FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE9523, 461 aa 1>>>pF1KE9523 461 - 461 aa - 461 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3097+/-0.000495; mu= 17.3467+/- 0.030 mean_var=68.7328+/-14.659, 0's: 0 Z-trim(108.7): 262 B-trim: 661 in 1/49 Lambda= 0.154701 statistics sampled from 16532 (16848) to 16532 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.545), E-opt: 0.2 (0.198), width: 16 Scan time: 6.900 The best scores are: opt bits E(85289) NP_001258680 (OMIM: 114190) calcitonin gene-relate ( 461) 3157 714.3 1.7e-205 NP_005786 (OMIM: 114190) calcitonin gene-related p ( 461) 3157 714.3 1.7e-205 XP_005246289 (OMIM: 114190) PREDICTED: calcitonin ( 472) 3157 714.3 1.7e-205 XP_005246288 (OMIM: 114190) PREDICTED: calcitonin ( 472) 3157 714.3 1.7e-205 XP_005246291 (OMIM: 114190) PREDICTED: calcitonin ( 472) 3157 714.3 1.7e-205 XP_016858640 (OMIM: 114190) PREDICTED: calcitonin ( 472) 3157 714.3 1.7e-205 NP_001158210 (OMIM: 114131,166710) calcitonin rece ( 474) 1872 427.5 3.7e-119 NP_001733 (OMIM: 114131,166710) calcitonin recepto ( 474) 1872 427.5 3.7e-119 NP_001158209 (OMIM: 114131,166710) calcitonin rece ( 508) 1209 279.6 1.4e-74 NP_001189411 (OMIM: 602034) corticotropin-releasin ( 410) 729 172.4 2e-42 NP_001189404 (OMIM: 602034) corticotropin-releasin ( 438) 723 171.1 5.4e-42 NP_001874 (OMIM: 602034) corticotropin-releasing f ( 411) 722 170.8 6e-42 XP_016867241 (OMIM: 602034) PREDICTED: corticotrop ( 397) 721 170.6 6.8e-42 NP_001189410 (OMIM: 602034) corticotropin-releasin ( 397) 721 170.6 6.8e-42 NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 710 168.2 4.1e-41 XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 709 168.0 4.9e-41 NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 703 166.6 1.2e-40 XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 703 166.6 1.2e-40 XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 703 166.6 1.2e-40 NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 703 166.6 1.2e-40 NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 703 166.6 1.2e-40 NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 698 165.5 2.5e-40 XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 692 164.1 6.2e-40 XP_011513430 (OMIM: 602034) PREDICTED: corticotrop ( 370) 685 162.6 1.7e-39 NP_001189412 (OMIM: 602034) corticotropin-releasin ( 387) 685 162.6 1.8e-39 XP_011513431 (OMIM: 602034) PREDICTED: corticotrop ( 387) 685 162.6 1.8e-39 NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 682 161.9 3.1e-39 NP_004373 (OMIM: 122561) corticotropin-releasing f ( 415) 672 159.7 1.4e-38 XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 656 156.1 1.7e-37 XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 656 156.1 1.7e-37 XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 643 153.2 1.1e-36 XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 640 152.5 1.9e-36 NP_001138619 (OMIM: 122561) corticotropin-releasin ( 375) 626 149.4 1.6e-35 NP_000155 (OMIM: 137241) gastric inhibitory polype ( 466) 626 149.4 1.9e-35 NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 625 149.2 2.2e-35 XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 600 143.6 9.4e-34 NP_001289949 (OMIM: 122561) corticotropin-releasin ( 314) 585 140.2 7.7e-33 NP_001138620 (OMIM: 122561) corticotropin-releasin ( 401) 575 138.0 4.4e-32 NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 574 137.8 5.6e-32 XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 574 137.8 5.8e-32 NP_001295347 (OMIM: 137241) gastric inhibitory pol ( 430) 562 135.1 3.5e-31 XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 560 134.7 5e-31 NP_001138618 (OMIM: 122561) corticotropin-releasin ( 444) 532 128.5 3.7e-29 NP_000814 (OMIM: 139191,612781) growth hormone-rel ( 423) 527 127.3 7.8e-29 XP_016867240 (OMIM: 602034) PREDICTED: corticotrop ( 558) 524 126.7 1.6e-28 XP_005263787 (OMIM: 182098) PREDICTED: secretin re ( 262) 518 125.2 2.1e-28 XP_005265401 (OMIM: 125350,156400,168468,215045,60 ( 562) 521 126.1 2.5e-28 NP_000307 (OMIM: 125350,156400,168468,215045,60000 ( 593) 521 126.1 2.6e-28 XP_016862422 (OMIM: 125350,156400,168468,215045,60 ( 593) 521 126.1 2.6e-28 NP_001171673 (OMIM: 125350,156400,168468,215045,60 ( 593) 521 126.1 2.6e-28 >>NP_001258680 (OMIM: 114190) calcitonin gene-related pe (461 aa) initn: 3157 init1: 3157 opt: 3157 Z-score: 3810.4 bits: 714.3 E(85289): 1.7e-205 Smith-Waterman score: 3157; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KE9 MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS 370 380 390 400 410 420 