FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6392, 418 aa 1>>>pF1KE6392 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4075+/-0.000464; mu= 16.3968+/- 0.028 mean_var=72.6440+/-14.626, 0's: 0 Z-trim(109.6): 308 B-trim: 13 in 1/51 Lambda= 0.150478 statistics sampled from 17491 (17809) to 17491 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.565), E-opt: 0.2 (0.209), width: 16 Scan time: 6.800 The best scores are: opt bits E(85289) NP_001107859 (OMIM: 611704) transmembrane protease ( 418) 2800 617.7 1.7e-176 NP_872412 (OMIM: 611704) transmembrane protease se ( 421) 2784 614.3 1.8e-175 NP_054777 (OMIM: 610399) transmembrane protease se ( 423) 1283 288.4 2.3e-77 NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 1195 269.3 1.3e-71 XP_011530198 (OMIM: 610399) PREDICTED: transmembra ( 345) 1123 253.6 5.6e-67 XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 930 211.7 2e-54 XP_016864340 (OMIM: 605369) PREDICTED: transmembra ( 234) 856 195.5 1.1e-49 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 693 160.3 8.8e-39 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 681 157.7 5.4e-38 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 660 153.3 2e-36 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 660 153.3 2e-36 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 640 148.8 2.2e-35 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 639 148.5 2.3e-35 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 640 148.8 2.6e-35 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 640 148.8 2.7e-35 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 640 148.8 2.7e-35 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 640 148.9 2.9e-35 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 635 148.0 1e-34 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 635 148.0 1.1e-34 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 635 148.0 1.1e-34 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 635 148.0 1.1e-34 XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 635 148.0 1.1e-34 XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 635 148.0 1.1e-34 XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 635 148.0 1.1e-34 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 627 146.0 2.1e-34 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 627 146.1 2.2e-34 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 627 146.1 2.2e-34 NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 615 143.3 8.3e-34 XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 612 142.8 2e-33 XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 612 142.8 2.2e-33 NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 612 142.8 2.2e-33 XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 612 142.8 2.2e-33 NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 603 140.7 4.7e-33 NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 603 140.8 6e-33 NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 603 140.8 6.2e-33 NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 603 140.8 6.4e-33 NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 603 140.8 6.5e-33 NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 603 140.8 6.5e-33 XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 600 140.2 1.3e-32 XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 597 139.4 1.3e-32 XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 597 139.4 1.3e-32 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 600 140.3 1.5e-32 NP_892018 (OMIM: 610477) transmembrane protease se (1059) 600 140.4 2.1e-32 XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 600 140.4 2.2e-32 XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 591 138.2 4.1e-32 XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 591 138.2 4.1e-32 XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 591 138.2 4.3e-32 XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 591 138.2 4.4e-32 XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 591 138.2 4.4e-32 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 589 137.7 5.1e-32 >>NP_001107859 (OMIM: 611704) transmembrane protease ser (418 aa) initn: 2800 init1: 2800 opt: 2800 Z-score: 3289.9 bits: 617.7 E(85289): 1.7e-176 Smith-Waterman score: 2800; 99.8% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE6 QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE6 FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 PLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 SFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPEASASF :::::::::::::::::::::::::::::::::::::::::::::::::.:::::::::: NP_001 SFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE6 QPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGI 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 YDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI 370 380 390 400 410 >>NP_872412 (OMIM: 611704) transmembrane protease serine (421 aa) initn: 