FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6689, 278 aa 1>>>pF1KE6689 278 - 278 aa - 278 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8976+/-0.000352; mu= 17.1199+/- 0.022 mean_var=63.5148+/-12.339, 0's: 0 Z-trim(114.0): 13 B-trim: 44 in 1/53 Lambda= 0.160930 statistics sampled from 23655 (23665) to 23655 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.277), width: 16 Scan time: 5.470 The best scores are: opt bits E(85289) NP_683762 (OMIM: 609713) checkpoint protein HUS1B ( 278) 1811 429.0 4.7e-120 NP_004498 (OMIM: 603760) checkpoint protein HUS1 [ ( 280) 927 223.8 2.9e-58 XP_016867604 (OMIM: 603760) PREDICTED: checkpoint ( 259) 856 207.3 2.5e-53 >>NP_683762 (OMIM: 609713) checkpoint protein HUS1B [Hom (278 aa) initn: 1811 init1: 1811 opt: 1811 Z-score: 2276.3 bits: 429.0 E(85289): 4.7e-120 Smith-Waterman score: 1811; 99.6% identity (99.6% similar) in 278 aa overlap (1-278:1-278) 10 20 30 40 50 60 pF1KE6 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 SLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 SLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 VEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_683 VEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFL 190 200 210 220 230 240 250 260 270 pF1KE6 EGQQIHPTTALCNIWDNTLLQLVLVQEYVSLQYFIPAL ::::::::::::::::::::::::::: :::::::::: NP_683 EGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL 250 260 270 >>NP_004498 (OMIM: 603760) checkpoint protein HUS1 [Homo (280 aa) initn: 760 init1: 760 opt: 927 Z-score: 1167.1 bits: 223.8 E(85289): 2.9e-58 Smith-Waterman score: 927; 48.9% identity (80.9% similar) in 282 aa overlap (1-278:1-279) 10 20 30 40 50 pF1KE6 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCF---GPAGSGGLHEARLWCE :::::::. .::. : ..:. .:.:::.:.::. ::.: : ..::. .::: NP_004 MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVS---MWCE 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 VRQ-GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAV ..: . :..:.::::: . .::.::::.:.:::: ..: .: .::..::.:. : :::.: NP_004 LEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE6 ELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVG ::.: . .: :.::.:..:.::..:.: : . :.:: :: .:..:.::.: :.. NP_004 ELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNIS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 SHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKL .:...::::.:...:.::::.: . ..::.::::: .. .. :.:..: :..:..: ::: NP_004 NHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKL 180 190 200 210 220 230 240 250 260 270 pF1KE6 LQFLEGQQIHPTTALCNIWDNTLLQLVLVQEYVSLQYFIPAL :::: :::..:: ::::: .: .... :..: :::::::::: NP_004 LQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS 240 250 260 270 280 >>XP_016867604 (OMIM: 603760) PREDICTED: checkpoint prot (259 aa) initn: 844 init1: 760 opt: 856 Z-score: 1078.4 bits: 207.3 E(85289): 2.5e-53 Smith-Waterman score: 856; 48.8% identity (81.2% similar) in 260 aa overlap (23-278:2-258) 10 20 30 40 50 pF1KE6 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCF---GPAGSGGLHEARLWCE .:.:::.:.::. ::.: : ..::. .::: XP_016 MIAKLAKTCTLRISPDKLNFILCDKLANGGVS---MWCE 10 20 30 60 70 80 90 100 110 pF1KE6 VRQ-GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAV ..: . :..:.::::: . .::.::::.:.:::: ..: .: .::..::.:. : :::.: XP_016 LEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSV 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE6 ELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVG ::.: . .: :.::.:..:.::..:.: : . :.:: :: .:..:.::.: :.. XP_016 ELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNIS 100 110 120 130 140 150 180 190 200 210 220 230 pF1KE6 SHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKL .:...::::.:...:.::::.: . ..::.::::: .. .. :.:..: :..:..: ::: XP_016 NHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKL 160 170 180 190 200 210 240 250 260 270 pF1KE6 LQFLEGQQIHPTTALCNIWDNTLLQLVLVQEYVSLQYFIPAL :::: :::..:: ::::: .: .... :..: :::::::::: XP_016 LQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS 220 230 240 250 278 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 15:25:51 2016 done: Tue Nov 8 15:25:52 2016 Total Scan time: 5.470 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]