FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB5790, 777 aa 1>>>pF1KB5790 777 - 777 aa - 777 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.9980+/-0.000527; mu= 2.6478+/- 0.032 mean_var=301.3151+/-65.297, 0's: 0 Z-trim(116.9): 507 B-trim: 327 in 1/53 Lambda= 0.073886 statistics sampled from 27656 (28394) to 27656 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.692), E-opt: 0.2 (0.333), width: 16 Scan time: 13.780 The best scores are: opt bits E(85289) NP_000456 (OMIM: 114480,601593) BRCA1-associated R ( 777) 5244 573.9 8.7e-163 NP_001269472 (OMIM: 114480,601593) BRCA1-associate ( 758) 4731 519.2 2.5e-146 XP_016860102 (OMIM: 114480,601593) PREDICTED: BRCA ( 810) 4728 519.0 3.2e-146 XP_016860103 (OMIM: 114480,601593) PREDICTED: BRCA ( 675) 3705 409.8 1.9e-113 NP_001269477 (OMIM: 114480,601593) BRCA1-associate ( 307) 1747 200.7 7.6e-51 NP_001269474 (OMIM: 114480,601593) BRCA1-associate ( 326) 1747 200.8 7.9e-51 NP_001269478 (OMIM: 114480,601593) BRCA1-associate ( 264) 1011 122.2 2.9e-27 XP_011523940 (OMIM: 610616) PREDICTED: ankyrin rep (1923) 439 62.2 2.4e-08 NP_001190985 (OMIM: 610616) ankyrin repeat domain- (2039) 439 62.2 2.5e-08 XP_016881152 (OMIM: 610616) PREDICTED: ankyrin rep (2039) 439 62.2 2.5e-08 NP_001077094 (OMIM: 610616) ankyrin repeat domain- (2039) 439 62.2 2.5e-08 XP_005258150 (OMIM: 610616) PREDICTED: ankyrin rep (2062) 439 62.2 2.5e-08 NP_056023 (OMIM: 610616) ankyrin repeat domain-con (2062) 439 62.2 2.5e-08 XP_005258149 (OMIM: 610616) PREDICTED: ankyrin rep (2062) 439 62.2 2.5e-08 XP_016881155 (OMIM: 610616) PREDICTED: ankyrin rep (2037) 434 61.7 3.6e-08 XP_005258153 (OMIM: 610616) PREDICTED: ankyrin rep (2037) 434 61.7 3.6e-08 XP_016881154 (OMIM: 610616) PREDICTED: ankyrin rep (2037) 434 61.7 3.6e-08 XP_016881153 (OMIM: 610616) PREDICTED: ankyrin rep (2037) 434 61.7 3.6e-08 XP_005258152 (OMIM: 610616) PREDICTED: ankyrin rep (2060) 434 61.7 3.7e-08 XP_016881150 (OMIM: 610616) PREDICTED: ankyrin rep (2060) 434 61.7 3.7e-08 XP_016881151 (OMIM: 610616) PREDICTED: ankyrin rep (2060) 434 61.7 3.7e-08 XP_006721247 (OMIM: 148050,611192) PREDICTED: anky (2564) 424 60.7 8.9e-08 XP_011521359 (OMIM: 148050,611192) PREDICTED: anky (2613) 424 60.7 9e-08 XP_011521358 (OMIM: 148050,611192) PREDICTED: anky (2620) 424 60.7 9e-08 XP_011521356 (OMIM: 148050,611192) PREDICTED: anky (2629) 424 60.7 9e-08 XP_011521357 (OMIM: 148050,611192) PREDICTED: anky (2629) 424 60.7 9e-08 XP_006721244 (OMIM: 148050,611192) PREDICTED: anky (2629) 424 60.7 9e-08 NP_001243111 (OMIM: 148050,611192) ankyrin repeat (2663) 424 60.7 9.1e-08 NP_001243112 (OMIM: 148050,611192) ankyrin repeat (2663) 424 60.7 9.1e-08 XP_011521353 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08 XP_016878675 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08 XP_016878671 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08 XP_016878674 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08 XP_016878676 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08 NP_037407 (OMIM: 148050,611192) ankyrin repeat dom (2663) 424 60.7 9.1e-08 XP_011521355 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08 XP_016878672 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08 XP_016878673 (OMIM: 148050,611192) PREDICTED: anky (2663) 424 60.7 9.1e-08 XP_011515352 (OMIM: 604546) PREDICTED: tonsoku-lik ( 953) 332 50.4 4.1e-05 XP_011515351 (OMIM: 604546) PREDICTED: tonsoku-lik (1042) 332 50.5 4.4e-05 XP_011515350 (OMIM: 604546) PREDICTED: tonsoku-lik (1054) 332 50.5 4.4e-05 NP_038460 (OMIM: 604546) tonsoku-like protein [Hom (1378) 332 50.6 5.3e-05 XP_011538517 (OMIM: 607128) PREDICTED: tankyrase-2 ( 695) 303 47.2 0.00028 XP_016872189 (OMIM: 607128) PREDICTED: tankyrase-2 ( 977) 303 47.4 0.00036 XP_016872188 (OMIM: 607128) PREDICTED: tankyrase-2 (1059) 303 47.4 0.00038 XP_016872187 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 303 47.4 0.00038 XP_016872186 (OMIM: 607128) PREDICTED: