FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4428, 445 aa 1>>>pF1KE4428 445 - 445 aa - 445 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.4037+/-0.000378; mu= 17.1425+/- 0.023 mean_var=70.4237+/-14.561, 0's: 0 Z-trim(114.3): 13 B-trim: 1123 in 2/50 Lambda= 0.152832 statistics sampled from 24036 (24049) to 24036 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.282), width: 16 Scan time: 8.730 The best scores are: opt bits E(85289) NP_000178 (OMIM: 203500,607474) homogentisate 1,2- ( 445) 3129 699.1 5.9e-201 XP_005247470 (OMIM: 203500,607474) PREDICTED: homo ( 338) 2348 526.9 3.2e-149 XP_016861766 (OMIM: 203500,607474) PREDICTED: homo ( 304) 2130 478.8 8.7e-135 XP_011511048 (OMIM: 203500,607474) PREDICTED: homo ( 294) 2052 461.6 1.3e-129 XP_005247471 (OMIM: 203500,607474) PREDICTED: homo ( 233) 1525 345.3 1e-94 XP_005247469 (OMIM: 203500,607474) PREDICTED: homo ( 370) 1330 302.4 1.3e-81 >>NP_000178 (OMIM: 203500,607474) homogentisate 1,2-diox (445 aa) initn: 3129 init1: 3129 opt: 3129 Z-score: 3728.8 bits: 699.1 E(85289): 5.9e-201 Smith-Waterman score: 3129; 99.8% identity (100.0% similar) in 445 aa overlap (1-445:1-445) 10 20 30 40 50 60 pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: NP_000 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD 370 380 390 400 410 420 430 440 pF1KE4 ENYHKCWEPLKSHFTPNSRNPAEPN ::::::::::::::::::::::::: NP_000 ENYHKCWEPLKSHFTPNSRNPAEPN 430 440 >>XP_005247470 (OMIM: 203500,607474) PREDICTED: homogent (338 aa) initn: 2348 init1: 2348 opt: 2348 Z-score: 2799.9 bits: 526.9 E(85289): 3.2e-149 Smith-Waterman score: 2348; 99.7% identity (100.0% similar) in 335 aa overlap (1-335:1-335) 10 20 30 40 50 60 pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_005 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG ::::::::::::::::::::::::::::::::::: XP_005 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHNLA 310 320 330 370 380 390 400 410 420 pF1KE4 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD >>XP_016861766 (OMIM: 203500,607474) PREDICTED: homogent (304 aa) initn: 2130 init1: 2130 opt: 2130 Z-score: 2540.8 bits: 478.8 E(85289): 8.7e-135 Smith-Waterman score: 2130; 100.0% identity (100.0% similar) in 304 aa overlap (142-445:1-304) 120 130 140 150 160 170 pF1KE4 FVSGLHTLCGAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGK :::::::::::::::::::::::::::::: XP_016 MENRCFYNSDGDFLIVPQKGNLLIYTEFGK 10 20 30 180 190 200 210 220 230 pF1KE4 MLVQPNEICVIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLVQPNEICVIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPI 40 50 60 70 80 90 240 250 260 270 280 290 pF1KE4 AWYEDRQVPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AWYEDRQVPGGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFD 100 110 120 130 140 150 300 310 320 330 340 350 pF1KE4 HADPSIFTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HADPSIFTVLTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYE 160 170 180 190 200 210 360 370 380 390 400 410 pF1KE4 AKQGGFLPGGGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AKQGGFLPGGGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKW 220 230 240 250 260 270 420 430 440 pF1KE4 GLKASRCLDENYHKCWEPLKSHFTPNSRNPAEPN :::::::::::::::::::::::::::::::::: XP_016 GLKASRCLDENYHKCWEPLKSHFTPNSRNPAEPN 280 290 300 >>XP_011511048 (OMIM: 203500,607474) PREDICTED: homogent (294 aa) initn: 2052 init1: 2052 opt: 2052 Z-score: 2448.1 bits: 461.6 E(85289): 1.3e-129 Smith-Waterman score: 2052; 99.7% identity (100.0% similar) in 293 aa overlap (1-293:1-293) 10 20 30 40 50 60 pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_011 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHAI 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG >>XP_005247471 (OMIM: 203500,607474) PREDICTED: homogent (233 aa) initn: 1524 init1: 1524 opt: 1525 Z-score: 1821.6 bits: 345.3 E(85289): 1e-94 Smith-Waterman score: 1525; 96.0% identity (97.8% similar) in 227 aa overlap (1-227:1-225) 10 20 30 40 50 60 pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_005 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP :::::::::::::::::::::::::::::::::::: . :: :. . XP_005 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIDSLGL--PKRYQTGNAVNL 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV >>XP_005247469 (OMIM: 203500,607474) PREDICTED: homogent (370 aa) initn: 1330 init1: 1330 opt: 1330 Z-score: 1586.2 bits: 302.4 E(85289): 1.3e-81 Smith-Waterman score: 2453; 82.9% identity (83.1% similar) in 445 aa overlap (1-445:1-370) 10 20 30 40 50 60 pF1KE4 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAELKYISGFGNECSSEDPRCPGSLPEGQNNPQVCPYNLYAEQLSGSAFTCPRSTNKRSW 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 LYRILPSVSHKPFESIDEGHVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_005 LYRILPSVSHKPFESIDEGQVTHNWDEVDPDPNQLRWKPFEIPKASQKKVDFVSGLHTLC 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GAGDIKSNNGLAIHIFLCNTSMENRCFYNSDGDFLIVPQKGNLLIYTEFGKMLVQPNEIC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 VIQRGMRFSIDVFEETRGYILEVYGVHFELPDLGPIGANGLANPRDFLIPIAWYEDRQVP ::: XP_005 VIQ--------------------------------------------------------- 250 260 270 280 290 300 pF1KE4 GGYTVINKYQGKLFAAKQDVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV :::::::::::::::::::::::::::::::::::::::::: XP_005 ------------------DVSPFNVVAWHGNYTPYKYNLKNFMVINSVAFDHADPSIFTV 190 200 210 220 310 320 330 340 350 360 pF1KE4 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LTAKSVRPGVAIADFVIFPPRWGVADKTFRPPYYHRNCMSEFMGLIRGHYEAKQGGFLPG 230 240 250 260 270 280 370 380 390 400 410 420 pF1KE4 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGSLHSTMTPHGPDADCFEKASKVKLAPERIADGTMAFMFESSLSLAVTKWGLKASRCLD 290 300 310 320 330 340 430 440 pF1KE4 ENYHKCWEPLKSHFTPNSRNPAEPN ::::::::::::::::::::::::: XP_005 ENYHKCWEPLKSHFTPNSRNPAEPN 350 360 370 445 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 00:40:22 2016 done: Sun Nov 6 00:40:23 2016 Total Scan time: 8.730 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]