FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1636, 152 aa 1>>>pF1KE1636 152 - 152 aa - 152 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7211+/-0.000273; mu= 15.1751+/- 0.017 mean_var=57.9448+/-11.290, 0's: 0 Z-trim(118.5): 34 B-trim: 3 in 1/57 Lambda= 0.168487 statistics sampled from 31498 (31536) to 31498 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.37), width: 16 Scan time: 4.970 The best scores are: opt bits E(85289) NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152) 1041 260.4 8.3e-70 NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152) 1041 260.4 8.3e-70 NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155) 371 97.5 9e-21 NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155) 371 97.5 9e-21 XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143) 312 83.1 1.7e-16 NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143) 312 83.1 1.7e-16 NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143) 312 83.1 1.7e-16 XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143) 312 83.1 1.7e-16 NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159) 312 83.2 1.9e-16 NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177) 312 83.2 2.1e-16 NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180) 312 83.2 2.1e-16 NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169) 235 64.5 8.6e-11 XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157) 234 64.2 9.6e-11 NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157) 234 64.2 9.6e-11 XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158) 232 63.7 1.4e-10 XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158) 232 63.7 1.4e-10 NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158) 232 63.7 1.4e-10 XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158) 232 63.7 1.4e-10 NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134) 216 59.8 1.8e-09 NP_775295 (OMIM: 605510) interleukin-37 isoform 3 ( 157) 216 59.8 2e-09 XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178) 206 57.4 1.2e-08 NP_775296 (OMIM: 605510) interleukin-37 isoform 4 ( 178) 206 57.4 1.2e-08 NP_775297 (OMIM: 605510) interleukin-37 isoform 5 ( 192) 206 57.5 1.3e-08 NP_775294 (OMIM: 605510) interleukin-37 isoform 2 ( 197) 206 57.5 1.3e-08 NP_055254 (OMIM: 605510) interleukin-37 isoform 1 ( 218) 206 57.5 1.4e-08 XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218) 206 57.5 1.4e-08 XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 147 43.2 0.00031 NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 147 43.2 0.00034 XP_011518013 (OMIM: 261100,602997) PREDICTED: cubi (2237) 137 41.4 0.01 >>NP_775184 (OMIM: 615296) interleukin-1 family member 1 (152 aa) initn: 1041 init1: 1041 opt: 1041 Z-score: 1374.2 bits: 260.4 E(85289): 8.3e-70 Smith-Waterman score: 1041; 98.7% identity (98.7% similar) in 152 aa overlap (1-152:1-152) 10 20 30 40 50 60 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICTLPNRGLDRTKVPIFLG ::::::::::::::::::::::::::::::::::::::::::: :::::: ::::::::: NP_775 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_775 IQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGW 70 80 90 100 110 120 130 140 150 pF1KE1 FLCGPAEPQQPVQLTKESEPSARTKFYFEQSW :::::::::::::::::::::::::::::::: NP_775 FLCGPAEPQQPVQLTKESEPSARTKFYFEQSW 130 140 150 >>NP_115945 (OMIM: 615296) interleukin-1 family member 1 (152 aa) initn: 1041 init1: 1041 opt: 1041 Z-score: 1374.2 bits: 260.4 E(85289): 8.3e-70 Smith-Waterman score: 1041; 98.7% identity (98.7% similar) in 152 aa overlap (1-152:1-152) 10 20 30 40 50 60 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICTLPNRGLDRTKVPIFLG ::::::::::::::::::::::::::::::::::::::::::: :::::: ::::::::: NP_115 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICILPNRGLARTKVPIFLG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 IQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_115 IQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGW 70 80 90 100 110 120 130 140 150 pF1KE1 FLCGPAEPQQPVQLTKESEPSARTKFYFEQSW :::::::::::::::::::::::::::::::: NP_115 FLCGPAEPQQPVQLTKESEPSARTKFYFEQSW 130 140 150 >>NP_775262 (OMIM: 605507,614204) interleukin-36 recepto (155 aa) initn: 348 init1: 210 opt: 371 Z-score: 493.9 bits: 97.5 E(85289): 9e-21 Smith-Waterman score: 371; 44.4% identity (69.4% similar) in 144 aa overlap (12-150:11-153) 10 20 30 40 50 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL .: . :.:: ...:::.: : . .:.: ..::: :: . :..: NP_775 MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVIL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG :.::::.::.: .: :.: :: ::: ::: :..:. :::.. . : . .:.::.:: NP_775 GVQGGSQCLSCGVGQE-PTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPG 60 70 80 90 100 110 120 130 140 150 pF1KE1 WFLCGPAEPQQPVQLTKESEPSAR----TKFYFEQSW :::: : .:::.::. : .. : :::.: NP_775 WFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD 120 130 140 150 >>NP_036407 (OMIM: 605507,614204) interleukin-36 recepto (155 aa) initn: 348 init1: 210 opt: 371 Z-score: 493.9 bits: 97.5 E(85289): 9e-21 Smith-Waterman score: 371; 44.4% identity (69.4% similar) in 144 aa overlap (12-150:11-153) 10 20 30 40 50 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL .: . :.:: ...:::.: : . .:.: ..::: :: . :..: NP_036 MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVIL 10 20 30 40 50 60 70 80 90 100 110 pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG :.::::.::.: .: :.: :: ::: ::: :..:. :::.. . : . .:.::.:: NP_036 GVQGGSQCLSCGVGQE-PTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPG 60 70 80 90 100 110 120 130 140 150 pF1KE1 WFLCGPAEPQQPVQLTKESEPSAR----TKFYFEQSW :::: : .:::.::. : .. : :::.: NP_036 WFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD 120 130 140 150 >>XP_011509423 (OMIM: 137215,147679,612628,612852) PREDI (143 aa) initn: 322 init1: 260 opt: 312 Z-score: 416.9 bits: 83.1 E(85289): 1.7e-16 Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:10-141) 10 20 30 40 50 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL .::..: :..::..: . : ::: ..: . .:: XP_011 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPH-----ALFL 10 20 30 40 60 70 80 90 100 110 pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG ::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . .:.:: :: XP_011 GIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPG 50 60 70 80 90 100 120 130 140 150 pF1KE1 WFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW :::: : .:::.::. .: :::::.. XP_011 WFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE 110 120 130 140 >>NP_001305843 (OMIM: 137215,147679,612628,612852) inter (143 aa) initn: 322 init1: 260 opt: 312 Z-score: 416.9 bits: 83.1 E(85289): 1.7e-16 Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:10-141) 10 20 30 40 50 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL .::..: :..::..: . : ::: ..: . .:: NP_001 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPH-----ALFL 10 20 30 40 60 70 80 90 100 110 pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG ::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . .:.:: :: NP_001 GIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPG 50 60 70 80 90 100 120 130 140 150 pF1KE1 WFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW :::: : .:::.::. .: :::::.. NP_001 WFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE 110 120 130 140 >>NP_776215 (OMIM: 137215,147679,612628,612852) interleu (143 aa) initn: 322 init1: 260 opt: 312 Z-score: 416.9 bits: 83.1 E(85289): 1.7e-16 Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:10-141) 10 20 30 40 50 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL .::..: :..::..: . : ::: ..: . .:: NP_776 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPH-----ALFL 10 20 30 40 60 70 80 90 100 110 pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG ::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . .:.:: :: NP_776 GIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPG 50 60 70 80 90 100 120 130 140 150 pF1KE1 WFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW :::: : .:::.::. .: :::::.. NP_776 WFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE 110 120 130 140 >>XP_005263718 (OMIM: 137215,147679,612628,612852) PREDI (143 aa) initn: 322 init1: 260 opt: 312 Z-score: 416.9 bits: 83.1 E(85289): 1.7e-16 Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:10-141) 10 20 30 40 50 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRGLDRTKVPIFL .::..: :..::..: . : ::: ..: . .:: XP_005 MQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPH-----ALFL 10 20 30 40 60 70 80 90 100 110 pF1KE1 GIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPG ::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . .:.:: :: XP_005 GIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPG 50 60 70 80 90 100 120 130 140 150 pF1KE1 WFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW :::: : .:::.::. .: :::::.. XP_005 WFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE 110 120 130 140 >>NP_000568 (OMIM: 137215,147679,612628,612852) interleu (159 aa) initn: 322 init1: 260 opt: 312 Z-score: 416.3 bits: 83.2 E(85289): 1.9e-16 Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:26-157) 10 20 30 40 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICTLPNRG .::..: :..::..: . : ::: ..: . NP_000 MALETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE1 LDRTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSA .::::.::. ::.::.. . :::: ::: .: .. .. ::.:..:.:: . NP_000 H-----ALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPT 70 80 90 100 110 110 120 130 140 150 pF1KE1 FRLEAAAWPGWFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW .:.:: :::::: : .:::.::. .: :::::.. NP_000 TSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE 120 130 140 150 >>NP_776214 (OMIM: 137215,147679,612628,612852) interleu (177 aa) initn: 322 init1: 260 opt: 312 Z-score: 415.6 bits: 83.2 E(85289): 2.1e-16 Smith-Waterman score: 312; 41.6% identity (67.9% similar) in 137 aa overlap (16-150:44-175) 10 20 30 40 pF1KE1 MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCC-AEKICT .::..: :..::..: . : ::: . NP_776 LLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDV 20 30 40 50 60 70 50 60 70 80 90 100 pF1KE1 LPNRGLDRTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQS .: . .::::.::. ::.::.. . :::: ::: .: .. .. ::.:..: NP_776 VPIEPH-----ALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRS 80 90 100 110 120 110 120 130 140 150 pF1KE1 SSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTK-ESEPSARTKFYFEQSW .:: . .:.:: :::::: : .:::.::. .: :::::.. NP_776 DSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE 130 140 150 160 170 152 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:18:19 2016 done: Sun Nov 6 18:18:20 2016 Total Scan time: 4.970 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]