FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3759, 481 aa 1>>>pF1KE3759 481 - 481 aa - 481 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2545+/-0.000337; mu= 14.1693+/- 0.021 mean_var=103.2482+/-20.605, 0's: 0 Z-trim(117.1): 6 B-trim: 277 in 1/58 Lambda= 0.126221 statistics sampled from 28832 (28838) to 28832 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.707), E-opt: 0.2 (0.338), width: 16 Scan time: 9.020 The best scores are: opt bits E(85289) NP_060793 (OMIM: 612101) phosphatidylinositol 4-ki ( 481) 3306 612.6 7.5e-175 XP_005248231 (OMIM: 612101) PREDICTED: phosphatidy ( 476) 3253 603.0 6e-172 XP_005248232 (OMIM: 612101) PREDICTED: phosphatidy ( 385) 2670 496.7 4.6e-140 NP_060895 (OMIM: 609763) phosphatidylinositol 4-ki ( 479) 1852 347.8 3.8e-95 >>NP_060793 (OMIM: 612101) phosphatidylinositol 4-kinase (481 aa) initn: 3306 init1: 3306 opt: 3306 Z-score: 3260.1 bits: 612.6 E(85289): 7.5e-175 Smith-Waterman score: 3306; 99.8% identity (99.8% similar) in 481 aa overlap (1-481:1-481) 10 20 30 40 50 60 pF1KE3 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEELPLPPGDVGVSRSSPAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVG ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_060 DEELPLPPGDVGVSRSSSAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 IFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 IPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 IPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 GRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 GRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYII 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 RNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAY 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE3 PFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 PFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE3 MRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSS 430 440 450 460 470 480 pF1KE3 W : NP_060 W >>XP_005248231 (OMIM: 612101) PREDICTED: phosphatidylino (476 aa) initn: 1719 init1: 1719 opt: 3253 Z-score: 3208.0 bits: 603.0 E(85289): 6e-172 Smith-Waterman score: 3253; 98.8% identity (98.8% similar) in 481 aa overlap (1-481:1-476) 10 20 30 40 50 60 pF1KE3 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 DEELPLPPGDVGVSRSSPAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVG ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_005 DEELPLPPGDVGVSRSSSAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 IPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 GRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYII :::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_005 GRKFHRIGLPPK-----LFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYII 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 RNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAY 300 310 320 330 340 350 370 380 390 400 410 420 pF1KE3 PFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSV 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE3 MRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSS 420 430 440 450 460 470 pF1KE3 W : XP_005 W >>XP_005248232 (OMIM: 612101) PREDICTED: phosphatidylino (385 aa) initn: 2670 init1: 2670 opt: 2670 Z-score: 2635.5 bits: 496.7 E(85289): 4.6e-140 Smith-Waterman score: 2670; 100.0% identity (100.0% similar) in 385 aa overlap (97-481:1-385) 70 80 90 100 110 120 pF1KE3 PPGDVGVSRSSPAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVGIFPERI :::::::::::::::::::::::::::::: XP_005 MNAFLDDPEFADIMLRAEQAIEVGIFPERI 10 20 30 130 140 150 160 170 180 pF1KE3 SQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLIPNQGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLIPNQGY 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 LSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKVGRKFHR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKVGRKFHR 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 IGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYIIRNTDRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYIIRNTDRG 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 NDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAYPFHWAW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAYPFHWAW 220 230 240 250 260 270 370 380 390 400 410 420 pF1KE3 LPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSVMRGQIL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSVMRGQIL 280 290 300 310 320 330 430 440 450 460 470 480 pF1KE3 NLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSSW ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSSW 340 350 360 370 380 >>NP_060895 (OMIM: 609763) phosphatidylinositol 4-kinase (479 aa) initn: 1925 init1: 1172 opt: 1852 Z-score: 1829.2 bits: 347.8 E(85289): 3.8e-95 Smith-Waterman score: 1890; 59.8% identity (78.6% similar) in 490 aa overlap (17-481:9-479) 10 20 30 40 50 pF1KE3 MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAH-PRRGAPGSAVRLLDAAGEEGEA :::. . . .: . :: :. .::.:::. ::: . NP_060 MDETSPLVSPERAQPPDY--TFPSGSGAHFPQ--VPGGAVRVAAAAG----S 10 20 30 40 60 70 80 90 pF1KE3 GDEELPLPPGDVGVSRSSPAELDRSRPAV----SVTIGTS-------------------E : : :::. : .: :::.: :. . :.... : NP_060 G----PSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRE 50 60 70 80 90 100 100 110 120 130 140 150 pF1KE3 MNAFLDDPEFADIMLRAEQAIEVGIFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYG : : .:::: .. .:: ::: :::::: ::::::::::::. .::.:::::.::::: NP_060 RNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYG 110 120 130 140 150 160 160 170 180 190 200 210 pF1KE3 QLNPKWTKYVHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSET .:::::::...:.:::::::: ::. :::::::::: :::.::.:.:::.::::.:.::: NP_060 HLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASET 170 180 190 200 210 220 220 230 240 250 260 270 pF1KE3 FNYNAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEAD :::.::::.:::::. :::::::::..:.:::::::.:::::::::::.:.::::.:::. NP_060 FNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAE 230 240 250 260 270 280 280 290 300 310 320 330 pF1KE3 PLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVRYEKQKCEKEIDH-KESKWIDDEE ::::: .:. ::::::.::::::::::::::::..:. : . . ... :. .: NP_060 PLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYD---CPMDSSSSRDTDWVVVKE 290 300 310 320 330 340 350 360 370 380 390 pF1KE3 FLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDL .::.::::::::::.:::: ::::::.::::::::::::.::..:::: ::: :::.:: NP_060 PVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDL 340 350 360 370 380 390 400 410 420 430 440 450 pF1KE3 CEDLYELFKTDKGFDKATFESQMSVMRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGG :::::::: : :::.. :..:..:::::::::::::.:.:::..:::.: :::: ... NP_060 EEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSH 400 410 420 430 440 450 460 470 480 pF1KE3 SQGRIVHLSNSFTQTVNCRKPFFSSW ... :.:.::. . :::::: : NP_060 QRSS----SESYTQSFQSRKPFFSWW 460 470 481 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 07:05:24 2016 done: Sun Nov 6 07:05:25 2016 Total Scan time: 9.020 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]