FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5418, 318 aa 1>>>pF1KE5418 318 - 318 aa - 318 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6675+/-0.000393; mu= 19.2395+/- 0.024 mean_var=65.8008+/-14.090, 0's: 0 Z-trim(113.1): 45 B-trim: 116 in 1/52 Lambda= 0.158110 statistics sampled from 22213 (22255) to 22213 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.622), E-opt: 0.2 (0.261), width: 16 Scan time: 6.120 The best scores are: opt bits E(85289) NP_078868 (OMIM: 611715,612379,612713) polyprenol ( 318) 2207 512.3 5.2e-145 XP_016864090 (OMIM: 611715,612379,612713) PREDICTE ( 273) 1701 396.8 2.6e-110 XP_005265823 (OMIM: 611715,612379,612713) PREDICTE ( 273) 1296 304.4 1.7e-82 XP_005265824 (OMIM: 611715,612379,612713) PREDICTE ( 207) 860 204.9 1.2e-52 XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-ox ( 169) 200 54.3 2.1e-07 XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-ox ( 180) 200 54.3 2.2e-07 NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-ster ( 254) 200 54.4 2.9e-07 NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 212) 165 46.4 6.4e-05 NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-d ( 259) 165 46.4 7.4e-05 NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid ( 186) 162 45.6 9.3e-05 >>NP_078868 (OMIM: 611715,612379,612713) polyprenol redu (318 aa) initn: 2207 init1: 2207 opt: 2207 Z-score: 2724.3 bits: 512.3 E(85289): 5.2e-145 Smith-Waterman score: 2207; 100.0% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KE5 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE5 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_078 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK 250 260 270 280 290 300 310 pF1KE5 SKFVSYPKHRKAFLPFLF :::::::::::::::::: NP_078 SKFVSYPKHRKAFLPFLF 310 >>XP_016864090 (OMIM: 611715,612379,612713) PREDICTED: p (273 aa) initn: 1701 init1: 1701 opt: 1701 Z-score: 2101.4 bits: 396.8 E(85289): 2.6e-110 Smith-Waterman score: 1701; 100.0% identity (100.0% similar) in 245 aa overlap (74-318:29-273) 50 60 70 80 90 100 pF1KE5 AIFQDLIRYGKTKCGEPSRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAP :::::::::::::::::::::::::::::: XP_016 MAQYRLTATSTSRVQAILLPKPPSSREHRYFSHFYIISVLWNGFLLWCLTQSLFLGAP 10 20 30 40 50 110 120 130 140 150 160 pF1KE5 FPSWLHGLLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FPSWLHGLLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQY 60 70 80 90 100 110 170 180 190 200 210 220 pF1KE5 CFGLVYYVLVGLTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CFGLVYYVLVGLTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVI 120 130 140 150 160 170 230 240 250 260 270 280 pF1KE5 LGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTN 180 190 200 210 220 230 290 300 310 pF1KE5 VFFNQALSAFLSHQFYKSKFVSYPKHRKAFLPFLF ::::::::::::::::::::::::::::::::::: XP_016 VFFNQALSAFLSHQFYKSKFVSYPKHRKAFLPFLF 240 250 260 270 >>XP_005265823 (OMIM: 611715,612379,612713) PREDICTED: p (273 aa) initn: 1319 init1: 1291 opt: 1296 Z-score: 1602.2 bits: 304.4 E(85289): 1.7e-82 Smith-Waterman score: 1792; 85.8% identity (85.8% similar) in 318 aa overlap (1-318:1-273) 10 20 30 40 50 60 pF1KE5 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE5 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH ::::::: :::::::: XP_005 VPMDGRN---------------------------------------------GVVIHCNH 