FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3970, 153 aa 1>>>pF1KE3970 153 - 153 aa - 153 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9185+/-0.000268; mu= 15.2450+/- 0.017 mean_var=112.1059+/-23.497, 0's: 0 Z-trim(122.3): 185 B-trim: 2113 in 2/51 Lambda= 0.121132 statistics sampled from 39950 (40339) to 39950 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.825), E-opt: 0.2 (0.473), width: 16 Scan time: 3.810 The best scores are: opt bits E(85289) NP_057578 (OMIM: 612490) E3 ubiquitin-protein liga ( 153) 1085 199.1 2.4e-51 XP_005264416 (OMIM: 612490) PREDICTED: E3 ubiquiti ( 187) 508 98.3 6.1e-21 NP_071763 (OMIM: 300420) E3 ubiquitin-protein liga ( 455) 255 54.6 2.1e-07 NP_001027568 (OMIM: 300420) E3 ubiquitin-protein l ( 588) 255 54.8 2.5e-07 XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 588) 255 54.8 2.5e-07 XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquiti ( 643) 255 54.8 2.6e-07 NP_660095 (OMIM: 300420) E3 ubiquitin-protein liga ( 643) 255 54.8 2.6e-07 XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquiti ( 284) 240 51.7 9.8e-07 NP_919442 (OMIM: 615177) E3 ubiquitin-protein liga ( 311) 240 51.8 1e-06 NP_001307292 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 195 43.9 0.00024 NP_001307294 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 195 43.9 0.00024 NP_001307293 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 195 43.9 0.00024 NP_001307291 (OMIM: 610431) E3 ubiquitin-protein l ( 315) 195 43.9 0.00024 NP_001307289 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 44.0 0.00026 NP_056343 (OMIM: 610431) E3 ubiquitin-protein liga ( 350) 195 44.0 0.00026 NP_001307286 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 44.0 0.00026 NP_001307290 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 44.0 0.00026 NP_001307287 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 44.0 0.00026 NP_001307288 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 44.0 0.00026 NP_001307285 (OMIM: 610431) E3 ubiquitin-protein l ( 350) 195 44.0 0.00026 XP_016879916 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 350) 195 44.0 0.00026 XP_016879917 (OMIM: 610431) PREDICTED: E3 ubiquiti ( 227) 192 43.2 0.00029 XP_016861150 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 193) 186 42.1 0.00054 XP_016861149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 250) 186 42.2 0.00063 XP_016861147 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 186 42.3 0.00065 XP_016861145 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 186 42.3 0.00065 XP_011510678 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 186 42.3 0.00065 XP_005247149 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 186 42.3 0.00065 XP_016861146 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 186 42.3 0.00065 XP_016861148 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 262) 186 42.3 0.00065 XP_011510676 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 186 42.5 0.00081 XP_011510675 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 186 42.5 0.00081 NP_899237 (OMIM: 609247) E3 ubiquitin-protein liga ( 381) 186 42.5 0.00081 NP_009213 (OMIM: 609247) E3 ubiquitin-protein liga ( 381) 186 42.5 0.00081 XP_016861144 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 186 42.5 0.00081 XP_016861143 (OMIM: 609247) PREDICTED: E3 ubiquiti ( 381) 186 42.5 0.00081 XP_016869786 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 180 41.5 0.0017 XP_016869785 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 402) 180 41.5 0.0017 NP_859061 (OMIM: 612063) E3 ubiquitin-protein liga ( 429) 180 41.5 0.0018 NP_919313 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 180 41.5 0.0018 XP_016869784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 180 41.5 0.0018 XP_006716784 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 180 41.5 0.0018 NP_919311 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 180 41.5 0.0018 XP_005251423 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 180 41.5 0.0018 NP_919309 (OMIM: 612488) E3 ubiquitin-protein