FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5732, 636 aa 1>>>pF1KE5732 636 - 636 aa - 636 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.4978+/-0.000414; mu= 23.8856+/- 0.026 mean_var=66.3010+/-13.849, 0's: 0 Z-trim(110.1): 105 B-trim: 62 in 1/49 Lambda= 0.157512 statistics sampled from 18225 (18350) to 18225 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.215), width: 16 Scan time: 8.720 The best scores are: opt bits E(85289) NP_055043 (OMIM: 606205) sodium-dependent proline ( 636) 4311 989.3 0 XP_016865259 (OMIM: 606205) PREDICTED: sodium-depe ( 555) 3731 857.4 0 XP_016865257 (OMIM: 606205) PREDICTED: sodium-depe ( 592) 2963 682.9 8.4e-196 XP_016865258 (OMIM: 606205) PREDICTED: sodium-depe ( 592) 2963 682.9 8.4e-196 XP_016865256 (OMIM: 606205) PREDICTED: sodium-depe ( 754) 2963 683.0 9.9e-196 NP_057699 (OMIM: 615097) sodium- and chloride-depe ( 602) 1833 426.2 1.7e-118 NP_001116320 (OMIM: 603080) sodium- and chloride-d ( 614) 1809 420.7 7.5e-117 XP_011519312 (OMIM: 603080) PREDICTED: sodium- and ( 614) 1809 420.7 7.5e-117 NP_001116319 (OMIM: 603080) sodium- and chloride-d ( 614) 1809 420.7 7.5e-117 NP_001193860 (OMIM: 603080) sodium- and chloride-d ( 614) 1809 420.7 7.5e-117 NP_003035 (OMIM: 603080) sodium- and chloride-depe ( 614) 1809 420.7 7.5e-117 XP_005253805 (OMIM: 603080) PREDICTED: sodium- and ( 571) 1790 416.4 1.4e-115 XP_006719068 (OMIM: 603080) PREDICTED: sodium- and ( 570) 1787 415.7 2.3e-115 XP_005253804 (OMIM: 603080) PREDICTED: sodium- and ( 610) 1787 415.7 2.4e-115 NP_005620 (OMIM: 300036,300352) sodium- and chlori ( 635) 1781 414.4 6.3e-115 NP_055044 (OMIM: 607952) sodium- and chloride-depe ( 632) 1773 412.5 2.2e-114 NP_001165972 (OMIM: 163970,604715) sodium-dependen ( 617) 1742 405.5 2.9e-112 NP_001034 (OMIM: 163970,604715) sodium-dependent n ( 617) 1742 405.5 2.9e-112 XP_011521597 (OMIM: 163970,604715) PREDICTED: sodi ( 628) 1742 405.5 2.9e-112 NP_001165975 (OMIM: 163970,604715) sodium-dependen ( 628) 1742 405.5 2.9e-112 XP_006721326 (OMIM: 163970,604715) PREDICTED: sodi ( 628) 1742 405.5 2.9e-112 NP_001136277 (OMIM: 300036,300352) sodium- and chl ( 625) 1727 402.1 3.1e-111 XP_011532332 (OMIM: 186854) PREDICTED: sodium- and ( 620) 1717 399.8 1.5e-110 NP_003034 (OMIM: 186854) sodium- and chloride-depe ( 620) 1717 399.8 1.5e-110 XP_006713370 (OMIM: 186854) PREDICTED: sodium- and ( 649) 1717 399.8 1.5e-110 NP_001127839 (OMIM: 186854) sodium- and chloride-d ( 721) 1717 399.9 1.6e-110 NP_001035 (OMIM: 126455,188890,613135) sodium-depe ( 620) 1713 398.9 2.8e-110 NP_001036 (OMIM: 164230,182138,607834) sodium-depe ( 630) 1655 385.7 2.6e-106 NP_001248309 (OMIM: 601019) sodium- and chloride-d ( 637) 1627 379.4 2.2e-104 NP_001020016 (OMIM: 601019) sodium- and chloride-d ( 633) 1528 356.9 1.3e-97 NP_001315558 (OMIM: 601019) sodium- and chloride-d ( 633) 1528 356.9 1.3e-97 NP_008865 (OMIM: 601019) sodium- and chloride-depe ( 652) 1528 356.9 1.3e-97 NP_964012 (OMIM: 601019) sodium- and chloride-depe ( 706) 1528 356.9 1.4e-97 NP_001315555 (OMIM: 601019) sodium- and chloride-d ( 522) 1526 356.3 1.5e-97 NP_001315557 (OMIM: 601019) sodium- and chloride-d ( 568) 1526 356.4 1.6e-97 XP_016857642 (OMIM: 601019) PREDICTED: sodium- and ( 595) 1526 356.4 1.7e-97 XP_016857641 (OMIM: 601019) PREDICTED: sodium- and ( 606) 1526 356.4 1.7e-97 NP_001315556 (OMIM: 601019) sodium- and chloride-d ( 612) 1526 356.4 1.7e-97 XP_016874034 (OMIM: 604159,614618) PREDICTED: sodi ( 450) 1487 347.4 6.4e-95 XP_016874033 (OMIM: 604159,614618) PREDICTED: sodi ( 505) 1487 347.5 6.9e-95 NP_001305298 (OMIM: 604159,614618) sodium- and chl ( 563) 1487 347.5 7.5e-95 NP_004202 (OMIM: 604159,614618) sodium- and chlori ( 797) 1487 347.7 9.6e-95 XP_011519314 (OMIM: 615097) PREDICTED: sodium- and ( 483) 1469 343.4 1.1e-93 NP_001136278 (OMIM: 300036,300352) sodium- and chl ( 520) 1460 341.3 5e-93 XP_016875333 (OMIM: 615097) PREDICTED: sodium- and ( 394) 1418 331.7 3.1e-90 NP_001165973 (OMIM: 163970,604715) sodium-dependen ( 512) 1380 323.2 1.5e-87 NP_001177926 (OMIM: 615097) sodium- and chloride-d ( 510) 1313 307.9 5.6e-83 XP_011519315 (OMIM: 615097) PREDICTED: sodium- and ( 440) 1304 305.8 2.1e-82 XP_011519316 (OMIM: 615097) PREDICTED: sodium- and ( 440) 1304 305.8 2.1e-82 NP_009162 (OMIM: 300306,300444) sodium- and chlori ( 642) 1278 300.1 1.6e-80 >>NP_055043 (OMIM: 606205) sodium-dependent