tankyrase-2 (1062) 303 47.4 0.00038 NP_079511 (OMIM: 607128) tankyrase-2 [Homo sapiens (1166) 303 47.5 0.0004 XP_016872185 (OMIM: 607128) PREDICTED: tankyrase-2 (1169) 303 47.5 0.0004 XP_011538515 (OMIM: 607128) PREDICTED: tankyrase-2 (1187) 303 47.5 0.00041 >>NP_000456 (OMIM: 114480,601593) BRCA1-associated RING (777 aa) initn: 5244 init1: 5244 opt: 5244 Z-score: 3043.6 bits: 573.9 E(85289): 8.7e-163 Smith-Waterman score: 5244; 99.7% identity (99.7% similar) in 777 aa overlap (1-777:1-777) 10 20 30 40 50 60 pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: NP_000 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB5 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB5 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB5 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_000 ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM 370 380 390 400 410 420 430 440 450 460 470 480 pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL 430 440 450 460 470 480 490 500 510 520 530 540 pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK 490 500 510 520 530 540 550 560 570 580 590 600 pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF 550 560 570 580 590 600 610 620 630 640 650 660 pF1KB5 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS 610 620 630 640 650 660 670 680 690 700 710 720 pF1KB5 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV 670 680 690 700 710 720 730 740 750 760 770 pF1KB5 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS 730 740 750 760 770 >>NP_001269472 (OMIM: 114480,601593) BRCA1-associated RI (758 aa) initn: 4727 init1: 4727 opt: 4731 Z-score: 2748.2 bits: 519.2 E(85289): 2.5e-146 Smith-Waterman score: 5052; 97.3% identity (97.3% similar) in 777 aa overlap (1-777:1-758) 10 20 30 40 50 60 pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP ::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_001 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRC------- 10 20 30 40 50 70 80 90 100 110 120 pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ------------NCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL 60 70 80 90 100 130 140 150 160 170 180 pF1KB5 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB5 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EFVSPSPPADVSERAKKASARSGKKQKKKTLAEINQKWNLEAEKEDGEFDSKEESKQKLV 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB5 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SFCSQPSVISSPQINGEIDLLASGSLTESECFGSLTEVSLPLAEQIESPDTKSRNEVVTP 230 240 250 260 270 280 310 320 330 340 350 360 pF1KB5 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKVCKNYLTSKKSLPLENNGKRGHHNRLSSPISKRCRTSILSTSGDFVKQTVPSENIPLP 290 300 310 320 330 340 370 380 390 400 410 420 pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: NP_001 ECSSPPSCKRKVGGTSGRKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM 350 360 370 380 390 400 430 440 450 460 470 480 pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL 410 420 430 440 450 460 490 500 510 520 530 540 pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK 470 480 490 500 510 520 550 560 570 580 590 600 pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF 530 540 550 560 570 580 610 620 630 640 650 660 pF1KB5 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSTVTHVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRS 590 600 610 620 630 640 670 680 690 700 710 720 pF1KB5 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTV 650 660 670 680 690 700 730 740 750 760 770 pF1KB5 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AYHARPDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS 710 720 730 740 750 >>XP_016860102 (OMIM: 114480,601593) PREDICTED: BRCA1-as (810 aa) initn: 5225 init1: 4727 opt: 4728 Z-score: 2746.1 bits: 519.0 E(85289): 3.2e-146 Smith-Waterman score: 5155; 95.6% identity (95.6% similar) in 809 aa overlap (2-777:2-810) 10 20 30 40 50 60 pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: XP_016 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP 10 20 30 40 50 60 70 80 pF1KB5 VCLGGCEHIFCS---------------------------------NCVSDCIGTGCPVCY ::::::::::: ::::::::::::::: XP_016 VCLGGCEHIFCRGLGPVTRNVLWCLGKMWLFNCYITYSVLLEPICNCVSDCIGTGCPVCY 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB5 TPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWF 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB5 SPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQK 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB5 KKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLT 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB5 ESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB5 LSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGSKNSNMSDEF :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: XP_016 LSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEF 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB5 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB5 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB5 DIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRD 550 560 570 580 590 600 570 580 590 600 610 620 pF1KB5 GPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNG 610 620 630 640 650 660 630 640 650 660 670 680 pF1KB5 CWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHP 670 680 690 700 710 720 690 700 710 720 730 740 pF1KB5 KDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFCTQYIIYEDLCNYHP 730 740 750 760 770 780 750 760 770 pF1KB5 ERVRQGKVWKAPSSWFIDCVMSFELLPLDS :::::::::::::::::::::::::::::: XP_016 ERVRQGKVWKAPSSWFIDCVMSFELLPLDS 790 800 810 >>XP_016860103 (OMIM: 114480,601593) PREDICTED: BRCA1-as (675 aa) initn: 4199 init1: 3701 opt: 3705 Z-score: 2157.7 bits: 409.8 E(85289): 1.9e-113 Smith-Waterman score: 4132; 94.5% identity (94.5% similar) in 668 aa overlap (2-635:2-669) 10 20 30 40 50 60 pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP :::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: XP_016 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP 10 20 30 40 50 60 70 80 pF1KB5 VCLGGCEHIFCS---------------------------------NCVSDCIGTGCPVCY ::::::::::: ::::::::::::::: XP_016 VCLGGCEHIFCRGLGPVTRNVLWCLGKMWLFNCYITYSVLLEPICNCVSDCIGTGCPVCY 70 80 90 100 110 120 90 100 110 120 130 140 pF1KB5 TPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TPAWIQDLKINRQLDSMIQLCSKLRNLLHDNELSDLKEDKPRKSLFNDAGNKKNSIKMWF 130 140 150 160 170 180 150 160 170 180 190 200 pF1KB5 SPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SPRSKKVRYVVSKASVQTQPAIKKDASAQQDSYEFVSPSPPADVSERAKKASARSGKKQK 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB5 KKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKTLAEINQKWNLEAEKEDGEFDSKEESKQKLVSFCSQPSVISSPQINGEIDLLASGSLT 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB5 ESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ESECFGSLTEVSLPLAEQIESPDTKSRNEVVTPEKVCKNYLTSKKSLPLENNGKRGHHNR 310 320 330 340 350 360 330 340 350 360 370 380 pF1KB5 LSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGSKNSNMSDEF :::::::::::::::::::::::::::::::::::::::::::::::::: ::::::::: XP_016 LSSPISKRCRTSILSTSGDFVKQTVPSENIPLPECSSPPSCKRKVGGTSGRKNSNMSDEF 370 380 390 400 410 420 390 400 410 420 430 440 pF1KB5 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNMAVKRNHRGETLLHIASIKGDIPSVEYL 430 440 450 460 470 480 450 460 470 480 490 500 pF1KB5 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQHKALVNTTGYQNDSPLHDAAKNGHV 490 500 510 520 530 540 510 520 530 540 550 560 pF1KB5 DIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRD 550 560 570 580 590 600 570 580 590 600 610 620 pF1KB5 GPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDAVQSTLKCMLGILNG 610 620 630 640 650 660 630 640 650 660 670 680 pF1KB5 CWILKFE-WVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHH ::::::: : XP_016 CWILKFECWTAVVQS 670 >>NP_001269477 (OMIM: 114480,601593) BRCA1-associated RI (307 aa) initn: 