Result of FASTA (omim) for
pFN21AE4444
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4444, 460 aa
1>>>pF1KE4444 460 - 460 aa - 460 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5397+/-0.000334; mu= 16.4133+/- 0.021
mean_var=66.4352+/-14.035, 0's: 0 Z-trim(114.4): 17 B-trim: 1097 in 1/55
Lambda= 0.157353
statistics sampled from 24187 (24200) to 24187 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.284), width: 16
Scan time: 9.290
The best scores are: opt bits E(85289)
NP_001012527 (OMIM: 227240,606202,606574) membrane ( 460) 3116 716.3 4.3e-206
NP_057264 (OMIM: 227240,606202,606574) membrane-as ( 530) 3075 707.0 3.1e-203
NP_001284346 (OMIM: 227240,606202,606574) membrane ( 243) 1262 295.3 1.2e-79
XP_011539832 (OMIM: 605763) PREDICTED: proton-asso ( 790) 740 177.0 1.6e-43
NP_001073866 (OMIM: 605763) proton-associated suga ( 782) 477 117.3 1.5e-25
XP_011539833 (OMIM: 605763) PREDICTED: proton-asso ( 759) 449 110.9 1.2e-23
XP_005245617 (OMIM: 605097) PREDICTED: solute carr ( 328) 427 105.8 1.9e-22
NP_149093 (OMIM: 605097) solute carrier family 45 ( 553) 427 105.9 2.9e-22
XP_005245613 (OMIM: 605097) PREDICTED: solute carr ( 553) 427 105.9 2.9e-22
XP_005245614 (OMIM: 605097) PREDICTED: solute carr ( 553) 427 105.9 2.9e-22
XP_016858127 (OMIM: 605097) PREDICTED: solute carr ( 553) 427 105.9 2.9e-22
>>NP_001012527 (OMIM: 227240,606202,606574) membrane-ass (460 aa)
initn: 3116 init1: 3116 opt: 3116 Z-score: 3821.0 bits: 716.3 E(85289): 4.3e-206
Smith-Waterman score: 3116; 100.0% identity (100.0% similar) in 460 aa overlap (1-460:1-460)
10 20 30 40 50 60
pF1KE4 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 HYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 MTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 LIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPN
370 380 390 400 410 420
430 440 450 460
pF1KE4 VYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKEVCCH
::::::::::::::::::::::::::::::::::::::::
NP_001 VYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKEVCCH
430 440 450 460
>>NP_057264 (OMIM: 227240,606202,606574) membrane-associ (530 aa)
initn: 3075 init1: 3075 opt: 3075 Z-score: 3769.7 bits: 707.0 E(85289): 3.1e-203
Smith-Waterman score: 3075; 100.0% identity (100.0% similar) in 456 aa overlap (1-456:1-456)
10 20 30 40 50 60
pF1KE4 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 HYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 HYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 PLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTRRA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 MTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 MTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 LIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_057 LIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPN
370 380 390 400 410 420
430 440 450 460
pF1KE4 VYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKEVCCH
::::::::::::::::::::::::::::::::::::
NP_057 VYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKERQQAPGGDPDNSVRGKGMDCATLT
430 440 450 460 470 480
NP_057 CMVQLAQILVGGGLGFLVNTAGTVVVVVITASAVALIGCCFVALFVRYVD
490 500 510 520 530
>>NP_001284346 (OMIM: 227240,606202,606574) membrane-ass (243 aa)
initn: 1260 init1: 1260 opt: 1262 Z-score: 1550.7 bits: 295.3 E(85289): 1.2e-79
Smith-Waterman score: 1262; 98.4% identity (98.4% similar) in 191 aa overlap (1-191:1-191)
10 20 30 40 50 60
pF1KE4 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 HYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEA
::::::: :
NP_001 HYHALFTDSQGNDIKVTAESTGEHASSLPLPLHQPPHWMDSLPVQHAVLHRFHGPDCVPR
190 200 210 220 230 240
>>XP_011539832 (OMIM: 605763) PREDICTED: proton-associat (790 aa)
initn: 1151 init1: 410 opt: 740 Z-score: 902.2 bits: 177.0 E(85289): 1.6e-43
Smith-Waterman score: 740; 46.1% identity (76.5% similar) in 243 aa overlap (28-269:114-355)
10 20 30 40 50
pF1KE4 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
:.: .:.... .:: :: ::.:.::::
XP_011 PKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVT
90 100 110 120 130 140
60 70 80 90 100 110
pF1KE4 PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGM
::::..:::..:::.:::.::::::::::..:. ::.: ::.:::::.::.:.. :.:.