430 440 450 460 pF1KE9 YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN ::::::::::::::::::::::::::::::::::::::::: NP_001 YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN 430 440 450 460 >>NP_005786 (OMIM: 114190) calcitonin gene-related pepti (461 aa) initn: 3157 init1: 3157 opt: 3157 Z-score: 3810.4 bits: 714.3 E(85289): 1.7e-205 Smith-Waterman score: 3157; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:1-461) 10 20 30 40 50 60 pF1KE9 MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE9 EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE9 WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE9 FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE9 IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE9 ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE9 AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS 370 380 390 400 410 420 430 440 450 460 pF1KE9 YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN ::::::::::::::::::::::::::::::::::::::::: NP_005 YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN 430 440 450 460 >>XP_005246289 (OMIM: 114190) PREDICTED: calcitonin gene (472 aa) initn: 3157 init1: 3157 opt: 3157 Z-score: 3810.3 bits: 714.3 E(85289): 1.7e-205 Smith-Waterman score: 3157; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:12-472) 10 20 30 40 pF1KE9 MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECY ::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLYSIFHFGLMMEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECY 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 QKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 SCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFW 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 MLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTH 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE9 LLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE9 VLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE9 FSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN 430 440 450 460 470 >>XP_005246288 (OMIM: 114190) PREDICTED: calcitonin gene (472 aa) initn: 3157 init1: 3157 opt: 3157 Z-score: 3810.3 bits: 714.3 E(85289): 1.7e-205 Smith-Waterman score: 3157; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:12-472) 10 20 30 40 pF1KE9 MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECY ::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLYSIFHFGLMMEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECY 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 QKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 SCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFW 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 MLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTH 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE9 LLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE9 VLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE9 FSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN 430 440 450 460 470 >>XP_005246291 (OMIM: 114190) PREDICTED: calcitonin gene (472 aa) initn: 3157 init1: 3157 opt: 3157 Z-score: 3810.3 bits: 714.3 E(85289): 1.7e-205 Smith-Waterman score: 3157; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:12-472) 10 20 30 40 pF1KE9 MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECY ::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLYSIFHFGLMMEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECY 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 QKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 SCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFW 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 MLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTH 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE9 LLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE9 VLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE9 FSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 FSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN 430 440 450 460 470 >>XP_016858640 (OMIM: 114190) PREDICTED: calcitonin gene (472 aa) initn: 3157 init1: 3157 opt: 3157 Z-score: 3810.3 bits: 714.3 E(85289): 1.7e-205 Smith-Waterman score: 3157; 100.0% identity (100.0% similar) in 461 aa overlap (1-461:12-472) 10 20 30 40 pF1KE9 MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECY ::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLYSIFHFGLMMEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECY 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE9 QKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE9 NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSL 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE9 SCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFW 190 200 210 220 230 240 230 240 250 260 270 280 pF1KE9 MLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTH 250 260 270 280 290 300 290 300 310 320 330 340 pF1KE9 LLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEF 310 320 330 340 350 360 350 360 370 380 390 400 pF1KE9 VLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNS 370 380 390 400 410 420 410 420 430 440 450 460 pF1KE9 FSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN :::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN 430 440 450 460 470 >>NP_001158210 (OMIM: 114131,166710) calcitonin receptor (474 aa) initn: 1851 init1: 1851 opt: 1872 Z-score: 2260.3 bits: 427.5 E(85289): 3.7e-119 Smith-Waterman score: 1872; 57.8% identity (81.6% similar) in 445 aa overlap (4-442:8-449) 10 20 30 40 50 pF1KE9 MEKKCTLYFLVL------LPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQ .: ::.: :: : . .: .: . : :.:.: :::.::. NP_001 MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYV---VGRKKMMDAQYKCYD 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 KIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGN ...: : :.:: ::::::::::::.:. ::. :.:.::::: :::::::::: ::. : NP_001 RMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 WFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLS ::.:: .::::.:::.::. : ::.:.: :.::.:.::.::: .:.:::::: .:.::. NP_001 WFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 CQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWM :::.:::::.:.... ::.. ::::. :. : :: .:::::. .:.: :.:.:::::: NP_001 CQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWM 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 LCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHL ::::::::::::::::.:::.: :::.:::::::.:. ::::.:..:.:::::.: .::: NP_001 LCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 LYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFV :::::::. :::.::.::::::::::.::.. ::.:::..:.:::.::.::::::::.:: NP_001 LYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE9 LIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSF ..:::: .:. ..:::.:: :.::::..:.::.:: :.:::. ..:.: :.:::... . NP_001 VFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRW 360 370 380 390 400 410 420 430 440 450 460 pF1KE9 SNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN . . ::: .... : . : .: : NP_001 GRRPSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSA 420 430 440 450 460 470 >>NP_001733 (OMIM: 114131,166710) calcitonin receptor is (474 aa) initn: 1851 init1: 1851 opt: 1872 Z-score: 2260.3 bits: 427.5 E(85289): 3.7e-119 Smith-Waterman score: 1872; 57.8% identity (81.6% similar) in 445 aa overlap (4-442:8-449) 10 20 30 40 50 pF1KE9 MEKKCTLYFLVL------LPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQ .: ::.: :: : . .: .: . : :.:.: :::.::. NP_001 MRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYV---VGRKKMMDAQYKCYD 10 20 30 40 50 60 70 80 90 100 110 pF1KE9 KIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGN ...: : :.:: ::::::::::::.:. ::. :.:.::::: :::::::::: ::. : NP_001 RMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYFPDFDPSEKVTKYCDEKGV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KE9 WFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLS ::.:: .::::.:::.::. : ::.:.: :.::.:.::.::: .:.:::::: .:.::. NP_001 WFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLSIFTLVISLGIFVFFRSLG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KE9 CQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWM :::.:::::.:.... ::.. ::::. :. : :: .:::::. .:.: :.:.:::::: NP_001 CQRVTLHKNMFLTYILNSMIIIIHLVEVVPNGELVRRDPVSCKILHFFHQYMMACNYFWM 180 190 200 210 220 230 240 250 260 270 280 290 pF1KE9 LCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHL ::::::::::::::::.:::.: :::.:::::::.:. ::::.:..:.:::::.: .::: NP_001 LCEGIYLHTLIVVAVFTEKQRLRWYYLLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHL 240 250 260 270 280 290 300 310 320 330 340 350 pF1KE9 LYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFV :::::::. :::.::.::::::::::.::.. ::.:::..:.:::.::.::::::::.:: NP_001 LYIIHGPVMAALVVNFFFLLNIVRVLVTKMRETHEAESHMYLKAVKATMILVPLLGIQFV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KE9 LIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSF ..:::: .:. ..:::.:: :.::::..:.::.:: :.:::. ..:.: :.:::... . NP_001 