FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6526, 150 aa 1>>>pF1KE6526 150 - 150 aa - 150 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2767+/-0.000277; mu= 12.3546+/- 0.017 mean_var=63.8862+/-12.957, 0's: 0 Z-trim(119.4): 16 B-trim: 1837 in 2/49 Lambda= 0.160461 statistics sampled from 33340 (33356) to 33340 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.772), E-opt: 0.2 (0.391), width: 16 Scan time: 3.560 The best scores are: opt bits E(85289) NP_006299 (OMIM: 604624,613376) heat shock protein ( 150) 1001 239.4 1.7e-63 NP_001532 (OMIM: 602179) heat shock protein beta-2 ( 182) 240 63.3 2.1e-10 NP_001531 (OMIM: 602195,606595,608634) heat shock ( 205) 224 59.6 3e-09 NP_653218 (OMIM: 610695) heat shock protein beta-6 ( 160) 221 58.8 4e-09 NP_000385 (OMIM: 123580,604219) alpha-crystallin A ( 173) 216 57.7 9.5e-09 XP_005261150 (OMIM: 123580,604219) PREDICTED: alph ( 136) 212 56.7 1.5e-08 NP_001317308 (OMIM: 123590,608810,613763,613869,61 ( 108) 198 53.4 1.1e-07 XP_011540910 (OMIM: 123590,608810,613763,613869,61 ( 175) 200 54.0 1.2e-07 NP_001876 (OMIM: 123590,608810,613763,613869,61518 ( 175) 200 54.0 1.2e-07 NP_001276737 (OMIM: 123590,608810,613763,613869,61 ( 175) 200 54.0 1.2e-07 NP_001276736 (OMIM: 123590,608810,613763,613869,61 ( 175) 200 54.0 1.2e-07 NP_055180 (OMIM: 158590,608014,608673) heat shock ( 196) 173 47.8 1e-05 >>NP_006299 (OMIM: 604624,613376) heat shock protein bet (150 aa) initn: 1001 init1: 1001 opt: 1001 Z-score: 1261.1 bits: 239.4 E(85289): 1.7e-63 Smith-Waterman score: 1001; 100.0% identity (100.0% similar) in 150 aa overlap (1-150:1-150) 10 20 30 40 50 60 pF1KE6 MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 ETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 ETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKL 70 80 90 100 110 120 130 140 150 pF1KE6 PDGVEIKDLSAVLCHDGILVVEVKDPVGTK :::::::::::::::::::::::::::::: NP_006 PDGVEIKDLSAVLCHDGILVVEVKDPVGTK 130 140 150 >>NP_001532 (OMIM: 602179) heat shock protein beta-2 [Ho (182 aa) initn: 257 init1: 236 opt: 240 Z-score: 307.8 bits: 63.3 E(85289): 2.1e-10 Smith-Waterman score: 240; 37.5% identity (66.3% similar) in 104 aa overlap (47-150:50-151) 20 30 40 50 60 70 pF1KE6 QEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLD . ::: . . :. . : ....:: .:: NP_001 NPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGSRAGASELRLSEGKFQAFLD 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE6 VVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHD : .: :... ..: .. : ..:.: :.:.:::.:: : : : :: :. . :.: :: NP_001 VSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHD 80 90 100 110 120 130 140 150 pF1KE6 GILVVEVKDPVGTK ::: .:. : : . NP_001 GILNLEA--PRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIVEP 140 150 160 170 180 >>NP_001531 (OMIM: 602195,606595,608634) heat shock prot (205 aa) initn: 213 init1: 213 opt: 224 Z-score: 287.0 bits: 59.6 E(85289): 3e-09 Smith-Waterman score: 224; 34.2% identity (67.6% similar) in 111 aa overlap (36-146:62-170) 10 20 30 40 50 60 pF1KE6 LRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPR :. .:... .:: . ....: : NP_001 AFGLPRLPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSRALSRQLSSGVSEI--R 40 50 60 70 80 70 80 90 100 110 120 pF1KE6 EGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVE . ..... ::: .: :... ..: .: . : ..: :.::::.::: :::.: :: ::. NP_001 HTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVD 90 100 110 120 130 140 130 140 150 pF1KE6 IKDLSAVLCHDGILVVEVKDPVGTK ..:. : .: :.::. : NP_001 PTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK 150 160 170 180 190 200 >>NP_653218 (OMIM: 610695) heat shock protein beta-6 [Ho (160 aa) initn: 204 init1: 189 opt: 221 Z-score: 284.9 bits: 58.8 E(85289): 4e-09 Smith-Waterman score: 222; 35.1% identity (60.3% similar) in 131 aa overlap (13-142:25-145) 10 20 30 40 pF1KE6 MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKT : : .. ..:: :. : :: :: . NP_653 MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGL----LEAELAAL-CPTTLAPYYL 10 20 30 40 50 50 60 70 80 90 100 pF1KE6 RAAQSP-PVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEH :: . :: :..: : ::..:::: .: ::.: ... . ..:.: : ::: NP_653 RAPSVALPV---AQVPTDPG--HFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEH 60 70 80 90 100 110 110 120 130 140 150 pF1KE6 GFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK ::..: : :.:.:: ::. ....: .:.: .. NP_653 GFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK 120 130 140 150 160 >>NP_000385 (OMIM: 123580,604219) alpha-crystallin A cha (173 aa) initn: 193 init1: 193 opt: 216 Z-score: 278.1 bits: 