proline tran (636 aa) initn: 4311 init1: 4311 opt: 4311 Z-score: 5291.4 bits: 989.3 E(85289): 0 Smith-Waterman score: 4311; 99.8% identity (100.0% similar) in 636 aa overlap (1-636:1-636) 10 20 30 40 50 60 pF1KE5 MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGNV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 WRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 AMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE5 VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVA 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE5 KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE5 PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 PKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQ 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE5 RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPPWAELLGI :::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_055 RFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGI 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE5 LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 LMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQS 550 560 570 580 590 600 610 620 630 pF1KE5 PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM :::::::::::::::::::::::::::::::::::: NP_055 PKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM 610 620 630 >>XP_016865259 (OMIM: 606205) PREDICTED: sodium-dependen (555 aa) initn: 3731 init1: 3731 opt: 3731 Z-score: 4579.8 bits: 857.4 E(85289): 0 Smith-Waterman score: 3731; 99.8% identity (100.0% similar) in 555 aa overlap (82-636:1-555) 60 70 80 90 100 110 pF1KE5 GYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKI :::::::::::::::::::::::::::::: XP_016 MLAICGIPLFFLELSLGQFSSLGPLAVWKI 10 20 30 120 130 140 150 160 170 pF1KE5 SPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRV 40 50 60 70 80 90 180 190 200 210 220 230 pF1KE5 SKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SKDGNGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLC 100 110 120 130 140 150 240 250 260 270 280 290 pF1KE5 ILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEA 160 170 180 190 200 210 300 310 320 330 340 350 pF1KE5 ALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQE 220 230 240 250 260 270 360 370 380 390 400 410 pF1KE5 LGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAV 280 290 300 310 320 330 420 430 440 450 460 470 pF1KE5 TDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TDEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCL 340 350 360 370 380 390 480 490 500 510 520 530 pF1KE5 AVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRF ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: XP_016 AVTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRF 400 410 420 430 440 450 540 550 560 570 580 590 pF1KE5 PPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMY 460 470 480 490 500 510 600 610 620 630 pF1KE5 VATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM ::::::::::::::::::::::::::::::::::::::::::::: XP_016 VATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM 520 530 540 550 >>XP_016865257 (OMIM: 606205) PREDICTED: sodium-dependen (592 aa) initn: 2956 init1: 2956 opt: 2963 Z-score: 3636.3 bits: 682.9 E(85289): 8.4e-196 Smith-Waterman score: 3647; 93.6% identity (93.8% similar) in 592 aa overlap (82-636:1-592) 60 70 80 90 100 110 pF1KE5 GYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKI :::::::::::::::::::::::::::::: XP_016 MLAICGIPLFFLELSLGQFSSLGPLAVWKI 10 20 30 120 130 140 150 160 170 pF1KE5 SPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRV 40 50 60 70 80 90 180 190 pF1KE5 SKDGNGALPLNLTCTVSPSEEYWS------------------------------------ :::::::::::::::::::::::: XP_016 SKDGNGALPLNLTCTVSPSEEYWSQTHTEAEEEGRRGRVVSNSYPQVIFLPQPPKAEEGV 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE5 -RYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLIL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE5 LMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNT 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE5 FHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQA 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE5 MTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE5 YLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKP 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE5 GLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGM :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_016 GLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGM 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE5 LVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGI 520 530 540 550 560 570 620 630 pF1KE5 TSFENTAIEVDREIAEEEESMM :::::::::::::::::::::: XP_016 TSFENTAIEVDREIAEEEESMM 580 590 >>XP_016865258 (OMIM: 606205) PREDICTED: sodium-dependen (592 aa) initn: 2956 init1: 2956 opt: 2963 Z-score: 3636.3 bits: 682.9 E(85289): 8.4e-196 Smith-Waterman score: 3647; 93.6% identity (93.8% similar) in 592 aa overlap (82-636:1-592) 60 70 80 90 100 110 pF1KE5 GYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKI :::::::::::::::::::::::::::::: XP_016 MLAICGIPLFFLELSLGQFSSLGPLAVWKI 10 20 30 120 130 140 150 160 170 pF1KE5 SPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRV 40 50 60 70 80 90 180 190 pF1KE5 SKDGNGALPLNLTCTVSPSEEYWS------------------------------------ :::::::::::::::::::::::: XP_016 SKDGNGALPLNLTCTVSPSEEYWSQTHTEAEEEGRRGRVVSNSYPQVIFLPQPPKAEEGV 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE5 -RYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLIL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLIL 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE5 LMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGFGGLLTFASYNT 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE5 FHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAFVVYPQA 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE5 MTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVAM 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE5 YLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKP 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE5 GLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGM :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_016 GLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGILMGLLSCLMIPAGM 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE5 LVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGSQSPKPLMVHMRKYGGI 520 530 540 550 560 570 620 630 pF1KE5 TSFENTAIEVDREIAEEEESMM :::::::::::::::::::::: XP_016 TSFENTAIEVDREIAEEEESMM 580 590 >>XP_016865256 (OMIM: 606205) PREDICTED: sodium-dependen (754 aa) initn: 2956 init1: 2956 opt: 2963 Z-score: 3635.0 bits: 683.0 E(85289): 9.9e-196 Smith-Waterman score: 4196; 94.3% identity (94.5% similar) in 668 aa overlap (6-636:87-754) 10 20 30 pF1KE5 MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAA :::::::::::::::::::::::::::::: XP_016 GQRTISRALALCAPGQLSPGHPLSKMKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAA 60 70 80 90 100 110 40 50 60 70 80 90 pF1KE5 HRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLEL 120 130 140 150 160 170 100 110 120 130 140 150 pF1KE5 SLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SLGQFSSLGPLAVWKISPLFKGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWE 180 190 200 210 220 230 160 170 180 190 pF1KE5 HCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWS-------------------- :::::::::::::::::::::::::::::::::::::::: XP_016 HCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSPSEEYWSQTHTEAEEEGRRGRVVSNSY 240 250 260 270 280 290 200 210 220 230 pF1KE5 -----------------RYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKS ::::::::::::::::::::::::::::::::::::::::::: XP_016 PQVIFLPQPPKAEEGVSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGVKS 300 310 320 330 340 350 240 250 260 270 280 290 pF1KE5 SGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYS 360 370 380 390 400 410 300 310 320 330 340 350 pF1KE5 LGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQ 420 430 440 450 460 470 360 370 380 390 400 410 pF1KE5 VAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYY 480 490 500 510 520 530 420 430 440 450 460 470 pF1KE5 LRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYG 540 550 560 570 580 590 480 490 500 510 520 530 pF1KE5 IQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPPWAELL :::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::: XP_016 IQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELL 600 610 620 630 640 650 540 550 560 570 580 590 pF1KE5 GILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYVATLAGS 660 670 680 690 700 710 600 610 620 630 pF1KE5 QSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM :::::::::::::::::::::::::::::::::::::: XP_016 QSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM 720 730 740 750 >>NP_057699 (OMIM: 615097) sodium- and chloride-dependen (602 aa) initn: 1762 init1: 905 opt: 1833 Z-score: 2248.4 bits: 426.2 E(85289): 1.7e-118 Smith-Waterman score: 1834; 48.5% identity (75.0% similar) in 573 aa overlap (11-578:15-573) 10 20 30 40 50 pF1KE5 MKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVG ::: : .: ... : . .::.:..:..:.:: : .: NP_057 MDSRVSGTTSNGETKPVYP--VMEKKEE-------DGTLERGHWNNKMEFVLSVAGEIIG 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 LGNVWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLF ::::::::: : ::::::..::...: ::::.:.:: .:::..: : ...: :: :.: NP_057 LGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIF 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 KGAGAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDG .: : : .:: :. .:: ...:..:::::.:.: :::: : . :::: :.: . . NP_057 EGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKT--- 120 130 140 150 160 180 190 200 210 220 230 pF1KE5 NGALPLNLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKG ::.: . ..:: :.: : ::.: :.:: : .::.: ::::::::: ..:: :: NP_057 NGSLNGTSENATSPVIEFWERRVLKI--SDGIQHLGALRWELALCLLLAWVICYFCIWKG 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE5 VKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQI :::.:::::::::::::.:..::.:::::::: .:::::: :.. .: . .::..:. :: NP_057 VKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQI 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE5 FYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVP :.:... .: : ...::: .:.: ::: . . . :. ::..:::::::.::.:::: ::: NP_057 FFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVP 290 300 310 320 330 340 360 370 380 390 400 410 pF1KE5 VDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEF ...::..::::::..::.:..:::.::.:. ::::.. :::::::. .:..:::..: . NP_057 ISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMY 350 360 370 380 390 400 420 430 440 450 460 470 pF1KE5 PYYLRPK--KAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSAS-FGLMVVVITTCLA :. .: : . :. . :. .:.:::. :.:::: . :.: :.:: . :. :.: : NP_057 PHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLC 410 420 430 440 450 460 480 490 500 510 520 530 pF1KE5 VTRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGS-YRF :. ::: .:: .:. :.:..: .. :::::.::. : ...:..:: : :.. : . NP_057 VAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTY 470 480 490 500 510 520 540 550 560 570 580 590 pF1KE5 PPWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMY : :.. :: :..: : . ::: : . .: . ::..: :: : NP_057 PWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPA 530 540 550 560 570 580 600 610 620 630 pF1KE5 VATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM NP_057 TPRTSLLRLTELESHC 590 600 >>NP_001116320 (OMIM: 603080) sodium- and chloride-depen (614 aa) initn: 1569 init1: 877 opt: 1809 Z-score: 2218.8 bits: 420.7 E(85289): 7.5e-117 Smith-Waterman score: 1809; 46.9% identity (75.6% similar) in 569 aa overlap (15-575:13-575) 10 20 30 40 50 pF1KE5 MKKLQGAHLRKPVTPDLLMTPSDQGDVDL-DVDFAAHRGNWTGKLDFLLSCIGYCVGLGN : . .: . .: : : . ::.::.:..:.:: : .:::: NP_001 MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 VWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGA :::::: : ::::::..:::... .::::.::::..:::..: : ...: :: :::.: NP_001 VWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 GAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGA : : ..: . . .:: .:.:..:::::.:.::.::: :.:.:::: : . ....: :. NP_001 GLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF-LNHSGAGT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 L-PL-NLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGV . :. :.: :: :.: : :: : ..:: . : .::.: ::::::::: ..:: ::: NP_001 VTPFENFT---SPVMEFWERRVLGI--TSGIHDLGSLRWELALCLLLAWVICYFCIWKGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 KSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIF ::.:::::::::::::.:..::.::::::::..:: .:: :.. .: . .::..:. ::: NP_001 KSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 YSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPV .:... : : ...::: .:.: :.: . . . :. ::..:::..::.::.:::: :::. NP_001 FSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPI 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 DQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFP ..::..::::::...:.:.::.::: .:: :::.::. :::::::. .: .::: : :: NP_001 SEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 YYLRP--KKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSAS-FGLMVVVITTCLAV :: .. .. : : ::.::.:.:.:::: . :.: :..: . :. . . . . NP_001 RQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCI 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE5 TRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGS-YRFP . ::: .:: .:. :.:..: . ::::.:. :: ...:. :: : .:.. : .: NP_001 SWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE5 PWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYV ::. .: ...: : . .: .....:. .: . .::.: : NP_001 PWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSA 540 550 560 570 580 590 600 610 620 630 pF1KE5 ATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM NP_001 GRNFGPSPTREGLIAGEKETHL 600 610 >>XP_011519312 (OMIM: 603080) PREDICTED: sodium- and chl (614 aa) initn: 1569 init1: 877 opt: 1809 Z-score: 2218.8 bits: 420.7 E(85289): 7.5e-117 Smith-Waterman score: 1809; 46.9% identity (75.6% similar) in 569 aa overlap (15-575:13-575) 10 20 30 40 50 pF1KE5 MKKLQGAHLRKPVTPDLLMTPSDQGDVDL-DVDFAAHRGNWTGKLDFLLSCIGYCVGLGN : . .: . .: : : . ::.::.:..:.:: : .:::: XP_011 MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 VWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGA :::::: : ::::::..:::... .::::.::::..:::..: : ...: :: :::.: XP_011 VWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 GAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGA : : ..: . . .:: .:.:..:::::.:.::.::: :.:.:::: : . ....: :. XP_011 GLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF-LNHSGAGT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 L-PL-NLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGV . :. :.: :: :.: : :: : ..:: . : .::.: ::::::::: ..:: ::: XP_011 VTPFENFT---SPVMEFWERRVLGI--TSGIHDLGSLRWELALCLLLAWVICYFCIWKGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 KSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIF ::.:::::::::::::.:..::.::::::::..:: .:: :.. .: . .::..:. ::: XP_011 KSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 YSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPV .:... : : ...::: .:.: :.: . . . :. ::..:::..::.::.:::: :::. XP_011 FSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPI 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 DQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFP ..::..::::::...:.:.::.::: .:: :::.::. :::::::. .: .::: : :: XP_011 SEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 YYLRP--KKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSAS-FGLMVVVITTCLAV :: .. .. : : ::.::.:.:.:::: . :.: :..: . :. . . . . XP_011 RQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCI 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE5 TRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGS-YRFP . ::: .:: .:. :.:..: . ::::.:. :: ...:. :: : .:.. : .: XP_011 SWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE5 PWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYV ::. .: ...: : . .: .....:. .: . .::.: : XP_011 PWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSA 540 550 560 570 580 590 600 610 620 630 pF1KE5 ATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM XP_011 GRNFGPSPTREGLIAGEKETHL 600 610 >>NP_001116319 (OMIM: 603080) sodium- and chloride-depen (614 aa) initn: 1569 init1: 877 opt: 1809 Z-score: 2218.8 bits: 420.7 E(85289): 7.5e-117 Smith-Waterman score: 1809; 46.9% identity (75.6% similar) in 569 aa overlap (15-575:13-575) 10 20 30 40 50 pF1KE5 MKKLQGAHLRKPVTPDLLMTPSDQGDVDL-DVDFAAHRGNWTGKLDFLLSCIGYCVGLGN : . .: . .: : : . ::.::.:..:.:: : .:::: NP_001 MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 VWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGA :::::: : ::::::..:::... .::::.::::..:::..: : ...: :: :::.: NP_001 VWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 GAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGA : : ..: . . .:: .:.:..:::::.:.::.::: :.:.:::: : . ....: :. NP_001 GLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF-LNHSGAGT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 L-PL-NLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGV . :. :.: :: :.: : :: : ..:: . : .::.: ::::::::: ..:: ::: NP_001 