FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2458, 276 aa 1>>>pF1KE2458 276 - 276 aa - 276 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9887+/-0.000446; mu= 11.6773+/- 0.028 mean_var=88.0260+/-17.354, 0's: 0 Z-trim(110.8): 114 B-trim: 298 in 2/51 Lambda= 0.136700 statistics sampled from 19095 (19202) to 19095 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.588), E-opt: 0.2 (0.225), width: 16 Scan time: 6.390 The best scores are: opt bits E(85289) NP_008929 (OMIM: 609202) secretagogin [Homo sapien ( 276) 1827 370.6 1.8e-102 XP_016865670 (OMIM: 609202) PREDICTED: secretagogi ( 222) 1455 297.2 1.8e-80 NP_001731 (OMIM: 114051) calretinin isoform 1 [Hom ( 271) 611 130.8 2.8e-30 NP_004920 (OMIM: 114050) calbindin [Homo sapiens] ( 261) 561 120.9 2.5e-27 NP_009019 (OMIM: 114051) calretinin isoform 22k [H ( 192) 466 102.1 8.5e-22 >>NP_008929 (OMIM: 609202) secretagogin [Homo sapiens] (276 aa) initn: 1827 init1: 1827 opt: 1827 Z-score: 1960.6 bits: 370.6 E(85289): 1.8e-102 Smith-Waterman score: 1827; 100.0% identity (100.0% similar) in 276 aa overlap (1-276:1-276) 10 20 30 40 50 60 pF1KE2 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLH 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 KVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 KVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDAD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE2 SSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 SSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILAL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE2 QENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_008 QENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGV 190 200 210 220 230 240 250 260 270 pF1KE2 DLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP :::::::::::::::::::::::::::::::::::: NP_008 DLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP 250 260 270 >>XP_016865670 (OMIM: 609202) PREDICTED: secretagogin is (222 aa) initn: 1455 init1: 1455 opt: 1455 Z-score: 1565.5 bits: 297.2 E(85289): 1.8e-80 Smith-Waterman score: 1455; 100.0% identity (100.0% similar) in 222 aa overlap (55-276:1-222) 30 40 50 60 70 80 pF1KE2 DADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLHKVKQQFMTTQDASKDGRIRMKELA :::::::::::::::::::::::::::::: XP_016 MKANLHKVKQQFMTTQDASKDGRIRMKELA 10 20 30 90 100 110 120 130 140 pF1KE2 GMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDADSSGFISAAELRNFLRDLFLHHKKA 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE2 ISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFKMDACSTEERKRDFEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILALQENFLLQFKMDACSTEERKRDFEK 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE2 IFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKS 160 170 180 190 200 210 270 pF1KE2 ELALCLGLKINP :::::::::::: XP_016 ELALCLGLKINP 220 >>NP_001731 (OMIM: 114051) calretinin isoform 1 [Homo sa (271 aa) initn: 343 init1: 317 opt: 611 Z-score: 664.7 bits: 130.8 E(85289): 2.8e-30 Smith-Waterman score: 611; 38.4% identity (71.1% similar) in 263 aa overlap (9-270:13-265) 10 20 30 40 50 pF1KE2 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHML-MKLGTDDTVM :..: :. : ..:..:::: .:::: :::. :: .. . :. NP_001 MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 KANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWR . :. . ..:: : ..::.:.: ::: ..: .::::: ::.. . ::.:::. :: NP_001 SDNFGEKMKEFMQKYDKNSDGKIEMAELA-QILPTEENFLLCFRQH--VGSSAEFMEAWR 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 KYDADSSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLA :::.: ::.: : ::..:: ::. . .. .: ::.::: :....:: : ::.: :.... NP_001 KYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 RILALQENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQP :.: .::::::.:. ..:: :. ::..:: ...: .. :.:...::..: . NP_001 RLLPVQENFLLKFQGMKLTSEE----FNAIFTFYDKDRSGYIDEHELDALLKDLYEKNKK 180 190 200 210 220 230 240 250 260 270 pF1KE2 SISGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP .. .: ..:. .. .. . ::. ...: . : NP_001 EMNIQQLTNYRKSVM---SLAEAGKLYRKDLEIVLCSEPPM 240 250 260 270 >>NP_004920 (OMIM: 114050) calbindin [Homo sapiens] (261 aa) initn: 352 init1: 352 opt: 561 Z-score: 611.6 bits: 120.9 E(85289): 2.5e-27 Smith-Waterman score: 561; 37.6% identity (66.2% similar) in 263 aa overlap (12-271:11-259) 10 20 30 40 50 60 pF1KE2 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHMLMKLGTDDTVMKANLH . :. :...: .:::: .::.: :::. .....: .: NP_004 MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQ----NLIQELQQARKKAGLELS 10 20 30 40 50 70 80 90 100 110 120 pF1KE2 KVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWRKYDAD . :. ::.: . ::: . : .:::::::: .. : : :::. :::::.: NP_004 PEMKTFVDQYGQRDDGKIGIVELAHV-LPTEENFLLLFRCQQ-LKSCEEFMKTWRKYDTD 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE2 SSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLARILAL :::: . ::.:::.::. . .:.....:: ::: :.:.:: :.::.:.:...::.: . NP_004 HSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDGKLELTEMARLLPV 120 130 140 150 160 170 190 200 210 220 230 pF1KE2 QENFLLQFK-MDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQPSISG ::::::.:. . :. : :.: : :: . .: .. :.:...::. : . ... NP_004 QENFLLKFQGIKMCGKE-----FNKAFELYDQDGNGYIDENELDALLKDLCEKNKQDLDI 180 190 200 210 220 240 250 260 270 pF1KE2 VDLDKFREILLRHCDVNKDGKIQKSELAL--CLGLKINP .. ... .. : ::. ...::: : : NP_004 NNITTYKKNIMALSD---GGKLYRTDLALILCAGDN 230 240 250 260 >>NP_009019 (OMIM: 114051) calretinin isoform 22k [Homo (192 aa) initn: 398 init1: 261 opt: 466 Z-score: 512.3 bits: 102.1 E(85289): 8.5e-22 Smith-Waterman score: 466; 44.2% identity (72.7% similar) in 172 aa overlap (9-179:13-181) 10 20 30 40 50 pF1KE2 MDSSREPTLGRLDAAGFWQVWQRFDADEKGYIEEKELDAFFLHML-MKLGTDDTVM :..: :. : ..:..:::: .:::: :::. :: .. . :. NP_009 MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENFFQELEKARKGSGMMSK 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 KANLHKVKQQFMTTQDASKDGRIRMKELAGMFLSEDENFLLLFRRENPLDSSVEFMQIWR . :. . ..:: : ..::.:.: ::: ..: .::::: ::.. . ::.:::. :: NP_009 SDNFGEKMKEFMQKYDKNSDGKIEMAELA-QILPTEENFLLCFRQH--VGSSAEFMEAWR 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 KYDADSSGFISAAELRNFLRDLFLHHKKAISEAKLEEYTGTMMKIFDRNKDGRLDLNDLA :::.: ::.: : ::..:: ::. . .. .: ::.::: :....:: : ::.: :.... NP_009 KYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTILRMFDLNGDGKLGLSEMS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE2 RILALQENFLLQFKMDACSTEERKRDFEKIFAYYDVSKTGALEGPEVDGFVKDMMELVQP :: : NP_009 RIEAATLTSMSWMPF 180 190 276 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 20:12:40 2016 done: Mon Nov 7 20:12:41 2016 Total Scan time: 6.390 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]