FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1955, 513 aa 1>>>pF1KE1955 513 - 513 aa - 513 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.8821+/-0.0003; mu= 3.2817+/- 0.019 mean_var=208.0029+/-42.807, 0's: 0 Z-trim(124.1): 76 B-trim: 453 in 1/55 Lambda= 0.088928 statistics sampled from 45148 (45231) to 45148 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.81), E-opt: 0.2 (0.53), width: 16 Scan time: 10.910 The best scores are: opt bits E(85289) NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 3570 470.2 6.2e-132 NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 1643 223.0 1.5e-57 NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 1591 216.3 1.5e-55 XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 1175 162.7 1.1e-39 NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 1153 160.1 1.1e-38 NP_001316683 (OMIM: 112265) bone morphogenetic pro ( 417) 1079 150.6 8.5e-36 XP_011513119 (OMIM: 112265) PREDICTED: bone morpho ( 357) 918 129.9 1.2e-29 NP_001316685 (OMIM: 112265) bone morphogenetic pro ( 348) 916 129.6 1.5e-29 XP_011540324 (OMIM: 602284) PREDICTED: bone morpho ( 357) 883 125.4 2.8e-28 XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 634 93.5 1.3e-18 XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 497 75.8 1.6e-13 NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 497 75.9 2.4e-13 NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 497 76.0 2.9e-13 NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 497 76.0 2.9e-13 XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 497 76.0 2.9e-13 XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 492 75.2 3.4e-13 XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 492 75.2 3.4e-13 XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 492 75.3 3.9e-13 XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 492 75.3 3.9e-13 NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 492 75.3 3.9e-13 NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 492 75.3 3.9e-13 NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 444 69.1 2.6e-11 NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 438 68.4 5.1e-11 NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 437 68.3 5.7e-11 XP_016857645 (OMIM: 602284) PREDICTED: bone morpho ( 236) 428 66.9 7.5e-11 XP_005271206 (OMIM: 602284) PREDICTED: bone morpho ( 231) 425 66.5 9.6e-11 XP_011540327 (OMIM: 602284) PREDICTED: bone morpho ( 230) 420 65.9 1.5e-10 NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 404 64.0 9.1e-10 NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 393 62.6 2.7e-09 NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 391 62.4 3.5e-09 NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 384 61.4 6e-09 XP_016857644 (OMIM: 602284) PREDICTED: bone morpho ( 382) 364 58.8 3.3e-08 NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 365 59.0 3.6e-08 NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 361 58.5 4.3e-08 NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 347 56.5 9.3e-08 NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 347 56.6 1.4e-07 NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 342 56.0 2.5e-07 XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 342 56.0 2.5e-07 XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 342 56.1 2.8e-07 XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 342 56.1 3.1e-07 NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 319 53.0 1.7e-06 NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 313 52.3 3e-06 NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 312 52.2 3.5e-06 XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 305 51.2 4.8e-06 XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 308 51.7 5e-06 NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 308 51.7 5e-06 XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 305 51.2 6e-06 NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 305 51.2 6e-06 XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 305 51.2 6e-06 NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 305 51.2 6e-06 >>NP_001709 (OMIM: 112266) bone morphogenetic protein 6 (513 aa) initn: 3570 init1: 3570 opt: 3570 Z-score: 2489.6 bits: 470.2 E(85289): 6.2e-132 Smith-Waterman score: 3570; 99.8% identity (100.0% similar) in 513 aa overlap (1-513:1-513) 10 20 30 40 50 60 pF1KE1 MPGLGRRAQWLCWWWGLLCSCCGPPPLQPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSP :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: NP_001 MPGLGRRAQWLCWWWGLLCSCCGPPPLRPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSSSGFLYRRLKTQEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 RGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGEPPPGRLKSAPLFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 PLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLNRKSLLAPGSGSGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 NLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 SEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMV 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 AFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVS 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 FQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAP 430 440 450 460 470 480 490 500 510 pF1KE1 TKLNAISVLYFDDNSNVILKKYRNMVVRACGCH ::::::::::::::::::::::::::::::::: NP_001 TKLNAISVLYFDDNSNVILKKYRNMVVRACGCH 490 500 510 >>NP_066551 (OMIM: 112265) bone morphogenetic protein 5 (454 aa) initn: 1074 init1: 810 opt: 1643 Z-score: 1154.2 bits: 223.0 E(85289): 1.5e-57 Smith-Waterman score: 1742; 59.4% identity (79.6% similar) in 451 aa overlap (64-513:36-454) 40 50 60 70 80 90 pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP :.:.::::...:.::.:.::::.::::::: NP_066 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRL-KSAPLFMLDLYNALSADNDEDGA ::. ::. .::::::::::::.. ... . NP_066 RPFS----------------------------PGKQASSAPLFMLDLYNAMTNEENPE-E 70 80 90 160 170 180 190 200 210 pF1KE1 SEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDA :: . : .:. .... : ..: : .: . . ::.: .:. ::::: NP_066 SEYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE1 DMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTF ::::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:. NP_066 DMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE1 LISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV :::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: . NP_066 KISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE1 TRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQ : :: .. ..::::::.:: .::::::::::.::: .:..: :...:..:.::.:.. : NP_066 TGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVR-AANKRKNQNRNKSSSHQ 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE1 DVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH : .:.::..:::.:: : ::.::::::::.:::::::::::.:::: ::::::::::::: NP_066 DSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAH 340 350 360 370 380 390 460 470 480 490 500 510 pF1KE1 MNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC :::::::::::::::: :..:::::::::::::::::::::.::::::::::::::.::: NP_066 MNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 400 410 420 430 440 450 pF1KE1 H : NP_066 H >>NP_001710 (OMIM: 112267) bone morphogenetic protein 7 (431 aa) initn: 1829 init1: 1591 opt: 1591 Z-score: 1118.5 bits: 216.3 E(85289): 1.5e-55 Smith-Waterman score: 1772; 60.2% identity (78.9% similar) in 450 aa overlap (64-513:39-431) 40 50 60 70 80 90 pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP :.:..:::..::.::::.::::.::::::: NP_001 AAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRP 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAPLFMLDLYNALSADNDEDGAS :: : :: :. .:::.::::::::... :.:.. NP_001 RP-H-LQ--------------------------GKHNSAPMFMLDLYNAMAV---EEGGG 70 80 90 160 170 180 190 200 210 pF1KE1 EGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDAD : . :.:..:. :.: .: ::.: ::: ::.::: NP_001 PGGQGFSYPYKAVFSTQ------------------GP--------PLASLQDSHFLTDAD 100 110 120 130 220 230 240 250 260 270 pF1KE1 MVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTFL ::::::::::.:::: . ::.::.:.::.:::::.::::::::::: . : :.:: NP_001 MVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFR 140 150 160 170 180 190 280 290 300 310 320 330 pF1KE1 ISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVT ::.::::::: :.:::::::.:..:::::::: :::::::: :::.:.::.:::::: : NP_001 ISVYQVLQEHLGRESDLFLLDSRTLWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVET 200 210 220 230 240 250 340 350 360 370 380 390 pF1KE1 RDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQD :: ..:. :::.:: :: .::::::::::..::: :. ::..:..:.:.:... ..:. NP_001 LDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQE 260 270 280 290 300 310 400 410 420 430 440 450 pF1KE1 VARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHM . :...... .::. . ::.::::::::.:::::::::::.:::: ::.:::.::::..: NP_001 ALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYM 320 330 340 350 360 370 460 470 480 490 500 510 pF1KE1 NATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH :::::::::::::..::: :::::::::.:::::::::::.::::::::::::::::::: NP_001 NATNHAIVQTLVHFINPETVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH 380 390 400 410 420 430 >>XP_016866687 (OMIM: 112265) PREDICTED: bone morphogene (239 aa) initn: 833 init1: 810 opt: 1175 Z-score: 833.7 bits: 162.7 E(85289): 1.1e-39 Smith-Waterman score: 1175; 73.2% identity (90.8% similar) in 228 aa overlap (286-513:13-239) 260 270 280 290 300 310 pF1KE1 FRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSN ::.:::::::: . : . ::: ::::.::: XP_016 MEAERAQVLPTVRDADLFLLDTRKAQALDVGWLVFDITVTSN 10 20 30 40 320 330 340 350 360 370 pF1KE1 LWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRS ::..::.:.:::: . : :: .. ..::::::.:: .::::::::::.::: .:..:. XP_016 HWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRA 50 60 70 80 90 100 380 390 400 410 420 430 pF1KE1 ASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKG :. .:..:.::.:.. :: .:.::..:::.:: : ::.::::::::.:::::::::::.: XP_016 AN-KRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEG 110 120 130 140 150 160 440 450 460 470 480 490 pF1KE1 YAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNS ::: ::::::::::::::::::::::::::::: :..:::::::::::::::::::::.: XP_016 YAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSS 170 180 190 200 210 220 500 510 pF1KE1 NVILKKYRNMVVRACGCH :::::::::::::.:::: XP_016 NVILKKYRNMVVRSCGCH 230 >>NP_001711 (OMIM: 602284) bone morphogenetic protein 8B (402 aa) initn: 1376 init1: 948 opt: 1153 Z-score: 815.2 bits: 160.1 E(85289): 1.1e-38 Smith-Waterman score: 1282; 46.5% identity (68.4% similar) in 471 aa overlap (44-513:18-402) 20 30 40 50 60 70 pF1KE1 WWGLLCSCCGPPPLQPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKT :: ::.:: . :: :: ::: . NP_001 MTALPGPLWLLGLALCALG-GGGPG-LRPPPGCPQ-------RRLGA 10 20 30 80 90 100 110 120 130 pF1KE1 QEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAP .:.:..:.:::.::::: :::: ::: ..:: ::: NP_001 RERRDVQREILAVLGLPGRPRP------RAPPA---------ASRLP---------ASAP 40 50 60 70 140 150 160 170 180 190 pF1KE1 LFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSG :::::::.:...:.::::: : : :: NP_001 LFMLDLYHAMAGDDDEDGA---------PAE------RR--------------------- 80 90 200 210 220 230 240 250 pF1KE1 SGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTA :. ::.::::::.:: :. .. .. : :::.:.:.::: ::.::: NP_001 ---------------LGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTA 100 110 120 130 140 260 270 280 290 300 310 pF1KE1 AEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITAT ::::::: . . :.:. .:..::.::...:.::::.:: ... :..:::: .:.::. NP_001 AEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAA 150 160 170 180 190 200 320 330 340 350 360 370 pF1KE1 SNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTT :. :.. ....::.: : :.:: : : :::.:. .: ..:::.:.::..: .:: NP_001 SDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTP 210 220 230 240 250 260 380 390 400 410 420 430 pF1KE1 RSASSRRRQQSRNRSTQSQDVARVSSA-SDYNSSELKTACRKHELYVSFQDLGWQDWIIA :.. ::.: . .:.. .. :. . .: ..:. . .::.:::::::::::: ::.:: NP_001 RAVRPLRRRQPK-KSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIA 270 280 290 300 310 320 440 450 460 470 480 490 pF1KE1 PKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFD :.::.: ::.:::::::.. ::::::::.:.::::: :. ::: :::::::.: ::::.: NP_001 PQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCAPTKLSATSVLYYD 330 340 350 360 370 380 500 510 pF1KE1 DNSNVILKKYRNMVVRACGCH ...::::.:.:::::.::::: NP_001 SSNNVILRKHRNMVVKACGCH 390 400 >>NP_001316683 (OMIM: 112265) bone morphogenetic protein (417 aa) initn: 1326 init1: 782 opt: 1079 Z-score: 763.7 bits: 150.6 E(85289): 8.5e-36 Smith-Waterman score: 1408; 51.7% identity (71.6% similar) in 451 aa overlap (64-513:36-417) 40 50 60 70 80 90 pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP :.:.::::...:.::.:.::::.::::::: NP_001 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRL-KSAPLFMLDLYNALSADNDEDGA ::. ::. .::::::::::::.. ... . NP_001 RPFS----------------------------PGKQASSAPLFMLDLYNAMTNEENPE-E 70 80 90 160 170 180 190 200 210 pF1KE1 SEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDA :: . : .:. .... : ..: : .: . . ::.: .:. ::::: NP_001 SEYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE1 DMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTF ::::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:. NP_001 DMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE1 LISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV :::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: . NP_001 KISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE1 TRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQ : :: .. ..::::::.:: .::::::::::.::: .:..: :...:..:.::.:.. : NP_001 TGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVR-AANKRKNQNRNKSSSHQ 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE1 DVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH : .:.::..:::.:: : ::.::::::::.::::: NP_001 DSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQ------------------------- 340 350 360 460 470 480 490 500 510 pF1KE1 MNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGC :::: :..:::::::::::::::::::::.::::::::::::::.::: NP_001 ------------VHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 370 380 390 400 410 pF1KE1 H : NP_001 H >>XP_011513119 (OMIM: 112265) PREDICTED: bone morphogene (357 aa) initn: 1089 init1: 782 opt: 918 Z-score: 653.0 bits: 129.9 E(85289): 1.2e-29 Smith-Waterman score: 1017; 49.4% identity (74.1% similar) in 340 aa overlap (64-402:36-343) 40 50 60 70 80 90 pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP :.:.::::...:.::.:.::::.::::::: XP_011 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRL-KSAPLFMLDLYNALSADNDEDGA ::. ::. .::::::::::::.. ... . XP_011 RPFS----------------------------PGKQASSAPLFMLDLYNAMTNEENPE-E 70 80 90 160 170 180 190 200 210 pF1KE1 SEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDA :: . : .:. .... : ..: : .: . . ::.: .:. ::::: XP_011 SEYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE1 DMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTF ::::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:. XP_011 DMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE1 LISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV :::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: . XP_011 KISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE1 TRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQ : :: .. ..::::::.:: .::::::::::.::: .:..:.:. .:..:.::.:.. : XP_011 TGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAAN-KRKNQNRNKSSSHQ 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE1 DVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH : .:.::... XP_011 DSSRMSSVGETLHKTTRWNSLDFS 340 350 >>NP_001316685 (OMIM: 112265) bone morphogenetic protein (348 aa) initn: 1046 init1: 782 opt: 916 Z-score: 651.8 bits: 129.6 E(85289): 1.5e-29 Smith-Waterman score: 1015; 49.9% identity (73.9% similar) in 337 aa overlap (64-399:36-340) 40 50 60 70 80 90 pF1KE1 AAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKTQEKREMQKEILSVLGLPHRP :.:.::::...:.::.:.::::.::::::: NP_001 FLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRP 10 20 30 40 50 60 100 110 120 130 140 150 pF1KE1 RPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRL-KSAPLFMLDLYNALSADNDEDGA ::. ::. .::::::::::::.. ... . NP_001 RPFS----------------------------PGKQASSAPLFMLDLYNAMTNEENPE-E 70 80 90 160 170 180 190 200 210 pF1KE1 SEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSGSGGASPLTSAQDSAFLNDA :: . : .:. .... : ..: : .: . . ::.: .:. ::::: NP_001 SEYSVRASLAEET-RGARKGYPASPNGYP-RRIQLSRTTPLTTQSPPLASLHDTNFLNDA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE1 DMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSFKNQTF ::::::::::: ::.:: ..::.:::.:.:.:::.::.::::::::::: . :.:.:. NP_001 DMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETI 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE1 LISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVV :::::...:. .::.:::::::: . : . ::: ::::.::: ::..::.:.:::: . NP_001 KISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAE 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE1 TRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQ : :: .. ..::::::.:: .::::::::::.::: .:..: :...:..:.::.:.. : NP_001 TGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVR-AANKRKNQNRNKSSSHQ 280 290 300 310 320 330 400 410 420 430 440 450 pF1KE1 DVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAH : .:.:: NP_001 DSSRMSSVGGSSDVS 