FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3038, 173 aa 1>>>pF1KE3038 173 - 173 aa - 173 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.6105+/-0.000404; mu= 16.0338+/- 0.025 mean_var=58.4325+/-12.165, 0's: 0 Z-trim(110.0): 38 B-trim: 0 in 0/51 Lambda= 0.167783 statistics sampled from 18300 (18331) to 18300 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.588), E-opt: 0.2 (0.215), width: 16 Scan time: 5.120 The best scores are: opt bits E(85289) NP_849199 (OMIM: 607891) CKLF-like MARVEL transmem ( 173) 1116 278.4 3.9e-75 XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like M ( 196) 827 208.5 4.9e-54 XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like M ( 130) 825 207.9 5e-54 XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like M ( 100) 659 167.6 5.1e-42 NP_001307237 (OMIM: 607891) CKLF-like MARVEL trans ( 115) 445 115.9 2.2e-26 NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens ( 182) 409 107.3 1.3e-23 NP_005425 (OMIM: 602022) MAL-like protein [Homo sa ( 153) 228 63.4 1.8e-10 NP_002362 (OMIM: 188860) myelin and lymphocyte pro ( 153) 227 63.2 2.1e-10 XP_011510111 (OMIM: 602022) PREDICTED: MAL-like pr ( 149) 218 61.0 9.5e-10 NP_852662 (OMIM: 607887) CKLF-like MARVEL transmem ( 208) 194 55.3 6.9e-08 XP_016878443 (OMIM: 607887) PREDICTED: CKLF-like M ( 221) 194 55.3 7.2e-08 NP_848933 (OMIM: 607887) CKLF-like MARVEL transmem ( 234) 194 55.3 7.5e-08 NP_443118 (OMIM: 609684) protein MAL2 [Homo sapien ( 176) 186 53.3 2.3e-07 XP_011521184 (OMIM: 607887) PREDICTED: CKLF-like M ( 179) 159 46.8 2.2e-05 NP_071883 (OMIM: 188860) myelin and lymphocyte pro ( 111) 148 44.0 9.5e-05 XP_016876442 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 127 39.0 0.0042 NP_612469 (OMIM: 607888) CKLF-like MARVEL transmem ( 156) 127 39.0 0.0042 XP_016876443 (OMIM: 607888) PREDICTED: CKLF-like M ( 156) 127 39.0 0.0042 NP_113672 (OMIM: 616970) MARVEL domain-containing ( 173) 124 38.3 0.0075 >>NP_849199 (OMIM: 607891) CKLF-like MARVEL transmembran (173 aa) initn: 1116 init1: 1116 opt: 1116 Z-score: 1469.9 bits: 278.4 E(85289): 3.9e-75 Smith-Waterman score: 1116; 98.8% identity (98.8% similar) in 173 aa overlap (1-173:1-173) 10 20 30 40 50 60 pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIA :::::::::::::::::::::::::::::::::::::::: ::::::::::::::::::: NP_849 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEIVLGLLVWTLIA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 GTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL :::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::: NP_849 GTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL 70 80 90 100 110 120 130 140 150 160 170 pF1KE3 SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_849 SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ 130 140 150 160 170 >>XP_011531718 (OMIM: 607891) PREDICTED: CKLF-like MARVE (196 aa) initn: 846 init1: 827 opt: 827 Z-score: 1091.1 bits: 208.5 E(85289): 4.9e-54 Smith-Waterman score: 1060; 87.2% identity (87.2% similar) in 196 aa overlap (1-173:1-196) 10 20 30 40 pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEI----------- :::::::::::::::::::::::::::::::::::::::: :::::::: XP_011 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEILISLPITDPLH 10 20 30 40 50 60 50 60 70 80 90 pF1KE3 ------------VLGLLVWTLIAGTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYT ::::::::::::::::::::::::::::: :::::::::::::::::: XP_011 