Result of FASTA (omim) for
pFN21AB7037
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB7037, 520 aa
1>>>pF1KB7037 520 - 520 aa - 520 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2417+/-0.000385; mu= 11.4334+/- 0.024
mean_var=188.7591+/-40.634, 0's: 0 Z-trim(119.7): 522 B-trim: 3470 in 2/53
Lambda= 0.093351
statistics sampled from 33379 (34116) to 33379 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.732), E-opt: 0.2 (0.4), width: 16
Scan time: 10.630
The best scores are: opt bits E(85289)
NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 3529 487.8 3.2e-137
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 2091 294.1 5.4e-79
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 2082 292.8 1.2e-78
XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 2082 293.0 1.6e-78
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 2072 291.4 3e-78
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 2071 291.3 3.1e-78
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 2066 290.6 4.9e-78
NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 1604 228.6 3.8e-59
NP_150645 (OMIM: 104221) alpha-1A adrenergic recep ( 429) 1517 216.8 1.1e-55
XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A ad ( 429) 1517 216.8 1.1e-55
NP_150647 (OMIM: 104221) alpha-1A adrenergic recep ( 455) 1517 216.8 1.1e-55
NP_000671 (OMIM: 104221) alpha-1A adrenergic recep ( 466) 1517 216.8 1.1e-55
NP_150646 (OMIM: 104221) alpha-1A adrenergic recep ( 475) 1517 216.8 1.1e-55
XP_016868584 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 1517 216.8 1.1e-55
XP_006716355 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 1517 216.8 1.1e-55
XP_016868583 (OMIM: 104221) PREDICTED: alpha-1A ad ( 475) 1517 216.8 1.1e-55
XP_016868585 (OMIM: 104221) PREDICTED: alpha-1A ad ( 317) 1274 183.9 6.1e-46
NP_001309431 (OMIM: 104221) alpha-1A adrenergic re ( 372) 1274 184.0 6.8e-46
XP_011542713 (OMIM: 104221) PREDICTED: alpha-1A ad ( 324) 1262 182.3 1.9e-45
XP_011542714 (OMIM: 104221) PREDICTED: alpha-1A ad ( 308) 1257 181.6 2.9e-45
NP_001309433 (OMIM: 104221) alpha-1A adrenergic re ( 342) 1252 181.0 5e-45
NP_001309432 (OMIM: 104221) alpha-1A adrenergic re ( 370) 1252 181.0 5.3e-45
NP_062874 (OMIM: 182137) 5-hydroxytryptamine recep ( 432) 797 119.8 1.6e-26
NP_000863 (OMIM: 182137) 5-hydroxytryptamine recep ( 445) 797 119.8 1.7e-26
NP_062873 (OMIM: 182137) 5-hydroxytryptamine recep ( 479) 797 119.9 1.8e-26
NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 654 100.5 9.9e-21
NP_076917 (OMIM: 601305) 5-hydroxytryptamine recep ( 357) 652 100.2 1.1e-20
NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 636 98.1 5.7e-20
NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 620 96.0 2.6e-19
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 563 88.3 5.2e-17
NP_000515 (OMIM: 109760,614674) 5-hydroxytryptamin ( 422) 558 87.6 7.9e-17
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 553 87.0 1.3e-16
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 539 85.1 5e-16
NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 532 84.1 9.5e-16
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 532 84.1 9.5e-16
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 510 81.1 6.3e-15
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 510 81.1 6.3e-15
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 510 81.1 6.7e-15
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 510 81.1 7e-15
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 510 81.1 7e-15
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 510 81.1 7e-15