57.7 E(85289): 9.5e-09 Smith-Waterman score: 216; 32.3% identity (64.6% similar) in 127 aa overlap (13-139:19-139) 10 20 30 40 50 pF1KE6 MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSP : : ..: ..:: ... : . . :: . .. NP_000 MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGL----FEYDLLPFLSSTISPYYRQSLFRTV 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 PVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSF .::. . : ...: :.::: .: :::. ... . .. :...:. :.:.::.::: : NP_000 -LDSGI-SEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREF 60 70 80 90 100 110 120 130 140 150 pF1KE6 TRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK :.:.::..:. . :: : ::.: NP_000 HRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS 120 130 140 150 160 170 >>XP_005261150 (OMIM: 123580,604219) PREDICTED: alpha-cr (136 aa) initn: 193 init1: 193 opt: 212 Z-score: 274.7 bits: 56.7 E(85289): 1.5e-08 Smith-Waterman score: 212; 41.3% identity (76.0% similar) in 75 aa overlap (65-139:28-102) 40 50 60 70 80 90 pF1KE6 YALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWL : ...: :.::: .: :::. ... . .. XP_005 MPVCPGDSHRPPKALPHLVCGRRGRQVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFV 10 20 30 40 50 100 110 120 130 140 150 pF1KE6 LIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK :...:. :.:.::.::: : :.:.::..:. . :: : ::.: XP_005 EIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATH 60 70 80 90 100 110 XP_005 AERAIPVSREEKPTSAPSS 120 130 >>NP_001317308 (OMIM: 123590,608810,613763,613869,615184 (108 aa) initn: 194 init1: 183 opt: 198 Z-score: 258.7 bits: 53.4 E(85289): 1.1e-07 Smith-Waterman score: 198; 37.7% identity (71.4% similar) in 77 aa overlap (65-141:2-78) 40 50 60 70 80 90 pF1KE6 YALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWL : :..:.. ::: .: ::.. .... . NP_001 MRLEKDRFSVNLDVKHFSPEELKVKVLGDVI 10 20 30 100 110 120 130 140 150 pF1KE6 LIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK ....: :.:::::::: : :.:..: :. ... : ::.:.: NP_001 EVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERT 40 50 60 70 80 90 NP_001 IPITREEKPAVTAAPKK 100 >>XP_011540910 (OMIM: 123590,608810,613763,613869,615184 (175 aa) initn: 196 init1: 183 opt: 200 Z-score: 258.0 bits: 54.0 E(85289): 1.2e-07 Smith-Waterman score: 200; 33.0% identity (66.0% similar) in 97 aa overlap (45-141:49-145) 20 30 40 50 60 70 pF1KE6 RYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQIL :: ..: ... . : :..:.. XP_011 SPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVN 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE6 LDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLC ::: .: ::.. .... . ....: :.:::::::: : :.:..: :. ... : XP_011 LDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLS 80 90 100 110 120 130 140 150 pF1KE6 HDGILVVEVKDPVGTK ::.:.: XP_011 SDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK 140 150 160 170 >>NP_001876 (OMIM: 123590,608810,613763,613869,615184) a (175 aa) initn: 196 init1: 183 opt: 200 Z-score: 258.0 bits: 54.0 E(85289): 1.2e-07 Smith-Waterman score: 200; 33.0% identity (66.0% similar) in 97 aa overlap (45-141:49-145) 20 30 40 50 60 70 pF1KE6 RYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQIL :: ..: ... . : :..:.. NP_001 SPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVN 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE6 LDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLC ::: .: ::.. .... . ....: :.:::::::: : :.:..: :. ... : NP_001 LDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLS 80 90 100 110 120 130 140 150 pF1KE6 HDGILVVEVKDPVGTK ::.:.: NP_001 SDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK 140 150 160 170 >>NP_001276737 (OMIM: 123590,608810,613763,613869,615184 (175 aa) initn: 196 init1: 183 opt: 200 Z-score: 258.0 bits: 54.0 E(85289): 1.2e-07 Smith-Waterman score: 200; 33.0% identity (66.0% similar) in 97 aa overlap (45-141:49-145) 20 30 40 50 60 70 pF1KE6 RYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQIL :: ..: ... . : :..:.. NP_001 SPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVN 20 30 40 50 60 70 80 90 100 110 120 130 pF1KE6 LDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLC ::: .: ::.. .... . ....: :.:::::::: : :.:..: :. ... : NP_001 LDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLS 80 90 100 110 120 130 140 150 pF1KE6 HDGILVVEVKDPVGTK ::.:.: NP_001 SDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK 140 150 160 170 150 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 14:06:37 2016 done: Tue Nov 8 14:06:38 2016 Total Scan time: 3.560 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]