FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE5245, 187 aa 1>>>pF1KE5245 187 - 187 aa - 187 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7517+/-0.000307; mu= 15.7315+/- 0.019 mean_var=56.9140+/-11.371, 0's: 0 Z-trim(115.6): 11 B-trim: 0 in 0/52 Lambda= 0.170006 statistics sampled from 26154 (26165) to 26154 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.307), width: 16 Scan time: 5.910 The best scores are: opt bits E(85289) NP_789785 (OMIM: 616588) dihydrofolate reductase, ( 187) 1249 314.0 8.8e-86 XP_011510839 (OMIM: 616588) PREDICTED: dihydrofola ( 187) 1249 314.0 8.8e-86 NP_001182572 (OMIM: 616588) dihydrofolate reductas ( 187) 1249 314.0 8.8e-86 NP_000782 (OMIM: 126060,613839) dihydrofolate redu ( 187) 1130 284.8 5.4e-77 NP_001277283 (OMIM: 126060,613839) dihydrofolate r ( 135) 821 209.0 2.7e-54 NP_001277286 (OMIM: 126060,613839) dihydrofolate r ( 129) 759 193.7 9.9e-50 >>NP_789785 (OMIM: 616588) dihydrofolate reductase, mito (187 aa) initn: 1249 init1: 1249 opt: 1249 Z-score: 1661.0 bits: 314.0 E(85289): 8.8e-86 Smith-Waterman score: 1249; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_789 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF 130 140 150 160 170 180 pF1KE5 EVCEKDD ::::::: NP_789 EVCEKDD >>XP_011510839 (OMIM: 616588) PREDICTED: dihydrofolate r (187 aa) initn: 1249 init1: 1249 opt: 1249 Z-score: 1661.0 bits: 314.0 E(85289): 8.8e-86 Smith-Waterman score: 1249; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF 130 140 150 160 170 180 pF1KE5 EVCEKDD ::::::: XP_011 EVCEKDD >>NP_001182572 (OMIM: 616588) dihydrofolate reductase, m (187 aa) initn: 1249 init1: 1249 opt: 1249 Z-score: 1661.0 bits: 314.0 E(85289): 8.8e-86 Smith-Waterman score: 1249; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF 130 140 150 160 170 180 pF1KE5 EVCEKDD ::::::: NP_001 EVCEKDD >>NP_000782 (OMIM: 126060,613839) dihydrofolate reductas (187 aa) initn: 1130 init1: 1130 opt: 1130 Z-score: 1503.3 bits: 284.8 E(85289): 5.4e-77 Smith-Waterman score: 1130; 93.4% identity (96.2% similar) in 183 aa overlap (5-187:5-187) 10 20 30 40 50 60 pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS :::::::::::::::::::: :::::::::::::::::::::::::::::.::::: NP_000 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS ::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.::::::: NP_000 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF :::::::: :::::::::::::::::::: :::::::::::::::::::::: : ::::: NP_000 VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF 130 140 150 160 170 180 pF1KE5 EVCEKDD :: ::.: NP_000 EVYEKND >>NP_001277283 (OMIM: 126060,613839) dihydrofolate reduc (135 aa) initn: 836 init1: 821 opt: 821 Z-score: 1095.7 bits: 209.0 E(85289): 2.7e-54 Smith-Waterman score: 821; 91.9% identity (95.6% similar) in 135 aa overlap (53-187:1-135) 30 40 50 60 70 80 pF1KE5 LPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINLVLSRELKE ::.:::::::::::::: :::::::::::: NP_001 MGKKTWFSIPEKNRPLKGRINLVLSRELKE 10 20 30 90 100 110 120 130 140 pF1KE5 PPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSSVYKEAMNHLGHLKLFVTRIMQD ::::::::.:::::::::::.:::::::::.::::::::::::::: ::::::::::::: NP_001 PPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQD 40 50 60 70 80 90 150 160 170 180 pF1KE5 FESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKFEVCEKDD ::::::: :::::::::::::::::::::: : ::::::: ::.: NP_001 FESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND 100 110 120 130 >>NP_001277286 (OMIM: 126060,613839) dihydrofolate reduc (129 aa) initn: 759 init1: 759 opt: 759 Z-score: 1013.8 bits: 193.7 E(85289): 9.9e-50 Smith-Waterman score: 759; 95.0% identity (98.3% similar) in 119 aa overlap (5-123:5-123) 10 20 30 40 50 60 pF1KE5 MFLLLNCIVAVSQNMGIGKNGDLPRPPLRNEFRYFQRMTTTSSVEGKQNLVIMGRKTWFS :::::::::::::::::::: :::::::::::::::::::::::::::::.::::: NP_001 MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE5 IPEKNRPLKDRINLVLSRELKEPPQGAHFLARSLDDALKLTERPELANKVDMIWIVGGSS ::::::::: ::::::::::::::::::::.:::::::::::.:::::::::.::::::: NP_001 IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE5 VYKEAMNHLGHLKLFVTRIMQDFESDTFFSEIDLEKYKLLPEYPGVLSDVQEGKHIKYKF ::: NP_001 VYKIPRCSL 187 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 22:50:04 2016 done: Mon Nov 7 22:50:05 2016 Total Scan time: 5.910 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]