Result of FASTA (omim) for
pFN21AE3036
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3036, 169 aa
1>>>pF1KE3036 169 - 169 aa - 169 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2545+/-0.000363; mu= 12.8223+/- 0.022
mean_var=86.2530+/-16.498, 0's: 0 Z-trim(115.4): 92 B-trim: 57 in 1/53
Lambda= 0.138098
statistics sampled from 25692 (25809) to 25692 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.688), E-opt: 0.2 (0.303), width: 16
Scan time: 4.730
The best scores are: opt bits E(85289)
NP_001423 (OMIM: 602061) proepiregulin preproprote ( 169) 1160 240.5 9.5e-64
NP_001720 (OMIM: 600345) probetacellulin isoform 1 ( 178) 213 51.9 6.1e-07
XP_011530513 (OMIM: 600345) PREDICTED: probetacell ( 178) 213 51.9 6.1e-07
XP_016863341 (OMIM: 131530,611718) PREDICTED: pro- (1010) 189 47.8 6e-05
NP_001093161 (OMIM: 190170) protransforming growth ( 159) 178 44.9 7.1e-05
NP_003227 (OMIM: 190170) protransforming growth fa ( 160) 178 44.9 7.1e-05
NP_001295088 (OMIM: 190170) protransforming growth ( 165) 178 44.9 7.3e-05
NP_001295087 (OMIM: 190170) protransforming growth ( 166) 178 44.9 7.3e-05
NP_003683 (OMIM: 603421) tomoregulin-1 precursor [ ( 380) 182 46.0 7.7e-05
XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin ( 365) 177 45.0 0.00015
NP_057276 (OMIM: 605734) tomoregulin-2 isoform 1 p ( 374) 177 45.0 0.00015
XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin ( 337) 175 44.6 0.00019
NP_001292063 (OMIM: 605734) tomoregulin-2 isoform ( 346) 175 44.6 0.00019
NP_053584 (OMIM: 603818) pro-neuregulin-2, membran ( 844) 177 45.3 0.00027
XP_016877436 (OMIM: 610894) PREDICTED: pro-neuregu ( 115) 166 42.4 0.00029
NP_612640 (OMIM: 610894) pro-neuregulin-4, membran ( 115) 166 42.4 0.00029
XP_016877434 (OMIM: 610894) PREDICTED: pro-neuregu ( 115) 166 42.4 0.00029
XP_016877435 (OMIM: 610894) PREDICTED: pro-neuregu ( 115) 166 42.4 0.00029
XP_016877437 (OMIM: 610894) PREDICTED: pro-neuregu ( 115) 166 42.4 0.00029
XP_016877433 (OMIM: 610894) PREDICTED: pro-neuregu ( 123) 166 42.4 0.00031
XP_016877428 (OMIM: 610894) PREDICTED: pro-neuregu ( 129) 166 42.4 0.00032
XP_016877429 (OMIM: 610894) PREDICTED: pro-neuregu ( 129) 166 42.4 0.00032
XP_016877432 (OMIM: 610894) PREDICTED: pro-neuregu ( 129) 166 42.4 0.00032
XP_016877430 (OMIM: 610894) PREDICTED: pro-neuregu ( 129) 166 42.4 0.00032
XP_016877431 (OMIM: 610894) PREDICTED: pro-neuregu ( 129) 166 42.4 0.00032
XP_016877427 (OMIM: 610894) PREDICTED: pro-neuregu ( 129) 166 42.4 0.00032
XP_016877426 (OMIM: 610894) PREDICTED: pro-neuregu ( 129) 166 42.4 0.00032
NP_001936 (OMIM: 126150) proheparin-binding EGF-li ( 208) 144 38.2 0.0095
>>NP_001423 (OMIM: 602061) proepiregulin preproprotein [ (169 aa)
initn: 1160 init1: 1160 opt: 1160 Z-score: 1265.5 bits: 240.5 E(85289): 9.5e-64
Smith-Waterman score: 1160; 100.0% identity (100.0% similar) in 169 aa overlap (1-169:1-169)
10 20 30 40 50 60
pF1KE3 MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 AQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVA
70 80 90 100 110 120
130 140 150 160
pF1KE3 LTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
130 140 150 160
>>NP_001720 (OMIM: 600345) probetacellulin isoform 1 pre (178 aa)
initn: 161 init1: 128 opt: 213 Z-score: 245.5 bits: 51.9 E(85289): 6.1e-07
Smith-Waterman score: 213; 29.3% identity (57.5% similar) in 167 aa overlap (11-167:7-167)
10 20 30 40 50
pF1KE3 MTAGRRMEMLCAG--RVPALL-LCLGFHLLQAVLS---TTVIPSC---IPGESSDNCTAL
:.: .: :: : ::. .:. :.. .: : . :. .::.:
NP_001 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAAT
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 VQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHF-FLTV
: .. : .. : .: .... ::..:.: ..: . : :. :: :.:::. .. .
