FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3975, 247 aa 1>>>pF1KE3975 247 - 247 aa - 247 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.6045+/-0.000427; mu= 14.6064+/- 0.026 mean_var=137.3515+/-29.498, 0's: 0 Z-trim(115.1): 132 B-trim: 1230 in 2/49 Lambda= 0.109435 statistics sampled from 25156 (25341) to 25156 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.681), E-opt: 0.2 (0.297), width: 16 Scan time: 6.130 The best scores are: opt bits E(85289) NP_116062 (OMIM: 610231) polycomb group RING finge ( 259) 1693 278.6 7.3e-75 NP_005171 (OMIM: 164831) polycomb complex protein ( 326) 571 101.6 1.8e-21 XP_005257698 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 543 97.2 3.9e-20 XP_005257697 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 543 97.2 3.9e-20 NP_009075 (OMIM: 600346) polycomb group RING finge ( 344) 543 97.2 3.9e-20 XP_005257699 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 543 97.2 3.9e-20 XP_016880505 (OMIM: 600346) PREDICTED: polycomb gr ( 344) 543 97.2 3.9e-20 NP_001011663 (OMIM: 607816) polycomb group RING fi ( 350) 524 94.2 3.2e-19 NP_115530 (OMIM: 607816) polycomb group RING finge ( 275) 310 60.3 4.1e-09 NP_001308678 (OMIM: 612489) RING finger protein 24 ( 148) 178 39.1 0.0052 NP_001127809 (OMIM: 612489) RING finger protein 24 ( 148) 178 39.1 0.0052 NP_009150 (OMIM: 612489) RING finger protein 24 is ( 148) 178 39.1 0.0052 XP_011527448 (OMIM: 612489) PREDICTED: RING finger ( 163) 178 39.2 0.0056 NP_001127810 (OMIM: 612489) RING finger protein 24 ( 169) 178 39.2 0.0057 XP_016883110 (OMIM: 612489) PREDICTED: RING finger ( 169) 178 39.2 0.0057 XP_011527447 (OMIM: 612489) PREDICTED: RING finger ( 169) 178 39.2 0.0057 XP_016883109 (OMIM: 612489) PREDICTED: RING finger ( 169) 178 39.2 0.0057 >>NP_116062 (OMIM: 610231) polycomb group RING finger pr (259 aa) initn: 1693 init1: 1693 opt: 1693 Z-score: 1465.0 bits: 278.6 E(85289): 7.3e-75 Smith-Waterman score: 1693; 100.0% identity (100.0% similar) in 247 aa overlap (1-247:13-259) 10 20 30 40 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTI :::::::::::::::::::::::::::::::::::::::::::::::: NP_116 MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTI 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE3 TECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 TECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEE 70 80 90 100 110 120 110 120 130 140 150 160 pF1KE3 KRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 KRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGK 130 140 150 160 170 180 170 180 190 200 210 220 pF1KE3 DKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_116 DKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSR 190 200 210 220 230 240 230 240 pF1KE3 WFGKPSPLLLQYSVKEKRR ::::::::::::::::::: NP_116 WFGKPSPLLLQYSVKEKRR 250 >>NP_005171 (OMIM: 164831) polycomb complex protein BMI- (326 aa) initn: 511 init1: 478 opt: 571 Z-score: 506.5 bits: 101.6 E(85289): 1.8e-21 Smith-Waterman score: 578; 41.6% identity (70.0% similar) in 233 aa overlap (23-243:6-228) 10 20 30 40 50 60 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI :.:: .:: :..: ::.:::.::::: ::::.:::.:: NP_005 MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCI 10 20 30 40 70 80 90 100 110 120 pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL :.::.::::::.:....:.:.::::.. :...::::::::::: .: :: :.:: . NP_005 VRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAA--- 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLE-----RLSS--GKDKNKS .:... :: . :..: . :: ..: .: ::. .:::.:: NP_005 ----HPSADAANGSNEDRGEVA-DEDK-RIITDDEIISLSIEFFDQNRLDRKVNKDKEKS 110 120 130 140 150 180 190 200 210 220 pF1KE3 ---VLQNKYVRCSVRAEVRHLRRVLCHRLML-NPQHVQLLFDNEVLPDHMTMKQI-WLSR : ...:.:: . : :::. : .. . : ........: : :..:. .: .. NP_005 KEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYT 160 170 180 190 200 210 230 240 pF1KE3 WFGKPSPLLLQYSVKEKRR : . .:: :.: :. NP_005 WR-RNGPLPLKYRVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLP 220 230 240 250 260 270 >>XP_005257698 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20 Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230) 10 20 30 40 50 60 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI :.:: .:: :..: ::.:::.:::::.::::.:::.:: XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI 10 20 30 40 70 80 90 100 110 120 pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL :.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . : XP_005 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN- .: :.: . ... ... :. :: ..: .: ...:.. :. :.: XP_005 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG 110 120 130 140 150 180 190 200 210 220 pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL ...:: . : :: . : ... . .. :..:...: : ...:. .: .. XP_005 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI 160 170 180 190 200 210 230 240 pF1KE3 SRWFGKPSPLLLQYSVKEKRR : . .:: :.: :. XP_005 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS 220 230 240 250 260 270 >>XP_005257697 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20 Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230) 10 20 30 40 50 60 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI :.:: .:: :..: ::.:::.:::::.::::.:::.:: XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI 10 20 30 40 70 80 90 100 110 120 pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL :.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . : XP_005 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN- .: :.: . ... ... :. :: ..: .: ...:.. :. :.: XP_005 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG 110 120 130 140 150 180 190 200 210 220 pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL ...:: . : :: . : ... . .. :..:...: : ...:. .: .. XP_005 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI 160 170 180 190 200 210 230 240 pF1KE3 SRWFGKPSPLLLQYSVKEKRR : . .:: :.: :. XP_005 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS 220 230 240 250 260 270 >>NP_009075 (OMIM: 600346) polycomb group RING finger pr (344 aa) initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20 Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230) 10 20 30 40 50 60 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI :.:: .:: :..: ::.:::.:::::.::::.:::.:: NP_009 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI 10 20 30 40 70 80 90 100 110 120 pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL :.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . : NP_009 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN- .: :.: . ... ... :. :: ..: .: ...:.. :. :.: NP_009 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG 110 120 130 140 150 180 190 200 210 220 pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL ...:: . : :: . : ... . .. :..:...: : ...:. .: .. NP_009 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI 160 170 180 190 200 210 230 240 pF1KE3 SRWFGKPSPLLLQYSVKEKRR : . .:: :.: :. NP_009 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS 220 230 240 250 260 270 >>XP_005257699 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20 Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230) 10 20 30 40 50 60 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI :.:: .:: :..: ::.:::.:::::.::::.:::.:: XP_005 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI 10 20 30 40 70 80 90 100 110 120 pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL :.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . : XP_005 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN- .: :.: . ... ... :. :: ..: .: ...:.. :. :.: XP_005 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG 110 120 130 140 150 180 190 200 210 220 pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL ...:: . : :: . : ... . .. :..:...: : ...:. .: .. XP_005 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI 160 170 180 190 200 210 230 240 pF1KE3 SRWFGKPSPLLLQYSVKEKRR : . .:: :.: :. XP_005 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS 220 230 240 250 260 270 >>XP_016880505 (OMIM: 600346) PREDICTED: polycomb group (344 aa) initn: 513 init1: 486 opt: 543 Z-score: 482.4 bits: 97.2 E(85289): 3.9e-20 Smith-Waterman score: 552; 38.3% identity (69.8% similar) in 235 aa overlap (23-243:6-230) 10 20 30 40 50 