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 510 81.1 7e-15
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 510 81.1 7e-15
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 506 80.6 1e-14
NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 506 80.7 1.1e-14
NP_057658 (OMIM: 126450,159900) D(2) dopamine rece ( 414) 502 80.1 1.5e-14
NP_001309137 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 501 79.9 1.5e-14
XP_011531966 (OMIM: 182134) PREDICTED: 5-hydroxytr ( 366) 501 79.9 1.5e-14
NP_001309138 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 501 79.9 1.5e-14
NP_001309139 (OMIM: 182134) 5-hydroxytryptamine re ( 366) 501 79.9 1.5e-14
>>NP_000670 (OMIM: 104220) alpha-1B adrenergic receptor (520 aa)
initn: 3529 init1: 3529 opt: 3529 Z-score: 2584.5 bits: 487.8 E(85289): 3.2e-137
Smith-Waterman score: 3529; 100.0% identity (100.0% similar) in 520 aa overlap (1-520:1-520)
10 20 30 40 50 60
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB7 RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB7 LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT
430 440 450 460 470 480
490 500 510 520
pF1KB7 EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
::::::::::::::::::::::::::::::::::::::::
NP_000 EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
490 500 510 520
>>XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B adrene (402 aa)
initn: 2105 init1: 2066 opt: 2091 Z-score: 1539.2 bits: 294.1 E(85289): 5.4e-79
Smith-Waterman score: 2091; 88.0% identity (93.1% similar) in 376 aa overlap (1-370:1-370)
10 20 30 40 50 60
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVF--WLGYFNSCLN-PIIYP--CSSKEF
:::::::::::::::: . .:: . ..:: : :. .: .: :.. : . .:
XP_011 GMFILCWLPFFIALPL----DPDSPPPTHLRVVPAPW-GH-SSIMNLPLVLPLDATRSES
310 320 330 340 350
360 370 380 390 400 410
pF1KB7 KRAF-VRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCL
: .. .. :. :..:
XP_011 KGSLSLKTLNACCKSRKEMNEHNLNLSSLESGHVRDTGATLHHHIIRY
360 370 380 390 400
>>XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B adrene (389 aa)
initn: 2105 init1: 2066 opt: 2082 Z-score: 1532.8 bits: 292.8 E(85289): 1.2e-78
Smith-Waterman score: 2082; 92.6% identity (95.5% similar) in 352 aa overlap (1-349:1-346)
10 20 30 40 50 60
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVF--WLGYFNSCLN-PIIYPCSSKEFKR
:::::::::::::::: . .:: . ..:: : :. .: .: :.. :
XP_011 GMFILCWLPFFIALPL----DPDSPPPTHLRVVPAPW-GH-SSIMNLPLVLPLDATRSVC
310 320 330 340 350
360 370 380 390 400 410
pF1KB7 AFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGS
XP_011 FSYPLNIQFLLVCKHAVLLTPFSRSLPGSHPFPHQ
360 370 380
>>XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B adrene (556 aa)
initn: 3515 init1: 2066 opt: 2082 Z-score: 1530.9 bits: 293.0 E(85289): 1.6e-78
Smith-Waterman score: 3414; 93.5% identity (93.5% similar) in 552 aa overlap (1-516:1-552)
10 20 30 40 50 60
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
250 260 270 280 290 300
310 320
pF1KB7 GMFILCWLPFFIALPL------------------------------------GSLFSTLK
:::::::::::::::: ::::::::
XP_011 GMFILCWLPFFIALPLDPDSPPPTHLRVVPAPWGHSSIMNLPLVLPLDATRSGSLFSTLK
310 320 330 340 350 360
330 340 350 360 370 380
pF1KB7 PPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGC
370 380 390 400 410 420
390 400 410 420 430 440
pF1KB7 AYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAF
430 440 450 460 470 480
450 460 470 480 490 500
pF1KB7 PEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVAN
490 500 510 520 530 540
510 520
pF1KB7 GQPGFKSNMPLAPGQF