1747 init1: 1747 opt: 1747 Z-score: 1033.8 bits: 200.7 E(85289): 7.6e-51 Smith-Waterman score: 1747; 100.0% identity (100.0% similar) in 254 aa overlap (524-777:54-307) 500 510 520 530 540 550 pF1KB5 NDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSS :::::::::::::::::::::::::::::: NP_001 PAMEPDGRGAWAHSRAALDRLEKLLRCSRCNIFGLRPVDYTDDESMKSLLLLPEKNESSS 30 40 50 60 70 80 560 570 580 590 600 610 pF1KB5 ASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDA 90 100 110 120 130 140 620 630 640 650 660 670 pF1KB5 VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFD 150 160 170 180 190 200 680 690 700 710 720 730 pF1KB5 GCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFC 210 220 230 240 250 260 740 750 760 770 pF1KB5 TQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS :::::::::::::::::::::::::::::::::::::::::::: NP_001 TQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS 270 280 290 300 >-- initn: 373 init1: 373 opt: 373 Z-score: 242.2 bits: 54.3 E(85289): 9.4e-07 Smith-Waterman score: 373; 98.1% identity (98.1% similar) in 53 aa overlap (1-53:1-53) 10 20 30 40 50 60 pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP ::::::::::::::::::::::: ::::::::::::::::::::::::::::: NP_001 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCNIFGLRP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL NP_001 VDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAV 70 80 90 100 110 120 >>NP_001269474 (OMIM: 114480,601593) BRCA1-associated RI (326 aa) initn: 1747 init1: 1747 opt: 1747 Z-score: 1033.5 bits: 200.8 E(85289): 7.9e-51 Smith-Waterman score: 1747; 100.0% identity (100.0% similar) in 254 aa overlap (524-777:73-326) 500 510 520 530 540 550 pF1KB5 NDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMKSLLLLPEKNESSS :::::::::::::::::::::::::::::: NP_001 RLEKLLRCSRCTNILREPVCLGGCEHIFCSNIFGLRPVDYTDDESMKSLLLLPEKNESSS 50 60 70 80 90 100 560 570 580 590 600 610 pF1KB5 ASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEFDSTVTHVVVPGDA 110 120 130 140 150 160 620 630 640 650 660 670 pF1KB5 VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFD 170 180 190 200 210 220 680 690 700 710 720 730 pF1KB5 GCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHARPDSDQRFC 230 240 250 260 270 280 740 750 760 770 pF1KB5 TQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS :::::::::::::::::::::::::::::::::::::::::::: NP_001 TQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS 290 300 310 320 >-- initn: 517 init1: 517 opt: 517 Z-score: 324.9 bits: 69.6 E(85289): 2.3e-11 Smith-Waterman score: 517; 98.6% identity (98.6% similar) in 72 aa overlap (1-72:1-72) 10 20 30 40 50 60 pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: NP_001 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL :::::::::::: NP_001 VCLGGCEHIFCSNIFGLRPVDYTDDESMKSLLLLPEKNESSSASHCSVMNTGQRRDGPLV 70 80 90 100 110 120 >>NP_001269478 (OMIM: 114480,601593) BRCA1-associated RI (264 aa) initn: 1011 init1: 1011 opt: 1011 Z-score: 610.6 bits: 122.2 E(85289): 2.9e-27 Smith-Waterman score: 1011; 100.0% identity (100.0% similar) in 142 aa overlap (636-777:123-264) 610 620 630 640 650 660 pF1KB5 HVVVPGDAVQSTLKCMLGILNGCWILKFEWVKACLRRKVCEQEEKYEIPEGPRRSRLNRE :::::::::::::::::::::::::::::: NP_001 QDLKINRQLDSMIQLCSKLRNLLHDNELSGVKACLRRKVCEQEEKYEIPEGPRRSRLNRE 100 110 120 130 140 150 670 680 690 700 710 720 pF1KB5 QLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLLPKLFDGCYFYLWGTFKHHPKDNLIKLVTAGGGQILSRKPKPDSDVTQTINTVAYHAR 160 170 180 190 200 210 730 740 750 760 770 pF1KB5 PDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDSDQRFCTQYIIYEDLCNYHPERVRQGKVWKAPSSWFIDCVMSFELLPLDS 220 230 240 250 260 >-- initn: 871 init1: 871 opt: 871 Z-score: 529.9 bits: 107.3 E(85289): 8.9e-23 Smith-Waterman score: 871; 99.2% identity (99.2% similar) in 121 aa overlap (1-121:1-121) 10 20 30 40 50 60 pF1KB5 MPDNRQPRNRQPRIRSGNEPRSASAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP ::::::::::::::::::::::: :::::::::::::::::::::::::::::::::::: NP_001 MPDNRQPRNRQPRIRSGNEPRSAPAMEPDGRGAWAHSRAALDRLEKLLRCSRCTNILREP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB5 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VCLGGCEHIFCSNCVSDCIGTGCPVCYTPAWIQDLKINRQLDSMIQLCSKLRNLLHDNEL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB5 SDLKEDKPRKSLFNDAGNKKNSIKMWFSPRSKKVRYVVSKASVQTQPAIKKDASAQQDSY : NP_001 SGVKACLRRKVCEQEEKYEIPEGPRRSRLNREQLLPKLFDGCYFYLWGTFKHHPKDNLIK 130 140 150 160 170 180 >>XP_011523940 (OMIM: 610616) PREDICTED: ankyrin repeat (1923 aa) initn: 464 init1: 428 opt: 439 Z-score: 270.8 bits: 62.2 E(85289): 2.4e-08 Smith-Waterman score: 439; 45.8% identity (73.2% similar) in 153 aa overlap (391-543:149-300) 370 380 390 400 410 420 pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM :: . :. :... . ..::. . . XP_011 KSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQ-KKTPSSSSRQKDK 120 130 140 150 160 170 430 440 450 460 470 480 pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL . :::.:::: ::.:.:.::. .:. :.. :.. :::: ::::::::::: :. :...: XP_011 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 180 190 200 210 220 230 490 500 510 520 530 540 pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK . : ::: : ..:.::::.:..:: ::::::: .:.. .: : :::: .. : .. XP_011 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE 240 250 260 270 280 290 550 560 570 580 590 600 pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF :: XP_011 LLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSA 300 310 320 330 340 350 >>NP_001190985 (OMIM: 610616) ankyrin repeat domain-cont (2039 aa) initn: 464 init1: 428 opt: 439 Z-score: 270.5 bits: 62.2 E(85289): 2.5e-08 Smith-Waterman score: 439; 45.8% identity (73.2% similar) in 153 aa overlap (391-543:126-277) 370 380 390 400 410 420 pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM :: . :. :... . ..::. . . NP_001 KSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQ-KKTPSSSSRQKDK 100 110 120 130 140 150 430 440 450 460 470 480 pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL . :::.:::: ::.:.:.::. .:. :.. :.. :::: ::::::::::: :. :...: NP_001 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 160 170 180 190 200 210 490 500 510 520 530 540 pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK . : ::: : ..:.::::.:..:: ::::::: .:.. .: : :::: .. : .. NP_001 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE 220 230 240 250 260 270 550 560 570 580 590 600 pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF :: NP_001 LLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSA 280 290 300 310 320 330 >>XP_016881152 (OMIM: 610616) PREDICTED: ankyrin repeat (2039 aa) initn: 464 init1: 428 opt: 439 Z-score: 270.5 bits: 62.2 E(85289): 2.5e-08 Smith-Waterman score: 439; 45.8% identity (73.2% similar) in 153 aa overlap (391-543:126-277) 370 380 390 400 410 420 pF1KB5 ECSSPPSCKRKVGGTSGSKNSNMSDEFISLSPGTPPSTLSSSSYRRVMSSPSAMKLLPNM :: . :. :... . ..::. . . XP_016 KSTPVSILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQ-KKTPSSSSRQKDK 100 110 120 130 140 150 430 440 450 460 470 480 pF1KB5 AVKRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELL . :::.:::: ::.:.:.::. .:. :.. :.. :::: ::::::::::: :. :...: XP_016 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 160 170 180 190 200 210 490 500 510 520 530 540 pF1KB5 LQHKALVNTTGYQNDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVDYTDDESMK . : ::: : ..:.::::.:..:: ::::::: .:.. .: : :::: .. : .. XP_016 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE 220 230 240 250 260 270 550 560 570 580 590 600 pF1KB5 SLLLLPEKNESSSASHCSVMNTGQRRDGPLVLIGSGLSSEQQKMLSELAVILKAKKYTEF :: XP_016 LLLKREVPLSDDDESYTDSEEAQSVNPSSVDENIDSETEKDSLICESKQILPSKTPLPSA 280 290 300 310 320 330 777 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:02:23 2016 done: Sun Nov 6 18:02:25 2016 Total Scan time: 13.780 Total Display time: 0.140 Function used was FASTA [36.3.4 Apr, 2011]