FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1833, 351 aa 1>>>pF1KE1833 351 - 351 aa - 351 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0572+/-0.000398; mu= 18.3829+/- 0.025 mean_var=78.4361+/-16.058, 0's: 0 Z-trim(113.6): 59 B-trim: 47 in 1/47 Lambda= 0.144816 statistics sampled from 22904 (22963) to 22904 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.269), width: 16 Scan time: 6.190 The best scores are: opt bits E(85289) NP_490645 (OMIM: 606360) protein Wnt-8a isoform 3 ( 351) 2477 527.1 2.2e-149 NP_001287868 (OMIM: 606360) protein Wnt-8a isoform ( 369) 2324 495.2 9.6e-140 XP_016865314 (OMIM: 606360) PREDICTED: protein Wnt ( 391) 2323 495.0 1.2e-139 NP_001287867 (OMIM: 606360) protein Wnt-8a isoform ( 386) 2185 466.1 5.5e-131 XP_016865313 (OMIM: 606360) PREDICTED: protein Wnt ( 408) 2184 466.0 6.6e-131 XP_016865315 (OMIM: 606360) PREDICTED: protein Wnt ( 255) 1826 391.0 1.5e-108 XP_011541927 (OMIM: 606360) PREDICTED: protein Wnt ( 337) 1819 389.6 5.2e-108 NP_003384 (OMIM: 601396) protein Wnt-8b precursor ( 351) 1626 349.3 7.4e-96 NP_005421 (OMIM: 164820,615220,615221) proto-oncog ( 370) 876 192.6 1.1e-48 NP_116031 (OMIM: 606361) protein Wnt-5b precursor ( 359) 868 191.0 3.5e-48 NP_110402 (OMIM: 606361) protein Wnt-5b precursor ( 359) 868 191.0 3.5e-48 XP_011532387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 854 188.0 2.7e-47 XP_011532390 (OMIM: 164975,180700) PREDICTED: prot ( 365) 854 188.0 2.7e-47 XP_006713387 (OMIM: 164975,180700) PREDICTED: prot ( 365) 854 188.0 2.7e-47 XP_011532389 (OMIM: 164975,180700) PREDICTED: prot ( 365) 854 188.0 2.7e-47 NP_001243034 (OMIM: 164975,180700) protein Wnt-5a ( 365) 854 188.0 2.7e-47 XP_016862617 (OMIM: 164975,180700) PREDICTED: prot ( 365) 854 188.0 2.7e-47 XP_011532388 (OMIM: 164975,180700) PREDICTED: prot ( 365) 854 188.0 2.7e-47 XP_011532391 (OMIM: 164975,180700) PREDICTED: prot ( 365) 854 188.0 2.7e-47 NP_003383 (OMIM: 164975,180700) protein Wnt-5a iso ( 380) 854 188.1 2.8e-47 XP_016862616 (OMIM: 164975,180700) PREDICTED: prot ( 394) 854 188.1 2.9e-47 NP_478679 (OMIM: 601967) protein Wnt-7b precursor ( 349) 840 185.1 2e-46 XP_011528668 (OMIM: 601967) PREDICTED: protein Wnt ( 353) 840 185.1 2e-46 NP_110380 (OMIM: 165330,273395) proto-oncogene Wnt ( 355) 840 185.1 2e-46 NP_149122 (OMIM: 606359) protein Wnt-3a precursor ( 352) 837 184.5 3.1e-46 XP_011542621 (OMIM: 606359) PREDICTED: protein Wnt ( 446) 837 184.6 3.7e-46 NP_004616 (OMIM: 228930,276820,601570) protein Wnt ( 349) 821 181.1 3.1e-45 XP_011532393 (OMIM: 228930,276820,601570) PREDICTE ( 282) 806 177.9 2.3e-44 NP_003382 (OMIM: 147870) protein Wnt-2 precursor [ ( 360) 751 166.5 8.1e-41 XP_011539900 (OMIM: 158330,603490,611812) PREDICTE ( 296) 746 165.4 1.4e-40 NP_110388 (OMIM: 158330,603490,611812) protein Wnt ( 351) 746 165.5 1.6e-40 XP_011539899 (OMIM: 158330,603490,611812) PREDICTE ( 373) 746 165.5 1.7e-40 NP_001278809 (OMIM: 601968) protein Wnt-2b isoform ( 299) 732 162.5 1.1e-39 NP_004176 (OMIM: 601968) protein Wnt-2b isoform WN ( 372) 732 162.6 1.3e-39 NP_078613 (OMIM: 601968) protein Wnt-2b isoform WN ( 391) 732 162.6 1.3e-39 XP_011542573 (OMIM: 602863) PREDICTED: protein Wnt ( 295) 674 150.4 4.8e-36 NP_003386 (OMIM: 602863) protein Wnt-9a precursor ( 365) 674 150.4 5.7e-36 NP_057171 (OMIM: 606267) protein Wnt-16 isoform 2 ( 355) 615 138.1 2.9e-32 NP_476509 (OMIM: 606267) protein Wnt-16 isoform 1 ( 365) 615 138.1 2.9e-32 XP_005274288 (OMIM: 603699) PREDICTED: protein Wnt ( 354) 607 136.4 9.1e-32 NP_004617 (OMIM: 603699) protein Wnt-11 precursor ( 354) 607 136.4 9.1e-32 NP_003387 (OMIM: 602864) protein Wnt-9b isoform 1 ( 357) 596 134.1 