Result of FASTA (omim) for
pFN21AE2298
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2298, 424 aa
1>>>pF1KE2298 424 - 424 aa - 424 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4442+/-0.000407; mu= 16.8055+/- 0.025
mean_var=72.8656+/-14.276, 0's: 0 Z-trim(111.2): 80 B-trim: 113 in 1/53
Lambda= 0.150249
statistics sampled from 19680 (19760) to 19680 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.599), E-opt: 0.2 (0.232), width: 16
Scan time: 8.690
The best scores are: opt bits E(85289)
NP_055297 (OMIM: 608748) bone morphogenetic protei ( 424) 2815 619.8 4e-177
NP_057288 (OMIM: 605120,615506) growth/differentia ( 429) 1052 237.7 4.5e-62
NP_001001557 (OMIM: 118100,601147,613094,613703,61 ( 455) 443 105.7 2.6e-22
XP_011527625 (OMIM: 112261,112600,235200) PREDICTE ( 240) 430 102.7 1.1e-21
NP_878248 (OMIM: 604651) growth/differentiation fa ( 450) 433 103.5 1.1e-21
NP_001191 (OMIM: 112261,112600,235200) bone morpho ( 396) 430 102.8 1.6e-21
XP_016877094 (OMIM: 112262,600625,607932) PREDICTE ( 345) 411 98.7 2.5e-20
XP_016877093 (OMIM: 112262,600625,607932) PREDICTE ( 345) 411 98.7 2.5e-20
XP_016877092 (OMIM: 112262,600625,607932) PREDICTE ( 408) 411 98.7 2.9e-20
NP_001193 (OMIM: 112262,600625,607932) bone morpho ( 408) 411 98.7 2.9e-20
XP_005268072 (OMIM: 112262,600625,607932) PREDICTE ( 408) 411 98.7 2.9e-20
NP_570911 (OMIM: 112262,600625,607932) bone morpho ( 408) 411 98.7 2.9e-20
XP_011527377 (OMIM: 112600,113100,200700,201250,22 ( 501) 409 98.3 4.6e-20
NP_000548 (OMIM: 112600,113100,200700,201250,22890 ( 501) 409 98.3 4.6e-20
NP_001306067 (OMIM: 112600,113100,200700,201250,22 ( 501) 409 98.3 4.6e-20
NP_001710 (OMIM: 112267) bone morphogenetic protei ( 431) 394 95.0 3.9e-19
XP_016866687 (OMIM: 112265) PREDICTED: bone morpho ( 239) 383 92.5 1.2e-18
XP_011540326 (OMIM: 602284) PREDICTED: bone morpho ( 427) 384 92.9 1.7e-18
NP_001709 (OMIM: 112266) bone morphogenetic protei ( 513) 384 92.9 2e-18
NP_066551 (OMIM: 112265) bone morphogenetic protei ( 454) 383 92.7 2.1e-18
NP_001711 (OMIM: 602284) bone morphogenetic protei ( 402) 363 88.3 3.8e-17
NP_001316835 (OMIM: 270100,601265) nodal homolog i ( 214) 338 82.7 9.8e-16
NP_060525 (OMIM: 270100,601265) nodal homolog isof ( 347) 338 82.8 1.5e-15
NP_001483 (OMIM: 187500,208530,217095,602880,61385 ( 372) 329 80.9 6e-15
NP_065685 (OMIM: 606522,613702,613703,613704) grow ( 364) 325 80.0 1.1e-14
NP_005439 (OMIM: 300247,300510) bone morphogenetic ( 392) 316 78.1 4.4e-14
XP_006719257 (OMIM: 603936) PREDICTED: growth/diff ( 407) 314 77.7 6.1e-14
NP_005802 (OMIM: 603936) growth/differentiation fa ( 407) 314 77.7 6.1e-14
NP_001192 (OMIM: 112263) bone morphogenetic protei ( 472) 308 76.4 1.7e-13
NP_004953 (OMIM: 601361) growth/differentiation fa ( 478) 308 76.4 1.7e-13
NP_005250 (OMIM: 601788,614160) growth/differentia ( 375) 298 74.2 6.3e-13
NP_002183 (OMIM: 147290) inhibin beta A chain prep ( 426) 293 73.1 1.5e-12
XP_016867665 (OMIM: 147290) PREDICTED: inhibin bet ( 426) 293 73.1 1.5e-12
XP_016867664 (OMIM: 147290) PREDICTED: inhibin bet ( 483) 293 73.2 1.7e-12
XP_016867663 (OMIM: 147290) PREDICTED: inhibin bet ( 548) 293 73.2 1.8e-12
NP_002184 (OMIM: 147390) inhibin beta B chain prep ( 407) 287 71.8 3.5e-12
NP_113667 (OMIM: 612031) inhibin beta E chain prep ( 350) 282 70.7 6.6e-12
XP_011541613 (OMIM: 601918) PREDICTED: growth/diff ( 276) 251 63.9 5.8e-10
XP_005272014 (OMIM: 601918) PREDICTED: growth/diff ( 366) 251 64.0 7.2e-10
XP_006714648 (OMIM: 601918) PREDICTED: growth/diff ( 366) 251 64.0 7.2e-10
XP_011541611 (OMIM: 601918) PREDICTED: growth/diff ( 366) 251 64.0 7.2e-10
NP_001275754 (OMIM: 601918) growth/differentiation ( 366) 251 64.0 7.2e-10
NP_001275757 (OMIM: 601918) growth/differentiation ( 366) 251 64.0 7.2e-10
NP_001275756 (OMIM: 601918) growth/differentiation ( 366) 251 64.0 7.2e-10
XP_011541612 (OMIM: 601918) PREDICTED: growth/diff ( 366) 251 64.0 7.2e-10