190 250 260 270 280 290 300 pF1KE5 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK 200 210 220 230 240 250 310 pF1KE5 SKFVSYPKHRKAFLPFLF :::::::::::::::::: XP_005 SKFVSYPKHRKAFLPFLF 260 270 >>XP_005265824 (OMIM: 611715,612379,612713) PREDICTED: p (207 aa) initn: 879 init1: 860 opt: 860 Z-score: 1066.3 bits: 204.9 E(85289): 1.2e-52 Smith-Waterman score: 1224; 65.1% identity (65.1% similar) in 318 aa overlap (1-318:1-207) 10 20 30 40 50 60 pF1KE5 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAPWAEAEHSALNPLRAVWLTLTAAFLLTLLLQLLPPGLLPGCAIFQDLIRYGKTKCGEP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SRPAACRAFDVPKRYFSHFYIISVLWNGFLLWCLTQSLFLGAPFPSWLHGLLRILGAAQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 QGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVYYVLVGLTVLSQ :: XP_005 QG---------------------------------------------------------- 190 200 210 220 230 240 pF1KE5 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGVVIHCNH ::::::: XP_005 -----------------------------------------------------VVIHCNH 250 260 270 280 290 300 pF1KE5 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLSHQFYK 130 140 150 160 170 180 310 pF1KE5 SKFVSYPKHRKAFLPFLF :::::::::::::::::: XP_005 SKFVSYPKHRKAFLPFLF 190 200 >>XP_011531374 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (169 aa) initn: 204 init1: 108 opt: 200 Z-score: 253.8 bits: 54.3 E(85289): 2.1e-07 Smith-Waterman score: 200; 36.4% identity (65.3% similar) in 118 aa overlap (205-318:63-169) 180 190 200 210 220 230 pF1KE5 LTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGV ::...:: . . . . :: .:: : : XP_011 FCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLR--KPGE 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE5 VIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWL-VVTNVFFNQ---AL . ..::: : : :::. :.:.:.. ....:.. :: : ... .::. .: XP_011 I---SYRIPQGGLFTYVSGANFLGEIIEWIGYALA------TWSLPALAFAFFSLCFLGL 100 110 120 130 140 300 310 pF1KE5 SAFLSHQFYKSKFVSYPKHRKAFLPFLF :: :.:: . : .::: :::..::.: XP_011 RAFHHHRFYLKMFEDYPKSRKALIPFIF 150 160 >>XP_011531371 (OMIM: 264600,607306) PREDICTED: 3-oxo-5- (180 aa) initn: 204 init1: 108 opt: 200 Z-score: 253.4 bits: 54.3 E(85289): 2.2e-07 Smith-Waterman score: 200; 36.4% identity (65.3% similar) in 118 aa overlap (205-318:74-180) 180 190 200 210 220 230 pF1KE5 LTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGV ::...:: . . . . :: .:: : : XP_011 FCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLR--KPGE 50 60 70 80 90 100 240 250 260 270 280 290 pF1KE5 VIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWL-VVTNVFFNQ---AL . ..::: : : :::. :.:.:.. ....:.. :: : ... .::. .: XP_011 I---SYRIPQGGLFTYVSGANFLGEIIEWIGYALA------TWSLPALAFAFFSLCFLGL 110 120 130 140 150 300 310 pF1KE5 SAFLSHQFYKSKFVSYPKHRKAFLPFLF :: :.:: . : .::: :::..::.: XP_011 RAFHHHRFYLKMFEDYPKSRKALIPFIF 160 170 180 >>NP_000339 (OMIM: 264600,607306) 3-oxo-5-alpha-steroid (254 aa) initn: 204 init1: 108 opt: 200 Z-score: 251.5 bits: 54.4 E(85289): 2.9e-07 Smith-Waterman score: 200; 36.4% identity (65.3% similar) in 118 aa overlap (205-318:148-254) 180 190 200 210 220 230 pF1KE5 LTVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHVILGNLRKNKAGV ::...:: . . . . :: .:: : : NP_000 FCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLR--KPGE 