Result of FASTA (omim) for
pFN21AE4216
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4216, 748 aa
1>>>pF1KE4216 748 - 748 aa - 748 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6554+/-0.000513; mu= 5.0425+/- 0.032
mean_var=228.3090+/-48.559, 0's: 0 Z-trim(115.5): 446 B-trim: 855 in 1/50
Lambda= 0.084881
statistics sampled from 25430 (25971) to 25430 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.65), E-opt: 0.2 (0.305), width: 16
Scan time: 12.750
The best scores are: opt bits E(85289)
NP_001020787 (OMIM: 610586) rho GTPase-activating ( 748) 4997 625.9 1.8e-178
NP_001274734 (OMIM: 610586) rho GTPase-activating ( 663) 4356 547.4 7e-155
NP_001036134 (OMIM: 610586) rho GTPase-activating ( 653) 4306 541.3 4.8e-153
XP_011530602 (OMIM: 610586) PREDICTED: rho GTPase- ( 653) 4306 541.3 4.8e-153
NP_112595 (OMIM: 610586) rho GTPase-activating pro ( 655) 4067 512.0 3.1e-144
NP_001333022 (OMIM: 610586) rho GTPase-activating ( 555) 3588 453.3 1.3e-126
NP_067049 (OMIM: 610585) rho GTPase-activating pro ( 698) 1590 208.7 6.7e-53
NP_001242954 (OMIM: 610585) rho GTPase-activating ( 704) 1590 208.7 6.7e-53
XP_011538306 (OMIM: 610585) PREDICTED: rho GTPase- ( 704) 1590 208.7 6.7e-53
XP_016871965 (OMIM: 610585) PREDICTED: rho GTPase- ( 414) 1493 196.6 1.7e-49
XP_016871962 (OMIM: 610585) PREDICTED: rho GTPase- ( 420) 1493 196.6 1.7e-49
NP_001242955 (OMIM: 610585) rho GTPase-activating ( 608) 1298 172.9 3.5e-42
XP_011531509 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 1241 165.9 4.5e-40
XP_011531508 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 1241 165.9 4.5e-40
XP_011531510 (OMIM: 610587) PREDICTED: rho GTPase- ( 620) 1241 165.9 4.5e-40
NP_001159748 (OMIM: 610587) rho GTPase-activating ( 639) 1241 165.9 4.6e-40
NP_001007232 (OMIM: 610587) rho GTPase-activating ( 646) 1241 165.9 4.6e-40
XP_016860912 (OMIM: 610587) PREDICTED: rho GTPase- ( 650) 1241 165.9 4.7e-40
NP_055697 (OMIM: 610587) rho GTPase-activating pro ( 638) 1239 165.7 5.5e-40
XP_005264732 (OMIM: 610587) PREDICTED: rho GTPase- ( 645) 1239 165.7 5.5e-40
XP_016860913 (OMIM: 610587) PREDICTED: rho GTPase- ( 649) 1239 165.7 5.5e-40
XP_005270071 (OMIM: 610585) PREDICTED: rho GTPase- ( 624) 1109 149.7 3.3e-35
XP_011538307 (OMIM: 610585) PREDICTED: rho GTPase- ( 624) 1109 149.7 3.3e-35
XP_011538309 (OMIM: 610585) PREDICTED: rho GTPase- ( 637) 1109 149.8 3.4e-35
NP_001242953 (OMIM: 610585) rho GTPase-activating ( 714) 1109 149.8 3.7e-35
XP_011538304 (OMIM: 610585) PREDICTED: rho GTPase- ( 720) 1109 149.8 3.7e-35
XP_011538305 (OMIM: 610585) PREDICTED: rho GTPase- ( 720) 1109 149.8 3.7e-35
XP_011538313 (OMIM: 610585) PREDICTED: rho GTPase- ( 565) 1105 149.2 4.3e-35
XP_016871961 (OMIM: 610585) PREDICTED: rho GTPase- ( 552) 1102 148.8 5.5e-35
XP_011538314 (OMIM: 610585) PREDICTED: rho GTPase- ( 552) 1102 148.8 5.5e-35
XP_016871960 (OMIM: 610585) PREDICTED: rho GTPase- ( 552) 1102 148.8 5.5e-35
XP_016871959 (OMIM: 610585) PREDICTED: rho GTPase- ( 655) 1102 148.9 6.2e-35
XP_011538308 (OMIM: 610585) PREDICTED: rho GTPase- ( 661) 1102 148.9 6.3e-35
XP_011538315 (OMIM: 610585) PREDICTED: rho GTPase- ( 436) 1012 137.7 9.6e-32
XP_011538317 (OMIM: 610585) PREDICTED: rho GTPase- ( 359) 1002 136.4 1.9e-31
XP_016860917 (OMIM: 610587) PREDICTED: rho GTPase- ( 313) 905 124.5 6.6e-28
XP_011531511 (OMIM: 610587) PREDICTED: rho GTPase- ( 528) 848 117.7 1.2e-25
NP_001159749 (OMIM: 610587) rho GTPase-activating ( 606) 848 117.8 1.4e-25
XP_005264733 (OMIM: 610587) PREDICTED: rho GTPase- ( 607) 848 117.8 1.4e-25
XP_016860914 (OMIM: 610587) PREDICTED: rho GTPase- ( 611) 848 117.8 1.4e-25
XP_016871966 (OMIM: 610585) PREDICTED: rho GTPase- ( 396) 450 68.9 4.7e-11
XP_016871963 (OMIM: 610585) PREDICTED: rho GTPase- ( 415) 450 68.9 4.8e-11
XP_016871964 (OMIM: 610585) PREDICTED: rho GTPase- ( 415) 450 68.9 4.8e-11
XP_011532605 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 591) 402 63.1 3.7e-09
XP_016863069 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 709) 399 62.9 5.4e-09
XP_016863068 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 876) 399 62.9 6.4e-09
XP_011532603 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 941) 399 63.0 6.7e-09
XP_016863065 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 979) 399 63.0 6.9e-09
XP_016863067 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 979) 399 63.0 6.9e-09
XP_016863066 (OMIM: 606525) PREDICTED: SLIT-ROBO R ( 979) 399 63.0 6.9e-09
>>NP_001020787 (OMIM: 610586) rho GTPase-activating prot (748 aa)
initn: 4997 init1: 4997 opt: 4997 Z-score: 3325.1 bits: 625.9 E(85289): 1.8e-178
Smith-Waterman score: 4997; 100.0% identity (100.0% similar) in 748 aa overlap (1-748:1-748)
10 20 30 40 50 60
