Result of FASTA (omim) for
pFN21AE6527
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6527, 174 aa
1>>>pF1KE6527 174 - 174 aa - 174 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8264+/-0.000331; mu= 15.2088+/- 0.021
mean_var=61.2914+/-12.197, 0's: 0 Z-trim(114.7): 34 B-trim: 253 in 1/49
Lambda= 0.163823
statistics sampled from 24720 (24756) to 24720 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.29), width: 16
Scan time: 4.770
The best scores are: opt bits E(85289)
NP_008822 (OMIM: 115700,123690) gamma-crystallin D ( 174) 1248 303.0 1.6e-82
NP_005201 (OMIM: 123670,615188) gamma-crystallin B ( 175) 951 232.8 2.2e-61
XP_016858891 (OMIM: 123670,615188) PREDICTED: gamm ( 177) 947 231.8 4.2e-61
NP_055432 (OMIM: 123660) gamma-crystallin A [Homo ( 174) 931 228.1 5.7e-60
NP_066269 (OMIM: 123680,604307) gamma-crystallin C ( 174) 920 225.5 3.5e-59
XP_011508964 (OMIM: 123680,604307) PREDICTED: gamm ( 174) 920 225.5 3.5e-59
NP_060011 (OMIM: 116100,123730) beta-crystallin S ( 178) 660 164.0 1.1e-40
XP_011514139 (OMIM: 609603) PREDICTED: gamma-cryst ( 260) 417 106.7 2.9e-23
NP_005199 (OMIM: 123610,600881) beta-crystallin A3 ( 215) 363 93.9 1.7e-19
XP_016879687 (OMIM: 123610,600881) PREDICTED: beta ( 316) 363 94.0 2.4e-19
NP_004067 (OMIM: 123630,609741) beta-crystallin B3 ( 211) 360 93.2 2.8e-19
XP_011528204 (OMIM: 123630,609741) PREDICTED: beta ( 267) 360 93.2 3.4e-19
NP_001878 (OMIM: 600929,611544) beta-crystallin B1 ( 252) 357 92.5 5.3e-19
XP_011528201 (OMIM: 600929,611544) PREDICTED: beta ( 252) 357 92.5 5.3e-19
NP_000487 (OMIM: 123620,601547) beta-crystallin B2 ( 205) 348 90.3 2e-18
XP_006724204 (OMIM: 123620,601547) PREDICTED: beta ( 205) 348 90.3 2e-18
XP_011528202 (OMIM: 123620,601547) PREDICTED: beta ( 205) 348 90.3 2e-18
NP_001615 (OMIM: 601797) absent in melanoma 1 prot (1723) 276 73.9 1.4e-12
XP_005266896 (OMIM: 601797) PREDICTED: absent in m (2131) 276 74.0 1.7e-12
NP_001295221 (OMIM: 609603) gamma-crystallin N iso ( 125) 214 58.5 4.5e-09
XP_016867262 (OMIM: 609603) PREDICTED: gamma-cryst ( 125) 214 58.5 4.5e-09
NP_653328 (OMIM: 609603) gamma-crystallin N isofor ( 182) 214 58.6 6.1e-09
XP_005250009 (OMIM: 609603) PREDICTED: gamma-cryst ( 182) 214 58.6 6.1e-09
XP_011514138 (OMIM: 609603) PREDICTED: gamma-cryst ( 295) 214 58.8 9e-09
NP_476434 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 177 49.9 2.8e-06
NP_476435 (OMIM: 115900,600836) beta-crystallin A2 ( 197) 177 49.9 2.8e-06
NP_001877 (OMIM: 123631,610425) beta-crystallin A4 ( 196) 176 49.7 3.3e-06
XP_006724203 (OMIM: 123631,610425) PREDICTED: beta ( 201) 176 49.7 3.3e-06
XP_016884087 (OMIM: 123631,610425) PREDICTED: beta ( 207) 176 49.7 3.4e-06
XP_016884088 (OMIM: 123630,609741) PREDICTED: beta ( 169) 172 48.7 5.6e-06
XP_016865822 (OMIM: 601797) PREDICTED: absent in m (1544) 180 51.2 8.7e-06
>>NP_008822 (OMIM: 115700,123690) gamma-crystallin D [Ho (174 aa)
initn: 1248 init1: 1248 opt: 1248 Z-score: 1602.5 bits: 303.0 E(85289): 1.6e-82
Smith-Waterman score: 1248; 100.0% identity (100.0% similar) in 174 aa overlap (1-174:1-174)
10 20 30 40 50 60
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
130 140 150 160 170
>>NP_005201 (OMIM: 123670,615188) gamma-crystallin B [Ho (175 aa)
initn: 987 init1: 500 opt: 951 Z-score: 1223.1 bits: 232.8 E(85289): 2.2e-61
Smith-Waterman score: 951; 72.4% identity (91.4% similar) in 174 aa overlap (1-173:1-174)
10 20 30 40 50 60
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
:::::.::::.:::: :::..: ::::::.::::: ::.:::::.::.:::.: ::::::
NP_005 MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRR
10 20 30 40 50 60
70 80 90 100 110
pF1KE6 GDYADHQQWMGLSDSVRSCRLIP-HSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFN
:.: :.:::::::::.::: ::: :::..:...:.:.. :::: :.:.:: .::::...
