FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE1973, 541 aa 1>>>pF1KE1973 541 - 541 aa - 541 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8697+/-0.000521; mu= 21.2354+/- 0.032 mean_var=76.5267+/-15.153, 0's: 0 Z-trim(108.1): 156 B-trim: 0 in 0/49 Lambda= 0.146611 statistics sampled from 16005 (16184) to 16005 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.533), E-opt: 0.2 (0.19), width: 16 Scan time: 6.980 The best scores are: opt bits E(85289) NP_003846 (OMIM: 604494) interleukin-18 receptor 1 ( 541) 3587 769.1 0 XP_005264096 (OMIM: 604494) PREDICTED: interleukin ( 540) 3570 765.5 0 XP_016860670 (OMIM: 604494) PREDICTED: interleukin ( 386) 2529 545.2 1.3e-154 NP_001269328 (OMIM: 604494) interleukin-18 recepto ( 385) 2512 541.6 1.6e-153 XP_005264097 (OMIM: 604494) PREDICTED: interleukin ( 488) 2472 533.2 6.8e-151 XP_011510401 (OMIM: 604494) PREDICTED: interleukin ( 487) 2125 459.8 8.4e-129 XP_016860671 (OMIM: 604494) PREDICTED: interleukin ( 292) 1905 413.1 6e-115 XP_016860672 (OMIM: 604494) PREDICTED: interleukin ( 291) 1888 409.5 7.2e-114 XP_016860673 (OMIM: 604494) PREDICTED: interleukin ( 291) 1888 409.5 7.2e-114 XP_011529207 (OMIM: 300277) PREDICTED: X-linked in ( 562) 655 149.0 3.7e-35 XP_016884892 (OMIM: 300277) PREDICTED: X-linked in ( 686) 655 149.1 4.3e-35 NP_059112 (OMIM: 300277) X-linked interleukin-1 re ( 686) 655 149.1 4.3e-35 XP_016884730 (OMIM: 300143,300206) PREDICTED: inte ( 570) 625 142.6 3e-33 XP_016884729 (OMIM: 300143,300206) PREDICTED: inte ( 696) 625 142.7 3.5e-33 NP_055086 (OMIM: 300143,300206) interleukin-1 rece ( 696) 625 142.7 3.5e-33 NP_001307912 (OMIM: 147810) interleukin-1 receptor ( 425) 597 136.6 1.5e-31 XP_011509418 (OMIM: 147810) PREDICTED: interleukin ( 569) 597 136.7 1.8e-31 XP_011509419 (OMIM: 147810) PREDICTED: interleukin ( 569) 597 136.7 1.8e-31 XP_005263987 (OMIM: 147810) PREDICTED: interleukin ( 569) 597 136.7 1.8e-31 XP_011509417 (OMIM: 147810) PREDICTED: interleukin ( 569) 597 136.7 1.8e-31 XP_005263991 (OMIM: 147810) PREDICTED: interleukin ( 569) 597 136.7 1.8e-31 XP_011509420 (OMIM: 147810) PREDICTED: interleukin ( 569) 597 136.7 1.8e-31 NP_001307910 (OMIM: 147810) interleukin-1 receptor ( 569) 597 136.7 1.8e-31 NP_000868 (OMIM: 147810) interleukin-1 receptor ty ( 569) 597 136.7 1.8e-31 XP_016859478 (OMIM: 147810) PREDICTED: interleukin ( 569) 597 136.7 1.8e-31 NP_001307911 (OMIM: 147810) interleukin-1 receptor ( 569) 597 136.7 1.8e-31 NP_001307909 (OMIM: 147810) interleukin-1 receptor ( 569) 597 136.7 1.8e-31 NP_001307907 (OMIM: 147810) interleukin-1 receptor ( 569) 597 136.7 1.8e-31 NP_001161401 (OMIM: 602626) interleukin-1 receptor ( 570) 578 132.7 3e-30 NP_001161400 (OMIM: 602626) interleukin-1 receptor ( 570) 578 132.7 3e-30 NP_002173 (OMIM: 602626) interleukin-1 receptor ac ( 570) 578 132.7 3e-30 XP_011510389 (OMIM: 604509) PREDICTED: interleukin ( 457) 561 129.0 3.1e-29 XP_011510390 (OMIM: 604509) PREDICTED: interleukin ( 457) 561 129.0 3.1e-29 NP_003844 (OMIM: 604509) interleukin-18 receptor a ( 599) 561 129.1 3.7e-29 NP_001307913 (OMIM: 147810) interleukin-1 receptor ( 386) 558 128.3 4.2e-29 NP_001161403 (OMIM: 602626) interleukin-1 receptor ( 687) 544 125.6 5e-28 XP_016861837 (OMIM: 602626) PREDICTED: interleukin ( 376) 540 124.5 5.8e-28 NP_003845 (OMIM: 604512) interleukin-1 receptor-li ( 575) 542 125.1 5.9e-28 XP_005264093 (OMIM: 604512) PREDICTED: interleukin ( 575) 542 125.1 5.9e-28 XP_011510396 (OMIM: 604512) PREDICTED: interleukin ( 595) 542 125.1 6e-28 XP_005264092 (OMIM: 604512) PREDICTED: interleukin ( 603) 542 125.1 6.1e-28 XP_016860663 (OMIM: 604512) PREDICTED: interleukin ( 606) 542 125.1 6.1e-28 XP_011510394 (OMIM: 604512) PREDICTED: interleukin ( 617) 542 125.1 6.2e-28 XP_011510393 (OMIM: 604512) PREDICTED: interleukin ( 622) 535 123.6 1.7e-27 XP_016860667 (OMIM: 604512) PREDICTED: interleukin ( 424) 532 