VFPWRPSNKMLGKIYDYVMHSLIHFQGFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRW 360 370 380 390 400 410 420 430 440 450 460 pF1KE9 SNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN . . ::: .... : . : .: : NP_001 GRRPSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSA 420 430 440 450 460 470 >>NP_001158209 (OMIM: 114131,166710) calcitonin receptor (508 aa) initn: 1201 init1: 1201 opt: 1209 Z-score: 1460.1 bits: 279.6 E(85289): 1.4e-74 Smith-Waterman score: 1830; 55.7% identity (78.7% similar) in 461 aa overlap (4-442:26-483) 10 20 30 pF1KE9 MEKKCTLYFLVL------LPFFMILVTAELEESPEDSI .: ::.: :: : . .: .: . NP_001 MQFSGEKISGQRDLQKSKMRFTFTSRCLALFLLLNHPTPILPAFSNQTYPTIEPKPFLYV 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE9 QLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYF : :.:.: :::.::....: : :.:: ::::::::::::.:. ::. :.:.::::: NP_001 ---VGRKKMMDAQYKCYDRMQQLPAYQGEGPYCNRTWDGWLCWDDTPAGVLSYQFCPDYF 70 80 90 100 110 100 110 120 130 140 150 pF1KE9 QDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLS :::::::::: ::. : ::.:: .::::.:::.::. : ::.:.: :.::.:.::.:: NP_001 PDFDPSEKVTKYCDEKGVWFKHPENNRTWSNYTMCNAFTPEKLKNAYVLYYLAIVGHSLS 120 130 140 150 160 170 160 170 180 190 pF1KE9 IASLLISLGIFFYFK----------------SLSCQRITLHKNLFFSFVCNSVVTIIHLT : .:.:::::: .:. ::.:::.:::::.:.... ::.. ::::. NP_001 IFTLVISLGIFVFFRKLTTIFPLNWKYRKALSLGCQRVTLHKNMFLTYILNSMIIIIHLV 180 190 200 210 220 230 200 210 220 230 240 250 pF1KE9 AVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYY :. : :: .:::::. .:.: :.:.::::::::::::::::::::::.:::.: ::: NP_001 EVVPNGELVRRDPVSCKILHFFHQYMMACNYFWMLCEGIYLHTLIVVAVFTEKQRLRWYY 240 250 260 270 280 290 260 270 280 290 300 310 pF1KE9 FLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVL .:::::::.:. ::::.:..:.:::::.: .::::::::::. :::.::.:::::::::: NP_001 LLGWGFPLVPTTIHAITRAVYFNDNCWLSVETHLLYIIHGPVMAALVVNFFFLLNIVRVL 300 310 320 330 340 350 320 330 340 350 360 370 pF1KE9 ITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQ .::.. ::.:::..:.:::.::.::::::::.::..:::: .:. ..:::.:: :.::: NP_001 VTKMRETHEAESHMYLKAVKATMILVPLLGIQFVVFPWRPSNKMLGKIYDYVMHSLIHFQ 360 370 380 390 400 410 380 390 400 410 420 430 pF1KE9 GLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDC :..:.::.:: :.:::. ..:.: :.:::... .. . ::: .... : . : NP_001 GFFVATIYCFCNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYIC 420 430 440 450 460 470 440 450 460 pF1KE9 PSEHLNGKSIHDIENVLLKPENLYN .: : NP_001 HQELRNEPANNQGEESAEIIPLNIIEQESSA 480 490 500 >>NP_001189411 (OMIM: 602034) corticotropin-releasing fa (410 aa) initn: 568 init1: 218 opt: 729 Z-score: 882.5 bits: 172.4 E(85289): 2e-42 Smith-Waterman score: 729; 34.8% identity (65.2% similar) in 359 aa overlap (56-403:29-377) 30 40 50 60 70 80 pF1KE9 ESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEG--VYCNRTWDGW-LCWNDVAAGT : . :: ::: : : :: :::. NP_001 MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTLDQIGTCWPRSAAGA 10 20 30 40 50 90 100 110 120 130 140 pF1KE9 ESMQLCPDYFQD--FDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALN . ::.::. .. .... . : ..:.: ::. ::.::. .: : :. NP_001 LVERPCPEYFNGVKYNTTRNAYRECLENGTW----ASK---INYSQCEPILDDKRKYDLH 60 70 80 90 100 110 150 160 170 180 190 pF1KE9 L---FYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTA . .. .:: .:.:.:. .. .:. ..:. : : ..: ::. .:. .:. .. : NP_001 YRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFILRNVMWFL-LQL 120 130 140 150 160 170 200 210 220 230 240 250 pF1KE9 VANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYF : .. . .: : :. : :.. :.:::. :: :::: ::.. .:. . . : NP_001 V--DHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTERLRKCLFLF 180 190 200 210 220 260 270 280 290 300 310 pF1KE9 LGWGFPLIPACIHAIARSLYYNDNCWISSDTHLL--YIIHGPICAALLVNLFFLLNIVRV .:: .:. ::.. : :..::.... : :: .::: .::.:. ::.::::. NP_001 IGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRI 230 240 250 260 270 280 320 330 340 350 360 370 pF1KE9 LITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRP-EGKIAEEVYDYIMHILMH :.:::... .:. : :::.:::.:.::::: ..:. : : ... .. :. .:. NP_001 LMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIMFIYFNSFLQS 290 300 310 320 330 340 380 390 400 410 420 430 pF1KE9 FQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSH :::..::...:::::::.. .:. :.... NP_001 FQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMSIPTSPTRISFHSIKQTA 350 360 370 380 390 400 461 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:10:36 2016 done: Sun Nov 6 18:10:38 2016 Total Scan time: 6.900 Total Display time: 0.080 Function used was FASTA [36.3.4 Apr, 2011]