::::::::::::
XP_011 GQPGFKSNMPLAPGQF
550
>>XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B adrene (366 aa)
initn: 2068 init1: 2068 opt: 2072 Z-score: 1525.8 bits: 291.4 E(85289): 3e-78
Smith-Waterman score: 2072; 97.0% identity (97.6% similar) in 332 aa overlap (1-331:1-332)
10 20 30 40 50 60
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
250 260 270 280 290 300
310 320 330 340 350
pF1KB7 GMFILCWLPFFIALPLGSLFS-TLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAF
:::::::::::::::: : : .:: .: :
XP_005 GMFILCWLPFFIALPLESKGSLSLKTLNACCKSRKEMNEHNLNLSSLESGHVRDTGATLH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB7 VRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQR
XP_005 HHIIRY
>>XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B adrene (331 aa)
initn: 2071 init1: 2071 opt: 2071 Z-score: 1525.6 bits: 291.3 E(85289): 3.1e-78
Smith-Waterman score: 2071; 98.5% identity (98.8% similar) in 324 aa overlap (1-324:1-324)
10 20 30 40 50 60
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
:::::::::::::::: . :: :
XP_006 GMFILCWLPFFIALPLELFTSTPKGLEKDWK
310 320 330
>>XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B adrene (328 aa)
initn: 2066 init1: 2066 opt: 2066 Z-score: 1522.0 bits: 290.6 E(85289): 4.9e-78
Smith-Waterman score: 2066; 100.0% identity (100.0% similar) in 316 aa overlap (1-316:1-316)
10 20 30 40 50 60
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB7 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB7 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB7 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB7 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB7 GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV
::::::::::::::::
XP_005 GMFILCWLPFFIALPLAFRIPKDKKGLW
310 320
>>NP_000669 (OMIM: 104219) alpha-1D adrenergic receptor (572 aa)
initn: 1666 init1: 1016 opt: 1604 Z-score: 1182.8 bits: 228.6 E(85289): 3.8e-59
Smith-Waterman score: 1605; 58.5% identity (78.8% similar) in 424 aa overlap (44-451:95-501)
20 30 40 50 60 70
pF1KB7 PAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACN
....::. :.::::.:..::.:::::::::
NP_000 NRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACN
70 80 90 100 110 120
80 90 100 110 120 130
pF1KB7 RHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASI
:::.: :::::::::.:::::: :::::::..::::.:..:: :::.:::::::::::::
NP_000 RHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASI
130 140 150 160 170 180
140 150 160 170 180 190
pF1KB7 LSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDK
::::.::.:::.:::.::.::...:.::: : .::.. :.:.:::::::::.: :..
NP_000 LSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDER
190 200 210 220 230 240
200 210 220 230 240 250
pF1KB7 ECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTL
::.::: ::.:::. :::.:.:::.:::::::.::. ::..::::: .: ....:..:
NP_000 FCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVL
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB7 RIHSKN--FHEDTLSSTK-AKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPF
::: .. : . . ::::. :::..:.:.::::::::::::.::::.:.:::.::
NP_000 RIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPF
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB7 FIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGR
:..::::::: ::: ..::::.:::::::::.::.::::::.::::::.:.: ::::
NP_000 FFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCR--
370 380 390 400 410 420
380 390 400 410 420
pF1KB7 GRRRRRRRRRLGGCAYTYRPWTRGGSLERSQS---RKDSLDDSGSCLSGSQ---RTLPSA
:::::: : : : :... :.: .::. :. .::.
