FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2592, 224 aa 1>>>pF1KE2592 224 - 224 aa - 224 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.2663+/-0.000337; mu= 19.5088+/- 0.021 mean_var=58.3976+/-11.597, 0's: 0 Z-trim(116.0): 25 B-trim: 394 in 1/50 Lambda= 0.167833 statistics sampled from 26771 (26794) to 26771 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.7), E-opt: 0.2 (0.314), width: 16 Scan time: 3.780 The best scores are: opt bits E(85289) NP_001161302 (OMIM: 616876) transmembrane emp24 do ( 193) 261 70.9 1.6e-12 NP_006818 (OMIM: 605406) transmembrane emp24 domai ( 219) 258 70.3 3e-12 NP_006849 (OMIM: 605395) transmembrane emp24 domai ( 227) 256 69.8 4.2e-12 NP_001289990 (OMIM: 612038) transmembrane emp24 do ( 168) 242 66.3 3.6e-11 NP_001289991 (OMIM: 612038) transmembrane emp24 do ( 168) 242 66.3 3.6e-11 NP_872353 (OMIM: 612038) transmembrane emp24 domai ( 227) 242 66.4 4.4e-11 XP_006722694 (OMIM: 605395) PREDICTED: transmembra ( 189) 176 50.3 2.5e-06 NP_057124 (OMIM: 616876) transmembrane emp24 domai ( 229) 145 42.9 0.00053 NP_001289989 (OMIM: 612038) transmembrane emp24 do ( 127) 126 38.1 0.0084 >>NP_001161302 (OMIM: 616876) transmembrane emp24 domain (193 aa) initn: 221 init1: 139 opt: 261 Z-score: 345.7 bits: 70.9 E(85289): 1.6e-12 Smith-Waterman score: 261; 28.9% identity (62.2% similar) in 180 aa overlap (21-190:13-188) 10 20 30 40 50 pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALL--LLVPGPGG-----ASEITFELPDNAKQCFYEDI ::: : .:.:: .: :..:: :: . :.:::. . NP_001 MGDKIWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPM 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 AQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNE .. .:.::. :. :.: .: .:.::.: :..:. :. . .. : : :::.: NP_001 PLKASLEIEYQVLDGAGLDIDFHLASPEGKTLVFEQRKS-DGVHTVETEVGDYMFCFDNT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 FSTFTHKTVYFDF---QVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRL :::...:...:.. ..::. .:. . .: . ..... : .: . .. NP_001 FSTISEKVIFFELILDNMGEQAQ--EQEDWKKYITGTDILDMKLEDILDPIIKIASDVQI 120 130 140 150 160 180 190 200 210 220 pF1KE2 REAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRVGS : : . ....:. :. NP_001 RLHLGIHQQHQVQTK-QKWAHTNSA 170 180 190 >>NP_006818 (OMIM: 605406) transmembrane emp24 domain-co (219 aa) initn: 224 init1: 104 opt: 258 Z-score: 341.0 bits: 70.3 E(85289): 3e-12 Smith-Waterman score: 258; 27.5% identity (56.5% similar) in 207 aa overlap (16-216:10-216) 10 20 30 40 50 pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALLLL-VPGPGGASEITFELPDNAKQCFYEDIAQGTKC : : :::::: . :: . :.:.:: :...:. :.: . NP_006 MSGLSGPPARRGPFPLALLLLFLLGPRLVLAISFHLPINSRKCLREEIHKDLLV 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 TLEFQVI--TGGHYDVDCRLE--DPDGKVLYKEMKKQYDSFTFTASKNGTYKFCF-SNEF : ... .:: . .:. : :..::.. .:.::. .. :: :. NP_006 TGAYEISDQSGGAGGLRSHLKITDSAGHILYSKEDATKGKFAFTTEDYDMFEVCFESKGT 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 STFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQ . . . : .:.. : . . .: : .: ... .:... .... :: . NP_006 GRIPDQLVILDMKHGVEAKNYEEIAKVEKLKPLEVELRRLEDLSESIVNDFAYMKKREEE 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 GRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRVGS :. :. :::: :.:. . :. .. ::: :. ::. :. NP_006 MRDTNESTNTRVLYFSIFSMFCLIGLATWQVFYLRRFFKAKKLIE 180 190 200 210 >>NP_006849 (OMIM: 605395) transmembrane emp24 domain-co (227 aa) initn: 372 init1: 246 opt: 256 Z-score: 338.2 bits: 69.8 E(85289): 4.2e-12 Smith-Waterman score: 362; 