122.8 2.1e-27 XP_016860668 (OMIM: 604512) PREDICTED: interleukin ( 424) 532 122.8 2.1e-27 XP_006712885 (OMIM: 604512) PREDICTED: interleukin ( 444) 532 122.9 2.1e-27 XP_006712883 (OMIM: 604512) PREDICTED: interleukin ( 529) 526 121.7 5.8e-27 XP_016860666 (OMIM: 604512) PREDICTED: interleukin ( 443) 525 121.4 5.9e-27 XP_016860664 (OMIM: 604512) PREDICTED: interleukin ( 508) 519 120.2 1.6e-26 >>NP_003846 (OMIM: 604494) interleukin-18 receptor 1 iso (541 aa) initn: 3587 init1: 3587 opt: 3587 Z-score: 4104.0 bits: 769.1 E(85289): 0 Smith-Waterman score: 3587; 100.0% identity (100.0% similar) in 541 aa overlap (1-541:1-541) 10 20 30 40 50 60 pF1KE1 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV 370 380 390 400 410 420 430 440 450 460 470 480 pF1KE1 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT 430 440 450 460 470 480 490 500 510 520 530 540 pF1KE1 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE 490 500 510 520 530 540 pF1KE1 S : NP_003 S >>XP_005264096 (OMIM: 604494) PREDICTED: interleukin-18 (540 aa) initn: 2125 init1: 2125 opt: 3570 Z-score: 4084.6 bits: 765.5 E(85289): 0 Smith-Waterman score: 3570; 99.8% identity (99.8% similar) in 541 aa overlap (1-541:1-540) 10 20 30 40 50 60 pF1KE1 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR :::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: XP_005 ASTGGTDTKSFILVRK-DMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR 310 320 330 340 350 370 380 390 400 410 420 pF1KE1 HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV 360 370 380 390 400 410 430 440 450 460 470 480 pF1KE1 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT 420 430 440 450 460 470 490 500 510 520 530 540 pF1KE1 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE 480 490 500 510 520 530 pF1KE1 S : XP_005 S 540 >>XP_016860670 (OMIM: 604494) PREDICTED: interleukin-18 (386 aa) initn: 2529 init1: 2529 opt: 2529 Z-score: 2896.5 bits: 545.2 E(85289): 1.3e-154 Smith-Waterman score: 2529; 100.0% identity (100.0% similar) in 385 aa overlap (157-541:2-386) 130 140 150 160 170 180 pF1KE1 SKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCV :::::::::::::::::::::::::::::: XP_016 MNCKKLLLENNKNPTIKKNAEFEDQGYYSCV 10 20 30 190 200 210 220 230 240 pF1KE1 HFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDV 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE1 IYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGT 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE1 DTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRD 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE1 ETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVV 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE1 DEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLP 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE1 QSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES 340 350 360 370 380 >>NP_001269328 (OMIM: 604494) interleukin-18 receptor 1 (385 aa) initn: 1459 init1: 1459 opt: 2512 Z-score: 2877.1 bits: 541.6 E(85289): 1.6e-153 Smith-Waterman score: 2512; 99.7% identity (99.7% similar) in 385 aa overlap (157-541:2-385) 130 140 150 160 170 180 pF1KE1 SKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCV :::::::::::::::::::::::::::::: NP_001 MNCKKLLLENNKNPTIKKNAEFEDQGYYSCV 10 20 30 190 200 210 220 230 240 pF1KE1 HFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDV 40 50 60 70 80 90 250 260 270 280 290 300 pF1KE1 IYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGT 100 110 120 130 140 150 310 320 330 340 350 360 pF1KE1 DTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRD :::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTKSFILVRK-DMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRD 160 170 180 190 200 210 370 380 390 400 410 420 pF1KE1 ETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVV 220 230 240 250 260 270 430 440 