liga ( 432) 180 41.5 0.0018 XP_011516014 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 180 41.5 0.0018 XP_011516015 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 180 41.5 0.0018 XP_005251424 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 180 41.5 0.0018 XP_005251425 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 432) 180 41.5 0.0018 XP_016869783 (OMIM: 612488) PREDICTED: E3 ubiquiti ( 444) 180 41.5 0.0018 >>NP_057578 (OMIM: 612490) E3 ubiquitin-protein ligase R (153 aa) initn: 1085 init1: 1085 opt: 1085 Z-score: 1042.8 bits: 199.1 E(85289): 2.4e-51 Smith-Waterman score: 1085; 100.0% identity (100.0% similar) in 153 aa overlap (1-153:1-153) 10 20 30 40 50 60 pF1KE3 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 NLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYEL 70 80 90 100 110 120 130 140 150 pF1KE3 PTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT ::::::::::::::::::::::::::::::::: NP_057 PTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT 130 140 150 >>XP_005264416 (OMIM: 612490) PREDICTED: E3 ubiquitin-pr (187 aa) initn: 541 init1: 508 opt: 508 Z-score: 496.9 bits: 98.3 E(85289): 6.1e-21 Smith-Waterman score: 508; 96.1% identity (96.1% similar) in 77 aa overlap (1-77:1-77) 10 20 30 40 50 60 pF1KE3 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 NLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYEL :::::::::::: : : XP_005 NLPRTVIRGSQAALTVPWAQYSSFFLFMDCWGMEEEWQLGAGEGGYQLMKIRPRLEHYST 70 80 90 100 110 120 >>NP_071763 (OMIM: 300420) E3 ubiquitin-protein ligase P (455 aa) initn: 248 init1: 209 opt: 255 Z-score: 253.8 bits: 54.6 E(85289): 2.1e-07 Smith-Waterman score: 255; 32.7% identity (65.5% similar) in 113 aa overlap (14-121:343-452) 10 20 30 40 pF1KE3 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRM-DFEDLGL ::. : . .::... . . .:.:.. NP_071 SSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAV 320 330 340 350 360 370 50 60 70 80 90 pF1KE3 VVDWDHHLPPPAAKTVVENLPRTVIRGSQA----ELKCPVCLLEFEEEETAIEMPCHHLF :. . :::.: .. ::. .. ... :. ::.: :. . :.: :.:::: : NP_071 DVEVAN---PPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYF 380 390 400 410 420 100 110 120 130 140 150 pF1KE3 HSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT :. :. ::.:...::.:: .: NP_071 HKPCVSIWLQKSGTCPVCRCMFPPPL 430 440 450 >>NP_001027568 (OMIM: 300420) E3 ubiquitin-protein ligas (588 aa) initn: 248 init1: 209 opt: 255 Z-score: 252.7 bits: 54.8 E(85289): 2.5e-07 Smith-Waterman score: 255; 32.7% identity (65.5% similar) in 113 aa overlap (14-121:476-585) 10 20 30 40 pF1KE3 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRM-DFEDLGL ::. : . .::... . . .:.:.. NP_001 SSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAV 450 460 470 480 490 500 50 60 70 80 90 pF1KE3 VVDWDHHLPPPAAKTVVENLPRTVIRGSQA----ELKCPVCLLEFEEEETAIEMPCHHLF :. . :::.: .. ::. .. ... :. ::.: :. . :.: :.:::: : NP_001 DVEVAN---PPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYF 510 520 530 540 550 560 100 110 120 130 140 150 pF1KE3 HSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT :. :. ::.:...::.:: .: NP_001 HKPCVSIWLQKSGTCPVCRCMFPPPL 570 580 >>XP_005262349 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (588 aa) initn: 248 init1: 209 opt: 255 Z-score: 252.7 bits: 54.8 E(85289): 2.5e-07 Smith-Waterman score: 255; 32.7% identity (65.5% similar) in 113 aa overlap (14-121:476-585) 10 20 30 40 pF1KE3 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRM-DFEDLGL ::. : . .::... . . .:.:.. XP_005 SSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAV 450 460 470 480 490 500 50 60 70 80 90 pF1KE3 VVDWDHHLPPPAAKTVVENLPRTVIRGSQA----ELKCPVCLLEFEEEETAIEMPCHHLF :. . :::.: .. ::. .. ... :. ::.: :. . :.: :.:::: : XP_005 DVEVAN---PPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYF 510 520 530 540 550 560 100 110 120 130 140 150 pF1KE3 HSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT :. :. ::.:...::.:: .: XP_005 HKPCVSIWLQKSGTCPVCRCMFPPPL 570 580 >>XP_011529313 (OMIM: 300420) PREDICTED: E3 ubiquitin-pr (643 aa) initn: 248 init1: 209 opt: 255 Z-score: 252.2 bits: 54.8 