XP_011 PVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGL
150 160 170 180 190 200
120 130 140 150 160 170
pF1KE4 ALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKE
.: ::: . :: :. . :.. .:. ::::.::.:: :.: .::..:::: :..
XP_011 SLLLNGRDIGIAL-ADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQD
210 220 230 240 250 260
180 190 200 210 220 230
pF1KE4 KGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSI
.::. :::..:.::..::..:.: : . .:: :: ...:...:.:..:.. .. : ::
XP_011 RGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVTTVLTLVSI
270 280 290 300 310 320
240 250 260 270 280 290
pF1KE4 SEAPLTEVAKGIPPQQTPQDP-PLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQ
: :: .. ...:. : : : . : :
XP_011 PERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISPPSPLTPKY
330 340 350 360 370 380
300 310 320 330 340 350
pF1KE4 TRRAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHN
XP_011 GSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLAIPGSVPRPPISVSFPRAP
390 400 410 420 430 440
>--
initn: 443 init1: 371 opt: 451 Z-score: 547.7 bits: 111.4 E(85289): 9.1e-24
Smith-Waterman score: 451; 32.7% identity (65.0% similar) in 214 aa overlap (253-454:489-702)
230 240 250 260 270 280
pF1KE4 ALVLTLCFTVHLCSISEAPLTEVAKGIPPQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPE
:: : .. : : . ..: . .
XP_011 ALTSGCDGDILRVGSLDTSKPRSSGILKRPQTLAIPDAAGGGGPETSRRRNVTFSQQVAN
460 470 480 490 500 510
290 300 310 320 330
pF1KE4 LAMQGAKNKNH----AEQTRRAMTLKSLLRALVNMPPHYRYLCISHLIG--------WTA
. ..:.: ... .:.... ... : .. ::: : ::..:..: : .
XP_011 ILLNGVKYESELTGSSERAEQPLSVGRLCSTICNMPKALRTLCVNHFLGELPAKPPRWLS
520 530 540 550 560 570
340 350 360 370 380 390
pF1KE4 FLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGFCINSVFSSLYSYFQKV
: . .::.:::::..:..::: . :.: . :. :: .::::.:: . ...:: . .
XP_011 FEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGMCIYAFSAAFYSAILEK
580 590 600 610 620 630
400 410 420 430 440 450
pF1KE4 LVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVMSSTLYTVPFNLITEYH
: ..... ::: .:: ::::::. : :.: .: :: .:.. ::: :.:..:. .:.
XP_011 LEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGILFSTLCTLPYSLLCDYY
640 650 660 670 680 690
460
pF1KE4 REEEKEVCCH
. ..
XP_011 QSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTSAVGSANGVMYFSSLVS
700 710 720 730 740 750
>>NP_001073866 (OMIM: 605763) proton-associated sugar tr (782 aa)
initn: 1186 init1: 461 opt: 477 Z-score: 579.6 bits: 117.3 E(85289): 1.5e-25
Smith-Waterman score: 558; 26.8% identity (50.4% similar) in 470 aa overlap (140-454:225-694)
110 120 130 140 150 160
pF1KE4 GVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFD
:.. .:. ::::.::.:: :.: .::..:
NP_001 LAIGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMD
200 210 220 230 240 250
170 180 190 200 210 220
pF1KE4 VCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLC
::: :...::. :::..:.::..::..:.: : . .:: :: ...:...:.:..:..