2257 init1: 2257 opt: 2784 Z-score: 3271.0 bits: 614.3 E(85289): 1.8e-175 Smith-Waterman score: 2784; 99.0% identity (99.3% similar) in 421 aa overlap (1-418:1-421) 10 20 30 40 50 60 pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP 10 20 30 40 50 60 70 80 90 100 110 pF1KE6 QINNNFGQSNTYQLKDLRETTENLV---DEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDV ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_872 QINNNFGQSNTYQLKDLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDV 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 IMVFQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 IMVFQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 RVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 RVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQ 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 WTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPEAS ::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::: NP_872 WTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEAS 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE6 ASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 ASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYM 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 EGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_872 EGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTG 370 380 390 400 410 420 pF1KE6 I : NP_872 I >>NP_054777 (OMIM: 610399) transmembrane protease serine (423 aa) initn: 1099 init1: 980 opt: 1283 Z-score: 1509.9 bits: 288.4 E(85289): 2.3e-77 Smith-Waterman score: 1283; 43.0% identity (75.4% similar) in 423 aa overlap (1-418:1-423) 10 20 30 40 50 pF1KE6 MMYRTVGFGTRSR-NLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEY-YHGSFKIL :::: .:.: .::.:...: .:: :.:: ::: ::.. ..::: : :...... NP_054 MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE6 DPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVI .. .::. . .. .. . :..: . : : .....:.::.... .. :: . .. NP_054 TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE6 MVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSSTGELTVQASCG- .. .: :::. . .: .: .:..:... . : .. ::... .... . .. :: NP_054 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE6 KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNP .: :. . ::..:. . .. ::::::::.:. :.::::::. ::::.::::: :::: NP_054 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE6 HQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPE .::.:::. :.: :::..::.:.::::. ...:::.....:: : ... ..:.:::. NP_054 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE6 ASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAG :: :::. .. .:::::: : ::: ::.:.: .:. .:..::.:.. : : :.::: NP_054 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE6 YMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASK .:: :::.::::::::. : .: ::: :::::::.:.. .::::::.:: :.::.:: NP_054 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK 370 380 390 400 410 420 pF1KE6 TGI ::: NP_054 TGI >>NP_004253 (OMIM: 605369) transmembrane protease serine (418 aa) initn: 1195 init1: 869 opt: 1195 Z-score: 1406.7 bits: 269.3 E(85289): 1.3e-71 Smith-Waterman score: 1195; 40.3% identity (75.2% similar) in 419 aa overlap (2-418:1-418) 10 20 30 40 50 60 pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP ::: . . :: :.:... ..: .....::::.:::.::.::::. .:..::..:. NP_004 MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNV 10 20 30 40 50 70 80 90 100 110 120 pF1KE6 QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV . :..... : . . : :.:. . : .: ....:. .:..: . .::..::.: NP_004 EYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMK 60 70 80 90 100 110 130 140 150 160 170 pF1KE6 FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK--R ::: ... : ...:.:.: : . : : :: :. .......... . :: NP_004 FQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPST-EITSLTDQAAANWLINECGAGPD 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE6 VVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQW .. :. .:: .:. : ...::::.::. .: :.::..::.: :..::::::.. .::..: NP_004 LITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDW 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE6 TVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPEASA .. : . . : .. :: ..::..:.::..: :::.:.. . :::. ::. .::: :. NP_004 IATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQ 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE6 SFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYME .. :. :...::.:: :.:.. .::...:.:::.:::. :. :.. : ::.::: . NP_004 NIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQ 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE6 GIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI : :::.:::::::: .: . :...:::::::.:: :::::::.:: : .:: ..::: NP_004 GGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI 360 370 380 390 400 410 >>XP_011530198 (OMIM: 610399) PREDICTED: transmembrane p (345 aa) initn: 1071 init1: 980 opt: 