NP_005 GEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHLT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 EIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
::::::::::::.:::. ::::::::: ::.:::. :::: ::.:::::::.:.
NP_005 EIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDLY
130 140 150 160 170
>>XP_016858891 (OMIM: 123670,615188) PREDICTED: gamma-cr (177 aa)
initn: 980 init1: 500 opt: 947 Z-score: 1217.9 bits: 231.8 E(85289): 4.2e-61
Smith-Waterman score: 947; 71.6% identity (90.3% similar) in 176 aa overlap (1-173:1-176)
10 20 30 40 50 60
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
:::::.::::.:::: :::..: ::::::.::::: ::.:::::.::.:::.: ::::::
XP_016 MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRR
10 20 30 40 50 60
70 80 90 100 110
pF1KE6 GDYADHQQWMGLSDSVRSCRLIP---HSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFR
:.: :.:::::::::.::: ::: :::..:...:.:.. :::: :.:.:: .::::.
XP_016 GEYPDYQQWMGLSDSIRSCCLIPPVSHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFH
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 FNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
..::::::::::::.:::. ::::::::: ::.:::. :::: ::.:::::::.:.
XP_016 LTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDLY
130 140 150 160 170
>>NP_055432 (OMIM: 123660) gamma-crystallin A [Homo sapi (174 aa)
initn: 1079 init1: 931 opt: 931 Z-score: 1197.6 bits: 228.1 E(85289): 5.7e-60
Smith-Waterman score: 931; 72.3% identity (89.6% similar) in 173 aa overlap (1-173:1-173)
10 20 30 40 50 60
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
:::::.:::: :::: :.: :: :::. :.::::: :::::::::::.:::.: ::::::
NP_055 MGKITFYEDRDFQGRCYNCISDCPNLRVYFSRCNSIRVDSGCWMLYERPNYQGHQYFLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE
: : :.:.::::::::.:::.:::..::..:::::.:::: : :.:.::.:. . ::. :
NP_055 GKYPDYQHWMGLSDSVQSCRIIPHTSSHKLRLYERDDYRGLMSELTDDCACVPELFRLPE
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
:.::.:::: :::::. ::::::::: :::::::.:::...:.::::::: :.
NP_055 IYSLHVLEGCWVLYEMPNYRGRQYLLRPGDYRRYHDWGGADAKVGSLRRVTDLY
130 140 150 160 170
>>NP_066269 (OMIM: 123680,604307) gamma-crystallin C [Ho (174 aa)
initn: 1060 init1: 920 opt: 920 Z-score: 1183.5 bits: 225.5 E(85289): 3.5e-59
Smith-Waterman score: 920; 71.7% identity (90.2% similar) in 173 aa overlap (1-173:1-173)
10 20 30 40 50 60
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
:::::.::::.:::: :: ..: ::::::.::::: ::.::::::::.:::.: ::.:::
NP_066 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE
:.: :.:::::::::.::: :::.. :::.:::::::..: :.:..::: .::::...:
NP_066 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
:.::.:::: :::::: ::::::::: : .::: ::::: .:..::::::.:.
NP_066 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
130 140 150 160 170
>>XP_011508964 (OMIM: 123680,604307) PREDICTED: gamma-cr (174 aa)
initn: 1060 init1: 920 opt: 920 Z-score: 1183.5 bits: 225.5 E(85289): 3.5e-59
Smith-Waterman score: 920; 71.7% identity (90.2% similar) in 173 aa overlap (1-173:1-173)
10 20 30 40 50 60
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
:::::.::::.:::: :: ..: ::::::.::::: ::.::::::::.:::.: ::.:::
XP_011 MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNE
:.: :.:::::::::.::: :::.. :::.:::::::..: :.:..::: .::::...:
XP_011 GEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSE
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 IHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
:.::.:::: :::::: ::::::::: : .::: ::::: .:..::::::.:.