NP_001 VCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVT
260 270 280 290 300 310
230 240 250
pF1KE4 FTVHLCSISEAPLTEVAK--------GIP--------PQQTPQD----------------
.. : :: : :: .. ..: :.. : :
NP_001 TVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISP
320 330 340 350 360 370
260
pF1KE4 ---------------------------------------------------------PPL
::.
NP_001 PSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLAIPGSVPRPPI
380 390 400 410 420 430
270
pF1KE4 S------SDGMYEY-----------------------GSIEKVK----------------
: ::.:. ::.. :
NP_001 SVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGILKRPQTLAIP
440 450 460 470 480 490
280 290 300 310
pF1KE4 --NGYVNPELA---------------MQGAKNKNH----AEQTRRAMTLKSLLRALVNMP
: .:: . ..:.: ... .:.... ... : .. :::
NP_001 DAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVGRLCSTICNMP
500 510 520 530 540 550
320 330 340 350 360 370
pF1KE4 PHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERGVEVGCWGF
: ::..:..:: .: . .::.:::::..:..::: . :.: . :. :: .::::.
NP_001 KALRTLCVNHFLGWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSGVTMGCWGM
560 570 580 590 600 610
380 390 400 410 420 430
pF1KE4 CINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLVLCSLFGVM
:: . ...:: . . : ..... ::: .:: ::::::. : :.: .: :: .:..
NP_001 CIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYVVLSLCITYGIL
620 630 640 650 660 670
440 450 460
pF1KE4 SSTLYTVPFNLITEYHREEEKEVCCH
::: :.:..:. .:.. ..
NP_001 FSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVSLVLGPLTS
680 690 700 710 720 730
>--
initn: 410 init1: 410 opt: 410 Z-score: 497.4 bits: 102.1 E(85289): 5.7e-21
Smith-Waterman score: 410; 57.3% identity (84.5% similar) in 103 aa overlap (28-130:114-216)
10 20 30 40 50
pF1KE4 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
:.: .:.... .:: :: ::.:.::::
NP_001 PKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVT
90 100 110 120 130 140
60 70 80 90 100 110
pF1KE4 PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGM
::::..:::..:::.:::.::::::::::..:. ::.: ::.:::::.::.:.. :.:.
NP_001 PVLLQMGLPDQLYSLVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAIGALLGL
150 160 170 180 190 200
120 130 140 150 160 170
pF1KE4 ALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKE
.: ::: . ::
NP_001 SLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMDVCSPADQDR
210 220 230 240 250 260
>>XP_011539833 (OMIM: 605763) PREDICTED: proton-associat (759 aa)
initn: 971 init1: 371 opt: 449 Z-score: 545.5 bits: 110.9 E(85289): 1.2e-23
Smith-Waterman score: 532; 26.4% identity (49.6% similar) in 478 aa overlap (140-454:194-671)
110 120 130 140 150 160
pF1KE4 GVMMLVGMALYLNGATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFD
:.. .:. ::::.::.:: :.: .::..:
XP_011 PILGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGVVLMDFSADSADNPSHAYMMD
170 180 190 200 210 220
170 180 190 200 210 220
pF1KE4 VCSHQDKEKGLHYHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLC
::: :...::. :::..:.::..::..:.: : . .:: :: ...:...:.:..:..
XP_011 VCSPADQDRGLNIHALLAGLGGGFGYVVGGIHWDKTGFGRALGGQLRVIYLFTAVTLSVT
230 240 250 260 270 280
230 240 250
pF1KE4 FTVHLCSISEAPLTEVAK--------GIP--------PQQTPQD----------------
.. : :: : :: .. ..: :.. : :
XP_011 TVLTLVSIPERPLRPPSEKRAAMKSPSLPLPPSPPVLPEEGPGDSLPSHTATNFSSPISP
290 300 310 320 330 340
260
pF1KE4 ---------------------------------------------------------PPL
::.