120 130 140 150 160 170 240 250 260 270 280 290 pF1KE5 VIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWL-VVTNVFFNQ---AL . ..::: : : :::. :.:.:.. ....:.. :: : ... .::. .: NP_000 I---SYRIPQGGLFTYVSGANFLGEIIEWIGYALA------TWSLPALAFAFFSLCFLGL 180 190 200 210 220 300 310 pF1KE5 SAFLSHQFYKSKFVSYPKHRKAFLPFLF :: :.:: . : .::: :::..::.: NP_000 RAFHHHRFYLKMFEDYPKSRKALIPFIF 230 240 250 >>NP_001311251 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (212 aa) initn: 218 init1: 95 opt: 165 Z-score: 209.3 bits: 46.4 E(85289): 6.4e-05 Smith-Waterman score: 165; 33.9% identity (55.4% similar) in 121 aa overlap (206-318:105-212) 180 190 200 210 220 230 pF1KE5 TVLSQVPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHV--ILGNLRKNKAG :. . .: .. . : :: :::: : NP_001 CRSTSTPASPPRVSAARPTASSWPCSSSTTGIGFGLWLTGMLINIHSDHILRNLRK--PG 80 90 100 110 120 130 240 250 260 270 280 290 pF1KE5 VVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAF ...:: : ::::.. ::..:.: . ..:.. .: : .. : : NP_001 ---DTGYKIPRGGLFEYVTAANYFGEIMEWCGYALA------SW--SVQGAAFAFFTFCF 140 150 160 170 180 300 310 pF1KE5 LS------HQFYKSKFVSYPKHRKAFLPFLF :: :..: :: ::: :: ..:::: NP_001 LSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 190 200 210 >>NP_001038 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-dehyd (259 aa) initn: 241 init1: 95 opt: 165 Z-score: 208.2 bits: 46.4 E(85289): 7.4e-05 Smith-Waterman score: 165; 27.9% identity (50.7% similar) in 201 aa overlap (141-318:79-259) 120 130 140 150 160 pF1KE5 LLRILGAAQFQGGELALSAFLVLVFLWLHSLRRLFECLYVSVFSNVMIHVVQYCFGLVY- :: .:. ...: ..: . : :.: NP_001 RVPARAAWVVQELPSLALPLYQYASESAPRLRSAPNCILLAMF---LVHYGHRC--LIYP 50 60 70 80 90 100 170 180 190 200 210 pF1KE5 YVLVG------LTVLSQVPMDGRNAYITGKNLLMQA----RWF----HILGMMMFIWSSA ... : :. . . :.:. .. : : : ..:. . : .. NP_001 FLMRGGKPMPLLACTMAIMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGL--WLTG 110 120 130 140 150 160 220 230 240 250 260 270 pF1KE5 HQYKCHV--ILGNLRKNKAGVVIHCNHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFH . : :: :::: : ...:: : ::::.. ::..:.: . ..:.. NP_001 MLINIHSDHILRNLRK--PG---DTGYKIPRGGLFEYVTAANYFGEIMEWCGYALA---- 170 180 190 200 210 280 290 300 310 pF1KE5 NLTWWLVVTNVFFNQALSAFLS------HQFYKSKFVSYPKHRKAFLPFLF .: : .. : ::: :..: :: ::: :: ..:::: NP_001 --SW--SVQGAAFAFFTFCFLSGRAKEHHEWYLRKFEEYPKFRKIIIPFLF 220 230 240 250 >>NP_001311252 (OMIM: 184753) 3-oxo-5-alpha-steroid 4-de (186 aa) initn: 234 init1: 95 opt: 162 Z-score: 206.4 bits: 45.6 E(85289): 9.3e-05 Smith-Waterman score: 162; 34.5% identity (55.2% similar) in 116 aa overlap (211-318:84-186) 190 200 210 220 230 pF1KE5 VPMDGRNAYITGKNLLMQARWFHILGMMMFIWSSAHQYKCHV--ILGNLRKNKAGVVIHC .: .. . : :: ::: : : NP_001 NGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLR--KPG---DT 60 70 80 90 100 240 250 260 270 280 290 pF1KE5 NHRIPFGDWFEYVSSPNYLAELMIYVSMAVTFGFHNLTWWLVVTNVFFNQALSAFLS--- ...:: : ::::.. ::..:.: . ..:.. .: : .. : ::: NP_001 GYKIPRGGLFEYVTAANYFGEIMEWCGYALA------SW--SVQGAAFAFFTFCFLSGRA 110 120 130 140 150 160 300 310 pF1KE5 ---HQFYKSKFVSYPKHRKAFLPFLF :..: :: ::: :: ..:::: NP_001 KEHHEWYLRKFEEYPKFRKIIIPFLF 170 180 318 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 00:33:49 2016 done: Tue Nov 8 00:33:50 2016 Total Scan time: 6.120 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]