FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9567, 488 aa 1>>>pF1KE9567 488 - 488 aa - 488 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9676+/-0.00035; mu= 20.7798+/- 0.022 mean_var=91.6219+/-20.882, 0's: 0 Z-trim(115.3): 397 B-trim: 2517 in 2/55 Lambda= 0.133991 statistics sampled from 25148 (25724) to 25148 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.666), E-opt: 0.2 (0.302), width: 16 Scan time: 10.450 The best scores are: opt bits E(85289) NP_000949 (OMIM: 601586) prostaglandin E2 receptor ( 488) 3172 623.6 3.8e-178 XP_016865146 (OMIM: 601586) PREDICTED: prostagland ( 326) 1896 376.8 5.1e-104 XP_016865148 (OMIM: 601586) PREDICTED: prostagland ( 313) 1890 375.6 1.1e-103 XP_016865147 (OMIM: 601586) PREDICTED: prostagland ( 325) 1890 375.6 1.1e-103 XP_016865145 (OMIM: 601586) PREDICTED: prostagland ( 350) 1890 375.7 1.2e-103 XP_005259152 (OMIM: 600022) PREDICTED: prostacycli ( 257) 499 106.6 8.6e-23 XP_005259150 (OMIM: 600022) PREDICTED: prostacycli ( 342) 499 106.8 1e-22 NP_000951 (OMIM: 600022) prostacyclin receptor [Ho ( 386) 499 106.8 1.1e-22 NP_000946 (OMIM: 176802) prostaglandin E2 receptor ( 402) 456 98.5 3.7e-20 NP_001268398 (OMIM: 604687,607277) prostaglandin D ( 296) 405 88.5 2.8e-17 XP_005267948 (OMIM: 604687,607277) PREDICTED: pros ( 359) 405 88.6 3.2e-17 NP_000944 (OMIM: 604687,607277) prostaglandin D2 r ( 359) 405 88.6 3.2e-17 NP_000947 (OMIM: 176804,208550) prostaglandin E2 r ( 358) 403 88.2 4.1e-17 NP_942010 (OMIM: 176806) prostaglandin E2 receptor ( 365) 355 78.9 2.6e-14 NP_942009 (OMIM: 176806) prostaglandin E2 receptor ( 374) 355 79.0 2.7e-14 NP_942008 (OMIM: 176806) prostaglandin E2 receptor ( 388) 355 79.0 2.7e-14 NP_942012 (OMIM: 176806) prostaglandin E2 receptor ( 390) 355 79.0 2.7e-14 NP_001119516 (OMIM: 176806) prostaglandin E2 recep ( 390) 355 79.0 2.7e-14 NP_942007 (OMIM: 176806) prostaglandin E2 receptor ( 390) 355 79.0 2.7e-14 XP_011540112 (OMIM: 176806) PREDICTED: prostagland ( 410) 355 79.0 2.8e-14 NP_942011 (OMIM: 176806) prostaglandin E2 receptor ( 418) 355 79.0 2.9e-14 XP_011526516 (OMIM: 188070,614009) PREDICTED: thro ( 343) 313 70.8 7e-12 NP_001051 (OMIM: 188070,614009) thromboxane A2 rec ( 343) 313 70.8 7e-12 NP_963998 (OMIM: 188070,614009) thromboxane A2 rec ( 407) 313 70.9 7.8e-12 NP_000670 (OMIM: 104220) alpha-1B adrenergic recep ( 520) 307 69.8 2.1e-11 NP_000612 (OMIM: 103780,164230,181500,182135,60678 ( 471) 279 64.4 8.2e-10 XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 270 62.5 2.1e-09 XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 265 61.6 4.7e-09 XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 265 61.6 4.8e-09 XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 264 61.3 4.8e-09 XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 264 61.4 5.2e-09 XP_011532737 (OMIM: 104220) PREDICTED: alpha-1B ad ( 556) 265 61.8 6e-09 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 248 58.4 5.3e-08 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 248 58.4 5.6e-08 XP_016857362 (OMIM: 600563) PREDICTED: prostagland ( 291) 243 57.2 7.4e-08 NP_001034674 (OMIM: 600563) prostaglandin F2-alpha ( 297) 243 57.2 7.5e-08 NP_000950 (OMIM: 600563) prostaglandin F2-alpha re ( 359) 243 57.3 8.5e-08 NP_473362 (OMIM: 300393,300943) probable G-protein ( 508) 243 57.5 1.1e-07 NP_004942 (OMIM: 605741) G-protein coupled recepto ( 361) 241 56.9 1.1e-07 XP_016875894 (OMIM: 605741) PREDICTED: G-protein c ( 361) 241 56.9 1.1e-07 NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 236 56.1 2.6e-07 NP_000859 (OMIM: 312861) 5-hydroxytryptamine recep ( 458) 236 56.1 2.6e-07 