FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE2220, 174 aa 1>>>pF1KE2220 174 - 174 aa - 174 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1501+/-0.000326; mu= 13.3929+/- 0.020 mean_var=66.7333+/-13.020, 0's: 0 Z-trim(116.2): 31 B-trim: 0 in 0/53 Lambda= 0.157001 statistics sampled from 27085 (27119) to 27085 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.318), width: 16 Scan time: 4.920 The best scores are: opt bits E(85289) XP_011508964 (OMIM: 123680,604307) PREDICTED: gamm ( 174) 1251 291.7 4.1e-79 NP_066269 (OMIM: 123680,604307) gamma-crystallin C ( 174) 1251 291.7 4.1e-79 NP_005201 (OMIM: 123670,615188) gamma-crystallin B ( 175) 1020 239.4 2.3e-63 XP_016858891 (OMIM: 123670,615188) PREDICTED: gamm ( 177) 1019 239.1 2.7e-63 NP_055432 (OMIM: 123660) gamma-crystallin A [Homo ( 174) 972 228.5 4.3e-60 NP_008822 (OMIM: 115700,123690) gamma-crystallin D ( 174) 920 216.7 1.5e-56 NP_060011 (OMIM: 116100,123730) beta-crystallin S ( 178) 698 166.4 2.1e-41 XP_011514138 (OMIM: 609603) PREDICTED: gamma-cryst ( 295) 464 113.6 2.9e-25 XP_005250009 (OMIM: 609603) PREDICTED: gamma-cryst ( 182) 448 109.8 2.4e-24 NP_004067 (OMIM: 123630,609741) beta-crystallin B3 ( 211) 400 99.0 5e-21 XP_011528204 (OMIM: 123630,609741) PREDICTED: beta ( 267) 400 99.0 6.1e-21 XP_011528202 (OMIM: 123620,601547) PREDICTED: beta ( 205) 388 96.2 3.2e-20 XP_006724204 (OMIM: 123620,601547) PREDICTED: beta ( 205) 388 96.2 3.2e-20 NP_000487 (OMIM: 123620,601547) beta-crystallin B2 ( 205) 388 96.2 3.2e-20 XP_011514139 (OMIM: 609603) PREDICTED: gamma-cryst ( 260) 384 95.4 7.3e-20 XP_011528201 (OMIM: 600929,611544) PREDICTED: beta ( 252) 382 94.9 9.8e-20 NP_001878 (OMIM: 600929,611544) beta-crystallin B1 ( 252) 382 94.9 9.8e-20 NP_005199 (OMIM: 123610,600881) beta-crystallin A3 ( 215) 371 92.4 4.8e-19 XP_016879687 (OMIM: 123610,600881) PREDICTED: beta ( 316) 371 92.5 6.6e-19 NP_001877 (OMIM: 123631,610425) beta-crystallin A4 ( 196) 351 87.9 1e-17 XP_006724203 (OMIM: 123631,610425) PREDICTED: beta ( 201) 351 87.9 1.1e-17 XP_016884087 (OMIM: 123631,610425) PREDICTED: beta ( 207) 351 87.9 1.1e-17 NP_476435 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 330 83.1 2.8e-16 NP_476434 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 330 83.1 2.8e-16 NP_653328 (OMIM: 609603) gamma-crystallin N isofor ( 182) 321 81.0 1.1e-15 NP_001615 (OMIM: 601797) absent in melanoma 1 prot (1723) 292 75.1 6.3e-13 XP_005266896 (OMIM: 601797) PREDICTED: absent in m (2131) 292 75.2 7.5e-13 NP_001295221 (OMIM: 609603) gamma-crystallin N iso ( 125) 275 70.5 1.1e-12 XP_016867262 (OMIM: 609603) PREDICTED: gamma-cryst ( 125) 275 70.5 1.1e-12 XP_016884088 (OMIM: 123630,609741) PREDICTED: beta ( 169) 205 54.7 8.3e-08 XP_016865822 (OMIM: 601797) PREDICTED: absent in m (1544) 162 45.6 0.00042 >>XP_011508964 (OMIM: 123680,604307) PREDICTED: gamma-cr (174 aa) initn: 1251 init1: 1251 opt: 1251 Z-score: 1541.4 bits: 291.7 E(85289): 4.1e-79 Smith-Waterman score: 1251; 100.0% identity (100.0% similar) in 174 aa overlap (1-174:1-174) 10 20 30 40 50 60 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY 130 140 150 160 170 >>NP_066269 (OMIM: 123680,604307) gamma-crystallin C [Ho (174 aa) initn: 1251 init1: 1251 opt: 1251 Z-score: 1541.4 bits: 291.7 E(85289): 4.1e-79 Smith-Waterman score: 1251; 100.0% identity (100.0% similar) in 174 aa overlap (1-174:1-174) 10 20 30 40 50 60 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY 130 140 150 160 170 >>NP_005201 (OMIM: 123670,615188) gamma-crystallin B [Ho (175 aa) initn: 592 init1: 592 opt: 1020 Z-score: 1258.6 bits: 239.4 E(85289): 2.3e-63 Smith-Waterman score: 1020; 78.9% identity (93.1% similar) in 175 aa overlap (1-174:1-175) 10 20 30 40 50 60 