4.5e-31 XP_011523480 (OMIM: 602864) PREDICTED: protein Wnt ( 363) 596 134.1 4.5e-31 XP_011510231 (OMIM: 150400,224750,257980,606268) P ( 385) 568 128.3 2.7e-29 NP_079492 (OMIM: 150400,224750,257980,606268) prot ( 417) 568 128.3 2.9e-29 NP_001307387 (OMIM: 602864) protein Wnt-9b isoform ( 329) 562 127.0 5.8e-29 XP_011543540 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 555 125.6 1.7e-28 XP_011543542 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 555 125.6 1.7e-28 XP_011543541 (OMIM: 603699) PREDICTED: protein Wnt ( 364) 555 125.6 1.7e-28 XP_016873730 (OMIM: 603699) PREDICTED: protein Wnt ( 251) 552 124.8 2e-28 >>NP_490645 (OMIM: 606360) protein Wnt-8a isoform 3 prec (351 aa) initn: 2477 init1: 2477 opt: 2477 Z-score: 2802.8 bits: 527.1 E(85289): 2.2e-149 Smith-Waterman score: 2477; 100.0% identity (100.0% similar) in 351 aa overlap (1-351:1-351) 10 20 30 40 50 60 pF1KE1 MGNLFMLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIEECKFQFAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_490 MGNLFMLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIEECKFQFAW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 ERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENCGCDGSNNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_490 ERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENCGCDGSNNG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 KTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAVRATMKRTC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_490 KTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAVRATMKRTC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 KCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAEGHWVPAEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_490 KCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAEGHWVPAEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 FLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGRLCTECGLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_490 FLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGRLCTECGLQ 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 VEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_490 VEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA 310 320 330 340 350 >>NP_001287868 (OMIM: 606360) protein Wnt-8a isoform 2 p (369 aa) initn: 2324 init1: 2324 opt: 2324 Z-score: 2629.8 bits: 495.2 E(85289): 9.6e-140 Smith-Waterman score: 2324; 98.2% identity (98.8% similar) in 337 aa overlap (15-351:33-369) 10 20 30 40 pF1KE1 MGNLFMLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVA : .:: . ::::::::::::::::::::: NP_001 CCIQCLCLVSPFPTLTPCQGGPHCLIPIHLCLTFSLFGRSVNNFLITGPKAYLTYTTSVA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 LGAQSGIEECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGAQSGIEECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 SMGDFENCGCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMGDFENCGCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 NRAGRLAVRATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRAGRLAVRATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 LRAGNSAEGHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRAGNSAEGHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE1 WERRSCGRLCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WERRSCGRLCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQ 310 320 330 340 350 360 350 pF1KE1 SLGKGSA ::::::: NP_001 SLGKGSA >>XP_016865314 (OMIM: 606360) PREDICTED: protein Wnt-8a (391 aa) initn: 2323 init1: 2323 opt: 2323 Z-score: 2628.3 bits: 495.0 E(85289): 1.2e-139 Smith-Waterman score: 2323; 100.0% identity (100.0% similar) in 