FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE6254, 295 aa
  1>>>pF1KE6254 295 - 295 aa - 295 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.3183+/-0.000306; mu= 16.3267+/- 0.019
 mean_var=76.4031+/-15.369, 0's: 0 Z-trim(117.3): 17  B-trim: 0 in 0/53
 Lambda= 0.146730
 statistics sampled from 29176 (29193) to 29176 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.702), E-opt: 0.2 (0.342), width:  16
 Scan time:  5.410

The best scores are:                                      opt bits E(85289)
NP_945349 (OMIM: 609789) aquaporin-12A precursor [ ( 295) 1964 424.7 1.1e-118
NP_766627 (OMIM: 609914) aquaporin-11 [Homo sapien ( 271)  347 82.4 1.1e-15
XP_005273974 (OMIM: 609914) PREDICTED: aquaporin-1 ( 232)  201 51.4   2e-06
NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens ( 282)  147 40.0  0.0063


>>NP_945349 (OMIM: 609789) aquaporin-12A precursor [Homo  (295 aa)
 initn: 1964 init1: 1964 opt: 1964  Z-score: 2252.0  bits: 424.7 E(85289): 1.1e-118
Smith-Waterman score: 1964; 100.0% identity (100.0% similar) in 295 aa overlap (1-295:1-295)

               10        20        30        40        50        60
pF1KE6 MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLL
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 LTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLC
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 LTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLC
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE6 WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE6 ALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 ALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQG
              190       200       210       220       230       240

              250       260       270       280       290     
pF1KE6 RLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS
       :::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 RLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS
              250       260       270       280       290     

>>NP_766627 (OMIM: 609914) aquaporin-11 [Homo sapiens]    (271 aa)
 initn: 362 init1: 224 opt: 347  Z-score: 402.6  bits: 82.4 E(85289): 1.1e-15
Smith-Waterman score: 347; 32.6% identity (65.3% similar) in 193 aa overlap (57-245:75-261)

         30        40        50        60        70        80      
pF1KE6 ALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSL
                                     :   :::.... :.::.:: :.:.::   .
NP_766 HAFVLEFLATFQLCCCTHELQLLSEQHPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCGVM
           50        60        70        80        90       100    

         90       100       110       120           130       140  
pF1KE6 QEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLC----WAWELSDLHLLQSLMAQSCSSA
       ...... .:     ..: :: ..  : :.  : :    :.  :.. :. .  .:  :.. 
NP_766 MQMMLGGMSPETGAVRLLAQLVS--ALCS--RYCTSALWSLGLTQYHVSERSFA--CKNP
          110       120         130         140       150          

            150       160       170       180       190       200  
pF1KE6 LRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPA
       .:... .....::.:.: :: .:::...         .: :.:  .:..: .:.: ::::
NP_766 IRVDLLKAVITEAVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPA
      160       170       180       190       200       210        

            210       220       230       240       250       260  
pF1KE6 LAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPR
       :: :. : :  ... ..  ::::.:  :..: .:. .  :: :                 
NP_766 LALSLHFMCFDEAFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE       
      220       230       240       250       260       270        

            270       280       290     
pF1KE6 GKPAPASGDTQTPAKGSSVREPGRSGVEGPHSS

>>XP_005273974 (OMIM: 609914) PREDICTED: aquaporin-11 is  (232 aa)
 initn: 201 init1: 100 opt: 201  Z-score: 236.5  bits: 51.4 E(85289): 2e-06
Smith-Waterman score: 201; 29.7% identity (61.3% similar) in 155 aa overlap (57-203:75-222)

         30        40        50        60        70        80      
pF1KE6 ALLPVGAYEVFAREAMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSL
                                     :   :::.... :.::.:: :.:.::   .
XP_005 HAFVLEFLATFQLCCCTHELQLLSEQHPAHPTWTLTLVYFFSLVHGLTLVGTSSNPCGVM
           50        60        70        80        90       100    

         90       100       110       120           130       140  
pF1KE6 QEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLC----WAWELSDLHLLQSLMAQSCSSA
       ...... .:     ..: :: .  .: :.  : :    :.  :.. :. .  .:  :.. 
XP_005 MQMMLGGMSPETGAVRLLAQLV--SALCS--RYCTSALWSLGLTQYHVSERSFA--CKNP
          110       120         130         140       150          

            150       160       170       180       190            
pF1KE6 LRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTS----AF
       .:... .....::.:.: :: .:::...         .: :.:  .: :: .      .:
XP_005 IRVDLLKAVITEAVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVY-AGILLMILMFSF
      160       170       180       190       200        210       

      200       210       220       230       240       250        
pF1KE6 FNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKY
       : : :                                                       
XP_005 FLPWLHNNHTINKKE                                             
       220       230                                               

>>NP_001643 (OMIM: 601383) aquaporin-6 [Homo sapiens]     (282 aa)
 initn: 151 init1:  81 opt: 147  Z-score: 173.5  bits: 40.0 E(85289): 0.0063
Smith-Waterman score: 156; 24.3% identity (52.4% similar) in 292 aa overlap (12-290:11-278)

               10        20            30         40        50     
pF1KE6 MAGLNVSLSFFFATFALCEAARRASKAL----LPVGAYEVFAR-EAMRTLVELGPWAGDF
                  .:..  :.  .  :.::    : .: :  :.   .::       :   .
NP_001  MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMR-------WPTAL
                10        20        30        40               50  

          60        70            80        90       100       110 
pF1KE6 GPDLLLTLLFLLFLAHGVTL----DGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQ
          : ... : :  : .: .    .:: :::.:.:  .. .. ::: ..  .::: .:  
NP_001 PSVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGAT
             60        70        80        90       100       110  

             120       130       140       150       160           
pF1KE6 AACTLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTL--LHLR
       .. .:.   ..   .:..   ..      ...:.::  :  : .   . ..:.:  .   
NP_001 VGAALL---YGVMPGDIRETLGI------NVVRNSVSTGQAVAVELLLTLQLVLCVFAST
               120       130             140       150       160   

     170       180        190        200       210       220       
pF1KE6 HSPPAYSGPAVALLVTVT-AYTAG-PFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGP
        :  . ..::. . ..:. ..  :  ::.  .::: . . ..  .  :.     :.:.::
NP_001 DSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVH---WVFWVGP
           170       180       190       200       210          220

       230       240       250       260       270       280       
pF1KE6 LTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRS
       : : .:: :...  :   :  .   .:.    .   . . ..:    : :  :  .:: .
NP_001 LMGALLASLIYNFVL---FPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKES--QPGSG
              230          240       250       260       270       

       290     
pF1KE6 GVEGPHSS
       .::     
NP_001 AVEMESV 
         280   




295 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 11:30:08 2016 done: Tue Nov  8 11:30:09 2016
 Total Scan time:  5.410 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]