NP_001275753 (OMIM: 601918) growth/differentiation ( 366) 251 64.0 7.2e-10
NP_001275755 (OMIM: 601918) growth/differentiation ( 366) 251 64.0 7.2e-10
NP_005251 (OMIM: 601918) growth/differentiation fa ( 454) 251 64.0 8.6e-10
XP_011541610 (OMIM: 601918) PREDICTED: growth/diff ( 454) 251 64.0 8.6e-10
NP_005529 (OMIM: 601233) inhibin beta C chain prep ( 352) 248 63.3 1.1e-09
>>NP_055297 (OMIM: 608748) bone morphogenetic protein 10 (424 aa)
initn: 2815 init1: 2815 opt: 2815 Z-score: 3300.9 bits: 619.8 E(85289): 4e-177
Smith-Waterman score: 2815; 100.0% identity (100.0% similar) in 424 aa overlap (1-424:1-424)
10 20 30 40 50 60
pF1KE2 MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 EFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 NGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 RNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 RNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE2 IDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE2 QMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE2 AEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSE
370 380 390 400 410 420
pF1KE2 CGCR
::::
NP_055 CGCR
>>NP_057288 (OMIM: 605120,615506) growth/differentiation (429 aa)
initn: 821 init1: 540 opt: 1052 Z-score: 1235.5 bits: 237.7 E(85289): 4.5e-62
Smith-Waterman score: 1052; 41.9% identity (71.6% similar) in 437 aa overlap (2-424:4-429)
10 20 30 40 50
pF1KE2 MGSLVLTLCALFCLAAYLVSGSPIMNLEQSPL----EEDMSLFGDVFSEQDGVDFNTL
:.: ..: :. : : ..:.:... .. . ... : . :. ... .
NP_057 MCPGALWVAL-PLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHT-FNLKMF
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 LQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLF
:...: .::..:::: .:.::...:.::.::..:::....:... :..::.:::. :: .
NP_057 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 SQPVSFN-GLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLES
: .. . ..:. ::::.:::.::.. ::::::. : . ...:..::..
NP_057 SITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDG
120 130 140 150 160 170
180 190 200 210 220
pF1KE2 KG--DNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGS--STHQLEVHIESKHD
:. : . . ::: .: . :::..:..:..:: .: : : ..::: .:: :
NP_057 TDAWDSATETKTF-LVSQDIQ--DEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVES-HR
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE2 EAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD-KERKEELNEMISHEQLPELDNLGLD
.. :. :.:.. ... :...:::.:.:: :: . :: ::::::: : .:. :
NP_057 KGCDT----LDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKD
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE2 SFSSGPGEEALLQ-MRSNIIYDST-ARIRRNA-KGNYCKRTPLYIDFKEIGWDSWIIAPP
. :. :: . . ... :: :: .:.: :..:..: : ..:..::::::::::
NP_057 G-STEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPK
300 310 320 330 340
350 360 370 380 390 400
pF1KE2 GYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDK-
::::::.: : .:::. .:::::::.:.::::: :..::::::::: :::.:: :
NP_057 EYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDM
350 360 370 380 390 400
410 420
pF1KE2 GVVTYKFKYEGMAVSECGCR
:: : :..::::.:.:::::
NP_057 GVPTLKYHYEGMSVAECGCR
410 420
>>NP_001001557 (OMIM: 118100,601147,613094,613703,615360 (455 aa)
initn: 588 init1: 433 opt: 443 Z-score: 521.7 bits: 105.7 E(85289): 2.6e-22
Smith-Waterman score: 510; 32.6% identity (52.7% similar) in 389 aa overlap (72-424:85-455)
50 60 70 80 90
pF1KE2 VFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKF---------
: . .: : :::: .: .
NP_001 PRDSDAGREGQEPQPRPQDEPRAQQPRAQEPPGRGPRVVPHEYMLSIYRTYSIAEKLGIN
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE2 ATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVSI-PHHEEVIMAELRLYTLV
:. : ::: : :: .. : . .: . ::. ::.::. .::.. :::::. .
NP_001 ASFFQSSKSANTITSFVDRGL--DDLSHTPLRRQKYLFDVSMLSDKEELVGAELRLFRQA
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE2 QRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSE-WETFDVTDAIRRW
. .. .: : .: . . :. ::.::: ...:.
