FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4195, 704 aa 1>>>pF1KE4195 704 - 704 aa - 704 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.6757+/-0.000445; mu= 3.9157+/- 0.028 mean_var=168.6714+/-35.815, 0's: 0 Z-trim(116.6): 97 B-trim: 1548 in 2/52 Lambda= 0.098754 statistics sampled from 27810 (27914) to 27810 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.327), width: 16 Scan time: 11.300 The best scores are: opt bits E(85289) NP_073737 (OMIM: 613334) E3 ubiquitin-protein liga ( 704) 4579 665.1 2.6e-190 XP_005246830 (OMIM: 613334) PREDICTED: E3 ubiquiti ( 704) 4579 665.1 2.6e-190 NP_001269734 (OMIM: 613334) E3 ubiquitin-protein l ( 704) 4579 665.1 2.6e-190 XP_005246831 (OMIM: 613334) PREDICTED: E3 ubiquiti ( 691) 4351 632.6 1.5e-180 XP_016860207 (OMIM: 613334) PREDICTED: E3 ubiquiti ( 691) 4351 632.6 1.5e-180 NP_001269736 (OMIM: 613334) E3 ubiquitin-protein l ( 666) 4252 618.5 2.6e-176 XP_016860209 (OMIM: 613334) PREDICTED: E3 ubiquiti ( 648) 3479 508.3 3.7e-143 XP_016860208 (OMIM: 613334) PREDICTED: E3 ubiquiti ( 648) 3479 508.3 3.7e-143 NP_001269735 (OMIM: 613334) E3 ubiquitin-protein l ( 635) 3251 475.9 2.2e-133 XP_016860210 (OMIM: 613334) PREDICTED: E3 ubiquiti ( 635) 3251 475.9 2.2e-133 XP_011522739 (OMIM: 613337) PREDICTED: probable E3 ( 807) 583 95.8 7.1e-19 NP_001094345 (OMIM: 613337) probable E3 ubiquitin- ( 808) 583 95.8 7.1e-19 NP_689811 (OMIM: 613337) probable E3 ubiquitin-pro ( 808) 583 95.8 7.1e-19 NP_001275708 (OMIM: 613337) probable E3 ubiquitin- ( 846) 583 95.8 7.4e-19 XP_005257163 (OMIM: 613337) PREDICTED: probable E3 ( 752) 572 94.2 2e-18 XP_005257160 (OMIM: 613337) PREDICTED: probable E3 ( 799) 572 94.2 2.1e-18 NP_001275709 (OMIM: 613337) probable E3 ubiquitin- ( 799) 572 94.2 2.1e-18 XP_005257159 (OMIM: 613337) PREDICTED: probable E3 ( 824) 572 94.2 2.1e-18 XP_011522738 (OMIM: 613337) PREDICTED: probable E3 ( 825) 572 94.2 2.1e-18 XP_005257157 (OMIM: 613337) PREDICTED: probable E3 ( 825) 572 94.2 2.1e-18 XP_005257155 (OMIM: 613337) PREDICTED: probable E3 ( 862) 572 94.2 2.2e-18 XP_011522737 (OMIM: 613337) PREDICTED: probable E3 ( 862) 572 94.2 2.2e-18 XP_005257154 (OMIM: 613337) PREDICTED: probable E3 ( 863) 572 94.2 2.2e-18 XP_005257152 (OMIM: 613337) PREDICTED: probable E3 ( 863) 572 94.2 2.2e-18 XP_005257153 (OMIM: 613337) PREDICTED: probable E3 ( 863) 572 94.2 2.2e-18 NP_055023 (OMIM: 125420,125485,125490,125500,60559 (1301) 290 54.1 3.9e-06 XP_016861969 (OMIM: 161565) PREDICTED: NK-tumor re (1094) 232 45.8 0.001 XP_016861967 (OMIM: 161565) PREDICTED: NK-tumor re (1095) 232 45.8 0.001 XP_016861968 (OMIM: 161565) PREDICTED: NK-tumor re (1095) 232 45.8 0.001 XP_016861966 (OMIM: 161565) PREDICTED: NK-tumor re (1163) 232 45.9 0.0011 XP_016861965 (OMIM: 161565) PREDICTED: NK-tumor re (1163) 232 45.9 0.0011 XP_011532052 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 232 45.9 0.0011 XP_011532049 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 232 45.9 0.0011 XP_016861964 (OMIM: 161565) PREDICTED: NK-tumor re (1210) 232 45.9 0.0011 XP_006713236 (OMIM: 161565) PREDICTED: NK-tumor re (1353) 232 45.9 0.0012 XP_016861963 (OMIM: 161565) PREDICTED: NK-tumor re (1435) 232 45.9 0.0013 XP_006713234 (OMIM: 161565) PREDICTED: NK-tumor re (1436) 232 45.9 0.0013 NP_005376 (OMIM: 161565) NK-tumor recognition prot (1462) 232 45.9 0.0013 XP_005265230 (OMIM: 161565) PREDICTED: NK-tumor re (1463) 232 45.9 0.0013 NP_001010909 (OMIM: 616991) mucin-21 isoform 1 pre ( 566) 208 42.3 0.0063 >>NP_073737 (OMIM: 613334) E3 ubiquitin-protein ligase M (704 aa) initn: 4579 init1: 4579 opt: 4579 Z-score: 3537.6 bits: 665.1 E(85289): 2.6e-190 Smith-Waterman score: 4579; 100.0% identity (100.0% similar) in 704 aa overlap (1-704:1-704) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_073 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 610 620 630 640 650 660 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::::::::::::::::::::::::::::::::::::: NP_073 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA 670 680 690 700 >>XP_005246830 (OMIM: 613334) PREDICTED: E3 ubiquitin-pr (704 aa) initn: 4579 init1: 