RSALSTTARDILVLGLLVWTLIAGTEYFRVPAFGWVMFVAVFYWVLTVFFLIIYITMTYT 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 RIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYA 130 140 150 160 170 180 160 170 pF1KE3 GNTYFSFIAWRSRTIQ :::::::::::::::: XP_011 GNTYFSFIAWRSRTIQ 190 >>XP_016861268 (OMIM: 607891) PREDICTED: CKLF-like MARVE (130 aa) initn: 825 init1: 825 opt: 825 Z-score: 1090.9 bits: 207.9 E(85289): 5e-54 Smith-Waterman score: 825; 99.2% identity (99.2% similar) in 124 aa overlap (50-173:7-130) 20 30 40 50 60 70 pF1KE3 AENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAVS ::::::::::::::::::::::::::::: XP_016 MFRRIQVLGLLVWTLIAGTEYFRVPAFGWVMFVAVF 10 20 30 80 90 100 110 120 130 pF1KE3 YWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNF 40 50 60 70 80 90 140 150 160 170 pF1KE3 NSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ :::::::::::::::::::::::::::::::::: XP_016 NSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ 100 110 120 130 >>XP_016861269 (OMIM: 607891) PREDICTED: CKLF-like MARVE (100 aa) initn: 659 init1: 659 opt: 659 Z-score: 875.3 bits: 167.6 E(85289): 5.1e-42 Smith-Waterman score: 659; 99.0% identity (99.0% similar) in 100 aa overlap (74-173:1-100) 50 60 70 80 90 100 pF1KE3 LIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVP ::::: :::::::::::::::::::::::: XP_016 MFVAVFYWVLTVFFLIIYITMTYTRIPQVP 10 20 30 110 120 130 140 150 160 pF1KE3 WTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 WTTVGLCFNGSAFVLYLSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFS 40 50 60 70 80 90 170 pF1KE3 FIAWRSRTIQ :::::::::: XP_016 FIAWRSRTIQ 100 >>NP_001307237 (OMIM: 607891) CKLF-like MARVEL transmemb (115 aa) initn: 464 init1: 445 opt: 445 Z-score: 594.5 bits: 115.9 E(85289): 2.2e-26 Smith-Waterman score: 606; 65.9% identity (65.9% similar) in 173 aa overlap (1-173:1-115) 10 20 30 40 50 60 pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIA :::::::::::::::::::::::::::::::::::::::: :::::::: NP_001 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLPGFLIVAEI----------- 10 20 30 40 70 80 90 100 110 120 pF1KE3 GTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL ::::::::::::: NP_001 -----------------------------------------------GLCFNGSAFVLYL 50 60 130 140 150 160 170 pF1KE3 SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ 70 80 90 100 110 >>NP_057077 (OMIM: 600340) plasmolipin [Homo sapiens] (182 aa) initn: 259 init1: 259 opt: 409 Z-score: 544.7 bits: 107.3 E(85289): 1.3e-23 Smith-Waterman score: 409; 42.1% identity (71.1% similar) in 159 aa overlap (12-168:8-166) 10 20 30 40 50 60 pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIA :.: .:: :.. .: :.. : :.:. : :.. ..:::::::.::: NP_057 MAEFPSKVSTRTSSPAQGAEASVSALRPDLGFVRSRLGALMLLQLVLGLLVWALIA 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 GTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL : : ::.:::::::: :..:. .. .:. . . .. .::: : . :: :: :::. NP_057 DTPYHLYPAYGWVMFVAVFLWLVTIVLFNLYLFQLHMKLYMVPWPLVLMIFNISATVLYI 60 70 80 90 100 110 130 140 150 160 170 pF1KE3 SAAVVDASSV--SPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ .: .. ...: . : .. .:. ::.:::: :: : :. ...::. ::: NP_057 TAFIACSAAVDLTSLRGTRPYNQRAAASFFACLVMIAYGVSAFFSYQAWRGVGSNAATSQ 120 130 140 150 160 170 NP_057 MAGGYA 180 >>NP_005425 (OMIM: 602022) MAL-like protein [Homo sapien (153 aa) initn: 194 init1: 136 opt: 228 Z-score: 308.9 bits: 63.4 E(85289): 1.8e-10 Smith-Waterman score: 228; 33.9% identity (67.7% similar) in 