FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4031, 242 aa 1>>>pF1KE4031 242 - 242 aa - 242 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7808+/-0.00041; mu= 14.6358+/- 0.026 mean_var=142.6699+/-31.097, 0's: 0 Z-trim(116.0): 108 B-trim: 2052 in 2/51 Lambda= 0.107376 statistics sampled from 26716 (26860) to 26716 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.69), E-opt: 0.2 (0.315), width: 16 Scan time: 5.900 The best scores are: opt bits E(85289) NP_116062 (OMIM: 610231) polycomb group RING finge ( 259) 448 80.6 2.9e-15 NP_009075 (OMIM: 600346) polycomb group RING finge ( 344) 426 77.3 3.7e-14 XP_005257698 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 426 77.3 3.7e-14 XP_005257699 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 426 77.3 3.7e-14 XP_005257697 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 426 77.3 3.7e-14 XP_016880505 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 426 77.3 3.7e-14 NP_005171 (OMIM: 164831) polycomb complex protein ( 326) 415 75.6 1.2e-13 NP_001011663 (OMIM: 607816) polycomb group RING fi ( 350) 411 75.0 1.9e-13 NP_115530 (OMIM: 607816) polycomb group RING finge ( 275) 291 56.3 6.4e-08 >>NP_116062 (OMIM: 610231) polycomb group RING finger pr (259 aa) initn: 612 init1: 448 opt: 448 Z-score: 394.9 bits: 80.6 E(85289): 2.9e-15 Smith-Waterman score: 599; 40.8% identity (69.3% similar) in 238 aa overlap (5-238:35-255) 10 20 30 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECL ..:. :.: ::.: ::.::..::::.:::: NP_116 QGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECL 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE4 HTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQR ::::.::.::::. .. :: : : ::...:: . ::.:::::::::::::..: .. : NP_116 HTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIR 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE4 EFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQ :::.. :.. . :: . :.. .. : :. . :.: ::: NP_116 EFYQSRGLDRVTQPTGE----EPALSNLGLPFSSFDHSKAH------------YYRYDEQ 130 140 150 160 160 170 180 190 200 210 pF1KE4 VSICLE-CNSSKLRG---LKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEIL ...::: .:.: .. :. :..:::..: : ::.. . ..: :. .....: ..:.: NP_116 LNLCLERLSSGKDKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNP-QHVQLLFDNEVL 170 180 190 200 210 220 220 230 240 pF1KE4 GKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL :.: . ..:: : .::::.: : NP_116 PDHMTMKQIWLSRWFGKPSPLLLQYSVKEKRR 230 240 250 >>NP_009075 (OMIM: 600346) polycomb group RING finger pr (344 aa) initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14 Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228) 10 20 30 40 50 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI : .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . . NP_009 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH :...:: : :.:.::::::::::: . ::...:.:: . :::. : . . . NP_009 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA :.... : . :. . . .: : ... :: ... . ...:: : NP_009 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP ::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.:: NP_009 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV 180 190 200 210 220 240 pF1KE4 KMDLL NP_009 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS 230 240 250 260 270 280 >>XP_005257698 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14 Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228) 10 20 30 40 50 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI : .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . . XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH :...:: : :.:.::::::::::: . ::...:.:: . :::. : . . . XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA :.... : . :. . . .: : ... :: ... . ...:: : XP_005 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP ::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.:: XP_005 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV 180 190 200 210 220 240 pF1KE4 KMDLL XP_005 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS 230 240 250 260 270 280 >>XP_005257699 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14 Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228) 10 20 30 40 50 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI : .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . . XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH :...:: : :.:.::::::::::: . ::...:.:: . :::. : . . . XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA :.... : . :. . . .: : ... :: ... . ...:: : XP_005 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP ::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.:: XP_005 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV 180 190 200 210 220 240 pF1KE4 KMDLL XP_005 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS 230 240 250 260 270 280 >>XP_005257697 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14 Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228) 10 20 30 40 50 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI : .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . . XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH :...:: : :.:.::::::::::: . ::...:.:: . :::. : . . . XP_005 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA :.... : . :. . . .: : ... :: ... . ...:: : XP_005 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP ::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.:: XP_005 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV 180 190 200 210 220 240 pF1KE4 KMDLL XP_005 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS 230 240 250 260 270 280 >>XP_016880505 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 530 init1: 419 opt: 426 Z-score: 375.1 bits: 77.3 E(85289): 3.7e-14 Smith-Waterman score: 528; 36.4% identity (66.9% similar) in 236 aa overlap (3-236:4-228) 10 20 30 40 50 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI : .::. ..: :. : ::.::.:::::..::::.::..:.:.::: :. :: : . . XP_016 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIVRYLETNKYCPMCDVQV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGM-EVPGDIKGETCSAKQH :...:: : :.:.::::::::::: . ::...:.:: . :::. : . . . XP_016 HKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPLTEVPN---GSNEDRGEV 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 LDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSA :.... : . :. . . .: : ... :: ... . ...:: : XP_016 LEQEK-GALSDDEIVSLSIEFYEGARDRDEKKGP------LENGDGDKEKTGVRFLRCPA 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE4 QATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHYRP ::.:: ::. .:... : ....: ..: : . .:: .. . :: ...:: :.:: XP_016 AMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYIYPWR-RNGPLPLKYRV 180 190 200 210 220 240 pF1KE4 KMDLL XP_016 QPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSLPSPATPSHGSPSS 230 240 250 260 270 280 >>NP_005171 (OMIM: 164831) polycomb complex protein BMI- (326 aa) initn: 558 init1: 412 opt: 415 Z-score: 366.2 bits: 75.6 E(85289): 1.2e-13 Smith-Waterman score: 524; 36.6% identity (66.0% similar) in 238 aa overlap (3-236:4-226) 10 20 30 40 50 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVI : .::. ..: :. : ::.::.:::::. ::::.::..:.:.::: .. :: : . . NP_005 MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQV 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE4 HQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHL :...:: : :.:.::::::::::: . ::...:.:: . .: . NP_005 HKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFY----------AAHPSADAANGS 70 80 90 100 110 120 130 140 150 160 170 pF1KE4 DSHRNGETKADDS---SNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRC . : ::. .:. .. : . : : .: :..:. . ..:: . ....:: NP_005 NEDR-GEVADEDKRIITDDEIISLSIEF-FDQNRLDRKVN--KDKEKSKEEVNDKRYLRC 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 SAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTL-KFVVVTRWRFKKAPLLLHY : ::.::.::. .:... . ..:.. .:: : .:: .. . :: ...:: :.: NP_005 PAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWR-RNGPLPLKY 170 180 190 200 210 220 240 pF1KE4 RPKMDLL : NP_005 RVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQ 230 240 250 260 270 280 >>NP_001011663 (OMIM: 607816) polycomb group RING finger (350 aa) initn: 532 init1: 411 opt: 411 Z-score: 362.5 bits: 75.0 E(85289): 1.9e-13 Smith-Waterman score: 506; 36.3% identity (67.9% similar) in 234 aa overlap (4-235:121-340) 10 20 30 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTEC : :.: ... .: : .:.::::::::.::: NP_001 EEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITEC 100 110 120 130 140 150 40 50 60 70 80 90 pF1KE4 LHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQ :::::.::.:... .: :: : ::.::..:: : :: .:::::::: .:.: : ... NP_001 LHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQM 160 170 180 190 200 210 100 110 120 130 140 150 pF1KE4 REFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDE ..::.. :.::: .. : . : .. :. .: . :: : : NP_001 HDFYKERGLEVPKP------AVPQPVPSSKGRSKKVLESVFRI----PPELDM----SLL 220 230 240 250 160 170 180 190 200 210 pF1KE4 QVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKD : . ...... :..:..: :..::. :..::. .:..:. ..::.:....: . NP_001 LEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQY 260 270 280 290 300 310 220 230 240 pF1KE4 HTLKFV--VVTRWRFKKAPLLLHYRPKMDLL .::. . .. .. . :.::: NP_001 QTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT 320 330 340 350 >>NP_115530 (OMIM: 607816) polycomb group RING finger pr (275 aa) initn: 407 init1: 286 opt: 291 Z-score: 263.2 bits: 56.3 E(85289): 6.4e-08 Smith-Waterman score: 291; 42.1% identity (69.2% similar) in 107 aa overlap (4-103:121-224) 10 20 30 pF1KE4 MLTRKIKLWDINAHITCRLCSGYLIDATTVTEC : :.: ... .: : .:.::::::::.::: NP_115 EEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITEC 100 110 120 130 140 150 40 50 60 70 80 pF1KE4 LHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYI------GHDRTMQDIVYKLVPGLQE :::::.::.:... .: :: : ::.::..:: : :: . .. . : : : NP_115 LHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNISANEGTGHFKPLEKKFVR-VSG--E 160 170 180 190 200 90 100 110 120 130 140 pF1KE4 AEMRKQREFYH-KLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDN : . . ..: . :.:.. NP_115 ATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGL 210 220 230 240 250 260 242 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 04:18:19 2016 done: Sun Nov 6 04:18:20 2016 Total Scan time: 5.900 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]