FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6295, 808 aa 1>>>pF1KB6295 808 - 808 aa - 808 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.0112+/-0.000503; mu= -5.4438+/- 0.031 mean_var=308.8782+/-61.574, 0's: 0 Z-trim(117.4): 82 B-trim: 64 in 1/54 Lambda= 0.072976 statistics sampled from 29336 (29418) to 29336 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.671), E-opt: 0.2 (0.345), width: 16 Scan time: 13.410 The best scores are: opt bits E(85289) NP_001131024 (OMIM: 603256) leucine-rich repeat fl ( 808) 5214 563.4 1.4e-159 NP_004726 (OMIM: 603256) leucine-rich repeat fligh ( 784) 4242 461.1 8.5e-129 NP_001131025 (OMIM: 603256) leucine-rich repeat fl ( 752) 4229 459.7 2.1e-128 XP_005246198 (OMIM: 603256) PREDICTED: leucine-ric ( 428) 1354 156.9 1.8e-37 XP_016860747 (OMIM: 603256) PREDICTED: leucine-ric ( 599) 1348 156.3 3.6e-37 XP_016860745 (OMIM: 603256) PREDICTED: leucine-ric ( 619) 1348 156.3 3.7e-37 NP_001131022 (OMIM: 603256) leucine-rich repeat fl ( 640) 1084 128.6 8.8e-29 XP_016860743 (OMIM: 603256) PREDICTED: leucine-ric ( 661) 1084 128.6 9e-29 XP_016860742 (OMIM: 603256) PREDICTED: leucine-ric ( 681) 1084 128.6 9.3e-29 XP_016862968 (OMIM: 614043) PREDICTED: leucine-ric ( 458) 943 113.6 2e-24 XP_016862960 (OMIM: 614043) PREDICTED: leucine-ric ( 523) 872 106.2 3.9e-22 XP_016862964 (OMIM: 614043) PREDICTED: leucine-ric ( 492) 870 106.0 4.3e-22 XP_016862963 (OMIM: 614043) PREDICTED: leucine-ric ( 492) 870 106.0 4.3e-22 NP_001131023 (OMIM: 603256) leucine-rich repeat fl ( 394) 862 105.0 6.5e-22 XP_005246199 (OMIM: 603256) PREDICTED: leucine-ric ( 404) 862 105.1 6.6e-22 XP_016860749 (OMIM: 603256) PREDICTED: leucine-ric ( 541) 862 105.1 8.4e-22 XP_011532524 (OMIM: 614043) PREDICTED: leucine-ric ( 656) 748 93.2 4e-18 XP_016860751 (OMIM: 603256) PREDICTED: leucine-ric ( 520) 744 92.7 4.4e-18 XP_016860750 (OMIM: 603256) PREDICTED: leucine-ric ( 540) 744 92.7 4.6e-18 XP_016862973 (OMIM: 614043) PREDICTED: leucine-ric ( 424) 733 91.5 8.4e-18 XP_016862972 (OMIM: 614043) PREDICTED: leucine-ric ( 424) 733 91.5 8.4e-18 NP_001127841 (OMIM: 614043) leucine-rich repeat fl ( 424) 733 91.5 8.4e-18 XP_005265608 (OMIM: 614043) PREDICTED: leucine-ric ( 540) 722 90.4 2.3e-17 XP_016862961 (OMIM: 614043) PREDICTED: leucine-ric ( 509) 720 90.2 2.5e-17 XP_011532531 (OMIM: 614043) PREDICTED: leucine-ric ( 504) 687 86.7 2.8e-16 XP_006713463 (OMIM: 614043) PREDICTED: leucine-ric ( 504) 687 86.7 2.8e-16 XP_005265607 (OMIM: 614043) PREDICTED: leucine-ric ( 577) 677 85.7 6.4e-16 XP_016862957 (OMIM: 614043) PREDICTED: leucine-ric ( 634) 677 85.7 6.9e-16 XP_016862954 (OMIM: 614043) PREDICTED: leucine-ric ( 670) 677 85.7 7.2e-16 XP_006713459 (OMIM: 614043) PREDICTED: leucine-ric ( 685) 677 85.7 7.4e-16 XP_011532523 (OMIM: 614043) PREDICTED: leucine-ric ( 685) 677 85.7 7.4e-16 XP_006713457 (OMIM: 614043) PREDICTED: leucine-ric ( 690) 677 85.7 7.4e-16 XP_006713453 (OMIM: 614043) PREDICTED: leucine-ric ( 704) 677 85.7 7.5e-16 XP_006713452 (OMIM: 614043) PREDICTED: leucine-ric ( 704) 677 85.7 7.5e-16 XP_006713451 (OMIM: 614043) PREDICTED: leucine-ric ( 705) 677 85.7 7.5e-16 XP_006713450 (OMIM: 614043) PREDICTED: leucine-ric ( 706) 677 85.7 7.6e-16 XP_006713449 (OMIM: 614043) PREDICTED: leucine-ric ( 707) 677 85.7 7.6e-16 XP_006713448 (OMIM: 614043) PREDICTED: leucine-ric ( 720) 677 85.7 7.7e-16 XP_011532521 (OMIM: 614043) PREDICTED: leucine-ric ( 721) 677 85.7 7.7e-16 NP_006300 (OMIM: 614043) leucine-rich repeat fligh ( 721) 677 85.7 7.7e-16 XP_005265597 (OMIM: 614043) PREDICTED: leucine-ric ( 721) 677 85.7 7.7e-16 XP_011532520 (OMIM: 614043) PREDICTED: leucine-ric ( 721) 677 85.7 7.7e-16 XP_005265596 (OMIM: 614043) PREDICTED: leucine-ric ( 721) 677 85.7 7.7e-16 