FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9437, 363 aa 1>>>pF1KE9437 363 - 363 aa - 363 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8364+/-0.000345; mu= 19.6736+/- 0.021 mean_var=89.6297+/-20.262, 0's: 0 Z-trim(115.4): 316 B-trim: 1398 in 1/49 Lambda= 0.135472 statistics sampled from 25393 (25796) to 25393 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.302), width: 16 Scan time: 8.210 The best scores are: opt bits E(85289) NP_543009 (OMIM: 606921) G-protein coupled recepto ( 363) 2391 477.5 2.1e-134 NP_703143 (OMIM: 604847) G-protein coupled recepto ( 337) 1105 226.1 9.2e-59 NP_000862 (OMIM: 601109) 5-hydroxytryptamine recep ( 440) 307 70.2 9.7e-12 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 293 67.4 5.9e-11 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 290 66.8 8.5e-11 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 290 66.9 8.9e-11 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 290 66.9 9e-11 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 290 66.9 9.3e-11 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 290 66.9 9.6e-11 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 273 63.6 9.6e-10 XP_011534457 (OMIM: 606915) PREDICTED: probable G- ( 419) 261 61.2 4.8e-09 XP_006715633 (OMIM: 606915) PREDICTED: probable G- ( 419) 261 61.2 4.8e-09 NP_110411 (OMIM: 606915) probable G-protein couple ( 419) 261 61.2 4.8e-09 XP_011534455 (OMIM: 606915) PREDICTED: probable G- ( 419) 261 61.2 4.8e-09 XP_011534456 (OMIM: 606915) PREDICTED: probable G- ( 419) 261 61.2 4.8e-09 XP_011534461 (OMIM: 606915) PREDICTED: probable G- ( 419) 261 61.2 4.8e-09 XP_011534459 (OMIM: 606915) PREDICTED: probable G- ( 419) 261 61.2 4.8e-09 NP_001137429 (OMIM: 606915) probable G-protein cou ( 419) 261 61.2 4.8e-09 XP_016866823 (OMIM: 606915) PREDICTED: probable G- ( 419) 261 61.2 4.8e-09 NP_009158 (OMIM: 604838) probable G-protein couple ( 372) 240 57.1 7.6e-08 NP_000785 (OMIM: 126449) D(1A) dopamine receptor [ ( 446) 240 57.2 8.6e-08 NP_000789 (OMIM: 126453,143465,606798) D(1B) dopam ( 477) 234 56.0 2e-07 XP_016856596 (OMIM: 602392) PREDICTED: orexin rece ( 389) 229 54.9 3.5e-07 XP_011508789 (OMIM: 604153) PREDICTED: neuromedin- ( 403) 229 55.0 3.6e-07 XP_016856594 (OMIM: 602392) PREDICTED: orexin rece ( 425) 229 55.0 3.7e-07 XP_016856595 (OMIM: 602392) PREDICTED: orexin rece ( 425) 229 55.0 3.7e-07 NP_001516 (OMIM: 602392) orexin receptor type 1 [H ( 425) 229 55.0 3.7e-07 NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [ ( 426) 229 55.0 3.7e-07 NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 227 54.6 5.1e-07 XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 227 54.6 5.1e-07 NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 225 54.1 5.8e-07 NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 219 53.1 1.7e-06 NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 219 53.1 1.7e-06 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 217 52.6 1.7e-06 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 217 52.6 1.7e-06 NP_000016 (OMIM: 109691,601665) beta-3 adrenergic ( 408) 216 52.4 2.1e-06 NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 213 51.8 2.9e-06 XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 213 51.8 2.9e-06 NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 213 51.8 3e-06 NP_001040 (OMIM: 182451) somatostatin receptor typ ( 391) 213 51.8 3.1e-06 NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 213 51.8 3.1e-06 NP_001265426 (OMIM: 102776) adenosine receptor A2a ( 412) 213 51.8 3.2e-06 NP_000666 (OMIM: 102776) adenosine receptor A2a [H ( 412) 213 51.8 3.2e-06 NP_001265429 (OMIM: 102776) adenosine receptor A2a ( 412) 213 51.8 3.2e-06 NP_001265427 (OMIM: 102776) adenosine receptor A2a ( 412) 213 51.8 3.2e-06 NP_001265428 (OMIM: 102776) adenosine receptor A2a ( 412) 213 51.8 3.2e-06 NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 212 51.5 3.2e-06 XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 213 51.9 3.2e-06 XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 