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR :::::::::::::::::: :::::::::::::::::::::::::.::::::::.::.::: NP_005 MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRR 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 GEYPDYQQWMGLSDSIRSCCLIP-QTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLS ::::::::::::::::::::::: .. ..:...:.:.. .: : ::..:: :.::::::. NP_005 GEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHLT 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 EIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY ::.::.:::: :.:::.:::::::::::: :::: :::: .::.::::::.::: NP_005 EIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDLY 130 140 150 160 170 >>XP_016858891 (OMIM: 123670,615188) PREDICTED: gamma-cr (177 aa) initn: 593 init1: 593 opt: 1019 Z-score: 1257.3 bits: 239.1 E(85289): 2.7e-63 Smith-Waterman score: 1019; 79.2% identity (91.0% similar) in 178 aa overlap (1-174:1-177) 10 20 30 40 50 60 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR :::::::::::::::::: :::::::::::::::::::::::::.::::::::.::.::: XP_016 MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRR 10 20 30 40 50 60 70 80 90 100 110 pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSH----RLRLYEREDHKGLMMELSEDCPSIQDRF ::::::::::::::::::::::: ::: :...:.:.. .: : ::..:: :.:::: XP_016 GEYPDYQQWMGLSDSIRSCCLIPP-VSHSGAYRMKIYDRDELRGQMSELTDDCISVQDRF 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 HLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY ::.::.::.:::: :.:::.:::::::::::: :::: :::: .::.::::::.::: XP_016 HLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDLY 120 130 140 150 160 170 >>NP_055432 (OMIM: 123660) gamma-crystallin A [Homo sapi (174 aa) initn: 972 init1: 972 opt: 972 Z-score: 1199.9 bits: 228.5 E(85289): 4.3e-60 Smith-Waterman score: 972; 74.7% identity (90.2% similar) in 174 aa overlap (1-174:1-174) 10 20 30 40 50 60 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR :::::::::: :::: :. .:::::. ::::::::::.::::::::::::::.::.::: NP_055 MGKITFYEDRDFQGRCYNCISDCPNLRVYFSRCNSIRVDSGCWMLYERPNYQGHQYFLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE :.:::::.:::::::..:: .::.: ::.::::::.:..::: ::..:: . . :.: : NP_055 GKYPDYQHWMGLSDSVQSCRIIPHTSSHKLRLYERDDYRGLMSELTDDCACVPELFRLPE 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY : :::::::::::::.:::::::::::: .::: .:::. :::.::::::.::: NP_055 IYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKVGSLRRVTDLY 130 140 150 160 170 >>NP_008822 (OMIM: 115700,123690) gamma-crystallin D [Ho (174 aa) initn: 1060 init1: 920 opt: 920 Z-score: 1136.2 bits: 216.7 E(85289): 1.5e-56 Smith-Waterman score: 920; 71.7% identity (90.2% similar) in 173 aa overlap (1-173:1-173) 10 20 30 40 50 60 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR :::::.::::.:::: :: ..: ::::::.::::: ::.::::::::.:::.: ::.::: NP_008 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE2 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE :.: :.:::::::::.::: :::.. :::.:::::::..: :.:..::: .::::...: NP_008 GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE 70 80 90 100 110 120 130 140 150 160 170 pF1KE2 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY :.::.:::: :::::: ::::::::: : .::: ::::: .:..::::::.:. NP_008 IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS 130 140 150 160 170 >>NP_060011 (OMIM: 116100,123730) beta-crystallin S [Hom (178 aa) initn: 649 init1: 367 opt: 698 Z-score: 864.3 bits: 166.4 E(85289): 2.1e-41 Smith-Waterman score: 698; 53.5% identity (79.7% similar) in 172 aa overlap (3-172:7-178) 10 20 30 40 50 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQY :::::::. :::: :. :: ... :.::::::.::.: : .:::::. : .: NP_060 MSKTGTKITFYEDKNFQGRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMY 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 LLRRGEYPDYQQWMGLSDSIRSCCLI--PQTVSHRLRLYEREDHKGLMMELSEDCPSIQD .: .::::.::.::::.: . :: . :. .......:. : .: :.: .::::::.. NP_060 ILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIME 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 RFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY .::. ::.: .:::: :..::::::::::::: .:::. :::: . . :.::.:. NP_060 QFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIVE 130 140 150 160 170 >>XP_011514138 (OMIM: 609603) PREDICTED: gamma-crystalli (295 aa) initn: 583 init1: 195 opt: 464 Z-score: 574.7 bits: 113.6 E(85289): 2.9e-25 Smith-Waterman score: 464; 38.8% identity (72.5% similar) in 178 aa overlap (2-174:6-183) 10 20 30 40 50 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQP--YFSRCNSIRVESGCWMLYERPNYQGQ ::::.:: . : :.. :. :: :.: ...: :::.:::: :. ...:...:: XP_011 MAQRSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 QYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSH-RLRLYEREDHKGLMMELSEDCPSIQ :..:..:.:::. .: . :: . :: . . : ::...: . : .:. :: : .: XP_011 QFILEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 DRFHLSE-IRSLHVL-EGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVV .: ... . ...: .: ::::: :::.::.:... ..: .:: : .:.. ::..:: XP_011 SRGWVKNCVNTIKVYGDGAWVLYEEPNYHGRMYVVESGDFRSFSDWEAHSARVQSLHKVV 130 140 150 160 170 180 pF1KE2 DLY ... XP_011 NFFQPSPPTGMAGRSSGDRGNPLRSHPDLGTLGDKSPQSQRAASECSLGSGHPSPGRSWM 190 200 210 220 230 240 >>XP_005250009 (OMIM: 609603) PREDICTED: gamma-crystalli (182 aa) initn: 567 init1: 195 opt: 448 Z-score: 558.1 bits: 109.8 E(85289): 2.4e-24 Smith-Waterman score: 448; 38.1% identity (71.6% similar) in 176 aa overlap (2-172:6-181) 10 20 30 40 50 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNLQP--YFSRCNSIRVESGCWMLYERPNYQGQ ::::.:: . : :.. :. :: :.: ...: :::.:::: :. ...:...:: XP_005 MAQRSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHVESGAWVCFNHPDFRGQ 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE2 QYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSH-RLRLYEREDHKGLMMELSEDCPSIQ :..:..:.:::. .: . :: . :: . . : ::...: . : .:. :: : .: XP_005 QFILEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQ 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE2 DRFHLSE-IRSLHVL-EGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVV .: ... . ...: .: ::::: :::.::.:... ..: .:: : .:.. ::.. . XP_005 SRGWVKNCVNTIKVYGDGAWVLYEEPNYHGRMYVVESGDFRSFSDWEAHSARVQSLHKSM 130 140 150 160 170 180 pF1KE2 DLY . XP_005 EP >>NP_004067 (OMIM: 123630,609741) beta-crystallin B3 [Ho (211 aa) initn: 347 init1: 168 opt: 400 Z-score: 498.5 bits: 99.0 E(85289): 5e-21 Smith-Waterman score: 400; 34.9% identity (68.0% similar) in 175 aa overlap (3-172:25-199) 10 20 30 pF1KE2 MGKITFYEDRAFQGRSYETTTDCPNL-QPYFSRCNSIR :. .:: . :::. : ...::.: . . . .::. NP_004 MAEQHGAPEQAAAGKSHGDLGGSYKVILYELENFQGKRCELSAECPSLTDSLLEKVGSIQ 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE2 VESGCWMLYERPNYQGQQYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVS---HRLRLYE :::: :. .: ..:.:..:..:.:: .. : . :: : : ... :.:.:.: NP_004 VESGPWLAFESRAFRGEQFVLEKGDYPRWDAWSNSRDSDSLLSLRPLNIDSPHHKLHLFE 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE2 REDHKGLMMEL-SEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRR .: ::. ..: ::. . ... :.....: :: ::.:.::::::... :::. NP_004 NPAFSGRKMEIVDDDVPSLWAHGFQDRVASVRAINGTWVGYEFPGYRGRQYVFERGEYRH 130 140 150 160 170 180 160 170 pF1KE2 CQDWGAMDAKAGSLRRVVDLY ..: : . . :.::. : NP_004 WNEWDASQPQLQSVRRIRDQKWHKRGRFPSS 190 200 210 174 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:05:05 2016 done: Sun Nov 6 18:05:06 2016 Total Scan time: 4.920 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]