKISMATETSQTLIDMIPY
:. ..:.. . :: : :. ... . .. ::
NP_599 TAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPA
270 280 290 300 310 320
240 250 260 270 280 290
pF1KE5 SFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNV
... ::.:. .:. :.. .::....:. . : ::: .: :.: :.:::.:.:.:: :.
NP_599 GLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNL
330 340 350 360 370 380
300 310 320 330 340 350
pF1KE5 VSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGI
....:. . ...:...:...:: .: :. ... .::..::.:..:. ::.::::.:
NP_599 IGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAI
390 400 410 420 430 440
360 370 380 390 400 410
pF1KE5 ILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRS
:. :. .:. .:.. :::. .. : .:..::...:.:.::.::...:. ......::.
NP_599 IIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRT
450 460 470 480 490 500
420 430 440 450 460 470
pF1KE5 HRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMV
. . .:::.:.:.:::.. .: : . :::.:. ... :.:. . . : .. .
NP_599 QMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGV-
510 520 530 540 550 560
480 490 500 510 520 530
pF1KE5 KVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKL-DPEASSVN
:... .. . . . ..:. : .. :..... .:...::.
NP_599 ----------------DVDFLISQKKKLLKKQEQLK-LKQLQKEEKLRKQAASPKGASVS
570 580 590 600 610
540 550 560 570 580 590
pF1KE5 LIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDV
. . .:.: .... :: . ::: ..: . . :. :..:. .. :::.
NP_599 INVNTSLEDMRSNNV--ED-CKMMVSS-GDKMEDATANGQEDSKAPDGSTLKAL-GLPQ-
620 630 640 650 660
600 610 620 630 640 650
pF1KE5 AESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAG
:. :..:::.. . .::. : :..: . :.. .. . .:.
NP_599 ------------------PDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAA
670 680 690 700
660 670 680 690 700 710
pF1KE5 CHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSR-KVIGSSELSIDESETVIRETY
::: .: .: . ::::.::: .:: :::::: :::.. . . .: .:.
NP_599 CHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
710 720 730 740 750
720 730 740 750 760 770
pF1KE5 SETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLD
>>NP_075062 (OMIM: 610068) solute carrier family 26 memb (759 aa)
initn: 1081 init1: 613 opt: 648 Z-score: 598.5 bits: 121.6 E(85289): 1.3e-26
Smith-Waterman score: 904; 27.2% identity (59.4% similar) in 739 aa overlap (63-703:61-756)
40 50 60 70 80 90
pF1KE5 ETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWL
.:: : .: .: : :. : ..:::
NP_075 MERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWL
40 50 60 70 80 90
100 110 120 130 140 150
pF1KE5 LGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFF
:::::.:.::...:.::::. .::: .::. :..: :: .::. ...:.:.:
NP_075 LGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFLFGTSRHISVGTFA
100 110 120 130 140
160 170 180
pF1KE5 LVSALLINVLK-VSP--FNNG-------------------------QLVMG----SFVKN
..:... .: . ..: .:.. :. .: .:: .
NP_075 VMSVMVGSVTESLAPQALNDSMINETARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVT
150 160 170 180 190 200
190 200
pF1KE5 EFSAP------------------SYLMGYNKS-----LSVVAT-----------------
.: : .:..: . : ::.. :
NP_075 YLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVV
210 220 230 240 250 260
210 220 230
pF1KE5 TTFLTGIIQI------------------------IGFTVIANKISMATETSQTLIDMIPY
:. ..:.. . :: : :. ... . .. ::
NP_075 TAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPA
270 280 290 300 310 320
240 250 260 270 280 290
pF1KE5 SFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNV
... ::.:. .:. :.. .::....:. . : ::: .: :.: :.:::.:.:.:: :.
NP_075 GLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNL
330 340 350 360 370 380
300 310 320 330 340 350
pF1KE5 VSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGI
....:. . ...:...:...:: .: :. ... .::..::.:..:. ::.::::.:
NP_075 IGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAI
390 400 410 420 430 440
360 370 380 390 400 410
pF1KE5 ILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRS
:. :. .:. .:.. :::. .. : .:..::...:.:.::.::...:. ......::.
NP_075 IIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRT
450 460 470 480 490 500
420 430 440 450 460 470
pF1KE5 HRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMV
. . .:::.:.:.:::.. .: : . :::.:. ... :.:. . . : .. .