pF1KE4 MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 GTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 RRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 EEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 KENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 KKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 TVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 MMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 LSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKI
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 EYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQK
670 680 690 700 710 720
730 740
pF1KE4 EMEQFFSTFGELTVEPRRTERGNTIWIQ
::::::::::::::::::::::::::::
NP_001 EMEQFFSTFGELTVEPRRTERGNTIWIQ
730 740
>>NP_001274734 (OMIM: 610586) rho GTPase-activating prot (663 aa)
initn: 4356 init1: 4356 opt: 4356 Z-score: 2901.6 bits: 547.4 E(85289): 7e-155
Smith-Waterman score: 4356; 99.8% identity (99.8% similar) in 661 aa overlap (88-748:3-663)
60 70 80 90 100 110
pF1KE4 KPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWV
: ::::::::::::::::::::::::::::
NP_001 MFVQGGDRDRMTANHESYLLMASTQNDMEDWV
10 20 30
120 130 140 150 160 170
pF1KE4 KSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLP
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE4 GQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKL
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE4 LSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNIL
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE4 RPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQ
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE4 LQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPP
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE4 LMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSV
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE4 QNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQ
400 410 420 430 440 450
540 550 560 570 580 590
pF1KE4 QFSMMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QFSMMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPP
460 470 480 490 500 510
600 610 620 630 640 650
pF1KE4 QDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTK
520 530 540 550 560 570
660 670 680 690 700 710
pF1KE4 QKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDM
580 590 600 610 620 630
720 730 740
pF1KE4 LQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
:::::::::::::::::::::::::::::::
NP_001 LQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
640 650 660
>>NP_001036134 (OMIM: 610586) rho GTPase-activating prot (653 aa)
initn: 4306 init1: 4306 opt: 4306 Z-score: 2868.6 bits: 541.3 E(85289): 4.8e-153
Smith-Waterman score: 4306; 100.0% identity (100.0% similar) in 653 aa overlap (96-748:1-653)
70 80 90 100 110 120
pF1KE4 PGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIW
::::::::::::::::::::::::::::::
NP_001 MTANHESYLLMASTQNDMEDWVKSIRRVIW
10 20 30
130 140 150 160 170 180
pF1KE4 GPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKE
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE4 LQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE4 VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE4 TIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNN
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE4 TKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPA
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE4 FNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMG
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE4 ILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLD
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE4 DKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPR
460 470 480 490 500 510
610 620 630 640 650 660
pF1KE4 DYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESR
520 530 540 550 560 570
670 680 690 700 710 720
pF1KE4 IKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQF
580 590 600 610 620 630
730 740
pF1KE4 FSTFGELTVEPRRTERGNTIWIQ
:::::::::::::::::::::::
NP_001 FSTFGELTVEPRRTERGNTIWIQ
640 650
>>XP_011530602 (OMIM: 610586) PREDICTED: rho GTPase-acti (653 aa)
initn: 4306 init1: 4306 opt: 4306 Z-score: 2868.6 bits: 541.3 E(85289): 4.8e-153
Smith-Waterman score: 4306; 100.0% identity (100.0% similar) in 653 aa overlap (96-748:1-653)
70 80 90 100 110 120
pF1KE4 PGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIW
::::::::::::::::::::::::::::::
XP_011 MTANHESYLLMASTQNDMEDWVKSIRRVIW
10 20 30
130 140 150 160 170 180
pF1KE4 GPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKE
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE4 LQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE4 VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPL
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE4 TIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNN
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE4 TKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPA
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE4 FNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMG
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE4 ILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLD
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE4 DKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPR
460 470 480 490 500 510
610 620 630 640 650 660
pF1KE4 DYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESR
520 530 540 550 560 570
670 680 690 700 710 720
pF1KE4 IKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQF
580 590 600 610 620 630
730 740
pF1KE4 FSTFGELTVEPRRTERGNTIWIQ
:::::::::::::::::::::::
XP_011 FSTFGELTVEPRRTERGNTIWIQ
640 650
>>NP_112595 (OMIM: 610586) rho GTPase-activating protein (655 aa)
initn: 4061 init1: 4061 opt: 4067 Z-score: 2710.4 bits: 512.0 E(85289): 3.1e-144
Smith-Waterman score: 4067; 97.0% identity (97.8% similar) in 643 aa overlap (106-748:15-655)
80 90 100 110 120 130
pF1KE4 NEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQ
.::: . . :.: . : :::::
NP_112 MPEDRNSGGCPAGALASTPFIPKTTYRRIKRCF--SFRKGIFGQ
10 20 30 40
140 150 160 170 180 190
pF1KE4 KLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 KLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEK
50 60 70 80 90 100
200 210 220 230 240 250
pF1KE4 PSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 PSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKS
110 120 130 140 150 160
260 270 280 290 300 310
pF1KE4 LPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 LPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQ
170 180 190 200 210 220
320 330 340 350 360 370
pF1KE4 QLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 QLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCS
230 240 250 260 270 280
380 390 400 410 420 430
pF1KE4 WDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 WDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTN
290 300 310 320 330 340
440 450 460 470 480 490
pF1KE4 GSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNP
350 360 370 380 390 400
500 510 520 530 540 550
pF1KE4 TNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLDDKQSIDSATW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 TNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLDDKQSIDSATW
410 420 430 440 450 460
560 570 580 590 600 610
pF1KE4 STSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 STSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRS
470 480 490 500 510 520
620 630 640 650 660 670
pF1KE4 VGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 VGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLT
530 540 550 560 570 580
680 690 700 710 720 730
pF1KE4 LETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 LETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVE
590 600 610 620 630 640
740
pF1KE4 PRRTERGNTIWIQ
:::::::::::::
NP_112 PRRTERGNTIWIQ
650
>>NP_001333022 (OMIM: 610586) rho GTPase-activating prot (555 aa)
initn: 3588 init1: 3588 opt: 3588 Z-score: 2394.3 bits: 453.3 E(85289): 1.3e-126
Smith-Waterman score: 3588; 100.0% identity (100.0% similar) in 549 aa overlap (200-748:7-555)
170 180 190 200 210 220
pF1KE4 EEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYE
::::::::::::::::::::::::::::::
NP_001 MGTFRRSNTDVHTVASLLKLYLRELPEPVIPYAKYE
10 20 30
230 240 250 260 270 280
pF1KE4 DFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLA
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 TVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEI
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE4 QKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHK
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE4 LDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSG
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE4 TKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRL
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE4 STYDNVHQQFSMMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STYDNVHQQFSMMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFE
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE4 DPVLDGPPQDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPVLDGPPQDDLSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVS
400 410 420 430 440 450
650 660 670 680 690 700
pF1KE4 SLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKE
460 470 480 490 500 510
710 720 730 740
pF1KE4 DAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
:::::::::::::::::::::::::::::::::::::::
NP_001 DAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