60 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCI :.:: .:: :..: ::.:::.:::::.::::.:::.:: XP_016 MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCI 10 20 30 40 70 80 90 100 110 120 pF1KE3 VKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGL :.::.:.::::::....:.:.:::... :...::::::::::: .: :: :.:: . : XP_016 VRYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYPL 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 DRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKN--KSVLQN- .: :.: . ... ... :. :: ..: .: ...:.. :. :.: XP_016 TEV--PNGSNEDRGEV------LEQEKGALSD-DEIVSLSIEFYEGARDRDEKKGPLENG 110 120 130 140 150 180 190 200 210 220 pF1KE3 ---------KYVRCSVRAEVRHLRRVLCHRLMLNPQH-VQLLFDNEVLPDHMTMKQI-WL ...:: . : :: . : ... . .. :..:...: : ...:. .: .. XP_016 DGDKEKTGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEVLYEDEPLKEYYTLMDIAYI 160 170 180 190 200 210 230 240 pF1KE3 SRWFGKPSPLLLQYSVKEKRR : . .:: :.: :. XP_016 YPWR-RNGPLPLKYRVQPACKRLTLATVPTPSEGTNTSGASECESVSDKAPSPATLPATS 220 230 240 250 260 270 >>NP_001011663 (OMIM: 607816) polycomb group RING finger (350 aa) initn: 443 init1: 443 opt: 524 Z-score: 466.1 bits: 94.2 E(85289): 3.2e-19 Smith-Waterman score: 524; 38.9% identity (74.4% similar) in 211 aa overlap (18-224:117-322) 10 20 30 40 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATT .::: .....:. .:.: .: ::..:::: NP_001 EEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATT 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE3 ITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSE ::::::::::::::... :. :: ::: .:.:::: :..::: .:::::::: .:.. : NP_001 ITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEERE 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE3 EKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLN--LCLERLS .:....::. :::. : .:. .:. :. : . .. .: .:. : :: .. NP_001 KKQMHDFYKERGLE-VPKPAVPQPVPSSKGRSKKVLES----VFRIPPELDMSLLLEFIG 210 220 230 240 250 260 170 180 190 200 210 220 pF1KE3 SGKDKNK-SVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQ-HVQLLFDNEVLPDHMTMKQ ... .. . :..:.:: : .: . :... : ... :.: .:... ...: ...:... NP_001 ANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLRE 270 280 290 300 310 320 230 240 pF1KE3 IWLSRWFGKPSPLLLQYSVKEKRR : NP_001 IRRAIGDAAMQDGLLVLHYGLVVSPLKIT 330 340 350 >>NP_115530 (OMIM: 607816) polycomb group RING finger pr (275 aa) initn: 325 init1: 307 opt: 310 Z-score: 284.7 bits: 60.3 E(85289): 4.1e-09 Smith-Waterman score: 310; 41.1% identity (72.3% similar) in 112 aa overlap (18-125:117-228) 10 20 30 40 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATT .::: .....:. .:.: .: ::..:::: NP_115 EEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATT 90 100 110 120 130 140 50 60 70 80 90 100 pF1KE3 ITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRV---MQDIVYKLVPGLQ ::::::::::::::... :. :: ::: .:.:::: :.. .. .. . :.: NP_115 ITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNISANEGTGHFKPLEKKFVRVSG 150 160 170 180 190 200 110 120 130 140 150 160 pF1KE3 DSEEKRIREFYQSR-GLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLER .. ....: . . ::: . : NP_115 EATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYG 210 220 230 240 250 260 >>NP_001308678 (OMIM: 612489) RING finger protein 24 iso (148 aa) initn: 175 init1: 137 opt: 178 Z-score: 175.0 bits: 39.1 E(85289): 0.0052 Smith-Waterman score: 178; 31.5% identity (59.8% similar) in 92 aa overlap (1-90:47-134) 10 20 30 pF1KE3 MRLRNQLQSVYKMDPLRNEEEVRVKIKDLN .:::.: .. . .. .. :.:.:: NP_001 FQNLPLNIYIVVFGTAIFVFILSLLFCCYLIRLRHQAHKEFYA---YKQVILKEKVKELN 20 30 40 50 60 70 40 50 60 70 80 pF1KE3 EHIVCCLCAGYFV--DATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKL : .: .: : : : : :.: ..:..:.:.. : ::.::. . . : . : NP_001 LHELCAVCLEDFKPRDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQL-HSKQ 80 90 100 110 120 130 90 100 110 120 130 140 pF1KE3 DRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKA :: NP_001 DRGPPQGPLPGAENIV 140 247 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 08:25:58 2016 done: Sun Nov 6 08:25:59 2016 Total Scan time: 6.130 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]