1123 Z-score: 1323.5 bits: 253.6 E(85289): 5.6e-67 Smith-Waterman score: 1123; 44.9% identity (76.8% similar) in 345 aa overlap (77-418:1-345) 50 60 70 80 90 100 pF1KE6 KKEYYHGSFKILDPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRL . . :..: . : : .....:.::... XP_011 MSQRLESMVKNAFYKSPLREEFVKSQVIKF 10 20 30 110 120 130 140 150 160 pF1KE6 TPEEDGVKVDVIMVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSS . .. :: . .... .: :::. . .: .: .:..:... . : .. ::... .... XP_011 SQQKHGVLAHMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKT 40 50 60 70 80 90 170 180 190 200 210 220 pF1KE6 TGELTVQASCG-KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLV . .. :: .: :. . ::..:. . .. ::::::::.:. :.::::::. :::: XP_011 ETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLV 100 110 120 130 140 150 230 240 250 260 270 280 pF1KE6 TAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVT .::::: :::: .::.:::. :.: :::..::.:.::::. ...:::.....:: : XP_011 SAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVP 160 170 180 190 200 210 290 300 310 320 330 340 pF1KE6 FSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVY ... ..:.:::.:: :::. .. .:::::: : ::: ::.:.: .:. .:..::.: XP_011 YTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAY 220 230 240 250 260 270 350 360 370 380 390 400 pF1KE6 GNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYT .. : : :.::: .:: :::.::::::::. : .: ::: :::::::.:.. .:::::: XP_011 NDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYT 280 290 300 310 320 330 410 pF1KE6 QVTYYRNWIASKTGI .:: :.::.::::: XP_011 RVTALRDWITSKTGI 340 >>XP_005265767 (OMIM: 605369) PREDICTED: transmembrane p (301 aa) initn: 869 init1: 869 opt: 930 Z-score: 1097.9 bits: 211.7 E(85289): 2e-54 Smith-Waterman score: 930; 43.0% identity (75.5% similar) in 302 aa overlap (119-418:1-301) 90 100 110 120 130 140 pF1KE6 FIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREKKIQSILNQKIRNLR : ::: ... : ...:.:.: : . : XP_005 MKFQFTRNNNGASMKSRIESVLRQMLNNSG 10 20 30 150 160 170 180 190 200 pF1KE6 ALPINASSVQVNAMSSSTGELTVQASCGK--RVVPLNVNRIASGVIAPKAAWPWQASLQY : :: :. .......... . :: .. :. .:: .:. : ...::::.::. XP_005 NLEINPST-EITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRL 40 50 60 70 80 210 220 230 240 250 260 pF1KE6 DNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRS .: :.::..::.: :..::::::.. .::..: .. : . . : .. :: ..::..:.: XP_005 NNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKS 90 100 110 120 130 140 270 280 290 300 310 320 pF1KE6 AAREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLRE :..: :::.:.. . :::. ::. .::: :. .. :. :...::.:: :.:.. .::. XP_005 ATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQ 150 160 170 180 190 200 330 340 350 360 370 380 pF1KE6 ARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGI ..:.:::.:::. :. :.. : ::.::: .: :::.:::::::: .: . :...:: XP_005 GQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGI 210 220 230 240 250 260 390 400 410 pF1KE6 VSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI :::::.:: :::::::.:: : .:: ..::: XP_005 VSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI 270 280 290 300 >>XP_016864340 (OMIM: 605369) PREDICTED: transmembrane p (234 aa) initn: 856 init1: 856 opt: 856 Z-score: 1012.7 bits: 195.5 E(85289): 1.1e-49 Smith-Waterman score: 856; 48.5% identity (79.8% similar) in 233 aa overlap (186-418:2-234) 160 170 180 190 200 210 pF1KE6 SVQVNAMSSSTGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGAT :: .:. : ...::::.::. .: :.::.. XP_016 MRILGGTEAEEGSWPWQVSLRLNNAHHCGGS 10 20 30 220 230 240 250 260 270 pF1KE6 LISNTWLVTAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAV ::.: :..::::::.. .::..: .. : . . : .. :: ..::..:.::..: :::. XP_016 LINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIAL 40 50 60 70 80 90 280 290 300 310 320 330 pF1KE6 VQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDD :.. . :::. ::. .::: :. .. :. :...::.:: :.:.. .::...:.:::.: XP_016 VRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISND 100 110 120 130 140 150 340 350 360 370 380 390 pF1KE6 VCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQ ::. :. :.. : ::.::: .: :::.:::::::: .: . :...:::::::.:: XP_016 VCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGL 160 170 180 190 200 210 400 410 pF1KE6 KDKPGVYTQVTYYRNWIASKTGI :::::::.:: : .:: ..::: XP_016 PDKPGVYTRVTAYLDWIRQQTGI 220 230 >>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa) initn: 670 init1: 303 opt: 693 Z-score: 817.3 bits: 160.3 E(85289): 8.8e-39 Smith-Waterman score: 693; 32.5% identity (62.0% similar) in 416 aa overlap (15-412:46-443) 10 20 30 40 pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVF :: . : :. ...: ..:..::: .:: NP_001 RSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIAL-ILALAIGLGIHF--- 20 30 40 50 60 70 50 60 70 80 90 pF1KE6 DQKKEYY-HGSFKILDPQINNNFGQSNTYQLKD----LRETTENLVDEIFIDSAWK---- : . .: ..::: .. : : :. . .: .: .: : ..: ..:: NP_001 DCSGKYRCRSSFKCIE-LIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCS 80 90 100 110 120 130 100 110 120 130 140 pF1KE6 ---KNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREK--KIQSIL-NQKIRNLRA :.. : . . :. : . : :. . ::. .:. .: ..:. :. NP_001 DDWKGHYANVACAQLGFPSYVSSDNLRV----SSLEGQFREEFVSIDHLLPDDKVTALH- 140 150 160 170 180 150 160 170 180 190 200 pF1KE6 LPINASSVQVNAMSSSTGELTVQAS-CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDN :: : .: .:.: . ::.: .::..: .. . ::::::::... NP_001 -----HSVYVREGCASGHVVTLQCTACGHRR--GYSSRIVGGNMSLLSQWPWQASLQFQG 190 200 210 220 230 210 220 230 240 250 260 pF1KE6 IHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFG--TKINPPLMKRNVRRFIIHEKYRS : ::...:. :..::::: :..::.. : . .. : .. :.... : ::. NP_001 YHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKP 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE6 AAREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLRE :::...... .::.. :. .:::.. .: . . .:.:: ::... : . NP_001 KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNH 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE6 ARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGI : : .::. .:.. .:::. :.:.:.::::. : :.:.:::::::: .. . : :.: NP_001 AAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGA 360 370 380 390 400 410 390 400 410 pF1KE6 VSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI .:.: .:.. .::::::.:: . .:: NP_001 TSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 420 430 440 450 >>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa) initn: 441 init1: 211 opt: 681 Z-score: 803.2 bits: 157.7 E(85289): 5.4e-38 Smith-Waterman score: 681; 32.4% identity (61.9% similar) in 417 aa overlap (15-412:46-444) 10 20 30 40 pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVF :: . : :. ...: ..:..::: .:: NP_076 RSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIAL-ILALAIGLGIHF--- 20 30 40 50 60 70 50 60 70 80 90 pF1KE6 DQKKEYY-HGSFKILDPQINNNFGQSNTYQLKD----LRETTENLVDEIFIDSAWK---- : . .: ..::: .. : : :. . .: .: .: : ..: ..:: NP_076 DCSGKYRCRSSFKCIE-LIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCS 80 90 100 110 120 130 100 110 120 130 140 pF1KE6 ---KNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREK--KIQSIL-NQKIRNLRA :.. : . . :. : . : :. . ::. .:. .: ..:. :. NP_076 DDWKGHYANVACAQLGFPSYVSSDNLRV----SSLEGQFREEFVSIDHLLPDDKVTALH- 140 150 160 170 180 150 160 170 180 190 200 pF1KE6 LPINASSVQVNAMSSSTGELTVQAS-CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDN :: : .: .:.: . ::.: .::..: .. . ::::::::... NP_076 -----HSVYVREGCASGHVVTLQCTACGHRR--GYSSRIVGGNMSLLSQWPWQASLQFQG 190 200 210 220 230 210 220 230 240 250 260 pF1KE6 IHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFG--TKINPPLMKRNVRRFIIHEKYRS : ::...:. :..::::: :..::.. : . .. : .. :.... : ::. NP_076 YHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKP 240 250 260 270 280 290 270 280 290 300 310 320 pF1KE6 AAREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYG-GESQNDLR :::...... .::.. :. .:::.. .: . . .:.:: : :... : NP_076 KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLN 300 310 320 330 340 350 330 340 350 360 370 380 pF1KE6 EARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIG .: : .::. .:.. .:::. :.:.:.::::. : :.:.:::::::: .. . : :.: NP_076 HAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVG 360 370 380 390 400 410 390 400 410 pF1KE6 IVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI .:.: .:.. .::::::.:: . .:: NP_076 ATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 420 430 440 450 >>NP_001275930 (OMIM: 206200,609862) transmembrane prote (802 aa) initn: 634 init1: 279 opt: 660 Z-score: 774.9 bits: 153.3 E(85289): 2e-36 Smith-Waterman score: 660; 42.1% identity (70.6% similar) in 235 aa overlap (185-412:566-797) 160 170 180 190 200 210 pF1KE6 SSVQVNAMSSSTGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGA .::..:... .. :::::::: . : ::. NP_001 KKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGG 540 550 560 570 580 590 220 230 240 250 260 pF1KE6 TLISNTWLVTAAHCFQK--YKNPHQWTVSFGTKI--N---PPLMKRNVRRFIIHEKYRSA .::.. :..:::::::. . . ::: .: :. : : .. .: :...: .. NP_001 ALIADRWVITAAHCFQEDSMASTVLWTVFLG-KVWQNSRWPGEVSFKVSRLLLHPYHEED 600 610 620 630 640 650 270 280 290 300 310 320 pF1KE6 AREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLREA ...::.:..:.. :. : .: .::: : :.:.: :::.::: :: .: :... NP_001 SHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKV 660 670 680 690 700 710 330 340 350 360 370 380 pF1KE6 RVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIV :..: .:.:. .:: .. : :.:::: .: :::.:::::::: . :. :.: :.: NP_001 DVQLIPQDLCS--EVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLV 720 730 740 750 760 770 390 400 410 pF1KE6 SWGDNCGQKDKPGVYTQVTYYRNWIASKTGI ::: .::. . ::::..: .:: NP_001 SWGLGCGRPNYFGVYTRITGVISWIQQVVT 780 790 800 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:51:52 2016 done: Tue Nov 8 12:51:53 2016 Total Scan time: 6.800 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]