4579 opt: 4579 Z-score: 3537.6 bits: 665.1 E(85289): 2.6e-190 Smith-Waterman score: 4579; 100.0% identity (100.0% similar) in 704 aa overlap (1-704:1-704) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 610 620 630 640 650 660 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::::::::::::::::::::::::::::::::::::: XP_005 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA 670 680 690 700 >>NP_001269734 (OMIM: 613334) E3 ubiquitin-protein ligas (704 aa) initn: 4579 init1: 4579 opt: 4579 Z-score: 3537.6 bits: 665.1 E(85289): 2.6e-190 Smith-Waterman score: 4579; 100.0% identity (100.0% similar) in 704 aa overlap (1-704:1-704) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 610 620 630 640 650 660 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::::::::::::::::::::::::::::::::::::: NP_001 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA 670 680 690 700 >>XP_005246831 (OMIM: 613334) PREDICTED: E3 ubiquitin-pr (691 aa) initn: 4381 init1: 4351 opt: 4351 Z-score: 3362.2 bits: 632.6 E(85289): 1.5e-180 Smith-Waterman score: 4351; 99.9% identity (100.0% similar) in 670 aa overlap (1-670:1-670) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 610 620 630 640 650 660 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::. XP_005 TNEPSTRVRLQRMIPKKTETITGHLILPNFI 670 680 690 >>XP_016860207 (OMIM: 613334) PREDICTED: E3 ubiquitin-pr (691 aa) initn: 4381 init1: 4351 opt: 4351 Z-score: 3362.2 bits: 632.6 E(85289): 1.5e-180 Smith-Waterman score: 4351; 99.9% identity (100.0% similar) in 670 aa overlap (1-670:1-670) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 490 500 510 520 530 540 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 550 560 570 580 590 600 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 610 620 630 640 650 660 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::. XP_016 TNEPSTRVRLQRMIPKKTETITGHLILPNFI 670 680 690 >>NP_001269736 (OMIM: 613334) E3 ubiquitin-protein ligas (666 aa) initn: 4251 init1: 4251 opt: 4252 Z-score: 3286.2 bits: 618.5 E(85289): 2.6e-176 Smith-Waterman score: 4252; 99.4% identity (99.4% similar) in 659 aa overlap (46-704:8-666) 20 30 40 50 60 70 pF1KE4 PSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQG : : :::::::::::::::::::::::: NP_001 MIGNYDHLMSLVTSTSASASASPFQSAWYSESEITQG 10 20 30 80 90 100 110 120 130 pF1KE4 ARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWRHSQVPRSSSMVLGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWRHSQVPRSSSMVLGSF 40 50 60 70 80 90 140 150 160 170 180 190 pF1KE4 GTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSYSQGARPKENSMSTLQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSYSQGARPKENSMSTLQ 100 110 120 130 140 150 200 210 220 230 240 250 pF1KE4 LNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQPGFSYSSSRDEAPIIS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQPGFSYSSSRDEAPIIS 160 170 180 190 200 210 260 270 280 290 300 310 pF1KE4 NSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLNSENSY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 NSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLNSENSY 220 230 240 250 260 270 320 330 340 350 360 370 pF1KE4 VSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQ 280 290 300 310 320 330 380 390 400 410 420 430 pF1KE4 ESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLE 340 350 360 370 380 390 440 450 460 470 480 490 pF1KE4 AQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILPGSLFRFAVPPALGSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILPGSLFRFAVPPALGSN 400 410 420 430 440 450 500 510 520 530 540 550 pF1KE4 LTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDLCRIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDLCRIC 460 470 480 490 500 510 560 570 580 590 600 610 pF1KE4 QMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNL 520 530 540 550 560 570 620 630 640 650 660 670 pF1KE4 EDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLAR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLAR 580 590 600 610 620 630 680 690 700 pF1KE4 TLQAHMEDLETSEDDSEEDGDHNRTFDIA ::::::::::::::::::::::::::::: NP_001 TLQAHMEDLETSEDDSEEDGDHNRTFDIA 