VTPFENFT---SPVMEFWERRVLGI--TSGIHDLGSLRWELALCLLLAWVICYFCIWKGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 KSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIF ::.:::::::::::::.:..::.::::::::..:: .:: :.. .: . .::..:. ::: NP_001 KSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 YSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPV .:... : : ...::: .:.: :.: . . . :. ::..:::..::.::.:::: :::. NP_001 FSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPI 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 DQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFP ..::..::::::...:.:.::.::: .:: :::.::. :::::::. .: .::: : :: NP_001 SEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 YYLRP--KKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSAS-FGLMVVVITTCLAV :: .. .. : : ::.::.:.:.:::: . :.: :..: . :. . . . . NP_001 RQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCI 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE5 TRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGS-YRFP . ::: .:: .:. :.:..: . ::::.:. :: ...:. :: : .:.. : .: NP_001 SWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE5 PWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYV ::. .: ...: : . .: .....:. .: . .::.: : NP_001 PWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSA 540 550 560 570 580 590 600 610 620 630 pF1KE5 ATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM NP_001 GRNFGPSPTREGLIAGEKETHL 600 610 >>NP_001193860 (OMIM: 603080) sodium- and chloride-depen (614 aa) initn: 1569 init1: 877 opt: 1809 Z-score: 2218.8 bits: 420.7 E(85289): 7.5e-117 Smith-Waterman score: 1809; 46.9% identity (75.6% similar) in 569 aa overlap (15-575:13-575) 10 20 30 40 50 pF1KE5 MKKLQGAHLRKPVTPDLLMTPSDQGDVDL-DVDFAAHRGNWTGKLDFLLSCIGYCVGLGN : . .: . .: : : . ::.::.:..:.:: : .:::: NP_001 MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGN 10 20 30 40 50 60 70 80 90 100 110 pF1KE5 VWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGA :::::: : ::::::..:::... .::::.::::..:::..: : ...: :: :::.: NP_001 VWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGI 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE5 GAAMLLIVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGA : : ..: . . .:: .:.:..:::::.:.::.::: :.:.:::: : . ....: :. NP_001 GLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDF-LNHSGAGT 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE5 L-PL-NLTCTVSPSEEYWSRYVLHIQGSQGIGSPGEIRWNLCLCLLLAWVIVFLCILKGV . :. :.: :: :.: : :: : ..:: . : .::.: ::::::::: ..:: ::: NP_001 VTPFENFT---SPVMEFWERRVLGI--TSGIHDLGSLRWELALCLLLAWVICYFCIWKGV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE5 KSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIF ::.:::::::::::::.:..::.::::::::..:: .:: :.. .: . .::..:. ::: NP_001 KSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIF 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE5 YSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPV .:... : : ...::: .:.: :.: . . . :. ::..:::..::.::.:::: :::. NP_001 FSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPI 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE5 DQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFP ..::..::::::...:.:.::.::: .:: :::.::. :::::::. .: .::: : :: NP_001 SEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFP 360 370 380 390 400 410 420 430 440 450 460 470 pF1KE5 YYLRP--KKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSAS-FGLMVVVITTCLAV :: .. .. : : ::.::.:.:.:::: . :.: :..: . :. . . . . NP_001 RQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCI 420 430 440 450 460 470 480 490 500 510 520 530 pF1KE5 TRVYGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALLVYSIVKYQPSEYGS-YRFP . ::: .:: .:. :.:..: . ::::.:. :: ...:. :: : .:.. : .: NP_001 SWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYP 480 490 500 510 520 530 540 550 560 570 580 590 pF1KE5 PWAELLGILMGLLSCLMIPAGMLVAVLREEGSLWERLQQASRPAMDWGPSLEENRTGMYV ::. .: ...: : . .: .....:. .: . .::.: : NP_001 PWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSA 540 550 560 570 580 590 600 610 620 630 pF1KE5 ATLAGSQSPKPLMVHMRKYGGITSFENTAIEVDREIAEEEESMM NP_001 GRNFGPSPTREGLIAGEKETHL 600 610 636 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:10:48 2016 done: Tue Nov 8 06:10:49 2016 Total Scan time: 8.720 Total Display time: 0.120 Function used was FASTA [36.3.4 Apr, 2011]