XP_011 PSPLTPKYGSFISRDSSLTGISEFASSFGTANIDSVLIDCFTGGHDSYLAIPGSVPRPPI
350 360 370 380 390 400
270
pF1KE4 S------SDGMYEY-----------------------GSIEKVK----------------
: ::.:. ::.. :
XP_011 SVSFPRAPDGFYRQDRGLLEGREGALTSGCDGDILRVGSLDTSKPRSSGILKRPQTLAIP
410 420 430 440 450 460
280 290 300 310
pF1KE4 --NGYVNPELA---------------MQGAKNKNH----AEQTRRAMTLKSLLRALVNMP
: .:: . ..:.: ... .:.... ... : .. :::
XP_011 DAAGGGGPETSRRRNVTFSQQVANILLNGVKYESELTGSSERAEQPLSVGRLCSTICNMP
470 480 490 500 510 520
320 330 340 350 360
pF1KE4 PHYRYLCISHLIG--------WTAFLSNMLFFTDFMGQIVYRGDPYSAHNSTEFLIYERG
: ::..:..: : .: . .::.:::::..:..::: . :.: . :. :
XP_011 KALRTLCVNHFLGELPAKPPRWLSFEGMLLFYTDFMGEVVFQGDPKAPHTSEAYQKYNSG
530 540 550 560 570 580
370 380 390 400 410 420
pF1KE4 VEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLFPNVYSTLV
: .::::.:: . ...:: . . : ..... ::: .:: ::::::. : :.: .:
XP_011 VTMGCWGMCIYAFSAAFYSAILEKLEEFLSVRTLYFIAYLAFGLGTGLATLSRNLYVVLS
590 600 610 620 630 640
430 440 450 460
pF1KE4 LCSLFGVMSSTLYTVPFNLITEYHREEEKEVCCH
:: .:.. ::: :.:..:. .:.. ..
XP_011 LCITYGILFSTLCTLPYSLLCDYYQSKKFAGSSADGTRRGMGVDISLLSCQYFLAQILVS
650 660 670 680 690 700
>--
initn: 230 init1: 230 opt: 230 Z-score: 276.8 bits: 61.2 E(85289): 1.1e-08
Smith-Waterman score: 230; 59.6% identity (86.0% similar) in 57 aa overlap (28-84:114-170)
10 20 30 40 50
pF1KE4 MGSNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVT
:.: .:.... .:: :: ::.:.::::
XP_011 PKRRKCIRPSPPPPPNTPCPLELVDFGDLHPQRSFRELLFNGCILFGIEFSYAMETAYVT
90 100 110 120 130 140
60 70 80 90 100 110
pF1KE4 PVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGM
::::..:::..:::.:::.::::: ::
XP_011 PVLLQMGLPDQLYSLVWFISPILGALLGLSLLLNGRDIGIALADVTGNHKWGLLLTVCGV
150 160 170 180 190 200
>>XP_005245617 (OMIM: 605097) PREDICTED: solute carrier (328 aa)
initn: 465 init1: 251 opt: 427 Z-score: 524.2 bits: 105.8 E(85289): 1.9e-22
Smith-Waterman score: 479; 29.6% identity (58.0% similar) in 345 aa overlap (33-373:16-327)
10 20 30 40 50 60
pF1KE4 SNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLS
..:.. .. :: : : :. .:: :.::
XP_005 MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLE
10 20 30 40
70 80 90 100 110 120
pF1KE4 VGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLN
::. .....: ..:.::.. :..:::::: :.:.:::::.: .:.. .:... :
XP_005 VGVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 GATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDK-EKGLH
.. ... : .:: ... ..:: :.:: .. :..: : :. :. ...
XP_005 AGWLAGLLCPDPR---PLELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 YHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAP
.:.. ..:: ::::: :::: :. :::. . .: . .:.. : .. : ::
XP_005 VYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAA
170 180 190 200 210 220
250 260 270 280 290
pF1KE4 L--TEVAKGIP-PQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTR
: :: :.:. :. .:. : ... .. : ::
XP_005 LGPTEPAEGLSAPSLSPHCCPC------------RARLAFRN-----LGA----------
230 240 250
300 310 320 330 340 350
pF1KE4 RAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNST
: : . :: : : ...: .: :... ::.:::.:. .:.: : . ..
XP_005 ---LLPRLHQLCCRMPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTE
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE4 EFLIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLF
:..: .. :
XP_005 ARRHYDEGRPLAALGV
320
>>NP_149093 (OMIM: 605097) solute carrier family 45 memb (553 aa)
initn: 599 init1: 251 opt: 427 Z-score: 520.6 bits: 105.9 E(85289): 2.9e-22
Smith-Waterman score: 598; 29.1% identity (59.2% similar) in 426 aa overlap (33-454:16-408)
10 20 30 40 50 60
pF1KE4 SNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLS
..:.. .. :: : : :. .:: :.::
NP_149 MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLE
10 20 30 40
70 80 90 100 110 120
pF1KE4 VGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLN
::. .....: ..:.::.. :..:::::: :.:.:::::.: .:.. .:... :
NP_149 VGVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 GATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDK-EKGLH
.. ... : .:: ... ..:: :.:: .. :..: : :. :. ...
NP_149 AGWLAGLLCPDPRP---LELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 YHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAP
.:.. ..:: ::::: :::: :. :::. . .: . .:.. : .. : ::
NP_149 VYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAA
170 180 190 200 210 220
250 260 270 280 290
pF1KE4 L--TEVAKGIP-PQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTR
: :: :.:. :. .:. : . .. . : . :.: : :
NP_149 LGPTEPAEGLSAPSLSPHCCPCRARLAFR-------NLGALLPRL---------HQLCCR
230 240 250 260
300 310 320 330 340 350
pF1KE4 RAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNST
:: : : ...: .: :... ::.:::.:. .:.: : . ..
NP_149 --------------MPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTE
270 280 290 300 310
360 370 380 390 400 410
pF1KE4 EFLIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLF
:..::..: :. .. ..: ..: . ::. .: ...:... : ...: :
NP_149 ARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLS
320 330 340 350 360 370
420 430 440 450 460
pF1KE4 PNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKEVCCH
.: . . .: : :.: .:..: . ::::..
NP_149 HSVAVVTASAALTGFTFSALQILPYTLASLYHREKQVFLPKYRGDTGGASSEDSLMTSFL
380 390 400 410 420 430
NP_149 PGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDVSVRVVVGEPTEARVVPGRGICLDL
440 450 460 470 480 490
>>XP_005245613 (OMIM: 605097) PREDICTED: solute carrier (553 aa)
initn: 599 init1: 251 opt: 427 Z-score: 520.6 bits: 105.9 E(85289): 2.9e-22
Smith-Waterman score: 598; 29.1% identity (59.2% similar) in 426 aa overlap (33-454:16-408)
10 20 30 40 50 60
pF1KE4 SNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLS
..:.. .. :: : : :. .:: :.::
XP_005 MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLE
10 20 30 40
70 80 90 100 110 120
pF1KE4 VGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLN
::. .....: ..:.::.. :..:::::: :.:.:::::.: .:.. .:... :
XP_005 VGVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 GATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDK-EKGLH
.. ... : .:: ... ..:: :.:: .. :..: : :. :. ...
XP_005 AGWLAGLLCPDPRP---LELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 YHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAP
.:.. ..:: ::::: :::: :. :::. . .: . .:.. : .. : ::
XP_005 VYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAA
170 180 190 200 210 220
250 260 270 280 290
pF1KE4 L--TEVAKGIP-PQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTR
: :: :.:. :. .:. : . .. . : . :.: : :
XP_005 LGPTEPAEGLSAPSLSPHCCPCRARLAFR-------NLGALLPRL---------HQLCCR
230 240 250 260
300 310 320 330 340 350
pF1KE4 RAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNST
:: : : ...: .: :... ::.:::.:. .:.: : . ..
XP_005 --------------MPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTE
270 280 290 300 310
360 370 380 390 400 410
pF1KE4 EFLIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLF
:..::..: :. .. ..: ..: . ::. .: ...:... : ...: :
XP_005 ARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLS
320 330 340 350 360 370
420 430 440 450 460
pF1KE4 PNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKEVCCH
.: . . .: : :.: .:..: . ::::..