213 51.9 3.2e-06 XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 213 51.9 3.2e-06 >>NP_543009 (OMIM: 606921) G-protein coupled receptor 78 (363 aa) initn: 2391 init1: 2391 opt: 2391 Z-score: 2534.0 bits: 477.5 E(85289): 2.1e-134 Smith-Waterman score: 2391; 99.7% identity (99.7% similar) in 363 aa overlap (1-363:1-363) 10 20 30 40 50 60 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 PFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 RYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSLRLPPEPERPRFAAFTATLHAVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 RYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSLRLPPEPERPRFAAFTATLHAVG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 FVLPLAVLCLTSLQVHRVARSHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRAT :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_543 FVLPLAVLCLTSLQVHRVARRHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRAT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 RKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLRRP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 RKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLRRP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 FRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_543 FRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQ 310 320 330 340 350 360 pF1KE9 QTH ::: NP_543 QTH >>NP_703143 (OMIM: 604847) G-protein coupled receptor 26 (337 aa) initn: 1140 init1: 1094 opt: 1105 Z-score: 1176.0 bits: 226.1 E(85289): 9.2e-59 Smith-Waterman score: 1105; 52.3% identity (81.2% similar) in 329 aa overlap (1-327:1-323) 10 20 30 40 50 60 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDM :. .: :::::: ...:.:::::::::: .::..: .: ... .::. :.:: ....: NP_703 MNSWDAGLAGLLVGTMGVSLLSNALVLLCLLHSADIRRQAPALFTLNLTCGNLLCTVVNM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 PFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRP :.:: ::. : :.. :.. .:::::::.:. ::.:::: :.:.:: ::: : ...: NP_703 PLTLAGVVAQRQPAGDRLCRLAAFLDTFLAANSMLSMAALSIDRWVAVVFPLSYRAKMRL 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 RYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSL--RLPPEPERPRFAAFTATLHA : :.:... .: ..:.: .:::. ::::. . .:::.: : : : : :::.::...:: NP_703 RDAALMVAYTWLHALTFPAAALALSWLGFHQLYASCTLCSRRPDE--RLRFAVFTGAFHA 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 VGFVLPLAVLCLTSLQVHRVARSHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHR ..:.: ..::: : :.: .::: ::.:.:..::..:.::.:::::::.::: .:::::.: NP_703 LSFLLSFVVLCCTYLKVLKVARFHCKRIDVITMQTLVLLVDLHPSVRERCLEEQKRRRQR 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 ATRKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLR ::.::. :.:::.::::::.:::.:: : ....::.:::::.::::..:::.::::: NP_703 ATKKISTFIGTFLVCFAPYVITRLVELFSTVPIGSHWGVLSKCLAYSKAASDPFVYSLLR 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 RPFRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSC . .:. ...:::.: : :.:.: NP_703 HQYRKSCKEILNRLLHRR----SIHSSGLTGDSHSQNILPVSE 300 310 320 330 >>NP_000862 (OMIM: 601109) 5-hydroxytryptamine receptor (440 aa) initn: 193 init1: 149 opt: 307 Z-score: 331.7 bits: 70.2 E(85289): 9.7e-12 Smith-Waterman score: 307; 25.7% identity (57.0% similar) in 358 aa overlap (4-343:25-362) 10 20 30 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVL-LCCAYSAELRT : . .:. : .:.:.. .:.:.. : :. : ::. NP_000 MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPA-LRN 10 20 30 40 50 40 50 60 70 80 90 pF1KE9 RASGVLLVNLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVA .:. .::.: . :... . :: ..:... :: : : : . .:.. : . :.. NP_000 -TSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLC 60 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 ALSADQWLAVGFPLRYAGRLRP-RYAGLLLGCAWGQSLAFSGAALGCSW--LGYSSAFAS .: :..: . :::: :. : : .:.:: ::. . : : .: ::.. NP_000 LISLDRYLLILSPLRYKLRMTPLRALALVLG-AWSLAALASFLPLLLGWHELGHAR---- 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE9 CSLRLPPEPERPRF-AAFTATLHAVG--FVLPLAVLCLTSLQVHRVARSHCQRMDTVTM- :: : . :. :.. .: : : : :: ...:.: .. .::.. .. ..: NP_000 -----PPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTG 180 190 200 210 220 220 230 240 250 260 pF1KE9 ------KALALLADLHPSVR----QRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTR ..: . .:.:. .: ...:. .:. .:: .. :.. . :. .. NP_000 MASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVAN 230 240 250 260 270 280 270 280 290 300 310 320 pF1KE9 LAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPAS ... : . . .:. : : ... .:. : :. : :...:. :.: : : NP_000 IVQAVCDCISPGLFDVLTW-LGYCNSTMNPIIYPLFMRDFKRALG----RFL---PCPRC 290 300 310 320 330 340 330 340 350 360 pF1KE9 THDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQQTH .. . ..:. . . ::: NP_000 PRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLL 350 360 370 380 390 400 >>NP_955525 (OMIM: 602164) 5-hydroxytryptamine receptor (378 aa) initn: 176 init1: 102 opt: 293 Z-score: 317.7 bits: 67.4 E(85289): 5.9e-11 Smith-Waterman score: 293; 22.3% identity (56.9% similar) in 350 aa overlap (5-341:19-363) 10 20 30 40 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLV ...: .: :. .:.:.: ::.. .. .:: .. ..: NP_955 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 NLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWL .:... ::...: ::: . ... . : : ::..:.. . . . .: :.. NP_955 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 AVGF-PLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSW--LGYSSAFASCSLRLPPE :. :: : ... : .:.:: : .: . .: .: . . . .. . NP_955 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 PERPRFAA---FTATLHAVGFVLPLAVLCLTSLQVHRVARSHCQRMDTVTMKALALLADL : . .. : .:.: .:. .. :. ... .:. : .... . ..: : .. NP_955 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ-MLQRAGAS-SES 190 200 210 220 230 230 240 250 260 270 pF1KE9 HPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFV--TVNAQ-WGI .:. .. .. : . .:.. . : .. : .:.::. .: ... ::. :: .: : NP_955 RPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD--PFIDYTVPGQVWTA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE9 LSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPA----STHDSSLDVAGMV . : : .. .:: :..: . ::... .. .: ::. .. :. . : . NP_955 FLW-LGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGST 300 310 320 330 340 350 340 350 360 pF1KE9 HQLLKRTPRPASTHNGSVDTENDSCLQQTH : : .: NP_955 HVLSGCSPVSSFLLLFCNRPVPV 360 370 >>NP_001035262 (OMIM: 602164) 5-hydroxytryptamine recept (360 aa) initn: 176 init1: 102 opt: 290 Z-score: 314.8 bits: 66.8 E(85289): 8.5e-11 Smith-Waterman score: 290; 22.3% identity (57.1% similar) in 345 aa overlap (5-336:19-358) 10 20 30 40 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLV ...: .: :. .:.:.: ::.. .. .:: .. ..: NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 NLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWL .:... ::...: ::: . ... . : : ::..:.. . . . .: :.. NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 AVGF-PLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSW--LGYSSAFASCSLRLPPE :. :: : ... : .:.:: : .: . .: .: . . . .. . NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 PERPRFAA---FTATLHAVGFVLPLAVLCLTSLQVHRVARSHCQRMDTVTMKALALLADL : . .. : .:.: .:. .. :. ... .:. : .... . ..: : .. NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ-MLQRAGAS-SES 190 200 210 220 230 230 240 250 260 270 pF1KE9 HPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFV--TVNAQ-WGI .:. .. .. : . .:.. . : .. : .:.::. .: ... ::. :: .: : NP_001 RPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD--PFIDYTVPGQVWTA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE9 LSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPA----STHDSSLDVAGMV . : : .. .:: :..: . ::... .. .: ::. .. :. . : . NP_001 FLW-LGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGST 300 310 320 330 340 350 340 350 360 pF1KE9 HQLLKRTPRPASTHNGSVDTENDSCLQQTH : : NP_001 HVLRF 360 >>NP_001035259 (OMIM: 602164) 5-hydroxytryptamine recept (387 aa) initn: 176 init1: 102 opt: 290 Z-score: 314.4 bits: 66.9 E(85289): 8.9e-11 Smith-Waterman score: 290; 22.3% identity (57.1% similar) in 