520 530 540 550
>>NP_067049 (OMIM: 610585) rho GTPase-activating protein (698 aa)
initn: 1677 init1: 1268 opt: 1590 Z-score: 1070.7 bits: 208.7 E(85289): 6.7e-53
Smith-Waterman score: 1960; 47.7% identity (69.6% similar) in 726 aa overlap (21-734:39-689)
10 20 30 40 50
pF1KE4 MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYY
.: :::.:: ...:.:. :::::.::::.:
NP_067 ARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFY
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 FKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGG--DRDRMTANHESYLLMAS
.::.:: :: : : : :..:.: : . :.::: :::. ::: .:... :: :. :::::
NP_067 YKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANPEALLLMAS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 TQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGL
.: ::::::..::::::.:.:::::::.::.::..:..:: ::::.::::::::::.:::
NP_067 SQRDMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 KEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKY
::::::.:::::::..:::.::::::: :::.:::::::::::::::::::::.:.:.:
NP_067 TEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARY
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 EDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNL
:::::::.::.:.: :. ::::::..:: .:::::.:::.::::::.::.:::::::::
NP_067 EDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 ATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDA-ELQSKPQDGVSNNN
:::::::::::.::::.:::::: .::.::.:.: ::. :: . : ..:. :.
NP_067 ATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHSQLFTAPVPEGPTSPRGGL----
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 EIQKKATMGQLQNKENNNTKDSPSRQCS--WDKSESPQRSSMNNGSPTALSGSKTNSPKN
::. : . : . :. . :.: .: . .:.: .
NP_067 -------------------------QCAVGWGSEEVTRDSQGEPGGP-GLPAHRTSSLDG
370 380 390
410 420 430 440 450 460
pF1KE4 SVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSL
.. . .::. : : : : . : .:.:: :. . . :. ::
NP_067 AAVAV-LSRTAPT----------GPG--------SRCSPG-KKVQTLPSWKSSFRQPRSL
400 410 420 430
470 480 490 500 510 520
pF1KE4 KVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGEL--
::. : : .... :..: :: :: :: .:: ... .. .:
NP_067 --SGSPKGGGS----SLEVPIISSG--GN--------WLMNGLSSLRGHRRASSGDRLKD
440 450 460 470 480
530 540 550 560 570 580
pF1KE4 -GQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWS-TSSCEISLPENSNSCRSSTTTCPEQ
:. .:::::::: . .. :. : .:: .:: : :. . .:: :.: .
NP_067 SGSVQRLSTYDNVPAPGLVPGIP---SVASMAWSGASSSESSVGGSLSSC----TACRAS
490 500 510 520 530
590 600 610 620 630
pF1KE4 DFFGGN--FEDPVLDGPPQDDLSH-PRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSS
: . . : .:. : . :. :.. . . .:. .: . : .: :
NP_067 DSSARSSLHTDWALEPSPLPSSSEDPKSLDLDHSMDEAGAGASNSEPSEPDSPTREHARR
540 550 560 570 580 590
640 650 660 670 680 690
pF1KE4 SNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIE
:. ::..::. :. :. .:. ::: .: .:. . :. .: :..:::::.::. :.:
NP_067 SE--ALQGLVTELRAELCRQRTEYERSVKRIEEGSADLRKRMSRLEEELDQEKKKYIMLE
600 610 620 630 640 650
700 710 720 730 740
pF1KE4 IKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
::.::.:::.::::.::..::.:::.::::.: :::
NP_067 IKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTVGAKGARAPK
660 670 680 690
>>NP_001242954 (OMIM: 610585) rho GTPase-activating prot (704 aa)
initn: 1677 init1: 1268 opt: 1590 Z-score: 1070.7 bits: 208.7 E(85289): 6.7e-53
Smith-Waterman score: 1960; 47.7% identity (69.6% similar) in 726 aa overlap (21-734:45-695)
10 20 30 40 50
pF1KE4 MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYY
.: :::.:: ...:.:. :::::.::::.:
NP_001 RYFTRSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFY
20 30 40 50 60 70
60 70 80 90 100
pF1KE4 FKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGG--DRDRMTANHESYLLMAS
.::.:: :: : : : :..:.: : . :.::: :::. ::: .:... :: :. :::::
NP_001 YKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANPEALLLMAS
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE4 TQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGL
.: ::::::..::::::.:.:::::::.::.::..:..:: ::::.::::::::::.:::
NP_001 SQRDMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE4 KEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKY
::::::.:::::::..:::.::::::: :::.:::::::::::::::::::::.:.:.:
NP_001 TEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARY
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE4 EDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNL
:::::::.::.:.: :. ::::::..:: .:::::.:::.::::::.::.:::::::::
NP_001 EDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNL
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE4 ATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDA-ELQSKPQDGVSNNN
:::::::::::.::::.:::::: .::.::.:.: ::. :: . : ..:. :.