XP_011 IRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY
130 140 150 160 170
>>NP_060011 (OMIM: 116100,123730) beta-crystallin S [Hom (178 aa)
initn: 761 init1: 336 opt: 660 Z-score: 851.3 bits: 164.0 E(85289): 1.1e-40
Smith-Waterman score: 660; 50.0% identity (80.2% similar) in 172 aa overlap (3-172:7-178)
10 20 30 40 50
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQY
:::.:::..::::.:.:. : ... ::::::: .:..: : .::.::..: .:
NP_060 MSKTGTKITFYEDKNFQGRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 FLRRGDYADHQQWMGLSDSVRSCRLI--PHSGSHRIRLYEREDYRGQMIEFTEDCSCLQD
.: .:.: ..:.::::.: . ::: . : .:...:...:. :. ::: : :::: ...
NP_060 ILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIME
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 RFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
.:.. :::: .:::: :..::: ::::::::: .::. ::::.. : :.::...
NP_060 QFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIVE
130 140 150 160 170
>>XP_011514139 (OMIM: 609603) PREDICTED: gamma-crystalli (260 aa)
initn: 373 init1: 173 opt: 417 Z-score: 538.6 bits: 106.7 E(85289): 2.9e-23
Smith-Waterman score: 417; 40.8% identity (72.1% similar) in 147 aa overlap (30-173:1-147)
10 20 30 40 50 60
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRR
..: :: .:.:: :. ...:.. : :..:..
XP_011 MNRVNSIHVESGAWVCFNHPDFRGQQFILEH
10 20 30
70 80 90 100 110
pF1KE6 GDYADHQQWMGLSDSVRSCRLIPHSGSH-RIRLYEREDYRGQMIEFTEDCSCLQDR-FRF
::: : .: . :: . ::: . : : :....: .. :: .:: :: ::.: .
XP_011 GDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEGCNFTGQCLEFLEDSPFLQSRGWVK
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE6 NEIHSLNVL-EGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS
: .....: .:.::::: ::.::.:.. ::.: ..:: : .::: ::..:..:
XP_011 NCVNTIKVYGDGAWVLYEEPNYHGRMYVVESGDFRSFSDWEAHSARVQSLHKVVNFFQPS
100 110 120 130 140 150
XP_011 PPTGMAGRSSGDRGNPLRSHPDLGTLGDKSPQSQRAASECSLGSGHPSPGRSWMIQGAFP
160 170 180 190 200 210
>>NP_005199 (OMIM: 123610,600881) beta-crystallin A3 [Ho (215 aa)
initn: 300 init1: 103 opt: 363 Z-score: 470.8 bits: 93.9 E(85289): 1.7e-19
Smith-Waterman score: 363; 33.3% identity (67.2% similar) in 183 aa overlap (3-170:32-213)
10 20 30
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPY-LS
:::.:....:::...: .:. ::.. ..
NP_005 ETQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSFD
10 20 30 40 50 60
40 50 60 70 80
pF1KE6 RCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIPH----SGS
: .:.:: :. ::. .. : :..:.::.: . : : :.. . ::. :..
NP_005 NVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSG-SNAYHIERLMSFRPICSAN
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE6 HR---IRLYEREDYRGQMIEFTEDCSCLQDRFRFN-EIHSLNVLEGSWVLYELSNYRGRQ
:. . ..:.:.. :.. :...: :: :: :. :... :.:: :. .::: :
NP_005 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ
130 140 150 160 170 180
150 160 170
pF1KE6 YLL----MPGDYRRYQDWG--ATNARVGSLRRVIDFS
:.: :::.....:: : .... :.::.
NP_005 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
190 200 210
>>XP_016879687 (OMIM: 123610,600881) PREDICTED: beta-cry (316 aa)
initn: 300 init1: 103 opt: 363 Z-score: 468.4 bits: 94.0 E(85289): 2.4e-19
Smith-Waterman score: 363; 33.3% identity (67.2% similar) in 183 aa overlap (3-170:133-314)
10 20 30
pF1KE6 MGKITLYEDRGFQGRHYECSSDHPNLQPY-LS
:::.:....:::...: .:. ::.. ..
XP_016 HHSCVLCLPETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSFD
110 120 130 140 150 160
40 50 60 70 80
pF1KE6 RCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIPH----SGS
: .:.:: :. ::. .. : :..:.::.: . : : :.. . ::. :..
XP_016 NVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSG-SNAYHIERLMSFRPICSAN
170 180 190 200 210 220
90 100 110 120 130 140
pF1KE6 HR---IRLYEREDYRGQMIEFTEDCSCLQDRFRFN-EIHSLNVLEGSWVLYELSNYRGRQ
:. . ..:.:.. :.. :...: :: :: :. :... :.:: :. .::: :
XP_016 HKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQ
230 240 250 260 270 280
150 160 170
pF1KE6 YLL----MPGDYRRYQDWG--ATNARVGSLRRVIDFS
:.: :::.....:: : .... :.::.
XP_016 YILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ
290 300 310
174 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:07:12 2016 done: Tue Nov 8 14:07:13 2016
Total Scan time: 4.770 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]