329 aa overlap (23-351:63-391) 10 20 30 40 50 pF1KE1 MGNLFMLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIE :::::::::::::::::::::::::::::: XP_016 LIIVLNASLGLLESHHHPGTLEVEGVFRITWSVNNFLITGPKAYLTYTTSVALGAQSGIE 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 ECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENC 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE1 GCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAV 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE1 RATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAE 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE1 GHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGR 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE1 LCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA 340 350 360 370 380 390 >>NP_001287867 (OMIM: 606360) protein Wnt-8a isoform 1 p (386 aa) initn: 2185 init1: 2185 opt: 2185 Z-score: 2472.6 bits: 466.1 E(85289): 5.5e-131 Smith-Waterman score: 2185; 98.1% identity (98.7% similar) in 316 aa overlap (15-330:33-348) 10 20 30 40 pF1KE1 MGNLFMLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVA : .:: . ::::::::::::::::::::: NP_001 CCIQCLCLVSPFPTLTPCQGGPHCLIPIHLCLTFSLFGRSVNNFLITGPKAYLTYTTSVA 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 LGAQSGIEECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGAQSGIEECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNC 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 SMGDFENCGCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SMGDFENCGCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE1 NRAGRLAVRATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NRAGRLAVRATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE1 LRAGNSAEGHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRAGNSAEGHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSR 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE1 WERRSCGRLCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQ :::::::::::::::::::::::::::::::::::::::::::::: NP_001 WERRSCGRLCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVTMSNPAVLLGIRRI 310 320 330 340 350 360 350 pF1KE1 SLGKGSA NP_001 EAKNERVLFRLLKSSLWLQIYADK 370 380 >>XP_016865313 (OMIM: 606360) PREDICTED: protein Wnt-8a (408 aa) initn: 2184 init1: 2184 opt: 2184 Z-score: 2471.2 bits: 466.0 E(85289): 6.6e-131 Smith-Waterman score: 2184; 100.0% identity (100.0% similar) in 308 aa overlap (23-330:63-370) 10 20 30 40 50 pF1KE1 MGNLFMLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIE :::::::::::::::::::::::::::::: XP_016 LIIVLNASLGLLESHHHPGTLEVEGVFRITWSVNNFLITGPKAYLTYTTSVALGAQSGIE 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 ECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENC 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE1 GCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAV 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE1 RATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAE 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE1 GHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGR 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE1 LCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA :::::::::::::::::::::::::::::::::::::: XP_016 LCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVTMSNPAVLLGIRRIEAKNERVL 340 350 360 370 380 390 XP_016 FRLLKSSLWLQIYADK 400 >>XP_016865315 (OMIM: 606360) PREDICTED: protein Wnt-8a (255 aa) initn: 1826 init1: 1826 opt: 1826 Z-score: 2069.6 bits: 391.0 E(85289): 1.5e-108 Smith-Waterman score: 1826; 100.0% identity (100.0% similar) in 255 aa overlap (97-351:1-255) 70 80 90 100 110 120 pF1KE1 ENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENCGCDGSNNGKTGGHG :::::::::::::::::::::::::::::: XP_016 MYIITKNCSMGDFENCGCDGSNNGKTGGHG 10 20 30 130 140 150 160 170 180 pF1KE1 WIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAVRATMKRTCKCHGIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAVRATMKRTCKCHGIS 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE1 GSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAEGHWVPAEAFLPSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAEGHWVPAEAFLPSAE 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE1 AELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGRLCTECGLQVEERKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGRLCTECGLQVEERKT 160 170 180 190 200 210 310 320 330 340 350 pF1KE1 EVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA ::::::::::::::::::::::::::::::::::::::::::::: XP_016 EVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA 220 230 240 250 >>XP_011541927 (OMIM: 606360) PREDICTED: protein Wnt-8a (337 aa) initn: 1819 init1: 1819 opt: 1819 Z-score: 2060.1 bits: 389.6 E(85289): 5.2e-108 Smith-Waterman score: 1819; 100.0% identity (100.0% similar) in 262 aa overlap (23-284:63-324) 10 20 30 40 50 pF1KE1 MGNLFMLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIE :::::::::::::::::::::::::::::: XP_011 LIIVLNASLGLLESHHHPGTLEVEGVFRITWSVNNFLITGPKAYLTYTTSVALGAQSGIE 40 50 60 70 80 90 60 70 80 90 100 110 pF1KE1 ECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ECKFQFAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENC 100 110 120 130 140 150 120 130 140 150 160 170 pF1KE1 GCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GCDGSNNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAV 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE1 RATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RATMKRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAE 220 230 240 250 260 270 240 250 260 270 280 290 pF1KE1 GHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGR :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GHWVPAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRPCPTQLCC 280 290 300 310 320 330 300 310 320 330 340 350 pF1KE1 LCTECGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA XP_011 WESGE >>NP_003384 (OMIM: 601396) protein Wnt-8b precursor [Hom (351 aa) initn: 1617 init1: 1111 opt: 1626 Z-score: 1842.0 bits: 349.3 E(85289): 7.4e-96 Smith-Waterman score: 1626; 63.4% identity (83.0% similar) in 352 aa overlap (4-348:1-349) 10 20 30 40 50 pF1KE1 MGNLFMLWAALGIC---CAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIEECKFQ .:. .. :: :. . .:::::::.::::::: :..::: ::::::::::.: NP_003 MFLSKPSVYICLFTCVLQLSHSWSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQ 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 FAWERWNCPENALQLSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENCGCDGS :::.:::::: :::::.:. ::::.:::.:.:::::::::: .:.:::.:::.::::: : NP_003 FAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE1 NNGKTGGHGWIWGGCSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAVRATMK ::. ::.::.:::::::: ::: ::: :::.:: :.:::: ::::::.::: ::..::: NP_003 RNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMK 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE1 RTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAEGHWVP :::::::.::::. ::::::: ::::.: .:: :: :::... . ::::: :. . NP_003 RTCKCHGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQG---AGNSAAGRGAI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE1 AEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGRLCTEC :..: . ::. ::.::::: :..::. ::::::::. .. .::::::: ::: .: NP_003 ADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRALGRWERRSCRRLCGDC 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE1 GLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARS--P--GSAQSLGKGSA :: ::::..:..:::::::.:::.:.:.:::. :.::.:.:. : :.:.. :. NP_003 GLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCSRAERPRGGAAHKPGRKP 300 310 320 330 340 350 >>NP_005421 (OMIM: 164820,615220,615221) proto-oncogene (370 aa) initn: 672 init1: 428 opt: 876 Z-score: 994.8 bits: 192.6 E(85289): 1.1e-48 Smith-Waterman score: 876; 42.4% identity (65.3% similar) in 297 aa overlap (42-336:81-369) 20 30 40 50 60 70 pF1KE1 GICCAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIEECKFQFAWERWNCPENALQ ::. : ::...:::.:: .::::: NP_005 KSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGP 60 70 80 90 100 110 80 90 100 110 120 130 pF1KE1 LSTHNRLRSATRETSFIHAISSAGVMYIITKNCSMGDFENCGCDGSNNGKTGGHGWIWGG . . . :::.:: ::.:::: . ....:: :..:.: :: : :: : ::: NP_005 HLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGP-GGPDWHWGG 120 130 140 150 160 140 150 160 170 180 190 pF1KE1 CSDNVEFGERISKLFVDSLEKGKDARALMNLHNNRAGRLAVRATMKRTCKCHGISGSCSI ::::..::. ... :::: :::.: : :::::::.::: .: . :.. :::::.::::.. NP_005 CSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTV 170 180 190 200 210 220 200 210 220 230 240 pF1KE1 QTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAEGHWVPAE--AFLPSAEAEL .:::..: .: .:: :. ..: : .. . .: .. :: . : : : . .: NP_005 RTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDL 230 240 250 260 270 280 250 260 270 280 290 300 pF1KE1 IFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGRLCTECGLQVEERKTEVI ...:.::..:: .. :: :: :: : :.: .: :: :: . : .: NP_005 VYFEKSPNFCTYSGRLGTAGTAGRAC-----NSSSPALDGCELLC--CGRGHRTRTQRVT 290 300 310 320 330 340 310 320 330 340 350 pF1KE1 SSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA ::: :.::: :.: .: :. . : NP_005 ERCNCTFHWCCHVSCRNCTHTRVLHECL 350 360 370 >>NP_116031 (OMIM: 606361) protein Wnt-5b precursor [Hom (359 aa) initn: 545 init1: 395 opt: 868 Z-score: 986.0 bits: 191.0 E(85289): 3.5e-48 Smith-Waterman score: 868; 41.6% identity (67.1% similar) in 310 aa overlap (36-336:65-358) 10 20 30 40 50 60 pF1KE1 MLWAALGICCAAFSASAWSVNNFLITGPKAYLTYTTSVALGAQSGIEECKFQFAWERWNC : . . .. ::..::.::. :: .:::: NP_116 QRPEMFIIGAQPVCSQLPGLSPGQRKLCQLYQEHMAYIGEGAKTGIKECQHQFRQRRWNC 40 50 60 70 80 90 70 80 90 100 110 120 pF1KE1 PENALQLSTHNR-LRSATRETSFIHAISSAGVMYIITKNCSMGDFENCGCDGSNNGKTGG .: . :. .: .. ..:::.: ::.:.:::. :.. : :.. .:::. . : NP_116 S-TADNASVFGRVMQIGSRETAFTHAVSAAGVVNAISRACREGELSTCGCSRTARPKDLP 100 110 120 130 140 150 130 140 150 160 170 pF1KE1 HGWIWGGCSDNVEFGERISKLFVDSLEKGKD--------ARALMNLHNNRAGRLAVRATM . :.::::.::::.: :..: :::. :. :. .:.::::.::.::: :: NP_116 RDWLWGGCGDNVEYGYRFAKEFVDAREREKNFAKGSEEQGRVLMNLQNNEAGRRAVYKMA 160 170 180 190 200 210 180 190 200 210 220 230 pF1KE1 KRTCKCHGISGSCSIQTCWLQLAEFREMGDYLKAKYDQALKIEMDKRQLRAGNSAEGHWV .:::::.:::::..::::::::::..:: :: :::.: . : : : . . : NP_116 DVACKCHGVSGSCSLKTCWLQLAEFRKVGDRLKEKYDSAAAM----RVTRKG---RLELV 220 230 240 250 260 240 250 260 270 280 290 pF1KE1 PAEAFLPSAEAELIFLEESPDYCTCNSSLGIYGTEGRECLQNSHNTSRWERRSCGRLCTE .. :. : .:.... ::::: : : : ::.:: : ..:.. . .: .: NP_116 NSRFTQPTPE-DLVYVDPSPDYCLRNESTGSLGTQGRLCNKTSEGMD-----GCELMC-- 270 280 290 300 310 300 310 320 330 340 350 pF1KE1 CGLQVEERKTEVISSCNCKFQWCCTVKCDQCRHVVSKYYCARSPGSAQSLGKGSA :: .. :. . :.:::.::: :.: .: ..:..: : NP_116 CGRGYNQFKSVQVERCHCKFHWCCFVRCKKCTEIVDQYICK 320 330 340 350 351 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:07:50 2016 done: Sun Nov 6 17:07:51 2016 Total Scan time: 6.190 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]