NP_075 QMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGV-
510 520 530 540 550 560
480 490 500 510 520 530
pF1KE5 KVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKL-DPEASSVN
:... .. . . . ..:. : .. :..... .:...::.
NP_075 ----------------DVDFLISQKKKLLKKQEQLK-LKQLQKEEKLRKQAASPKGASVS
570 580 590 600 610
540 550 560 570 580 590
pF1KE5 LIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDV
. . .:.: .... :: . ::: ..: . . :. :..:. .. :::.
NP_075 INVNTSLEDMRSNNV--EDCKMMQVSS-GDKMEDATANGQEDSKAPDGSTLKAL-GLPQ-
620 630 640 650 660
600 610 620 630 640 650
pF1KE5 AESQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAG
:. :..:::.. . .::. : :..: . :.. .. . .:.
NP_075 ------------------PDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAA
670 680 690 700
660 670 680 690 700 710
pF1KE5 CHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSR-KVIGSSELSIDESETVIRETY
::: .: .: . ::::.::: .:: :::::: :::.. . . .: .:.
NP_075 CHSPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
710 720 730 740 750
720 730 740 750 760 770
pF1KE5 SETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLD
>>NP_001268662 (OMIM: 610068) solute carrier family 26 m (651 aa)
initn: 1058 init1: 618 opt: 631 Z-score: 583.9 bits: 118.7 E(85289): 8.8e-26
Smith-Waterman score: 999; 28.9% identity (63.6% similar) in 686 aa overlap (22-703:21-648)
10 20 30 40 50
pF1KE5 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEET--FQQEHKRKASSSGNMNINITTFRH
:.:..:. :. : ..::: .. . :. : .
NP_001 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAP---RTHQW
10 20 30 40 50
60 70 80 90 100 110
pF1KE5 HVQCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLAR
.. .:: : .: .: : :. : ..::::::::.:.::...:.::::. .:::
NP_001 RTWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE5 QLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFV
.::. :..: :: .::. ...:. .: :. . : .: .. .
NP_001 --LPPVFGLYSSFYPVFIYFLFGTSRHISV--------VLEVCWKLPQSKVGTVVTAAVA
120 130 140 150 160
180 190 200 210 220 230
pF1KE5 KNEFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGFTVIANKISMATETSQTLIDMIPYSF
. . . : : .:. . .. .:: : :. ... . .. :: ..
NP_001 GVVLVVVKLL---NDKLQQQLPMPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGL
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE5 LLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVS
. ::.:. .:. :.. .::....:. . : ::: .: :.: :.:::.:.:.:: :...
NP_001 VPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIG
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE5 SFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIIL
..:. . ...:...:...:: .: :. ... .::..::.:..:. ::.::::.::.
NP_001 GIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIII
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE5 SNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHR
:. .:. .:.. :::. .. : .:..::...:.:.::.::...:. ......::..
NP_001 VNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQM
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE5 AKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKV
. .:::.:.:.:::.. .: : . :::.:. ... :.:. . . : .. .
NP_001 PHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGV---
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE5 PLKEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKL-DPEASSVNLI
:... .. . . . ..:. : .. :..... .:...::..
NP_001 --------------DVDFLISQKKKLLKKQEQLK-LKQLQKEEKLRKQAASPKGASVSIN
470 480 490 500
540 550 560 570 580 590
pF1KE5 HCSHFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAE
. .:.: .... :: . ::: ..: . . :. :..:. .. :::.
NP_001 VNTSLEDMRSNNV--ED-CKMMVSS-GDKMEDATANGQEDSKAPDGSTLKAL-GLPQ---
510 520 530 540 550
600 610 620 630 640 650
pF1KE5 SQGRRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCH
:. :..:::.. . .::. : :..: . :.. .. . .:.::
NP_001 ----------------PDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACH
560 570 580 590 600
660 670 680 690 700 710
pF1KE5 SSIVRAFERNDFFDAGITKTQLFLSVHDAVLFALSR-KVIGSSELSIDESETVIRETYSE
: .: .: . ::::.::: .:: :::::: :::.. . . .: .:.
NP_001 SPVVSQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
610 620 630 640 650
720 730 740 750 760 770
pF1KE5 TDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRE
865 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 06:52:55 2016 done: Tue Nov 8 06:52:57 2016
Total Scan time: 11.470 Total Display time: 0.260
Function used was FASTA [36.3.4 Apr, 2011]