NP_001 ATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHSQLFTAPVPEGPTSPRGGL----
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE4 EIQKKATMGQLQNKENNNTKDSPSRQCS--WDKSESPQRSSMNNGSPTALSGSKTNSPKN
::. : . : . :. . :.: .: . .:.: .
NP_001 -------------------------QCAVGWGSEEVTRDSQGEPGGP-GLPAHRTSSLDG
380 390 400
410 420 430 440 450 460
pF1KE4 SVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSL
.. . .::. : : : : . : .:.:: :. . . :. ::
NP_001 AAVAV-LSRTAPT----------GPG--------SRCSPG-KKVQTLPSWKSSFRQPRSL
410 420 430 440
470 480 490 500 510 520
pF1KE4 KVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGEL--
::. : : .... :..: :: :: :: .:: ... .. .:
NP_001 --SGSPKGGGS----SLEVPIISSG--GN--------WLMNGLSSLRGHRRASSGDRLKD
450 460 470 480
530 540 550 560 570 580
pF1KE4 -GQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWS-TSSCEISLPENSNSCRSSTTTCPEQ
:. .:::::::: . .. :. : .:: .:: : :. . .:: :.: .
NP_001 SGSVQRLSTYDNVPAPGLVPGIP---SVASMAWSGASSSESSVGGSLSSC----TACRAS
490 500 510 520 530 540
590 600 610 620 630
pF1KE4 DFFGGN--FEDPVLDGPPQDDLSH-PRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSS
: . . : .:. : . :. :.. . . .:. .: . : .: :
NP_001 DSSARSSLHTDWALEPSPLPSSSEDPKSLDLDHSMDEAGAGASNSEPSEPDSPTREHARR
550 560 570 580 590 600
640 650 660 670 680 690
pF1KE4 SNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIE
:. ::..::. :. :. .:. ::: .: .:. . :. .: :..:::::.::. :.:
NP_001 SE--ALQGLVTELRAELCRQRTEYERSVKRIEEGSADLRKRMSRLEEELDQEKKKYIMLE
610 620 630 640 650
700 710 720 730 740
pF1KE4 IKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
::.::.:::.::::.::..::.:::.::::.: :::
NP_001 IKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTVGAKGARAPK
660 670 680 690 700
>>XP_011538306 (OMIM: 610585) PREDICTED: rho GTPase-acti (704 aa)
initn: 1677 init1: 1268 opt: 1590 Z-score: 1070.7 bits: 208.7 E(85289): 6.7e-53
Smith-Waterman score: 1960; 47.7% identity (69.6% similar) in 726 aa overlap (21-734:45-695)
10 20 30 40 50
pF1KE4 MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYY
.: :::.:: ...:.:. :::::.::::.:
XP_011 RYFTRSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFY
20 30 40 50 60 70
60 70 80 90 100
pF1KE4 FKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGG--DRDRMTANHESYLLMAS
.::.:: :: : : : :..:.: : . :.::: :::. ::: .:... :: :. :::::
XP_011 YKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANPEALLLMAS
80 90 100 110 120 130
110 120 130 140 150 160
pF1KE4 TQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGL
.: ::::::..::::::.:.:::::::.::.::..:..:: ::::.::::::::::.:::
XP_011 SQRDMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGL
140 150 160 170 180 190
170 180 190 200 210 220
pF1KE4 KEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKY
::::::.:::::::..:::.::::::: :::.:::::::::::::::::::::.:.:.:
XP_011 TEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARY
200 210 220 230 240 250
230 240 250 260 270 280
pF1KE4 EDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNL
:::::::.::.:.: :. ::::::..:: .:::::.:::.::::::.::.:::::::::
XP_011 EDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNL
260 270 280 290 300 310
290 300 310 320 330 340
pF1KE4 ATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDA-ELQSKPQDGVSNNN
:::::::::::.::::.:::::: .::.::.:.: ::. :: . : ..:. :.