345 aa overlap (5-336:19-358) 10 20 30 40 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLV ...: .: :. .:.:.: ::.. .. .:: .. ..: NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 NLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWL .:... ::...: ::: . ... . : : ::..:.. . . . .: :.. NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 AVGF-PLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSW--LGYSSAFASCSLRLPPE :. :: : ... : .:.:: : .: . .: .: . . . .. . NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 PERPRFAA---FTATLHAVGFVLPLAVLCLTSLQVHRVARSHCQRMDTVTMKALALLADL : . .. : .:.: .:. .. :. ... .:. : .... . ..: : .. NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ-MLQRAGAS-SES 190 200 210 220 230 230 240 250 260 270 pF1KE9 HPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFV--TVNAQ-WGI .:. .. .. : . .:.. . : .. : .:.::. .: ... ::. :: .: : NP_001 RPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD--PFIDYTVPGQVWTA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE9 LSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPA----STHDSSLDVAGMV . : : .. .:: :..: . ::... .. .: ::. .. :. . : . NP_001 FLW-LGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGST 300 310 320 330 340 350 340 350 360 pF1KE9 HQLLKRTPRPASTHNGSVDTENDSCLQQTH : : NP_001 HVLRYTVLHRGHHQELEKLPIHNDPESLESCF 360 370 380 >>NP_000861 (OMIM: 602164) 5-hydroxytryptamine receptor (388 aa) initn: 176 init1: 102 opt: 290 Z-score: 314.4 bits: 66.9 E(85289): 9e-11 Smith-Waterman score: 290; 22.3% identity (57.1% similar) in 345 aa overlap (5-336:19-358) 10 20 30 40 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLV ...: .: :. .:.:.: ::.. .. .:: .. ..: NP_000 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 NLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWL .:... ::...: ::: . ... . : : ::..:.. . . . .: :.. NP_000 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 AVGF-PLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSW--LGYSSAFASCSLRLPPE :. :: : ... : .:.:: : .: . .: .: . . . .. . NP_000 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 PERPRFAA---FTATLHAVGFVLPLAVLCLTSLQVHRVARSHCQRMDTVTMKALALLADL : . .. : .:.: .:. .. :. ... .:. : .... . ..: : .. NP_000 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ-MLQRAGAS-SES 190 200 210 220 230 230 240 250 260 270 pF1KE9 HPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFV--TVNAQ-WGI .:. .. .. : . .:.. . : .. : .:.::. .: ... ::. :: .: : NP_000 RPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD--PFIDYTVPGQVWTA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE9 LSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPA----STHDSSLDVAGMV . : : .. .:: :..: . ::... .. .: ::. .. :. . : . NP_000 FLW-LGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGST 300 310 320 330 340 350 340 350 360 pF1KE9 HQLLKRTPRPASTHNGSVDTENDSCLQQTH : : NP_000 HVLRDAVECGGQWESQCHPPATSPLVAAQPSDT 360 370 380 >>NP_001273339 (OMIM: 602164) 5-hydroxytryptamine recept (411 aa) initn: 176 init1: 102 opt: 290 Z-score: 314.1 bits: 66.9 E(85289): 9.3e-11 Smith-Waterman score: 290; 22.3% identity (57.1% similar) in 345 aa overlap (5-336:19-358) 10 20 30 40 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLV ...: .: :. .:.:.: ::.. .. .:: .. ..: NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 NLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWL .:... ::...: ::: . ... . : : ::..:.. . . . .: :.. NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 AVGF-PLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSW--LGYSSAFASCSLRLPPE :. :: : ... : .:.:: : .: . .: .: . . . .. . NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 PERPRFAA---FTATLHAVGFVLPLAVLCLTSLQVHRVARSHCQRMDTVTMKALALLADL : . .. : .:.: .:. .. :. ... .:. : .... . ..: : .. NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ-MLQRAGAS-SES 190 200 210 220 230 230 240 250 260 270 pF1KE9 HPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFV--TVNAQ-WGI .:. .. .. : . .:.. . : .. : .:.::. .: ... ::. :: .: : NP_001 RPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD--PFIDYTVPGQVWTA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE9 LSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPA----STHDSSLDVAGMV . : : .. .:: :..: . ::... .. .: ::. .. :. . : . NP_001 FLW-LGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGST 300 310 320 330 340 350 340 350 360 pF1KE9 HQLLKRTPRPASTHNGSVDTENDSCLQQTH : : NP_001 HVLSSGTETDRKKLWNKEEKIDQTIQMPKRKRKKKASLSYEDLILLGRKSCFREGK 360 370 380 390 400 410 >>NP_001035263 (OMIM: 602164) 5-hydroxytryptamine recept (428 aa) initn: 176 init1: 102 opt: 290 Z-score: 313.9 bits: 66.9 E(85289): 9.6e-11 Smith-Waterman score: 290; 22.3% identity (57.1% similar) in 345 aa overlap (5-336:19-358) 10 20 30 40 pF1KE9 MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLV ...: .: :. .:.:.: ::.. .. .:: .. ..: NP_001 MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 NLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWL .:... ::...: ::: . ... . : : ::..:.. . . . .: :.. NP_001 SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 AVGF-PLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSW--LGYSSAFASCSLRLPPE :. :: : ... : .:.:: : .: . .: .: . . . .. . NP_001 AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 PERPRFAA---FTATLHAVGFVLPLAVLCLTSLQVHRVARSHCQRMDTVTMKALALLADL : . .. : .:.: .:. .. :. ... .:. : .... . ..: : .. NP_001 STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQ-MLQRAGAS-SES 190 200 210 220 230 230 240 250 260 270 pF1KE9 HPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFV--TVNAQ-WGI .:. .. .. : . .:.. . : .. : .:.::. .: ... ::. :: .: : NP_001 RPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVD--PFIDYTVPGQVWTA 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE9 LSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPA----STHDSSLDVAGMV . : : .. .:: :..: . ::... .. .: ::. .. :. . : . NP_001 FLW-LGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGST 300 310 320 330 340 350 340 350 360 pF1KE9 HQLLKRTPRPASTHNGSVDTENDSCLQQTH : : NP_001 HVLRTDFLFDRDILARYWTKPARAGPFSGTLSIRCLTARKPVLGDAVECGGQWESQCHPP 360 370 380 390 400 410 >>NP_937822 (OMIM: 606925) pyroglutamylated RFamide pept (431 aa) initn: 88 init1: 67 opt: 273 Z-score: 295.9 bits: 63.6 E(85289): 9.6e-10 Smith-Waterman score: 273; 20.6% identity (57.5% similar) in 339 aa overlap (3-326:41-365) 10 20 30 pF1KE9 MGPGEALLAGLL--VMVLAVALLSNALVLLCC ::.: :: .: :...:.::..::::. NP_937 FSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVV 20 30 40 50 60 70 40 50 60 70 80 90 pF1KE9 AYSAELRTRASGVLLVNLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLA . : .:: ...... .:.:. ::.. . .: :.: . .. :... :... . NP_937 TRSKAMRT-VTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAV 80 90 100 110 120 100 110 120 130 140 150 pF1KE9 SNAALSVAALSADQWLAVGFPLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSWLGYS . :... ..... .. :... . : : .:: .: .. .. . : . NP_937 VTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIK 130 140 150 160 170 180 160 170 180 190 200 pF1KE9 SAFAS-----CSLRLPPEPERPRFAAFTATLHAVGFVLPLAVLCLTSLQVHRVARSHCQR : : :. : . .. .:. . .. :.::: :. . .. . . NP_937 YDFLYEKEHICCLEEWTSPVHQKI--YTTFILVILFLLPLMVMLILYSKIGYELWIKKRV 190 200 210 220 230 240 210 220 230 240 250 260 pF1KE9 MDTVTMKALALLADLHPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPY-VMTRLAE : ... ... . . . :...::. . ..: : .:.::. :. . : NP_937 GDGSVLR----------TIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIE 250 260 270 280 290 270 280 290 300 310 pF1KE9 LVPF------VTVNAQWGILSKCLTYSKAVADPFTYSLLRRPFRQ-VLAGMVHRLLKRTP : ::.. ..:. . . .:... .:..:... . :.. ::... . ....: NP_937 YSNFEKEYDDVTIKMIFAIV-QIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTF 300 310 320 330 340 350 320 330 340 350 360 pF1KE9 RPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQQTH ::. : .: NP_937 SPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLAL 360 370 380 390 400 410 363 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 17:33:06 2016 done: Sun Nov 6 17:33:07 2016 Total Scan time: 8.210 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]