NP_001 --TTQSKRKGHFS--RCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYL
60 70 80 90 100 110
120 130 140 150 160
pF1KE3 HQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
. .. : . ....:.: :.: :. :.:. :. ::: : : : :
NP_001 RGDRGQILVICLIAVMVVFIILVIGVCT-CCHPLRKRR-KRKKKEEEMETLGKDITPINE
120 130 140 150 160 170
NP_001 DIEETNIA
>>XP_011530513 (OMIM: 600345) PREDICTED: probetacellulin (178 aa)
initn: 161 init1: 128 opt: 213 Z-score: 245.5 bits: 51.9 E(85289): 6.1e-07
Smith-Waterman score: 213; 29.3% identity (57.5% similar) in 167 aa overlap (11-167:7-167)
10 20 30 40 50
pF1KE3 MTAGRRMEMLCAG--RVPALL-LCLGFHLLQAVLS---TTVIPSC---IPGESSDNCTAL
:.: .: :: : ::. .:. :.. .: : . :. .::.:
XP_011 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAAT
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 VQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHF-FLTV
: .. : .. : .: .... ::..:.: ..: . : :. :: :.:::. .. .
XP_011 --TTQSKRKGHFS--RCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYL
60 70 80 90 100 110
120 130 140 150 160
pF1KE3 HQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
. .. : . ....:.: :.: :. :.:. :. ::: : : : :
XP_011 RGDRGQILVICLIAVMVVFIILVIGVCT-CCHPLRKRR-KRKKKEEEMETLGKDITPINE
120 130 140 150 160 170
XP_011 DIEETNIA
>>XP_016863341 (OMIM: 131530,611718) PREDICTED: pro-epid (1010 aa)
initn: 110 init1: 49 opt: 189 Z-score: 209.9 bits: 47.8 E(85289): 6e-05
Smith-Waterman score: 189; 27.4% identity (61.9% similar) in 113 aa overlap (52-157:837-949)
30 40 50 60 70 80
pF1KE3 LGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLH-GQ
.. .:. .. : ..: . .::::: :
XP_016 TNTEGGYTCMCAGRLSEPGLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGV
810 820 830 840 850 860
90 100 110 120 130
pF1KE3 CIYLVDMSQNYCRCEVGYTGVRCEH----FFLTVHQPLSKEYVALTVILIILFLITVVGS
:.:. ... : : ::: : ::.. .. : ... ...: . .. :. ..
XP_016 CMYIEALDKYACNCVVGYIGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLL
870 880 890 900 910 920
140 150 160
pF1KE3 TYYFCRWYRNRK--SKEPKKEYERVTSGDPELPQV
. . ..::..: ::.::. ::
XP_016 SLWGAHYYRTQKLLSKNPKNPYEESSRDVRSRRPADTEDGMSSCPQPWGQCNQLHGGRSP
930 940 950 960 970 980
>>NP_001093161 (OMIM: 190170) protransforming growth fac (159 aa)
initn: 165 init1: 144 opt: 178 Z-score: 208.5 bits: 44.9 E(85289): 7.1e-05
Smith-Waterman score: 178; 28.0% identity (59.8% similar) in 107 aa overlap (48-145:20-126)
20 30 40 50 60 70
pF1KE3 LLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTED---NPRVAQVSITK---CSSD
: :: .. . .: :: . ... : ..
NP_001 MVPSAGQLALFALGIVLAACQALENSTSPLSDPPVAAAVVSHFNDCPDS
10 20 30 40
80 90 100 110 120
pF1KE3 MNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEH--FFLTVHQPLSKEYV-ALTVILIIL
. .:.:: : .::. .. : :. ::.:.:::: .. .: .:. . ::.:. :.
NP_001 HTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVA
50 60 70 80 90 100
130 140 150 160
pF1KE3 FLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
. . .. . : :
NP_001 LAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
110 120 130 140 150
>>NP_003227 (OMIM: 190170) protransforming growth factor (160 aa)
initn: 165 init1: 144 opt: 178 Z-score: 208.5 bits: 44.9 E(85289): 7.1e-05
Smith-Waterman score: 178; 27.6% identity (59.5% similar) in 116 aa overlap (35-145:16-127)
10 20 30 40 50 60
pF1KE3 RRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRVAQV-
:. .: .. .: :. . . : : .: :
NP_003 MVPSAGQLALFALGIVLAAC---QALENSTSPL-SADPPVAAAVV
10 20 30 40
70 80 90 100 110
pF1KE3 -SITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEH--FFLTVHQPLSKEYV-
.. : .. . .:.:: : .::. .. : :. ::.:.:::: .. .: .:. .