35.6% identity (58.4% similar) in 219 aa overlap (22-220:10-227) 10 20 30 40 50 pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALLLLVPGP---GGAS-------EITFELPDNAKQCFY ::: ::.: : :::. :.:: :: . ::::: NP_006 MMAAGAALALALWLLMP-PVEVGGAGPPPIQDGEFTFLLPAGRKQCFY 10 20 30 40 60 70 80 90 100 110 pF1KE2 EDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCF .. ... :.::: :. ::: ::.:.: .: .: .: : .. : ::.:: NP_006 QSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYKLCF 50 60 70 80 90 100 120 130 140 150 160 pF1KE2 SNEFSTFTHKTVYF---------DFQV-GEDPPLFPSENRVSALTQMESACVSIHEALKS .: :::...: :.: : .: : . : : . ... . ... :. NP_006 DNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLER 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 VIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTT :.. : .: ::. :. : :: .::. .. .::.:.. :: :: ::.::: . : NP_006 SIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVAVLLLVAVLQVCTLKRFFQDKRPVPT 170 180 190 200 210 220 pF1KE2 RVGS >>NP_001289990 (OMIM: 612038) transmembrane emp24 domain (168 aa) initn: 242 init1: 156 opt: 242 Z-score: 321.6 bits: 66.3 E(85289): 3.6e-11 Smith-Waterman score: 242; 31.8% identity (62.4% similar) in 157 aa overlap (68-216:17-166) 40 50 60 70 80 90 pF1KE2 TFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDS-- : : .: .::::::. ...:: : NP_001 MWDKQKEVFLPSTPGLGMHVEV----KDPDGKVV---LSRQYGSEG 10 20 30 100 110 120 130 140 pF1KE2 -FTFTASKNGTYKFCF---SNEFSTFT--HKTVYFDFQVGEDPPLFPSENRVSALTQMES ::::. : ...:. :.... :. . :..:.:::: .: . ::... NP_001 RFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE2 ACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLK .. . .... : . : :: . : .:. : :: .::.....::....: :. :: NP_001 RARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLK 100 110 120 130 140 150 210 220 pF1KE2 SFFSDKRTTTTRVGS ::: :. NP_001 SFFEAKKLV 160 >>NP_001289991 (OMIM: 612038) transmembrane emp24 domain (168 aa) initn: 242 init1: 156 opt: 242 Z-score: 321.6 bits: 66.3 E(85289): 3.6e-11 Smith-Waterman score: 242; 31.8% identity (62.4% similar) in 157 aa overlap (68-216:17-166) 40 50 60 70 80 90 pF1KE2 TFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDS-- : : .: .::::::. ...:: : NP_001 MWDKQKEVFLPSTPGLGMHVEV----KDPDGKVV---LSRQYGSEG 10 20 30 100 110 120 130 140 pF1KE2 -FTFTASKNGTYKFCF---SNEFSTFT--HKTVYFDFQVGEDPPLFPSENRVSALTQMES ::::. : ...:. :.... :. . :..:.:::: .: . ::... NP_001 RFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE2 ACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLK .. . .... : . : :: . : .:. : :: .::.....::....: :. :: NP_001 RARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLK 100 110 120 130 140 150 210 220 pF1KE2 SFFSDKRTTTTRVGS ::: :. NP_001 SFFEAKKLV 160 >>NP_872353 (OMIM: 612038) transmembrane emp24 domain-co (227 aa) initn: 288 init1: 156 opt: 242 Z-score: 319.9 bits: 66.4 E(85289): 4.4e-11 Smith-Waterman score: 273; 30.4% identity (58.4% similar) in 214 aa overlap (23-216:16-225) 10 20 30 40 50 pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALLLLVPGPGGASEITFELPDNAKQCFYEDIAQGT--- :::::. ::. . :.. .. :.:: :.: . : NP_872 MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVI 10 20 30 40 50 60 70 80 90 100 pF1KE2 ---------KCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDS---FTFTASKNGT : : : : . ...::::::. ...:: : ::::. : NP_872 GNYRTQMWDKQKEVFLPSTPG-LGMHVEVKDPDGKVV---LSRQYGSEGRFTFTSHTPGD 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 YKFCF---SNEFSTFT--HKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKS ...:. :.... :. . :..:.:::: .: . ::... .. . ... NP_872 HQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQ 110 120 130 140 150 160 170 180 190 200 210 220 pF1KE2 VIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTT . : . : :: . : .:. : :: .::.....::....: :. ::::: :. NP_872 IQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV 170 180 190 200 210 220 pF1KE2 RVGS >>XP_006722694 (OMIM: 605395) PREDICTED: transmembrane e (189 aa) initn: 296 init1: 172 opt: 176 Z-score: 234.5 bits: 50.3 E(85289): 2.5e-06 Smith-Waterman score: 279; 33.7% identity (57.1% similar) in 175 aa overlap (56-220:16-189) 30 40 50 60 70 80 pF1KE2 LLVPGPGGASEITFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVL : :. ::: :. ::: ::.:.: .: XP_006 MRVEARGAATGTGWGGCGCA-AVQVIGGAGLDVDFTLESPQGVLL 10 20 30 40 90 100 110 120 130 pF1KE2 YKEMKKQYDSFTFTASKNGTYKFCFSNEFSTFTHKTVYF---------DFQV-GEDPPLF .: .: : .. : ::.::.: :::...: :.: : .: : . XP_006 VSESRKADGVHTVEPTEAGDYKLCFDNSFSTISEKLVFFELIFDSLQDDEEVEGWAEAVE 50 60 70 80 90 100 140 150 160 170 180 190 pF1KE2 PSENRVSALTQMESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEAL : : . ... . ... :. :.. : .: ::. :. : :: .::. .. XP_006 PEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEGNLERVNFWSAVNVA 110 120 130 140 150 160 200 210 220 pF1KE2 ILLVVSIGQVFLLKSFFSDKRTTTTRVGS .::.:.. :: :: ::.::: . : XP_006 VLLLVAVLQVCTLKRFFQDKRPVPT 170 180 >>NP_057124 (OMIM: 616876) transmembrane emp24 domain-co (229 aa) initn: 352 init1: 145 opt: 145 Z-score: 192.9 bits: 42.9 E(85289): 0.00053 Smith-Waterman score: 361; 32.6% identity (63.8% similar) in 218 aa overlap (21-220:13-229) 10 20 30 40 50 pF1KE2 MPRPGSAQRWAAVAGRWGCRLLALL--LLVPGPGG-----ASEITFELPDNAKQCFYEDI ::: : .:.:: .: :..:: :: . :.:::. . NP_057 MGDKIWLPFPVLLLAALPPVLLPGAAGFTPSLDSDFTFTLPAGQKECFYQPM 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 AQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKNGTYKFCFSNE .. .:.::. :. :.: .: .:.::.: :..:. :. . .. : : :::.: NP_057 PLKASLEIEYQVLDGAGLDIDFHLASPEGKTLVFEQRKS-DGVHTVETEVGDYMFCFDNT 60 70 80 90 100 110 120 130 140 150 160 pF1KE2 FSTFTHKTVYFDF---QVGEDPPLFPSENR-VSALTQMESACVSIHEALKSVIDY----- :::...:...:.. ..::. . .. ... .. .: :...:. . NP_057 FSTISEKVIFFELILDNMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKSG 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE2 --QTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLKSFFSDKRTTTTRV :: .: ::. :. :. :: .::. . ....::: ::..:::.: ::: . : NP_057 HIQTLLRAFEARDRNIQESNFDRVNFWSMVNLVVMVVVSAIQVYMLKSLFEDKRKSRT 180 190 200 210 220 pF1KE2 GS >>NP_001289989 (OMIM: 612038) transmembrane emp24 domain (127 aa) initn: 134 init1: 85 opt: 126 Z-score: 171.3 bits: 38.1 E(85289): 0.0084 Smith-Waterman score: 126; 29.4% identity (58.7% similar) in 109 aa overlap (68-165:17-118) 40 50 60 70 80 90 pF1KE2 TFELPDNAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDS-- : : .: .::::::. ...:: : NP_001 MWDKQKEVFLPSTPGLGMHVEV----KDPDGKVV---LSRQYGSEG 10 20 30 100 110 120 130 140 pF1KE2 -FTFTASKNGTYKFCF---SNEFSTFT--HKTVYFDFQVGEDPPLFP---SENRVSALTQ ::::. : ...:. :.... :. . :..:.:::: .: ...... : NP_001 RFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQL 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE2 MESACVSIHEALKSVIDYQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVF .. : ... ::: NP_001 RARQLLDQVEQIQKEQDYQRASAYLLVI 100 110 120 224 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 16:43:21 2016 done: Tue Nov 8 16:43:21 2016 Total Scan time: 3.780 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]