XP_011 ATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHSQLFTAPVPEGPTSPRGGL----
320 330 340 350 360 370
350 360 370 380 390 400
pF1KE4 EIQKKATMGQLQNKENNNTKDSPSRQCS--WDKSESPQRSSMNNGSPTALSGSKTNSPKN
::. : . : . :. . :.: .: . .:.: .
XP_011 -------------------------QCAVGWGSEEVTRDSQGEPGGP-GLPAHRTSSLDG
380 390 400
410 420 430 440 450 460
pF1KE4 SVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSL
.. . .::. : : : : . : .:.:: :. . . :. ::
XP_011 AAVAV-LSRTAPT----------GPG--------SRCSPG-KKVQTLPSWKSSFRQPRSL
410 420 430 440
470 480 490 500 510 520
pF1KE4 KVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGEL--
::. : : .... :..: :: :: :: .:: ... .. .:
XP_011 --SGSPKGGGS----SLEVPIISSG--GN--------WLMNGLSSLRGHRRASSGDRLKD
450 460 470 480
530 540 550 560 570 580
pF1KE4 -GQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWS-TSSCEISLPENSNSCRSSTTTCPEQ
:. .:::::::: . .. :. : .:: .:: : :. . .:: :.: .
XP_011 SGSVQRLSTYDNVPAPGLVPGIP---SVASMAWSGASSSESSVGGSLSSC----TACRAS
490 500 510 520 530 540
590 600 610 620 630
pF1KE4 DFFGGN--FEDPVLDGPPQDDLSH-PRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSS
: . . : .:. : . :. :.. . . .:. .: . : .: :
XP_011 DSSARSSLHTDWALEPSPLPSSSEDPKSLDLDHSMDEAGAGASNSEPSEPDSPTREHARR
550 560 570 580 590 600
640 650 660 670 680 690
pF1KE4 SNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIE
:. ::..::. :. :. .:. ::: .: .:. . :. .: :..:::::.::. :.:
XP_011 SE--ALQGLVTELRAELCRQRTEYERSVKRIEEGSADLRKRMSRLEEELDQEKKKYIMLE
610 620 630 640 650
700 710 720 730 740
pF1KE4 IKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTERGNTIWIQ
::.::.:::.::::.::..::.:::.::::.: :::
XP_011 IKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTVGAKGARAPK
660 670 680 690 700
>>XP_016871965 (OMIM: 610585) PREDICTED: rho GTPase-acti (414 aa)
initn: 1199 init1: 1199 opt: 1493 Z-score: 1009.5 bits: 196.6 E(85289): 1.7e-49
Smith-Waterman score: 1493; 68.4% identity (88.2% similar) in 313 aa overlap (21-327:39-351)
10 20 30 40 50
pF1KE4 MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYY
.: :::.:: ...:.:. :::::.::::.:
XP_016 ARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFY
10 20 30 40 50 60
60 70 80 90 100
pF1KE4 FKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGG--DRDRMTANHESYLLMAS
.::.:: :: : : : :..:.: : . :.::: :::. ::: .:... :: :. :::::
XP_016 YKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANPEALLLMAS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 TQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGL
.: ::::::..::::::.:.:::::::.::.::..:..:: ::::.::::::::::.:::
XP_016 SQRDMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGL
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 KEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKY
::::::.:::::::..:::.::::::: :::.:::::::::::::::::::::.:.:.:
XP_016 TEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARY
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 EDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNL
:::::::.::.:.: :. ::::::..:: .:::::.:::.::::::.::.:::::::::
XP_016 EDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNL
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 ATVFGPNILRPKVEDPLTIMEG----TVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVS
:::::::::::.::::.::::: . .:::... .:
XP_016 ATVFGPNILRPQVEDPVTIMEGFWTASRPLQQLFQLKRHTGSCSAGINICASCLIFFTYI
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 NNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPK
XP_016 IIRSDSDVNCDVPCESECLLKKNLRPCVVAHACNPSTLGGRGGWIT
370 380 390 400 410
748 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:19:51 2016 done: Sun Nov 6 03:19:53 2016
Total Scan time: 12.750 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]