FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3151, 367 aa 1>>>pF1KE3151 367 - 367 aa - 367 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 11.4988+/-0.000392; mu= -9.1110+/- 0.025 mean_var=422.4090+/-88.290, 0's: 0 Z-trim(125.2): 4 B-trim: 1650 in 1/61 Lambda= 0.062403 statistics sampled from 48574 (48580) to 48574 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.83), E-opt: 0.2 (0.57), width: 16 Scan time: 11.050 The best scores are: opt bits E(85289) NP_003927 (OMIM: 603764) cyclin-dependent kinase 5 ( 367) 2534 241.5 2.3e-63 NP_003876 (OMIM: 603460) cyclin-dependent kinase 5 ( 307) 820 87.1 5.6e-17 XP_011523740 (OMIM: 603460) PREDICTED: cyclin-depe ( 307) 820 87.1 5.6e-17 XP_016880770 (OMIM: 603460) PREDICTED: cyclin-depe ( 307) 820 87.1 5.6e-17 >>NP_003927 (OMIM: 603764) cyclin-dependent kinase 5 act (367 aa) initn: 2534 init1: 2534 opt: 2534 Z-score: 1258.7 bits: 241.5 E(85289): 2.3e-63 Smith-Waterman score: 2534; 100.0% identity (100.0% similar) in 367 aa overlap (1-367:1-367) 10 20 30 40 50 60 pF1KE3 MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKP 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 LAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 ASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 LLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 IQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 IQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKH 310 320 330 340 350 360 pF1KE3 WTMNLDR ::::::: NP_003 WTMNLDR >>NP_003876 (OMIM: 603460) cyclin-dependent kinase 5 act (307 aa) initn: 959 init1: 419 opt: 820 Z-score: 425.8 bits: 87.1 E(85289): 5.6e-17 Smith-Waterman score: 956; 52.7% identity (73.2% similar) in 328 aa overlap (1-328:1-292) 10 20 30 40 50 60 pF1KE3 MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVL :::::::::. : . : :. : ..: : : .:..: .. ::: :. NP_003 MGTVLSLSPS-----YRKATLFED-------GAATVGHYTAVQNSKNAK-DKNLKRHSI- 10 20 30 40 70 80 90 100 110 120 pF1KE3 ISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKP ::.: :::.::.:::::. :::: .: :. . . . : ::: .:. . . . :.: NP_003 ISVLPWKRIVAVSAKKKN-SKKV--QPNSSYQNN-ITHLNNENL-KKSLSCANLSTFAQP 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 LAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQ : :. : : ::.. ...: ::.. : : : . .:.:.::::: NP_003 ---P-PAQPPA-----PPASQLSGSQTGGSSSVKKAPHPAVTS-------AGTPKRVIVQ 110 120 130 140 190 200 210 220 230 240 pF1KE3 ASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVY :::.:::::::.:.::::::::.::: . : :.:.:::::::::::::.::::::.::.: NP_003 ASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLY 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE3 LLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRL .:::. . ..:..: ::::..::::::.:::::::::::::::::: :: ::.::: . NP_003 MLCRDVI-SSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSV 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE3 IQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKH :. .: .::..:::::.:::::.::::: NP_003 INLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 270 280 290 300 >>XP_011523740 (OMIM: 603460) PREDICTED: cyclin-dependen (307 aa) initn: 959 init1: 419 opt: 820 Z-score: 425.8 bits: 87.1 E(85289): 5.6e-17 Smith-Waterman score: 956; 52.7% identity (73.2% similar) in 328 aa overlap (1-328:1-292) 10 20 30 40 50 60 pF1KE3 MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVL :::::::::. : . : :. : ..: : : .:..: .. ::: :. XP_011 MGTVLSLSPS-----YRKATLFED-------GAATVGHYTAVQNSKNAK-DKNLKRHSI- 10 20 30 40 70 80 90 100 110 120 pF1KE3 ISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKP ::.: :::.::.:::::. :::: .: :. . . . : ::: .:. . . . :.: XP_011 ISVLPWKRIVAVSAKKKN-SKKV--QPNSSYQNN-ITHLNNENL-KKSLSCANLSTFAQP 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 LAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQ : :. : : ::.. ...: ::.. : : : . .:.:.::::: XP_011 ---P-PAQPPA-----PPASQLSGSQTGGSSSVKKAPHPAVTS-------AGTPKRVIVQ 110 120 130 140 190 200 210 220 230 240 pF1KE3 ASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVY :::.:::::::.:.::::::::.::: . : :.:.:::::::::::::.::::::.::.: XP_011 ASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLY 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE3 LLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRL .:::. . ..:..: ::::..::::::.:::::::::::::::::: :: ::.::: . XP_011 MLCRDVI-SSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSV 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE3 IQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKH :. .: .::..:::::.:::::.::::: XP_011 INLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 270 280 290 300 >>XP_016880770 (OMIM: 603460) PREDICTED: cyclin-dependen (307 aa) initn: 959 init1: 419 opt: 820 Z-score: 425.8 bits: 87.1 E(85289): 5.6e-17 Smith-Waterman score: 956; 52.7% identity (73.2% similar) in 328 aa overlap (1-328:1-292) 10 20 30 40 50 60 pF1KE3 MGTVLSLSPASSAKGRRPGGLPEEKKKAPPAGDEALGGYGAPPVGKGGKGESRLKRPSVL :::::::::. : . : :. : ..: : : .:..: .. ::: :. XP_016 MGTVLSLSPS-----YRKATLFED-------GAATVGHYTAVQNSKNAK-DKNLKRHSI- 10 20 30 40 70 80 90 100 110 120 pF1KE3 ISALTWKRLVAASAKKKKGSKKVTPKPASTGPDPLVQQRNRENLLRKGRDPPDGGGTAKP ::.: :::.::.:::::. :::: .: :. . . . : ::: .:. . . . :.: XP_016 ISVLPWKRIVAVSAKKKN-SKKV--QPNSSYQNN-ITHLNNENL-KKSLSCANLSTFAQP 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 LAVPVPTVPAAAATCEPPSGGSAAAQPPGSGGGKPPPPPPPAPQVAPPVPGGSPRRVIVQ : :. : : ::.. ...: ::.. : : : . .:.:.::::: XP_016 ---P-PAQPPA-----PPASQLSGSQTGGSSSVKKAPHPAVTS-------AGTPKRVIVQ 110 120 130 140 190 200 210 220 230 240 pF1KE3 ASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVY :::.:::::::.:.::::::::.::: . : :.:.:::::::::::::.::::::.::.: XP_016 ASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLY 150 160 170 180 190 200 250 260 270 280 290 300 pF1KE3 LLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRL .:::. . ..:..: ::::..::::::.:::::::::::::::::: :: ::.::: . XP_016 MLCRDVI-SSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSV 210 220 230 240 250 260 310 320 330 340 350 360 pF1KE3 IQRLSPQMLRLNADPHFFTQVFQDLKNEGEAAASGGGPPSGGAPAASSAARDSCAAGTKH :. .: .::..:::::.:::::.::::: XP_016 INLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR 270 280 290 300 367 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:01:40 2016 done: Sun Nov 6 18:01:42 2016 Total Scan time: 11.050 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]