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 234 55.6 3.1e-07 XP_016861176 (OMIM: 604836) PREDICTED: C-C chemoki ( 360) 233 55.4 3.2e-07 NP_005499 (OMIM: 604836) C-C chemokine receptor ty ( 360) 233 55.4 3.2e-07 NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 220 52.8 1.9e-06 XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 220 52.8 1.9e-06 NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 221 53.2 1.9e-06 NP_000675 (OMIM: 109630,607276) beta-1 adrenergic ( 477) 218 52.6 2.9e-06 NP_000669 (OMIM: 104219) alpha-1D adrenergic recep ( 572) 216 52.3 4.3e-06 >>NP_000949 (OMIM: 601586) prostaglandin E2 receptor EP4 (488 aa) initn: 3172 init1: 3172 opt: 3172 Z-score: 3319.4 bits: 623.6 E(85289): 3.8e-178 Smith-Waterman score: 3172; 100.0% identity (100.0% similar) in 488 aa overlap (1-488:1-488) 10 20 30 40 50 60 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE9 MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET 430 440 450 460 470 480 pF1KE9 LNLSEKCI :::::::: NP_000 LNLSEKCI >>XP_016865146 (OMIM: 601586) PREDICTED: prostaglandin E (326 aa) initn: 1890 init1: 1890 opt: 1896 Z-score: 1988.4 bits: 376.8 E(85289): 5.1e-104 Smith-Waterman score: 1896; 95.7% identity (98.0% similar) in 305 aa overlap (1-304:1-305) 10 20 30 40 50 60 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVV-RVFVNQLYQ ::::::::::::::::::::::::::::::::::::::::::::::::: .. ...::. XP_016 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVFPKLQMKNLYH 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE9 PSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERS . : XP_016 SATYRVAIGASIRQPVISAKFGARSQ 310 320 >>XP_016865148 (OMIM: 601586) PREDICTED: prostaglandin E (313 aa) initn: 1890 init1: 1890 opt: 1890 Z-score: 1982.3 bits: 375.6 E(85289): 1.1e-103 Smith-Waterman score: 1890; 100.0% identity (100.0% similar) in 289 aa overlap (1-289:1-289) 10 20 30 40 50 60 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVAINPISHHGRE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG XP_016 GQKRTPVTFPKNV 310 >>XP_016865147 (OMIM: 601586) PREDICTED: prostaglandin E (325 aa) initn: 1890 init1: 1890 opt: 1890 Z-score: 1982.1 bits: 375.6 E(85289): 1.1e-103 Smith-Waterman score: 1890; 100.0% identity (100.0% similar) in 289 aa overlap (1-289:1-289) 10 20 30 40 50 60 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVANWKWSHKTTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG XP_016 GMSDECEAHLYIQEKCHKFGFPSCK 310 320 >>XP_016865145 (OMIM: 601586) PREDICTED: prostaglandin E (350 aa) initn: 1890 init1: 1890 opt: 1890 Z-score: 1981.8 bits: 375.7 E(85289): 1.2e-103 Smith-Waterman score: 1890; 100.0% identity (100.0% similar) in 289 aa overlap (1-289:1-289) 10 20 30 40 50 60 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVANWKWSHKTTD 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG XP_016 GMSDECEAHLYIQEKCHKFGCEYSSTSYISQVWSEKSVKIQICRPSELLL 310 320 330 340 350 >>XP_005259152 (OMIM: 600022) PREDICTED: prostacyclin re (257 aa) initn: 532 init1: 358 opt: 499 Z-score: 530.2 bits: 106.6 E(85289): 8.6e-23 Smith-Waterman score: 499; 42.2% identity (67.3% similar) in 211 aa overlap (20-224:17-225) 10 20 30 40 50 60 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG :.: ..::. ::::: .:. .: ..:. . ..: .:: : XP_005 MADSCRNLTYVRGSVGPAT-STLMFVAGVVGNGLALGIL-SARRPARPSAFAVLVTG 10 20 30 40 50 70 80 90 100 110 pF1KE9 LAVTDLLGTLLVSPVTIATYMK-----GQWPGGQPLCEYSTFILLFFSLSGLSIICAMSV ::.:::::: ..::.....: . : :: ::. .: . ::.:... :. ::.: XP_005 LAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 ERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWT :: ::..: :.:.. : : :.: :.:: ::::::: .:::. . : .:::. XP_005 ERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 TNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRT-SLGTEQHHAAAAA . ::.: :::. ..:. : ::: : .: ::.:: :. ::: XP_005 WAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEV 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 SVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFV XP_005 DHLILLALMTVVMAVCSLPLTQ 240 250 >>XP_005259150 (OMIM: 600022) PREDICTED: prostacyclin re (342 aa) initn: 530 init1: 358 opt: 499 Z-score: 528.7 bits: 106.8 E(85289): 1e-22 Smith-Waterman score: 509; 34.2% identity (60.1% similar) in 316 aa overlap (20-328:17-287) 10 20 30 40 50 60 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG :.: ..::. ::::: .:. .: ..:. . ..: .:: : XP_005 MADSCRNLTYVRGSVGPAT-STLMFVAGVVGNGLALGIL-SARRPARPSAFAVLVTG 10 20 30 40 50 70 80 90 100 110 pF1KE9 LAVTDLLGTLLVSPVTIATYMK-----GQWPGGQPLCEYSTFILLFFSLSGLSIICAMSV ::.:::::: ..::.....: . : :: ::. .: . ::.:... :. ::.: XP_005 LAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 ERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWT :: ::..: :.:.. : : :.: :.:: ::::::: .:::. . : .:::. XP_005 ERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 TNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAS . ::.: :::. ..:. : ::: : .: ::.:: ...: . : XP_005 WAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQ---------QKRHQG---S 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 VASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVN .. : :: .. :.. .::: ..:. .::.::..: . XP_005 LGPR---------PRTGE------------DEVDHLILLALMTVVMAVCSLPLTMR---G 230 240 250 300 310 320 330 340 350 pF1KE9 QLYQPSLEREV-SKNPDLQAIRIASVNPILDP-WIYILLRKTVLSKAIEKIKCLFCRIGG ....: . .: .:.. :.: : : :. XP_005 SVFRPVTQSQVLVLGPSI-------VEPDLPPTWLPSASEQAPPLPLHLGFLRGPRPAPP 260 270 280 290 300 310 360 370 380 390 400 410 pF1KE9 SRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRN XP_005 QWEWHRPWYPLSVCDTWSCHLSSELQFLFL 320 330 340 >>NP_000951 (OMIM: 600022) prostacyclin receptor [Homo s (386 aa) initn: 659 init1: 358 opt: 499 Z-score: 528.0 bits: 106.8 E(85289): 1.1e-22 Smith-Waterman score: 631; 36.7% identity (62.1% similar) in 335 aa overlap (20-349:17-311) 10 20 30 40 50 60 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG :.: ..::. ::::: .:. .: ..:. . ..: .:: : NP_000 MADSCRNLTYVRGSVGPAT-STLMFVAGVVGNGLALGIL-SARRPARPSAFAVLVTG 10 20 30 40 50 70 80 90 100 110 pF1KE9 LAVTDLLGTLLVSPVTIATYMK-----GQWPGGQPLCEYSTFILLFFSLSGLSIICAMSV ::.:::::: ..::.....: . : :: ::. .: . ::.:... :. ::.: NP_000 LAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 ERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWT :: ::..: :.:.. : : :.: :.:: ::::::: .:::. . : .:::. NP_000 ERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMR 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 TNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAS . ::.: :::. ..:. : ::: : .: ::.:: ...: . : NP_000 WAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQ---------QKRHQG---S 180 190 200 210 220 240 250 260 270 280 290 pF1KE9 VASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVN .. : :: .. :.. .::: ..:. .::.::..: :. NP_000 LGPR---------PRTGE------------DEVDHLILLALMTVVMAVCSLPLTIRCFT- 230 240 250 260 300 310 320 330 340 350 pF1KE9 QLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSR : :. :.. :: :.:. . :::::::..::.::.:... . :: : NP_000 QAVAPDSSSEMG---DLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCL-CLGPAHG 270 280 290 300 310 360 370 380 390 400 410 pF1KE9 RERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLL NP_000 DSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKA 320 330 340 350 360 370 >>NP_000946 (OMIM: 176802) prostaglandin E2 receptor EP1 (402 aa) initn: 343 init1: 161 opt: 456 Z-score: 482.9 bits: 98.5 E(85289): 3.7e-20 Smith-Waterman score: 467; 30.9% identity (60.9% similar) in 353 aa overlap (2-339:19-361) 10 20 30 40 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLC ..: : ..... :. ::. .: . .:.:.::.:...: NP_000 MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSG-ASPA-LPIFSMTLGAVSNLLALALLA 10 20 30 40 50 50 60 70 80 90 pF1KE9 KS----RKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFIL .. :.... .:: .: .: .::: : .. . ... : :. :.: :.. . NP_000 QAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGA-CHFLGGCM 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 LFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLG .::.: : . :.:.::: ..... ... :. : :.: :: : . :: .: NP_000 VFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVG 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 SSRLQYPDTWCFIDW-TTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMH-RQF .:::: ::::: . .: . ..:... .::...::.: :::: . :. NP_000 RYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRR 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE9 MRRT--SLGTEQH-----HAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQM :: . : ... :. .::..: . :.. .. .. : : :: . ...: NP_000 SRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTF--FGGSRSSGSARRARAHDVEM 240 250 260 270 280 290 280 290 300 310 320 pF1KE9 VILLIATSLVVLICSIPLVVRVF--VNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWI : :.. .: :: :..: : :. . ::.: : . :.:.:: : :::::. NP_000 VGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQR-----PLFLAVRLASWNQILDPWV 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE9 YILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEI :::::..:: . NP_000 YILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF 360 370 380 390 400 >>NP_001268398 (OMIM: 604687,607277) prostaglandin D2 re (296 aa) initn: 445 init1: 218 opt: 405 Z-score: 431.2 bits: 88.5 E(85289): 2.8e-17 Smith-Waterman score: 454; 32.0% identity (61.5% similar) in 309 aa overlap (1-292:1-285) 10 20 30 40 50 pF1KE9 MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKS------RKEQKE--T :..: . . : .. :: : . .:.: :..:::.:. .: .: :. . . NP_001 MKSPFYRCQNTTSVEKGNSAV-MGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPS 10 20 30 40 50 60 70 80 90 100 pF1KE9 TFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQ-----WPG-GQPLCEYSTFILLFFSLSG .:: :::::.:::::: :.:::..:.: ... :. . ::. .:.. ::.::. NP_001 VFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSS 60 70 80 90 100 110 110 120 130 140 150 160 pF1KE9 LSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQY- . ::..: .:...: .:: ... ::..:. .: : .. ::::: ::.:. .:: NP_001 TLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKF-VQYC 120 130 140 150 160 170 170 180 190 200 210 220 pF1KE9 PDTWCFIDWTTNVTAHAA--YSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSL : :::::. . . . .. :: .:... ..:.:::::::. . : :::...:. NP_001 PGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRS 180 190 200 210 220 230 230 240 250 260 270 280 pF1KE9 GTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLI :.. : . :. :. : :.. ..:: ... . NP_001 CTRD-----CAEPRADGREASPQPLE-----------------ELDHLLLLALMTVLFTM 240 250 260 270 290 300 310 320 330 340 pF1KE9 CSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEK ::.:... : NP_001 CSLPVIAFVPGVPAKTPGSR 280 290 488 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:14:47 2016 done: Sun Nov 6 17:14:49 2016 Total Scan time: 10.450 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]