E(85289): 2.6e-07 Smith-Waterman score: 255; 32.7% identity (65.5% similar) in 113 aa overlap (14-121:531-640) 10 20 30 40 pF1KE3 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRM-DFEDLGL ::. : . .::... . . .:.:.. XP_011 SSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAV 510 520 530 540 550 560 50 60 70 80 90 pF1KE3 VVDWDHHLPPPAAKTVVENLPRTVIRGSQA----ELKCPVCLLEFEEEETAIEMPCHHLF :. . :::.: .. ::. .. ... :. ::.: :. . :.: :.:::: : XP_011 DVEVAN---PPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYF 570 580 590 600 610 100 110 120 130 140 150 pF1KE3 HSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT :. :. ::.:...::.:: .: XP_011 HKPCVSIWLQKSGTCPVCRCMFPPPL 620 630 640 >>NP_660095 (OMIM: 300420) E3 ubiquitin-protein ligase P (643 aa) initn: 248 init1: 209 opt: 255 Z-score: 252.2 bits: 54.8 E(85289): 2.6e-07 Smith-Waterman score: 255; 32.7% identity (65.5% similar) in 113 aa overlap (14-121:531-640) 10 20 30 40 pF1KE3 MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRM-DFEDLGL ::. : . .::... . . .:.:.. NP_660 SSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAV 510 520 530 540 550 560 50 60 70 80 90 pF1KE3 VVDWDHHLPPPAAKTVVENLPRTVIRGSQA----ELKCPVCLLEFEEEETAIEMPCHHLF :. . :::.: .. ::. .. ... :. ::.: :. . :.: :.:::: : NP_660 DVEVAN---PPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYF 570 580 590 600 610 100 110 120 130 140 150 pF1KE3 HSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT :. :. ::.:...::.:: .: NP_660 HKPCVSIWLQKSGTCPVCRCMFPPPL 620 630 640 >>XP_005259651 (OMIM: 615177) PREDICTED: E3 ubiquitin-pr (284 aa) initn: 238 init1: 197 opt: 240 Z-score: 241.9 bits: 51.7 E(85289): 9.8e-07 Smith-Waterman score: 240; 36.7% identity (64.4% similar) in 90 aa overlap (33-120:157-246) 10 20 30 40 50 60 pF1KE3 SYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENL : .: :. .... :::: : .. : XP_005 VNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQAL 130 140 150 160 170 180 70 80 90 100 110 120 pF1KE3 PRTVIRGSQ--AELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYEL : . . . . :.:::: .. : . ..::.::::..::.::: . .:::.:: : XP_005 PTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSL 190 200 210 220 230 240 130 140 150 pF1KE3 PTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT XP_005 TGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS 250 260 270 280 >>NP_919442 (OMIM: 615177) E3 ubiquitin-protein ligase R (311 aa) initn: 238 init1: 197 opt: 240 Z-score: 241.4 bits: 51.8 E(85289): 1e-06 Smith-Waterman score: 240; 36.7% identity (64.4% similar) in 90 aa overlap (33-120:184-273) 10 20 30 40 50 60 pF1KE3 SYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENL : .: :. .... :::: : .. : NP_919 VNGIITPATIPSLGPWGVLHSNPMDYAWGANGLDAIITQLLNQFENTGPPPADKEKIQAL 160 170 180 190 200 210 70 80 90 100 110 120 pF1KE3 PRTVIRGSQ--AELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYEL : . . . . :.:::: .. : . ..::.::::..::.::: . .:::.:: : NP_919 PTVPVTEEHVGSGLECPVCKDDYALGERVRQLPCNHLFHDGCIVPWLEQHDSCPVCRKSL 220 230 240 250 260 270 130 140 150 pF1KE3 PTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT NP_919 TGQNTATNPPGLTGVSFSSSSSSSSSSSPSNENATSNS 280 290 300 310 >>NP_001307292 (OMIM: 610431) E3 ubiquitin-protein ligas (315 aa) initn: 165 init1: 123 opt: 195 Z-score: 198.9 bits: 43.9 E(85289): 0.00024 Smith-Waterman score: 195; 37.9% identity (66.7% similar) in 66 aa overlap (68-129:188-252) 40 50 60 70 80 90 pF1KE3 EDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHL .:.: .. : .:: :.:. . .:: : NP_001 IARCIQHRKRLQRNRLTKEQLKQIPTHDYQKGDQYDV-CAICLDEYEDGDKLRVLPCAHA 160 170 180 190 200 210 100 110 120 130 140 150 pF1KE3 FHSSCILPWLSKT-NSCPLCRYEL---PTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT .:: :. :::..: ..::.:. . : :.: :: NP_001 YHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEPRDHPASERTPLL 220 230 240 250 260 270 NP_001 GSSPTLPTSFGSLAPAPLVFPGPSTDPPLSPPSSPVILV 280 290 300 310 153 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:27:51 2016 done: Sun Nov 6 08:27:51 2016 Total Scan time: 3.810 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]