FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5270, 208 aa 1>>>pF1KE5270 208 - 208 aa - 208 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9697+/-0.000305; mu= 10.9974+/- 0.019 mean_var=92.7907+/-18.172, 0's: 0 Z-trim(119.2): 74 B-trim: 192 in 2/51 Lambda= 0.133144 statistics sampled from 32825 (32906) to 32825 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.386), width: 16 Scan time: 5.990 The best scores are: opt bits E(85289) NP_001936 (OMIM: 126150) proheparin-binding EGF-li ( 208) 1389 276.2 2.7e-74 NP_001648 (OMIM: 104640) amphiregulin preproprotei ( 252) 281 63.4 3.7e-10 NP_001720 (OMIM: 600345) probetacellulin isoform 1 ( 178) 178 43.5 0.00025 XP_011530513 (OMIM: 600345) PREDICTED: probetacell ( 178) 178 43.5 0.00025 NP_001093161 (OMIM: 190170) protransforming growth ( 159) 171 42.1 0.00058 NP_003227 (OMIM: 190170) protransforming growth fa ( 160) 171 42.1 0.00058 NP_001295088 (OMIM: 190170) protransforming growth ( 165) 171 42.2 0.0006 NP_001295087 (OMIM: 190170) protransforming growth ( 166) 171 42.2 0.0006 XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin ( 337) 168 41.8 0.0016 NP_001292063 (OMIM: 605734) tomoregulin-2 isoform ( 346) 168 41.8 0.0016 XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin ( 365) 168 41.8 0.0017 NP_057276 (OMIM: 605734) tomoregulin-2 isoform 1 p ( 374) 168 41.8 0.0017 NP_001153468 (OMIM: 142445,603013) pro-neuregulin- ( 308) 161 40.4 0.0037 NP_003683 (OMIM: 603421) tomoregulin-1 precursor [ ( 380) 162 40.7 0.0039 NP_039254 (OMIM: 142445,603013) pro-neuregulin-1, ( 462) 161 40.5 0.0051 XP_016868860 (OMIM: 142445,603013) PREDICTED: pro- ( 469) 161 40.5 0.0052 XP_016868859 (OMIM: 142445,603013) PREDICTED: pro- ( 486) 161 40.6 0.0053 XP_005273543 (OMIM: 142445,603013) PREDICTED: pro- ( 695) 162 40.8 0.0062 NP_039258 (OMIM: 142445,603013) pro-neuregulin-1, ( 640) 161 40.6 0.0067 XP_016868854 (OMIM: 142445,603013) PREDICTED: pro- ( 647) 161 40.6 0.0067 >>NP_001936 (OMIM: 126150) proheparin-binding EGF-like g (208 aa) initn: 1389 init1: 1389 opt: 1389 Z-score: 1454.9 bits: 276.2 E(85289): 2.7e-74 Smith-Waterman score: 1389; 100.0% identity (100.0% similar) in 208 aa overlap (1-208:1-208) 10 20 30 40 50 60 pF1KE5 MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MKLLPSVVLKLFLAAVLSALVTGESLERLRRGLAAGTSNPDPPTVSTDQLLPLGGGRDRK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 VRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRDLQEADLDLLRVTLSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 CKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVAVVLSSVCLLVIVG 130 140 150 160 170 180 190 200 pF1KE5 LLMFRYHRRGGYDVENEEKVKLGMTNSH :::::::::::::::::::::::::::: NP_001 LLMFRYHRRGGYDVENEEKVKLGMTNSH 190 200 >>NP_001648 (OMIM: 104640) amphiregulin preproprotein [H (252 aa) initn: 259 init1: 195 opt: 281 Z-score: 303.5 bits: 63.4 E(85289): 3.7e-10 Smith-Waterman score: 281; 34.5% identity (60.8% similar) in 148 aa overlap (70-208:100-247) 40 50 60 70 80 90 pF1KE5 PDPPTVSTDQLLPLGGGRDRKVRDLQEADLDLLRVTLSSKP--QALATPNKEEHGKRKKK : .:: :: . . : .. ::::: NP_001 PSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPKRKKK 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE5 GKGLGK------KRDPCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVE : :: :..:: ....:::::::::...:.: .: :. : :::: :. .. NP_001 GGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTH 130 140 150 160 170 180 160 170 180 190 200 pF1KE5 NRLYTYDHTTILAVVAVVLSSVCLLVI-VGLLMFRYHRRGGYDVENEEKVKLGMTNSH . . . ::..:. .:.: : .. : ...: . :. : ::. :: . :.. NP_001 SMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVH 190 200 210 220 230 240 NP_001 AIA 250 >>NP_001720 (OMIM: 600345) probetacellulin isoform 1 pre (178 aa) initn: 161 init1: 161 opt: 178 Z-score: 198.7 bits: 43.5 E(85289): 0.00025 Smith-Waterman score: 178; 32.0% identity (66.7% similar) in 75 aa overlap (108-181:69-138) 80 90 100 110 120 130 pF1KE5 SKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPG : ..:: .::.:.:..: ..:::.: : NP_001 PETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEG 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE5 YHGERCHGLSLPVENRLYTY-DHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVEN : : ::. ..: .: :. ::.. ... : .....:. NP_001 YIGARCERVDL-----FYLRGDRGQILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKK 100 110 120 130 140 150 200 pF1KE5 EEKVKLGMTNSH NP_001 KEEEMETLGKDITPINEDIEETNIA 160 170 >>XP_011530513 (OMIM: 600345) PREDICTED: probetacellulin (178 aa) initn: 161 init1: 161 opt: 178 Z-score: 198.7 bits: 43.5 E(85289): 0.00025 Smith-Waterman score: 178; 32.0% identity (66.7% similar) in 75 aa overlap (108-181:69-138) 80 90 100 110 120 130 pF1KE5 SKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHPG : ..:: .::.:.:..: ..:::.: : XP_011 PETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEG 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE5 YHGERCHGLSLPVENRLYTY-DHTTILAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDVEN : : ::. ..: .: :. ::.. ... : .....:. XP_011 YIGARCERVDL-----FYLRGDRGQILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKK 100 110 120 130 140 150 200 pF1KE5 EEKVKLGMTNSH XP_011 KEEEMETLGKDITPINEDIEETNIA 160 170 >>NP_001093161 (OMIM: 190170) protransforming growth fac (159 aa) initn: 158 init1: 143 opt: 171 Z-score: 192.1 bits: 42.1 E(85289): 0.00058 Smith-Waterman score: 171; 31.8% identity (57.6% similar) in 85 aa overlap (106-187:44-128) 80 90 100 110 120 130 pF1KE5 LSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICH . : .. .::.:: :... . :.:.:: NP_001 GIVLAACQALENSTSPLSDPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCH 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE5 PGYHGERC-HGLSLPVENRLYTYDHTTILAVVAVVLSSVCLL--VIVGLLMFRYHRRGGY :: : :: :. : : . : :.::..: .: .. :.. . : : NP_001 SGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCR 80 90 100 110 120 130 200 pF1KE5 DVENEEKVKLGMTNSH NP_001 ALICRHEKPSALLKGRTACCHSETVV 140 150 >>NP_003227 (OMIM: 190170) protransforming growth factor (160 aa) initn: 158 init1: 143 opt: 171 Z-score: 192.1 bits: 42.1 E(85289): 0.00058 Smith-Waterman score: 171; 31.8% identity (57.6% similar) in 85 aa overlap (106-187:45-129) 80 90 100 110 120 130 pF1KE5 LSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICH . : .. .::.:: :... . :.:.:: NP_003 IVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCH 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE5 PGYHGERC-HGLSLPVENRLYTYDHTTILAVVAVVLSSVCLL--VIVGLLMFRYHRRGGY :: : :: :. : : . : :.::..: .: .. :.. . : : NP_003 SGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCR 80 90 100 110 120 130 200 pF1KE5 DVENEEKVKLGMTNSH NP_003 ALICRHEKPSALLKGRTACCHSETVV 140 150 160 >>NP_001295088 (OMIM: 190170) protransforming growth fac (165 aa) initn: 158 init1: 143 opt: 171 Z-score: 191.9 bits: 42.2 E(85289): 0.0006 Smith-Waterman score: 171; 31.8% identity (57.6% similar) in 85 aa overlap (106-187:50-134) 80 90 100 110 120 130 pF1KE5 LSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICH . : .. .::.:: :... . :.:.:: NP_001 GIVLAACQALENSTSPLSDPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCH 20 30 40 50 60 70 140 150 160 170 180 190 pF1KE5 PGYHGERC-HGLSLPVENRLYTYDHTTILAVVAVVLSSVCLL--VIVGLLMFRYHRRGGY :: : :: :. : : . : :.::..: .: .. :.. . : : NP_001 SGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCR 80 90 100 110 120 130 200 pF1KE5 DVENEEKVKLGMTNSH NP_001 ALICRHEKPSALLKGRTACCHSETVV 140 150 160 >>NP_001295087 (OMIM: 190170) protransforming growth fac (166 aa) initn: 158 init1: 143 opt: 171 Z-score: 191.8 bits: 42.2 E(85289): 0.0006 Smith-Waterman score: 171; 31.8% identity (57.6% similar) in 85 aa overlap (106-187:51-135) 80 90 100 110 120 130 pF1KE5 LSSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICH . : .. .::.:: :... . :.:.:: NP_001 IVLAACQALENSTSPLSADPPVAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCH 30 40 50 60 70 80 140 150 160 170 180 190 pF1KE5 PGYHGERC-HGLSLPVENRLYTYDHTTILAVVAVVLSSVCLL--VIVGLLMFRYHRRGGY :: : :: :. : : . : :.::..: .: .. :.. . : : NP_001 SGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIITCVLIHCCQVRKHCEWCR 90 100 110 120 130 140 200 pF1KE5 DVENEEKVKLGMTNSH NP_001 ALICRHEKPSALLKGRTACCHSETVV 150 160 >>XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin-2 i (337 aa) initn: 154 init1: 154 opt: 168 Z-score: 184.3 bits: 41.8 E(85289): 0.0016 Smith-Waterman score: 168; 28.9% identity (67.1% similar) in 76 aa overlap (107-178:255-330) 80 90 100 110 120 130 pF1KE5 SSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHP :: ..:. ::.::.:.. ... ::: : XP_016 TTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDA 230 240 250 260 270 280 140 150 160 170 180 190 pF1KE5 GYHGERCHGLSLPVENRL---YTYDHTTILAVVAVV-LSSVCLLVIVGLLMFRYHRRGGY :: :..:. . : . .... : ::.... .. .:..:. XP_016 GYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRAKL 290 300 310 320 330 200 pF1KE5 DVENEEKVKLGMTNSH >>NP_001292063 (OMIM: 605734) tomoregulin-2 isoform 2 pr (346 aa) initn: 154 init1: 154 opt: 168 Z-score: 184.2 bits: 41.8 E(85289): 0.0016 Smith-Waterman score: 168; 28.9% identity (67.1% similar) in 76 aa overlap (107-178:264-339) 80 90 100 110 120 130 pF1KE5 SSKPQALATPNKEEHGKRKKKGKGLGKKRDPCLRKYKDFCIHGECKYVKELRAPSCICHP :: ..:. ::.::.:.. ... ::: : NP_001 TTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDA 240 250 260 270 280 290 140 150 160 170 180 190 pF1KE5 GYHGERCHGLSLPVENRL---YTYDHTTILAVVAVV-LSSVCLLVIVGLLMFRYHRRGGY :: :..:. . : . .... : ::.... .. .:..:. NP_001 GYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRAKL 300 310 320 330 340 200 pF1KE5 DVENEEKVKLGMTNSH 208 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 07:26:05 2016 done: Tue Nov 8 07:26:06 2016 Total Scan time: 5.990 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]