XP_011532519 (OMIM: 614043) PREDICTED: leucine-ric ( 721) 677 85.7 7.7e-16 XP_006713458 (OMIM: 614043) PREDICTED: leucine-ric ( 690) 675 85.5 8.6e-16 XP_005265610 (OMIM: 614043) PREDICTED: leucine-ric ( 489) 662 84.1 1.7e-15 XP_005265611 (OMIM: 614043) PREDICTED: leucine-ric ( 489) 662 84.1 1.7e-15 XP_016862965 (OMIM: 614043) PREDICTED: leucine-ric ( 489) 662 84.1 1.7e-15 XP_016862970 (OMIM: 614043) PREDICTED: leucine-ric ( 455) 661 83.9 1.7e-15 XP_016862967 (OMIM: 614043) PREDICTED: leucine-ric ( 458) 660 83.8 1.8e-15 >>NP_001131024 (OMIM: 603256) leucine-rich repeat flight (808 aa) initn: 5214 init1: 5214 opt: 5214 Z-score: 2986.2 bits: 563.4 E(85289): 1.4e-159 Smith-Waterman score: 5214; 99.9% identity (100.0% similar) in 808 aa overlap (1-808:1-808) 10 20 30 40 50 60 pF1KB6 MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 SRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 LKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRAS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 EVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 TLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHT 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB6 ENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB6 AAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDT 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB6 QNEPLDMKEPDEEKSDQQGEAFDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNT :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: NP_001 QNEPLDMKEPDEEKSDQQGEALDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNT 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB6 DLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEG 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB6 DDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKS 670 680 690 700 710 720 730 740 750 760 770 780 pF1KB6 EDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGRE 730 740 750 760 770 780 790 800 pF1KB6 PGHFNPESREDTRGGNEKGKSKEDCTMS :::::::::::::::::::::::::::: NP_001 PGHFNPESREDTRGGNEKGKSKEDCTMS 790 800 >>NP_004726 (OMIM: 603256) leucine-rich repeat flightles (784 aa) initn: 4229 init1: 4229 opt: 4242 Z-score: 2433.3 bits: 461.1 E(85289): 8.5e-129 Smith-Waterman score: 5001; 96.9% identity (97.0% similar) in 808 aa overlap (1-808:1-784) 10 20 30 40 50 60 pF1KB6 MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 SRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ ::::::::::::::::: ::::::::::::::::::: NP_004 GDTSISIDTEASIREIK------------------------DSLAEVEEKYKKAMVSNAQ 130 140 150 190 200 210 220 230 240 pF1KB6 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 LKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRAS 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB6 EVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLG 280 290 300 310 320 330 370 380 390 400 410 420 pF1KB6 TLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 TLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHT 340 350 360 370 380 390 430 440 450 460 470 480 pF1KB6 ENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 ENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE 400 410 420 430 440 450 490 500 510 520 530 540 pF1KB6 AAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDT 460 470 480 490 500 510 550 560 570 580 590 600 pF1KB6 QNEPLDMKEPDEEKSDQQGEAFDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNT :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: NP_004 QNEPLDMKEPDEEKSDQQGEALDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNT 520 530 540 550 560 570 610 620 630 640 650 660 pF1KB6 DLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEG 580 590 600 610 620 630 670 680 690 700 710 720 pF1KB6 DDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 DDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKS 640 650 660 670 680 690 730 740 750 760 770 780 pF1KB6 EDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGRE 700 710 720 730 740 750 790 800 pF1KB6 PGHFNPESREDTRGGNEKGKSKEDCTMS :::::::::::::::::::::::::::: NP_004 PGHFNPESREDTRGGNEKGKSKEDCTMS 760 770 780 >>NP_001131025 (OMIM: 603256) leucine-rich repeat flight (752 aa) initn: 4529 init1: 4229 opt: 4229 Z-score: 2426.2 bits: 459.7 E(85289): 2.1e-128 Smith-Waterman score: 4725; 92.9% identity (93.1% similar) in 808 aa overlap (1-808:1-752) 10 20 30 40 50 60 pF1KB6 MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRR ::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKE--------- 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 SRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGS ::::::::::::::::::::::::::::::::::::: NP_001 -----------------------VEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGS 60 70 80 130 140 150 160 170 180 pF1KB6 GDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQ ::::::::::::::::: ::::::::::::::::::: NP_001 GDTSISIDTEASIREIK------------------------DSLAEVEEKYKKAMVSNAQ 90 100 110 120 190 200 210 220 230 240 pF1KB6 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEA 130 140 150 160 170 180 250 260 270 280 290 300 pF1KB6 LKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRAS 190 200 210 220 230 240 310 320 330 340 350 360 pF1KB6 EVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLG 250 260 270 280 290 300 370 380 390 400 410 420 pF1KB6 TLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHT 310 320 330 340 350 360 430 440 450 460 470 480 pF1KB6 ENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQE 370 380 390 400 410 420 490 500 510 520 530 540 pF1KB6 AAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDT 430 440 450 460 470 480 550 560 570 580 590 600 pF1KB6 QNEPLDMKEPDEEKSDQQGEAFDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNT :::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::: NP_001 QNEPLDMKEPDEEKSDQQGEALDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNT 490 500 510 520 530 540 610 620 630 640 650 660 pF1KB6 DLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEG 550 560 570 580 590 600 670 680 690 700 710 720 pF1KB6 DDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKS 610 620 630 640 650 660 730 740 750 760 770 780 pF1KB6 EDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGRE 670 680 690 700 710 720 790 800 pF1KB6 PGHFNPESREDTRGGNEKGKSKEDCTMS :::::::::::::::::::::::::::: NP_001 PGHFNPESREDTRGGNEKGKSKEDCTMS 730 740 750 >>XP_005246198 (OMIM: 603256) PREDICTED: leucine-rich re (428 aa) initn: 1367 init1: 1339 opt: 1354 Z-score: 793.9 bits: 156.9 E(85289): 1.8e-37 Smith-Waterman score: 1448; 67.0% identity (78.0% similar) in 391 aa overlap (11-389:22-379) 10 20 30 40 pF1KB6 MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQ : : :. :.. ::::::::::::::::::::::::::: XP_005 MDMGTQGSGRKRLPNRERLTAEDDALNQIARE-AEARLAAKRAARAEAREIRMKELERQQ 10 20 30 40 50 50 60 70 80 90 100 pF1KB6 KEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLA :: :::::::::::::::::::::::::: XP_005 KE--------------------------------VEERPEKDFTEKGSRNMPGLSAATLA 60 70 80 110 120 130 140 150 160 pF1KB6 SLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEE 90 100 110 120 130 140 170 180 190 200 210 220 pF1KB6 KYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 KYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSI 150 160 170 180 190 200 230 240 250 260 270 280 pF1KB6 LQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALK 210 220 230 240 250 260 290 300 310 320 330 340 pF1KB6 STGDGTLG---------RASEVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVF ::::::: : .: ... ... .:. . . .. . .:.... .:..:. XP_005 STGDGTLDIRLKKLVDERECLLEQIKKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVM 270 280 290 300 310 320 350 360 370 380 390 pF1KB6 PAGENTEDQKSSEDTAPFLGTLAGATYEEQV---QSQILESSSLPENTVQVESNEVMGAP .... : :. . .. :..: .::. . .: ::. ..: XP_005 DLQRDANRQISDLKFKLAKSEQEITALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKR 330 340 350 360 370 380 400 410 420 430 440 450 pF1KB6 DDRTRTPLEPSNCWSDLDGGNHTENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCM XP_005 KLQRELRSALDKTEELEVSNGHLVKRLEKMKANRSALLSQQ 390 400 410 420 >>XP_016860747 (OMIM: 603256) PREDICTED: leucine-rich re (599 aa) initn: 1705 init1: 1331 opt: 1348 Z-score: 788.3 bits: 156.3 E(85289): 3.6e-37 Smith-Waterman score: 1362; 67.3% identity (81.7% similar) in 355 aa overlap (47-389:197-550) 20 30 40 50 60 70 pF1KB6 PEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSV :. . :. :. : . .:.: . : : XP_016 EKLPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRAS- 170 180 190 200 210 220 80 90 100 110 120 130 pF1KB6 GSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI ..:.: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI 230 240 250 260 270 280 140 150 160 170 180 190 pF1KB6 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 290 300 310 320 330 340 200 210 220 230 240 250 pF1KB6 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILN 350 360 370 380 390 400 260 270 280 290 300 pF1KB6 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG---------RASEVEVKNE :::::::::::::::::::::::::::::::::::::::: : .: .. XP_016 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKK 410 420 430 440 450 460 310 320 330 340 350 360 pF1KB6 IVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGATY . ... .:. . . .. . .:.... .:..:. .... : :. . .. XP_016 LKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITAL 470 480 490 500 510 520 370 380 390 400 410 420 pF1KB6 EEQV---QSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHTENVG :..: .::. . .: ::. ..: XP_016 EQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVKRL 530 540 550 560 570 580 >>XP_016860745 (OMIM: 603256) PREDICTED: leucine-rich re (619 aa) initn: 1705 init1: 1331 opt: 1348 Z-score: 788.1 bits: 156.3 E(85289): 3.7e-37 Smith-Waterman score: 1362; 67.3% identity (81.7% similar) in 355 aa overlap (47-389:197-550) 20 30 40 50 60 70 pF1KB6 PEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSV :. . :. :. : . .:.: . : : XP_016 EKLPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRAS- 170 180 190 200 210 220 80 90 100 110 120 130 pF1KB6 GSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI ..:.: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI 230 240 250 260 270 280 140 150 160 170 180 190 pF1KB6 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 290 300 310 320 330 340 200 210 220 230 240 250 pF1KB6 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILN 350 360 370 380 390 400 260 270 280 290 300 pF1KB6 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG---------RASEVEVKNE :::::::::::::::::::::::::::::::::::::::: : .: .. XP_016 SEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQIKK 410 420 430 440 450 460 310 320 330 340 350 360 pF1KB6 IVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGATY . ... .:. . . .. . .:.... .:..:. .... : :. . .. XP_016 LKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEITAL 470 480 490 500 510 520 370 380 390 400 410 420 pF1KB6 EEQV---QSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHTENVG :..: .::. . .: ::. ..: XP_016 EQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQREDHSGRARWLTPIIPALWEAKLR 530 540 550 560 570 580 >>NP_001131022 (OMIM: 603256) leucine-rich repeat flight (640 