FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1652, 169 aa 1>>>pF1KE1652 169 - 169 aa - 169 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9491+/-0.000318; mu= 14.6928+/- 0.020 mean_var=65.4244+/-13.511, 0's: 0 Z-trim(116.8): 29 B-trim: 689 in 1/54 Lambda= 0.158564 statistics sampled from 28143 (28172) to 28143 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.33), width: 16 Scan time: 4.880 The best scores are: opt bits E(85289) NP_062564 (OMIM: 605542) interleukin-36 gamma isof ( 169) 1146 270.2 1.1e-72 NP_001265497 (OMIM: 605542) interleukin-36 gamma i ( 134) 779 186.2 1.7e-47 XP_011509267 (OMIM: 605509) PREDICTED: interleukin ( 158) 616 149.0 3.3e-36 NP_055255 (OMIM: 605509) interleukin-36 alpha [Hom ( 158) 616 149.0 3.3e-36 XP_005263696 (OMIM: 605509) PREDICTED: interleukin ( 158) 616 149.0 3.3e-36 XP_016859295 (OMIM: 605509) PREDICTED: interleukin ( 158) 616 149.0 3.3e-36 XP_011509264 (OMIM: 605508) PREDICTED: interleukin ( 157) 461 113.5 1.5e-25 NP_775270 (OMIM: 605508) interleukin-36 beta isofo ( 157) 461 113.5 1.5e-25 NP_775297 (OMIM: 605510) interleukin-37 isoform 5 ( 192) 313 79.7 2.8e-15 NP_775294 (OMIM: 605510) interleukin-37 isoform 2 ( 197) 313 79.7 2.9e-15 NP_055254 (OMIM: 605510) interleukin-37 isoform 1 ( 218) 313 79.7 3.1e-15 XP_011509265 (OMIM: 605510) PREDICTED: interleukin ( 218) 313 79.7 3.1e-15 NP_055253 (OMIM: 605508) interleukin-36 beta isofo ( 164) 259 67.3 1.3e-11 NP_775295 (OMIM: 605510) interleukin-37 isoform 3 ( 157) 258 67.1 1.5e-11 XP_011509266 (OMIM: 605510) PREDICTED: interleukin ( 178) 258 67.1 1.6e-11 NP_775296 (OMIM: 605510) interleukin-37 isoform 4 ( 178) 258 67.1 1.6e-11 NP_115945 (OMIM: 615296) interleukin-1 family memb ( 152) 232 61.1 8.8e-10 NP_775184 (OMIM: 615296) interleukin-1 family memb ( 152) 232 61.1 8.8e-10 NP_775262 (OMIM: 605507,614204) interleukin-36 rec ( 155) 230 60.7 1.2e-09 NP_036407 (OMIM: 605507,614204) interleukin-36 rec ( 155) 230 60.7 1.2e-09 NP_776213 (OMIM: 137215,147679,612628,612852) inte ( 180) 216 57.5 1.3e-08 NP_000568 (OMIM: 137215,147679,612628,612852) inte ( 159) 211 56.3 2.6e-08 XP_011509423 (OMIM: 137215,147679,612628,612852) P ( 143) 210 56.1 2.8e-08 XP_005263718 (OMIM: 137215,147679,612628,612852) P ( 143) 210 56.1 2.8e-08 NP_776215 (OMIM: 137215,147679,612628,612852) inte ( 143) 210 56.1 2.8e-08 NP_001305843 (OMIM: 137215,147679,612628,612852) i ( 143) 210 56.1 2.8e-08 NP_776214 (OMIM: 137215,147679,612628,612852) inte ( 177) 211 56.3 2.8e-08 XP_016859477 (OMIM: 137215,147720) PREDICTED: inte ( 238) 156 43.9 0.00022 NP_000567 (OMIM: 137215,147720) interleukin-1 beta ( 269) 156 43.9 0.00024 >>NP_062564 (OMIM: 605542) interleukin-36 gamma isoform (169 aa) initn: 1146 init1: 1146 opt: 1146 Z-score: 1425.9 bits: 270.2 E(85289): 1.1e-72 Smith-Waterman score: 1146; 100.0% identity (100.0% similar) in 169 aa overlap (1-169:1-169) 10 20 30 40 50 60 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY 70 80 90 100 110 120 130 140 150 160 pF1KE1 RAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND ::::::::::::::::::::::::::::::::::::::::::::::::: NP_062 RAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND 130 140 150 160 >>NP_001265497 (OMIM: 605542) interleukin-36 gamma isofo (134 aa) initn: 894 init1: 779 opt: 779 Z-score: 973.6 bits: 186.2 E(85289): 1.7e-47 Smith-Waterman score: 826; 78.7% identity (79.3% similar) in 169 aa overlap (1-169:1-134) 10 20 30 40 50 60 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT :::::::::::::::::: .:::::: NP_001 MRGTPGDADGGGRAVYQS-----------------------------------ITVAVIT 10 20 70 80 90 100 110 120 pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY 30 40 50 60 70 80 130 140 150 160 pF1KE1 RAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND 90 100 110 120 130 >>XP_011509267 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa) initn: 617 init1: 561 opt: 616 Z-score: 771.1 bits: 149.0 E(85289): 3.3e-36 Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (22-167:10-156) 10 20 30 40 50 60 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT : :.:.:.:..::.:: :.:.::::.: ..:::.:.:. XP_011 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS 10 20 30 40 70 80 90 100 110 120 pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY :.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: :::: XP_011 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY 50 60 70 80 90 100 130 140 150 160 pF1KE1 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND ....::.::.:::::: :::: ::. :.:::.::::. .: : :.. XP_011 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF 110 120 130 140 150 >>NP_055255 (OMIM: 605509) interleukin-36 alpha [Homo sa (158 aa) initn: 617 init1: 561 opt: 616 Z-score: 771.1 bits: 149.0 E(85289): 3.3e-36 Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (22-167:10-156) 10 20 30 40 50 60 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT : :.:.:.:..::.:: :.:.::::.: ..:::.:.:. NP_055 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS 10 20 30 40 70 80 90 100 110 120 pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY :.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: :::: NP_055 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY 50 60 70 80 90 100 130 140 150 160 pF1KE1 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND ....::.::.:::::: :::: ::. :.:::.::::. .: : :.. NP_055 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF 110 120 130 140 150 >>XP_005263696 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa) initn: 617 init1: 561 opt: 616 Z-score: 771.1 bits: 149.0 E(85289): 3.3e-36 Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (22-167:10-156) 10 20 30 40 50 60 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT : :.:.:.:..::.:: :.:.::::.: ..:::.:.:. XP_005 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS 10 20 30 40 70 80 90 100 110 120 pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY :.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: :::: XP_005 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY 50 60 70 80 90 100 130 140 150 160 pF1KE1 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND ....::.::.:::::: :::: ::. :.:::.::::. .: : :.. XP_005 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF 110 120 130 140 150 >>XP_016859295 (OMIM: 605509) PREDICTED: interleukin-36 (158 aa) initn: 617 init1: 561 opt: 616 Z-score: 771.1 bits: 149.0 E(85289): 3.3e-36 Smith-Waterman score: 616; 59.9% identity (87.8% similar) in 147 aa overlap (22-167:10-156) 10 20 30 40 50 60 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT : :.:.:.:..::.:: :.:.::::.: ..:::.:.:. XP_016 MEKALKIDTPQQGSIQDINHRVWVLQDQTLIAVPRKDRMSPVTIALIS 10 20 30 40 70 80 90 100 110 120 pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY :.. :.::. ::.:::::... ..::.: :::.::::::::. :::::.:::::: :::: XP_016 CRHVETLEKDRGNPIYLGLNGLNLCLMCAKVGDQPTLQLKEKDIMDLYNQPEPVKSFLFY 50 60 70 80 90 100 130 140 150 160 pF1KE1 RAKTGRTSTLESVAFPDWFIA-SSKRDQPIILTSELGKSYNTAFELNIND ....::.::.:::::: :::: ::. :.:::.::::. .: : :.. XP_016 HSQSGRNSTFESVAFPGWFIAVSSEGGCPLILTQELGKANTTDFGLTMLF 110 120 130 140 150 >>XP_011509264 (OMIM: 605508) PREDICTED: interleukin-36 (157 aa) initn: 462 init1: 388 opt: 461 Z-score: 579.5 bits: 113.5 E(85289): 1.5e-25 Smith-Waterman score: 461; 45.0% identity (74.2% similar) in 151 aa overlap (17-166:4-154) 10 20 30 40 50 60 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT : : . .: : :.::.:.:..:.:.: : :. :::. .:. XP_011 MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIA 10 20 30 40 70 80 90 100 110 120 pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY :. : .. .:. .::::.. ..::.: .. .:::::::..::::: . . :::::. XP_011 CRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFF 50 60 70 80 90 100 130 140 150 160 pF1KE1 RAKTGRTSTLESVAFPDWFIASSKRD-QPIILTSELGKSYNTAFELNIND . : : ::...::..: ::::.: . :::.::.: : . :: : :. XP_011 HNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE 110 120 130 140 150 >>NP_775270 (OMIM: 605508) interleukin-36 beta isoform 2 (157 aa) initn: 462 init1: 388 opt: 461 Z-score: 579.5 bits: 113.5 E(85289): 1.5e-25 Smith-Waterman score: 461; 45.0% identity (74.2% similar) in 151 aa overlap (17-166:4-154) 10 20 30 40 50 60 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVIT : : . .: : :.::.:.:..:.:.: : :. :::. .:. NP_775 MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIA 10 20 30 40 70 80 90 100 110 120 pF1KE1 CKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFY :. : .. .:. .::::.. ..::.: .. .:::::::..::::: . . :::::. NP_775 CRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKEKNIMDLYVEKKAQKPFLFF 50 60 70 80 90 100 130 140 150 160 pF1KE1 RAKTGRTSTLESVAFPDWFIASSKRD-QPIILTSELGKSYNTAFELNIND . : : ::...::..: ::::.: . :::.::.: : . :: : :. NP_775 HNKEGSTSVFQSVSYPGWFIATSTTSGQPIFLTKERGITNNTNFYLDSVE 110 120 130 140 150 >>NP_775297 (OMIM: 605510) interleukin-37 isoform 5 [Hom (192 aa) initn: 264 init1: 120 opt: 313 Z-score: 395.3 bits: 79.7 E(85289): 2.8e-15 Smith-Waterman score: 313; 36.3% identity (67.8% similar) in 146 aa overlap (22-163:31-175) 10 20 30 40 50 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSV : .:.: ...: .:.. ::.::: .. . NP_775 MSGCDRRETETKGKNSFKKRLRGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI 10 20 30 40 50 60 60 70 80 90 100 pF1KE1 TPVTVAVITCKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQ--PTLQLKEQKIMDLYG : ... . : . .:.:: ::... :.::::.: : :.::::..:.: : . NP_775 RPEIFFALASSLSSASAE-KGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAA 70 80 90 100 110 110 120 130 140 150 160 pF1KE1 QPEPVK-PFLFYRAKTGRTSTLESVAFPDWFIASSKR-DQPIILTSELGKSYNTAFELNI : : .. ::.::::..: . :::.: : ::: .: ..:. .:... . . : NP_775 QKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQP 120 130 140 150 160 170 pF1KE1 ND NP_775 VCKAEMSPSEVSD 180 190 >>NP_775294 (OMIM: 605510) interleukin-37 isoform 2 [Hom (197 aa) initn: 264 init1: 120 opt: 313 Z-score: 395.1 bits: 79.7 E(85289): 2.9e-15 Smith-Waterman score: 313; 36.3% identity (67.8% similar) in 146 aa overlap (22-163:36-180) 10 20 30 40 50 pF1KE1 MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSV : .:.: ...: .:.. ::.::: .. . NP_775 ENSGVKMGSEDWEKDEPQCCLEGPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYI 10 20 30 40 50 60 60 70 80 90 100 pF1KE1 TPVTVAVITCKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQ--PTLQLKEQKIMDLYG : ... . : . .:.:: ::... :.::::.: : :.::::..:.: : . NP_775 RPEIFFALASSLSSASAE-KGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAA 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE1 QPEPVK-PFLFYRAKTGRTSTLESVAFPDWFIASSKR-DQPIILTSELGKSYNTAFELNI : : .. ::.::::..: . :::.: : ::: .: ..:. .:... . . : NP_775 QKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQP 130 140 150 160 170 180 pF1KE1 ND NP_775 VCKAEMSPSEVSD 190 169 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:18:49 2016 done: Sun Nov 6 18:18:50 2016 Total Scan time: 4.880 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]