XP_005 HSVAVVTASAALTGFTFSALQILPYTLASLYHREKQVFLPKYRGDTGGASSEDSLMTSFL
380 390 400 410 420 430
XP_005 PGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDVSVRVVVGEPTEARVVPGRGICLDL
440 450 460 470 480 490
>>XP_005245614 (OMIM: 605097) PREDICTED: solute carrier (553 aa)
initn: 599 init1: 251 opt: 427 Z-score: 520.6 bits: 105.9 E(85289): 2.9e-22
Smith-Waterman score: 598; 29.1% identity (59.2% similar) in 426 aa overlap (33-454:16-408)
10 20 30 40 50 60
pF1KE4 SNSGQAGRHIYKSLADDGPFDSVEPPKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLS
..:.. .. :: : : :. .:: :.::
XP_005 MVQRLWVSRLLRHRKAQLLLVNLLTFGLEVCLAAGITYVPPLLLE
10 20 30 40
70 80 90 100 110 120
pF1KE4 VGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLVGMALYLN
::. .....: ..:.::.. :..:::::: :.:.:::::.: .:.. .:... :
XP_005 VGVEEKFMTMVLGIGPVLGLVCVPLLGSASDHWRGRYGRRRPFIWALSLGILLSLFLIPR
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 GATVVAALIANPRRKLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDK-EKGLH
.. ... : .:: ... ..:: :.:: .. :..: : :. :. ...
XP_005 AGWLAGLLCPDPRP---LELALLILGVGLLDFCGQVCFTPLEALLSDLFRDPDHCRQAYS
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 YHALFTGFGGALGYLLGAIDWAHLELGRLLGTEFQVMFFFSALVLTLCFTVHLCSISEAP
.:.. ..:: ::::: :::: :. :::. . .: . .:.. : .. : ::
XP_005 VYAFMISLGGCLGYLLPAIDWDTSALAPYLGTQEECLFGLLTLIFLTCVAATLLVAEEAA
170 180 190 200 210 220
250 260 270 280 290
pF1KE4 L--TEVAKGIP-PQQTPQDPPLSSDGMYEYGSIEKVKNGYVNPELAMQGAKNKNHAEQTR
: :: :.:. :. .:. : . .. . : . :.: : :
XP_005 LGPTEPAEGLSAPSLSPHCCPCRARLAFR-------NLGALLPRL---------HQLCCR
230 240 250 260
300 310 320 330 340 350
pF1KE4 RAMTLKSLLRALVNMPPHYRYLCISHLIGWTAFLSNMLFFTDFMGQIVYRGDPYSAHNST
:: : : ...: .: :... ::.:::.:. .:.: : . ..
XP_005 --------------MPRTLRRLFVAELCSWMALMTFTLFYTDFVGEGLYQGVPRAEPGTE
270 280 290 300 310
360 370 380 390 400 410
pF1KE4 EFLIYERGVEVGCWGFCINSVFSSLYSYFQKVLVSYIGLKGLYFTGYLLFGLGTGFIGLF
:..::..: :. .. ..: ..: . ::. .: ...:... : ...: :
XP_005 ARRHYDEGVRMGSLGLFLQCAISLVFSLVMDRLVQRFGTRAVYLASVAAFPVAAGATCLS
320 330 340 350 360 370
420 430 440 450 460
pF1KE4 PNVYSTLVLCSLFGVMSSTLYTVPFNLITEYHREEEKEVCCH
.: . . .: : :.: .:..: . ::::..
XP_005 HSVAVVTASAALTGFTFSALQILPYTLASLYHREKQVFLPKYRGDTGGASSEDSLMTSFL
380 390 400 410 420 430
XP_005 PGPKPGAPFPNGHVGAGGSGLLPPPPALCGASACDVSVRVVVGEPTEARVVPGRGICLDL
440 450 460 470 480 490
460 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 00:36:07 2016 done: Sun Nov 6 00:36:08 2016
Total Scan time: 9.290 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]