aa) initn: 1392 init1: 1046 opt: 1084 Z-score: 637.7 bits: 128.6 E(85289): 8.8e-29 Smith-Waterman score: 1228; 57.3% identity (69.5% similar) in 417 aa overlap (47-389:176-591) 20 30 40 50 60 70 pF1KB6 PEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSV :. . :. :. : . .:.: . : : NP_001 SGRPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRAS- 150 160 170 180 190 200 80 90 100 110 120 130 pF1KB6 GSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI ..:.: ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI 210 220 230 240 250 260 140 150 160 170 180 190 pF1KB6 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 270 280 290 300 310 320 200 210 220 230 240 pF1KB6 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLE------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQ 330 340 350 360 370 380 250 pF1KB6 -------------------------------------------------------KHGII ::::: NP_001 KQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGII 390 400 410 420 430 440 260 270 280 290 300 pF1KB6 LNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG---------RASEVEVK :::::::::::::::::::::::::::::::::::::::::: : .: NP_001 LNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQI 450 460 470 480 490 500 310 320 330 340 350 360 pF1KB6 NEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGA ... ... .:. . . .. . .:.... .:..:. .... : :. . . NP_001 KKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEIT 510 520 530 540 550 560 370 380 390 400 410 420 pF1KB6 TYEEQV---QSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHTEN . :..: .::. . .: ::. ..: NP_001 ALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVK 570 580 590 600 610 620 >>XP_016860743 (OMIM: 603256) PREDICTED: leucine-rich re (661 aa) initn: 1392 init1: 1046 opt: 1084 Z-score: 637.5 bits: 128.6 E(85289): 9e-29 Smith-Waterman score: 1228; 57.3% identity (69.5% similar) in 417 aa overlap (47-389:197-612) 20 30 40 50 60 70 pF1KB6 PEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSV :. . :. :. : . .:.: . : : XP_016 EKLPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRAS- 170 180 190 200 210 220 80 90 100 110 120 130 pF1KB6 GSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI ..:.: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI 230 240 250 260 270 280 140 150 160 170 180 190 pF1KB6 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 290 300 310 320 330 340 200 210 220 230 240 pF1KB6 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLE------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQ 350 360 370 380 390 400 250 pF1KB6 -------------------------------------------------------KHGII ::::: XP_016 KQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGII 410 420 430 440 450 460 260 270 280 290 300 pF1KB6 LNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG---------RASEVEVK :::::::::::::::::::::::::::::::::::::::::: : .: XP_016 LNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQI 470 480 490 500 510 520 310 320 330 340 350 360 pF1KB6 NEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGA ... ... .:. . . .. . .:.... .:..:. .... : :. . . XP_016 KKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEIT 530 540 550 560 570 580 370 380 390 400 410 420 pF1KB6 TYEEQV---QSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHTEN . :..: .::. . .: ::. ..: XP_016 ALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQRELRSALDKTEELEVSNGHLVK 590 600 610 620 630 640 >>XP_016860742 (OMIM: 603256) PREDICTED: leucine-rich re (681 aa) initn: 1392 init1: 1046 opt: 1084 Z-score: 637.3 bits: 128.6 E(85289): 9.3e-29 Smith-Waterman score: 1228; 57.3% identity (69.5% similar) in 417 aa overlap (47-389:197-612) 20 30 40 50 60 70 pF1KB6 PEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSV :. . :. :. : . .:.: . : : XP_016 EKLPSCLYSAARPSGSYRASVLDEGSFGGTRRGSTSGSRAPSEYSGHLNSSSRASSRAS- 170 180 190 200 210 220 80 90 100 110 120 130 pF1KB6 GSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI ..:.: ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SARASPVVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREI 230 240 250 260 270 280 140 150 160 170 180 190 pF1KB6 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLK 290 300 310 320 330 340 200 210 220 230 240 pF1KB6 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLE------- ::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEEIRQLQQ 350 360 370 380 390 400 250 pF1KB6 -------------------------------------------------------KHGII ::::: XP_016 KQASSIREISDLQETIEWKDKKIGALERQKEFFDSVRSERDDLREEVVMLKEELKKHGII 410 420 430 440 450 460 260 270 280 290 300 pF1KB6 LNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLG---------RASEVEVK :::::::::::::::::::::::::::::::::::::::::: : .: XP_016 LNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLDIRLKKLVDERECLLEQI 470 480 490 500 510 520 310 320 330 340 350 360 pF1KB6 NEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGA ... ... .:. . . .. . .:.... .:..:. .... : :. . . XP_016 KKLKGQLEERQKIGKLDNLRSEDDVLENGTDMHVMDLQRDANRQISDLKFKLAKSEQEIT 530 540 550 560 570 580 370 380 390 400 410 420 pF1KB6 TYEEQV---QSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHTEN . :..: .::. . .: ::. ..: XP_016 ALEQNVIRLESQVSRYKSAAENAEKIEDELKAEKRKLQREDHSGRARWLTPIIPALWEAK 590 600 610 620 630 640 >>XP_016862968 (OMIM: 614043) PREDICTED: leucine-rich re (458 aa) initn: 991 init1: 736 opt: 943 Z-score: 559.6 bits: 113.6 E(85289): 2e-24 Smith-Waterman score: 955; 43.9% identity (72.6% similar) in 412 aa overlap (1-389:1-409) 10 20 30 40 50 pF1KB6 MTSPAAAQSREI--DCLSPEAQKL------AEARLAAKRAARAEAREIRMKELERQQKEE : .::....: : .: : . : ::::::::::::::::.:::.::::::::: XP_016 MGTPASGRKRTPVKDRFSAEDEALSNIAREAEARLAAKRAARAEARDIRMRELERQQKEE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 DSER--YSRRSRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLAS :::: ::.:: .. .. .:. : :: :..:. .:...:. .: ::.. . XP_016 DSERARYSHRSSHHRPYLGVEDALSIRSVGSHRLDEKSDKQYAENYTRPSSRNSASATTP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEK :.:.:::::::::: :: ..:. :.... .::::::::::.:::::::.:.::.::::: XP_016 LSGNSSRRGSGDTSSLIDPDTSLSELRDIYDLKDQIQDVEGRYMQGLKELKESLSEVEEK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 YKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSIL :::::::::::::::.:..::::::::.. : :::.:: :. :::.::.::.:: :.: XP_016 YKKAMVSNAQLDNEKNNLIYQVDTLKDVIEEQEEQMAEFYRENEEKSKELERQKHMCSVL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 QFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKS : .. :.::.:.::.:..::::... . . ::..: .: . : ...: ..:.: XP_016 QHKMEELKEGLRQRDELIEKHGLVIIPDGTPNGDVSHE-PVAG--AITVVSQEAAQVLES 250 260 270 280 290 300 310 320 330 340 pF1KB6 TGDGTLG-RASEVE-VKNEIVANVGKREILHNTEKEQHTED--TVKDCVDIEVFPAGENT .:.: : : .. :.:..... : .. . :... ... :: : . .. . XP_016 AGEGPLDVRLRKLAGEKEELLSQIRKLKLQLEEERQKCSRNDGTVGDLAGLQNGSDLQFI 300 310 320 330 340 350 350 360 370 380 390 pF1KB6 EDQK-SSEDTAPFLGTLAGA-----TYEEQV---QSQILESSSLPENTVQVESNEVMGAP : :. .... . . :. : : :... ..:.:. .. ::. .:: XP_016 EMQRDANRQISEYKFKLSKAEQDITTLEQSISRLEGQVLRYKTAAENAEKVEDELKAEKR 360 370 380 390 400 410 400 410 420 430 440 450 pF1KB6 DDRTRTPLEPSNCWSDLDGGNHTENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCM XP_016 KLQRELRTALDKIEEMEMTNSHLAKRLEKMKANRTALLAQQ 420 430 440 450 808 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 06:24:32 2016 done: Tue Nov 8 06:24:34 2016 Total Scan time: 13.410 Total Display time: 0.090 Function used was FASTA [36.3.4 Apr, 2011]