124 aa overlap (36-156:23-143) 10 20 30 40 50 60 pF1KE3 RARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGTEYF :: .:.. :...:.::::..:.:. NP_005 MASPDPPATSYAPSDVPSGVALFLTIPFAFFL-PELIFGFLVWTMVAATHIV 10 20 30 40 50 70 80 90 100 110 120 pF1KE3 RVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAV- ::::.:... ......::. :. : :. . : .. ..:.. .::.:::: NP_005 YPLLQGWVMYVSLTSFLISLMFLLSYLFGFYKRFES--WRVLDSLYHGTTGILYMSAAVL 60 70 80 90 100 130 140 150 160 170 pF1KE3 -VDASSVSPER-DSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ : :. :: . : . . .:.:::::..:. : NP_005 QVHATIVSEKLLDPRIYYINSAASFFAFIATLLYILHAFSIYYH 110 120 130 140 150 >>NP_002362 (OMIM: 188860) myelin and lymphocyte protein (153 aa) initn: 161 init1: 125 opt: 227 Z-score: 307.6 bits: 63.2 E(85289): 2.1e-10 Smith-Waterman score: 227; 28.9% identity (65.1% similar) in 149 aa overlap (24-169:6-152) 10 20 30 40 50 60 pF1KE3 MEEPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIA .:..:.. . :: .:.. :...: ::: :.: NP_002 MAPAAATGGSTLPSGFSVFTTLPDLLFIFEFIFGGLVWILVA 10 20 30 40 70 80 90 100 110 120 pF1KE3 GTEYFRVPAFGWVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYL .. . ::::::.: .: :. ..:.:: .. .. :.:. .. .: ..:: NP_002 SSLVPWPLVQGWVMFVSVFCFVATTTLIILYIIGAHG--GETSWVTLDAAYHCTAALFYL 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 SAAVVDASSVSPERDSHNFNSW---AASSFFAFLVTICYAGNTYFSFIAWRSRTIQ ::.:..: .. .:. .. . :. :....:. :. .. ::.: :.: NP_002 SASVLEALATITMQDGFTYRHYHENIAAVVFSYIATLLYVVHAVFSLIRWKSS 110 120 130 140 150 >>XP_011510111 (OMIM: 602022) PREDICTED: MAL-like protei (149 aa) initn: 187 init1: 129 opt: 218 Z-score: 296.0 bits: 61.0 E(85289): 9.5e-10 Smith-Waterman score: 218; 34.2% identity (69.4% similar) in 111 aa overlap (49-156:31-139) 20 30 40 50 60 70 pF1KE3 FAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGTEYFRVPAFGWVMFVAV ...:.::::..:.:. ::::.:.. XP_011 MEKLTEDSRKKKKGAGIFGKETRIQNTTKLLIFGFLVWTMVAATHIVYPLLQGWVMYVSL 10 20 30 40 50 60 80 90 100 110 120 130 pF1KE3 SYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNGSAFVLYLSAAV--VDASSVSPER-D . ......::. :. : :. . : .. ..:.. .::.:::: : :. :: . : XP_011 TSFLISLMFLLSYLFGFYKRFES--WRVLDSLYHGTTGILYMSAAVLQVHATIVSEKLLD 70 80 90 100 110 140 150 160 170 pF1KE3 SHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ . . .:.:::::..:. : XP_011 PRIYYINSAASFFAFIATLLYILHAFSIYYH 120 130 140 >>NP_852662 (OMIM: 607887) CKLF-like MARVEL transmembran (208 aa) initn: 148 init1: 83 opt: 194 Z-score: 262.6 bits: 55.3 E(85289): 6.9e-08 Smith-Waterman score: 194; 31.7% identity (59.7% similar) in 139 aa overlap (33-168:46-176) 10 20 30 40 50 60 pF1KE3 EPQRARSHTVTTTASSFAENFSTSSSSFAYDREFLRTLHGFLIVAEIVLGLLVWTLIAGT : ..:: : : ::...:.:... : : NP_852 STSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIE-T 20 30 40 50 60 70 70 80 90 100 110 pF1KE3 EYFRVPAFG--WVMFVAVSYWVLTVFFLIIYITMTYTRIPQVPWTTVGLCFNG-SAFVLY . : : . ::. : .:.: .::.. . ::::. :. . : .: :::... NP_852 IMACSPCEGLYFFEFVSCSAFVVTGVLLIMFSLNLHMRIPQINWNLTDLVNTGLSAFLFF 80 90 100 110 120 130 120 130 140 150 160 170 pF1KE3 LSAAVVDASSVSPERDSHNFNSWAASSFFAFLVTICYAGNTYFSFIAWRSRTIQ ... :. : . : .. :. .:.::.: :: ::... :: NP_852 IASIVLAALN-------HRAGAEIAAVIFGFLATAAYAVNTFLAVQKWRVSVRQQSTNDY 140 150 160 170 180 NP_852 IRARTESRDVDSRPEIQRLDT 190 200 173 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 02:20:40 2016 done: Sun Nov 6 02:20:41 2016 Total Scan time: 5.120 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]