640 650 660 >>XP_016860209 (OMIM: 613334) PREDICTED: E3 ubiquitin-pr (648 aa) initn: 3460 init1: 3460 opt: 3479 Z-score: 2691.2 bits: 508.3 E(85289): 3.7e-143 Smith-Waterman score: 4088; 92.0% identity (92.0% similar) in 704 aa overlap (1-704:1-648) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSD---- 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::: XP_016 ----------------------------------------------------VQDRVPSY 120 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 430 440 450 460 470 480 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 490 500 510 520 530 540 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 550 560 570 580 590 600 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::::::::::::::::::::::::::::::::::::: XP_016 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA 610 620 630 640 >>XP_016860208 (OMIM: 613334) PREDICTED: E3 ubiquitin-pr (648 aa) initn: 3460 init1: 3460 opt: 3479 Z-score: 2691.2 bits: 508.3 E(85289): 3.7e-143 Smith-Waterman score: 4088; 92.0% identity (92.0% similar) in 704 aa overlap (1-704:1-648) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSD---- 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::: XP_016 ----------------------------------------------------VQDRVPSY 120 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 430 440 450 460 470 480 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 490 500 510 520 530 540 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 550 560 570 580 590 600 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::::::::::::::::::::::::::::::::::::: XP_016 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA 610 620 630 640 >>NP_001269735 (OMIM: 613334) E3 ubiquitin-protein ligas (635 aa) initn: 3968 init1: 3227 opt: 3251 Z-score: 2515.8 bits: 475.9 E(85289): 2.2e-133 Smith-Waterman score: 3860; 91.5% identity (91.6% similar) in 670 aa overlap (1-670:1-614) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSD---- 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::: NP_001 ----------------------------------------------------VQDRVPSY 120 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 430 440 450 460 470 480 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 490 500 510 520 530 540 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 550 560 570 580 590 600 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::. NP_001 TNEPSTRVRLQRMIPKKTETITGHLILPNFI 610 620 630 >>XP_016860210 (OMIM: 613334) PREDICTED: E3 ubiquitin-pr (635 aa) initn: 3968 init1: 3227 opt: 3251 Z-score: 2515.8 bits: 475.9 E(85289): 2.2e-133 Smith-Waterman score: 3860; 91.5% identity (91.6% similar) in 670 aa overlap (1-670:1-614) 10 20 30 40 50 60 pF1KE4 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR :::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSD---- 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY :::::::: XP_016 ----------------------------------------------------VQDRVPSY 120 190 200 210 220 230 240 pF1KE4 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP 130 140 150 160 170 180 250 260 270 280 290 300 pF1KE4 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS 190 200 210 220 230 240 310 320 330 340 350 360 pF1KE4 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL 250 260 270 280 290 300 370 380 390 400 410 420 pF1KE4 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR 310 320 330 340 350 360 430 440 450 460 470 480 pF1KE4 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE4 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL 430 440 450 460 470 480 550 560 570 580 590 600 pF1KE4 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA 490 500 510 520 530 540 610 620 630 640 650 660 pF1KE4 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN 550 560 570 580 590 600 670 680 690 700 pF1KE4 TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA :::::::::. XP_016 TNEPSTRVRLQRMIPKKTETITGHLILPNFI 610 620 630 704 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 09:46:47 2016 done: Sun Nov 6 09:46:48 2016 Total Scan time: 11.300 Total Display time: 0.160 Function used was FASTA [36.3.4 Apr, 2011]