450 460 470 480 pF1KE1 DEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLP 280 290 300 310 320 330 490 500 510 520 530 540 pF1KE1 QSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES 340 350 360 370 380 >>XP_005264097 (OMIM: 604494) PREDICTED: interleukin-18 (488 aa) initn: 3203 init1: 2471 opt: 2472 Z-score: 2830.0 bits: 533.2 E(85289): 6.8e-151 Smith-Waterman score: 3101; 90.2% identity (90.2% similar) in 541 aa overlap (1-541:1-488) 10 20 30 40 50 60 pF1KE1 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR 310 320 330 340 350 360 370 380 390 400 410 420 pF1KE1 HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV :::::::::: XP_005 HLTRRDETLT-------------------------------------------------- 370 430 440 450 460 470 480 pF1KE1 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ---AVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT 380 390 400 410 420 490 500 510 520 530 540 pF1KE1 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE 430 440 450 460 470 480 pF1KE1 S : XP_005 S >>XP_011510401 (OMIM: 604494) PREDICTED: interleukin-18 (487 aa) initn: 3227 init1: 2125 opt: 2125 Z-score: 2433.4 bits: 459.8 E(85289): 8.4e-129 Smith-Waterman score: 3123; 90.0% identity (90.0% similar) in 541 aa overlap (1-541:1-487) 10 20 30 40 50 60 pF1KE1 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE1 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE1 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE1 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSAL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE1 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE1 ASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYR :::::::::::::::: XP_011 ASTGGTDTKSFILVRK-------------------------------------------- 310 370 380 390 400 410 420 pF1KE1 HLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ----------DGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVV 320 330 340 350 360 430 440 450 460 470 480 pF1KE1 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVT 370 380 390 400 410 420 490 500 510 520 530 540 pF1KE1 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSE 430 440 450 460 470 480 pF1KE1 S : XP_011 S >>XP_016860671 (OMIM: 604494) PREDICTED: interleukin-18 (292 aa) initn: 1905 init1: 1905 opt: 1905 Z-score: 2184.7 bits: 413.1 E(85289): 6e-115 Smith-Waterman score: 1905; 100.0% identity (100.0% similar) in 292 aa overlap (250-541:1-292) 220 230 240 250 260 270 pF1KE1 PKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHAS :::::::::::::::::::::::::::::: XP_016 MFGEENGSDPNIHEEKEMRIMTPEGKWHAS 10 20 30 280 290 300 310 320 330 pF1KE1 KVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILV 40 50 60 70 80 90 340 350 360 370 380 390 pF1KE1 AVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEI 100 110 120 130 140 150 400 410 420 430 440 450 pF1KE1 LPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESG 160 170 180 190 200 210 460 470 480 490 500 510 pF1KE1 LHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYL 220 230 240 250 260 270 520 530 540 pF1KE1 MPAKTVKPGRDEPEVLPVLSES :::::::::::::::::::::: XP_016 MPAKTVKPGRDEPEVLPVLSES 280 290 >>XP_016860672 (OMIM: 604494) PREDICTED: interleukin-18 (291 aa) initn: 1459 init1: 1459 opt: 1888 Z-score: 2165.3 bits: 409.5 E(85289): 7.2e-114 Smith-Waterman score: 1888; 99.7% identity (99.7% similar) in 292 aa overlap (250-541:1-291) 220 230 240 250 260 270 pF1KE1 PKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHAS :::::::::::::::::::::::::::::: XP_016 MFGEENGSDPNIHEEKEMRIMTPEGKWHAS 10 20 30 280 290 300 310 320 330 pF1KE1 KVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILV ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: XP_016 KVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRK-DMADIPGHVFTRGMIIAVLILV 40 50 60 70 80 340 350 360 370 380 390 pF1KE1 AVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEI 90 100 110 120 130 140 400 410 420 430 440 450 pF1KE1 LPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESG 150 160 170 180 190 200 460 470 480 490 500 510 pF1KE1 LHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYL 210 220 230 240 250 260 520 530 540 pF1KE1 MPAKTVKPGRDEPEVLPVLSES :::::::::::::::::::::: XP_016 MPAKTVKPGRDEPEVLPVLSES 270 280 290 >>XP_016860673 (OMIM: 604494) PREDICTED: interleukin-18 (291 aa) initn: 1459 init1: 1459 opt: 1888 Z-score: 2165.3 bits: 409.5 E(85289): 7.2e-114 Smith-Waterman score: 1888; 99.7% identity (99.7% similar) in 292 aa overlap (250-541:1-291) 220 230 240 250 260 270 pF1KE1 PKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHAS :::::::::::::::::::::::::::::: XP_016 MFGEENGSDPNIHEEKEMRIMTPEGKWHAS 10 20 30 280 290 300 310 320 330 pF1KE1 KVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILV ::::::::::::::::::::::::::::::::::::: :::::::::::::::::::::: XP_016 KVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRK-DMADIPGHVFTRGMIIAVLILV 40 50 60 70 80 340 350 360 370 380 390 pF1KE1 AVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEI 90 100 110 120 130 140 400 410 420 430 440 450 pF1KE1 LPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESG 150 160 170 180 190 200 460 470 480 490 500 510 pF1KE1 LHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYL 210 220 230 240 250 260 520 530 540 pF1KE1 MPAKTVKPGRDEPEVLPVLSES :::::::::::::::::::::: XP_016 MPAKTVKPGRDEPEVLPVLSES 270 280 290 >>XP_011529207 (OMIM: 300277) PREDICTED: X-linked interl (562 aa) initn: 555 init1: 223 opt: 655 Z-score: 752.2 bits: 149.0 E(85289): 3.7e-35 Smith-Waterman score: 668; 33.4% identity (61.9% similar) in 446 aa overlap (109-523:7-435) 80 90 100 110 120 130 pF1KE1 HDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQI :.: . .. :.. : . :: : .: XP_011 MKVSMSLTVAENESGLCYNSRIRYLEKSEVTKRKEI 10 20 30 140 150 160 170 180 190 pF1KE1 TCEN--SYYQTLVNSTSL-YKNCK----KLLLENNKNPTIKKNAEFEDQGYYSCVHFLHH .: . .. .. . . ::.:: . .. .. : . .... :: : :.: :.. XP_011 SCPDMDDFKKSDQEPDVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCE--LKY 40 50 60 70 80 90 200 210 220 230 240 pF1KE1 NGKLFNITKTFNIT-IVEDRSNIVPVLLGPKLNH---VAVELGKNVRLNCSALLNEED-- .::: : ...: .. :. : : : :. . :.::: . . :.:... XP_011 EGKLVRRTTELKVTALLTDKP---PKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGES 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE1 --VIYWMFGEENGSDPNIH-EEKEMRIMTPE-GKWHASKVLRIENIGESNLNVLYNCTVA .:::: ::. . : .: :.:.. . :. .. .: .... :..: . :.: : XP_011 GPMIYWMKGEKFIEELAGHIREGEIRLLKEHLGEKEVELALIFDSVVEADL-ANYTCHVE 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE1 STGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRH . .: : .:.:: :. .. : . :...:.... .. : : ..:.::::. XP_011 NRNGRKHAS-VLLRKKDLIY---KIELAGGLGAIFLLLVLLVVIYKC--YNIELMLFYRQ 220 230 240 250 260 370 380 390 400 410 pF1KE1 LTRRDETLTDGKTYDAFVSYLK------ECRPENGEEHTFAVEILPRVLEKHFGYKLCIF ::: :.: :::..:: : .: .: ::. ::.:.:: :::::.:::: : XP_011 HFGADETNDDNKEYDAYLSYTKVDQDTLDC--DNPEEEQFALEVLPDVLEKHYGYKLFIP 270 280 290 300 310 320 420 430 440 450 460 470 pF1KE1 ERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNE--VRYELESGLHEALVERKIKIIL :::..:.:. .... .:.::::::::. .:. . .:::: ::. :: .::.:: XP_011 ERDLIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVIL 330 340 350 360 370 380 480 490 500 510 520 pF1KE1 IEFTPVT------DFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKP :: : . . : .:.:::. ..:::..:: . ::.:::.:.: :: : XP_011 IECTELKGKVNCQEVESLKRSIKLLS---LIKWKGSKSSKLNSKFWKHLVYEMPIKKKEM 390 400 410 420 430 530 540 pF1KE1 GRDEPEVLPVLSES XP_011 LPRCHVLDSAEQGLFGELQPIPSIAMTSTSATLVSSQADLPEFHPSDSMQIRHCCRGYKH 440 450 460 470 480 490 541 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:22:42 2016 done: Sun Nov 6 18:22:43 2016 Total Scan time: 6.980 Total Display time: 0.070 Function used was FASTA [36.3.4 Apr, 2011]