NP_003 SHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAIT
50 60 70 80 90 100
120 130 140 150 160
pF1KE3 ALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
::.:. :. . . .. . : :
NP_003 ALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
110 120 130 140 150 160
>>NP_001295088 (OMIM: 190170) protransforming growth fac (165 aa)
initn: 165 init1: 144 opt: 178 Z-score: 208.3 bits: 44.9 E(85289): 7.3e-05
Smith-Waterman score: 178; 28.0% identity (59.8% similar) in 107 aa overlap (48-145:26-132)
20 30 40 50 60 70
pF1KE3 LLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTED---NPRVAQVSITK---CSSD
: :: .. . .: :: . ... : ..
NP_001 MFKIGRGALDLFSELLSFGGIVLAACQALENSTSPLSDPPVAAAVVSHFNDCPDS
10 20 30 40 50
80 90 100 110 120
pF1KE3 MNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEH--FFLTVHQPLSKEYV-ALTVILIIL
. .:.:: : .::. .. : :. ::.:.:::: .. .: .:. . ::.:. :.
NP_001 HTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVA
60 70 80 90 100 110
130 140 150 160
pF1KE3 FLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
. . .. . : :
NP_001 LAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
120 130 140 150 160
>>NP_001295087 (OMIM: 190170) protransforming growth fac (166 aa)
initn: 165 init1: 144 opt: 178 Z-score: 208.3 bits: 44.9 E(85289): 7.3e-05
Smith-Waterman score: 178; 27.6% identity (59.5% similar) in 116 aa overlap (35-145:22-133)
10 20 30 40 50 60
pF1KE3 RRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRVAQV-
:. .: .. .: :. . . : : .: :
NP_001 MFKIGRGALDLFSELLSFGGIVLAAC---QALENSTSPL-SADPPVAAAVV
10 20 30 40
70 80 90 100 110
pF1KE3 -SITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEH--FFLTVHQPLSKEYV-
.. : .. . .:.:: : .::. .. : :. ::.:.:::: .. .: .:. .
NP_001 SHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAIT
50 60 70 80 90 100
120 130 140 150 160
pF1KE3 ALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
::.:. :. . . .. . : :
NP_001 ALVVVSIVALAVLIITCVLIHCCQVRKHCEWCRALICRHEKPSALLKGRTACCHSETVV
110 120 130 140 150 160
>>NP_003683 (OMIM: 603421) tomoregulin-1 precursor [Homo (380 aa)
initn: 194 init1: 168 opt: 182 Z-score: 207.9 bits: 46.0 E(85289): 7.7e-05
Smith-Waterman score: 182; 28.4% identity (58.8% similar) in 102 aa overlap (68-161:275-376)
40 50 60 70 80 90
pF1KE3 SCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVG
: ..::::.::.: .. . .. :::: :
NP_003 GKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESG
250 260 270 280 290 300
100 110 120 130 140
pF1KE3 YTGVRCEH------FFLTVHQPLSKEYVALTVILI-ILFLITVVGSTYYFC-RWYRNRKS
::: .::. . . .: :.. .: . . : .....: : . :.:..
NP_003 YTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQ
310 320 330 340 350 360
150 160
pF1KE3 KEPKKEYERVTSGDPELPQV
:. .. ::
NP_003 KQNLGHFTSDTSSRMV
370 380
>>XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin-2 i (365 aa)
initn: 210 init1: 164 opt: 177 Z-score: 202.7 bits: 45.0 E(85289): 0.00015
Smith-Waterman score: 177; 28.9% identity (61.9% similar) in 97 aa overlap (68-156:256-352)
40 50 60 70 80 90
pF1KE3 SCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVG
: .::.:.::.: . ..:.. :::..:
XP_011 TKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCDAG
230 240 250 260 270 280
100 110 120 130 140
pF1KE3 YTGVRCEH----FFLTVHQPLSKEYVALTVIL----IILFLITVVGSTYYFCRWYRNRKS
::: .::. . .: :. .:: ..... : .. ..:. : : : ...
XP_011 YTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIHRQ
290 300 310 320 330 340
150 160
pF1KE3 KEPKKEYERVTSGDPELPQV
:. .:
XP_011 KQNTGHYSSDNTTRASTRLI
350 360
169 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:52:56 2016 done: Sat Nov 5 22:52:57 2016
Total Scan time: 4.730 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]