340 >>XP_011540324 (OMIM: 602284) PREDICTED: bone morphogene (357 aa) initn: 1080 init1: 652 opt: 883 Z-score: 628.7 bits: 125.4 E(85289): 2.8e-28 Smith-Waterman score: 1012; 43.4% identity (65.6% similar) in 422 aa overlap (44-464:18-353) 20 30 40 50 60 70 pF1KE1 WWGLLCSCCGPPPLQPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKT :: ::.:: . :: :: ::: . XP_011 MTALPGPLWLLGLALCALG-GGGPG-LRPPPGCPQ-------RRLGA 10 20 30 80 90 100 110 120 130 pF1KE1 QEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAP .:.:..:.:::.::::: :::: ::: ..:: ::: XP_011 RERRDVQREILAVLGLPGRPRPR------APPA---------ASRLP---------ASAP 40 50 60 70 140 150 160 170 180 190 pF1KE1 LFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSG :::::::.:...:.::::: : : :: XP_011 LFMLDLYHAMAGDDDEDGA---------PAE------RR--------------------- 80 90 200 210 220 230 240 250 pF1KE1 SGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTA :. ::.::::::.:: :. .. .. : :::.:.:.::: ::.::: XP_011 ---------------LGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTA 100 110 120 130 140 260 270 280 290 300 310 pF1KE1 AEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITAT ::::::: . . :.:. .:..::.::...:.::::.:: ... :..:::: .:.::. XP_011 AEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAA 150 160 170 180 190 200 320 330 340 350 360 370 pF1KE1 SNLWVVTPQHNMGLQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTT :. :.. ....::.: : :.:: : : :::.:. .: ..:::.:.::..: .:: XP_011 SDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTP 210 220 230 240 250 260 380 390 400 410 420 430 pF1KE1 RSASSRRRQQSRNRSTQSQDVARVSSA-SDYNSSELKTACRKHELYVSFQDLGWQDWIIA :.. ::.: . .:.. .. :. . .: ..:. . .::.:::::::::::: ::.:: XP_011 RAVRPLRRRQPK-KSNELPQANRLPGIFDDVHGSHGRQVCRRHELYVSFQDLGWLDWVIA 270 280 290 300 310 320 440 450 460 470 480 490 pF1KE1 PKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFD :.::.: ::.:::::::.. ::::::::.:.: XP_011 PQGYSAYYCEGECSFPLDSCMNATNHAILQSLEVQR 330 340 350 500 510 pF1KE1 DNSNVILKKYRNMVVRACGCH >>XP_011540326 (OMIM: 602284) PREDICTED: bone morphogene (427 aa) initn: 1271 init1: 631 opt: 634 Z-score: 455.0 bits: 93.5 E(85289): 1.3e-18 Smith-Waterman score: 1124; 42.5% identity (63.6% similar) in 497 aa overlap (44-513:18-427) 20 30 40 50 60 70 pF1KE1 WWGLLCSCCGPPPLQPPLPAAAAAAAGGQLLGDGGSPGRTEQPPPSPQSSSGFLYRRLKT :: ::.:: . :: :: ::: . XP_011 MTALPGPLWLLGLALCALG-GGGPG-LRPPPGCPQ-------RRLGA 10 20 30 80 90 100 110 120 130 pF1KE1 QEKREMQKEILSVLGLPHRPRPLHGLQQPQPPALRQQEEQQQQQQLPRGEPPPGRLKSAP .:.:..:.:::.::::: :::: ::: ..:: ::: XP_011 RERRDVQREILAVLGLPGRPRP------RAPPA---------ASRLP---------ASAP 40 50 60 70 140 150 160 170 180 190 pF1KE1 LFMLDLYNALSADNDEDGASEGERQQSWPHEAASSSQRRQPPPGAAHPLNRKSLLAPGSG :::::::.:...:.::::: : : :: XP_011 LFMLDLYHAMAGDDDEDGA---------PAE------RR--------------------- 80 90 200 210 220 230 240 250 pF1KE1 SGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTA :. ::.::::::.:: :. .. .. : :::.:.:.::: ::.::: XP_011 ---------------LGRADLVMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTA 100 110 120 130 140 260 270 280 290 300 310 pF1KE1 AEFRIYKDCVMGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITAT ::::::: . . :.:. .:..::.::...:.::::.:: ... :..:::: .:.::. XP_011 AEFRIYKVPSI-HLLNRTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAA 150 160 170 180 190 200 320 330 340 350 pF1KE1 SNLWVVTPQHNMGLQLSVVTRDG--------------------VHVHPRAAGLVGRDGPY :. :.. ....::.: : :.:: . : . .: . :: XP_011 SDCWLLKRHKDLGLRLYVETEDGETWTGWGWTKDSRLQMWKLRLSRTPWVLSLHA-PGPA 210 220 230 240 250 260 360 370 380 390 400 pF1KE1 D---KQPFMVAF---FKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVARVSSA-SDYNSS . ..:.. . .: .:: :.. ::.: . .:.. .. :. . .: ..: XP_011 QAPAERPLLCLLQGHCPASPSPIRTPRAVRPLRRRQPK-KSNELPQANRLPGIFDDVHGS 270 280 290 300 310 320 410 420 430 440 450 460 pF1KE1 ELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVH . . .::.:::::::::::: ::.:::.::.: ::.:::::::.. ::::::::.:.::: XP_011 HGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVH 330 340 350 360 370 380 470 480 490 500 510 pF1KE1 LMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH :: :. ::: :::::::.: ::::.:...::::.:.:::::.::::: XP_011 LMMPDAVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH 390 400 410 420 513 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 16:59:56 2016 done: Sun Nov 6 16:59:57 2016 Total Scan time: 10.910 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]