NP_000 ---RRRRRRPL---------WRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDP
430 440 450 460 470
430 440 450 460 470
pF1KB7 SPSP-GYLGRGAP------PPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFK
.: : : :: :: :: ::. :
NP_000 DPEPPGTPEMQAPVASRRKPP---SAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQ
480 490 500 510 520
480 490 500 510 520
pF1KB7 LLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
NP_000 RAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
530 540 550 560 570
>>NP_150645 (OMIM: 104221) alpha-1A adrenergic receptor (429 aa)
initn: 1498 init1: 1037 opt: 1517 Z-score: 1121.0 bits: 216.8 E(85289): 1.1e-55
Smith-Waterman score: 1523; 60.3% identity (84.3% similar) in 370 aa overlap (25-390:4-362)
10 20 30 40 50
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQ--LDITRAISVGLVLGAFILF
..: . ::: : : ..:..:: .:..::..:::
NP_150 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF
10 20 30
60 70 80 90 100 110
pF1KB7 AIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFC
...:::::::::::.:::.. :.:.:::::.:::::. ::::::: .::::::..::.::
NP_150 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFC
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB7 DIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISI
.::::::::::::::..:: ::::::::: : :.:::.::.:....::: ::.:: ::::
NP_150 NIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISI
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB7 GPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLE
:::.::..:::.:. : ..::: :.:::.:::::.:::.:::::::::.:::: ...:.
NP_150 GPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLK
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB7 AGVMKEMSNSKELTLRIHSKNFHE--DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTL
.:. . :.:...::::: :: . ..:.:.: : ..:.:.::::::::::::
NP_150 SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTH-----FSVRLLKFSREKKAAKTL
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB7 GIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFK
::::: :.:::::::...:.::.: .:: ..:::.::::::.:::.:::::::::.:::
NP_150 GIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB7 RAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSG
.:: .: :: :.. .. :: :: .:
NP_150 KAFQNVLRIQCLC---RKQSSKHALG---YTLHPPSQAVEGQHKDMVRIPVGSRETFYRI
340 350 360 370 380
420 430 440 450 460 470
pF1KB7 SQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTF
NP_150 SKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARGHTPMT
390 400 410 420
>>XP_006716356 (OMIM: 104221) PREDICTED: alpha-1A adrene (429 aa)
initn: 1498 init1: 1037 opt: 1517 Z-score: 1121.0 bits: 216.8 E(85289): 1.1e-55
Smith-Waterman score: 1523; 60.3% identity (84.3% similar) in 370 aa overlap (25-390:4-362)
10 20 30 40 50
pF1KB7 MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQ--LDITRAISVGLVLGAFILF
..: . ::: : : ..:..:: .:..::..:::
XP_006 MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILF
10 20 30
60 70 80 90 100 110
pF1KB7 AIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFC
...:::::::::::.:::.. :.:.:::::.:::::. ::::::: .::::::..::.::
XP_006 GVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFC
40 50 60 70 80 90
120 130 140 150 160 170
pF1KB7 DIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISI
.::::::::::::::..:: ::::::::: : :.:::.::.:....::: ::.:: ::::
XP_006 NIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISI
100 110 120 130 140 150
180 190 200 210 220 230
pF1KB7 GPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLE
:::.::..:::.:. : ..::: :.:::.:::::.:::.:::::::::.:::: ...:.
XP_006 GPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLK
160 170 180 190 200 210
240 250 260 270 280 290
pF1KB7 AGVMKEMSNSKELTLRIHSKNFHE--DTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTL
.:. . :.:...::::: :: . ..:.:.: : ..:.:.::::::::::::
XP_006 SGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTH-----FSVRLLKFSREKKAAKTL
220 230 240 250 260 270
300 310 320 330 340 350
pF1KB7 GIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFK
::::: :.:::::::...:.::.: .:: ..:::.::::::.:::.:::::::::.:::
XP_006 GIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK
280 290 300 310 320 330
360 370 380 390 400 410
pF1KB7 RAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSG
.:: .: :: :.. .. :: :: .:
XP_006 KAFQNVLRIQCLC---RKQSSKHALG---YTLHPPSQAVEGQHKDMVRIPVGSRETFYRI
340 350 360 370 380
420 430 440 450 460 470
pF1KB7 SQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTF
XP_006 SKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARGHTPMT
390 400 410 420
520 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 17:03:22 2016 done: Sun Nov 6 17:03:24 2016
Total Scan time: 10.630 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]