NP_001 PSAPWGPPAGPLHVQLFPCLSPL--------LLDARTLDPQGAPPAGWEVFDVWQGLRHQ
180 190 200 210 220
220 230 240 250
pF1KE2 QKSGSSTHQLEVHIESKHDEAEDASSGRLEI---DTSAQN--------KHNPLLIVFSDD
. . . : ::: . : . : . . .. ::.::. .
NP_001 PWKQLCLELRAAWGELDAGEAEARARGPQQPPPPDLRSLGFGRRVRPPQERALLVVFTRS
230 240 250 260 270 280
260 270 280 290 300
pF1KE2 QSSDKERKEELNEMISHEQLPELDNLGLDSFSSG--------PGEEALL----QMRSNII
: ::. . :: .::: . : . . : : . : . :
NP_001 Q-----RKNLFAEM--REQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLPSPGRRRRRTA
290 300 310 320 330
310 320 330 340 350 360
pF1KE2 YDSTARIRRNAKGNY-CKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTP
. : :.. :. :.. ::...:::.:::.::::: ::::.:.:::..:: :: :
NP_001 FASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEP
340 350 360 370 380 390
370 380 390 400 410 420
pF1KE2 TKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGV-VTYKFKYEGMAVSECGCR
:.:::::.:.. . .. .::::::: ::::::.: : :.:: .:: :.: ::::
NP_001 TNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILYIDAGNNVVYK-QYEDMVVESCGCR
400 410 420 430 440 450
>>XP_011527625 (OMIM: 112261,112600,235200) PREDICTED: b (240 aa)
initn: 406 init1: 294 opt: 430 Z-score: 510.5 bits: 102.7 E(85289): 1.1e-21
Smith-Waterman score: 505; 34.5% identity (61.4% similar) in 267 aa overlap (164-424:14-240)
140 150 160 170 180 190
pF1KE2 IPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYG
.:.:.:... : .: . .
XP_011 MQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQ
10 20 30 40
200 210 220 230 240 250
pF1KE2 TNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSA-QNKHN--
. :.::.:::: :. :: .: ..: . :.. .. .: . .:. ...:. : :..:.
XP_011 NASRWESFDVTPAVMRWTAQGHANHGFVVEV-AHLEEKQGVSKRHVRISRSLHQDEHSWS
50 60 70 80 90 100
260 270 280 290 300
pF1KE2 ---PLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNII
:::..:. : .. .:.: ... .:.:
XP_011 QIRPLLVTFGHDGKGHPLHKRE-KRQAKHKQ-----------------------------
110 120 130
310 320 330 340 350 360
pF1KE2 YDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPT
:. :.. ::: :::.::...::..::.:::::.:. :.: : .:::.::. :
XP_011 -------RKRLKSS-CKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNST
140 150 160 170 180
370 380 390 400 410 420
pF1KE2 KHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR
.:::.:.::. :: : :::::::.: ::.::::.. . .:. :.: ::::
XP_011 NHAIVQTLVNSVNS-KIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
190 200 210 220 230 240
>>NP_878248 (OMIM: 604651) growth/differentiation factor (450 aa)
initn: 508 init1: 428 opt: 433 Z-score: 510.0 bits: 103.5 E(85289): 1.1e-21
Smith-Waterman score: 473; 29.4% identity (56.2% similar) in 377 aa overlap (76-424:83-450)
50 60 70 80 90
pF1KE2 QDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFA---------TDR
...: : ..:. :: ..: ..
NP_878 LAQAAGAAAVPAAAVPRARAARRAAGSGFRNGSVVPHHFMMSLYRSLAGRAPAGAAAVSA
60 70 80 90 100 110
100 110 120 130 140 150
pF1KE2 TSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVS-IPHHEEVIMAELRLYTLVQRDR
.. :. : .: .. .. .. .: .::.:: . .::. ::::. : . .
NP_878 SGHGRADTITGFTDQATQDESAAETG---QSFLFDVSSLNDADEVVGAELRV--LRRGSP
120 130 140 150 160
160 170 180 190 200 210
pF1KE2 MIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGS
: . .. . : .. : . .. . : ..::.:::.::.:: ..
NP_878 ESGPGSWTSPPLLLLSTCPGAARAPRLLYSRAAEPLVG--QRWEAFDVADAMRRHRREPR
170 180 190 200 210 220
220 230 240 250 260
pF1KE2 STHQLEVHIESKHDEAEDASSGR-----LEIDTSAQNKHNPLLIVFSDDQSSDKERKE--
. . . ... . . . : .. .. .:.: : : ... .:
NP_878 PPRAFCLLLRAVAGPVPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQRKESLFREIR
230 240 250 260 270 280
270 280 290 300 310
pF1KE2 ----ELNEMISHEQLPELDNLGLDSFSSGPG-----EEALLQMRSNIIYDSTARIRRNAK
:. .. : ::. . : : . : . :: :. . : .. .
NP_878 AQARALGAALASEPLPD-PGTGTASPRAVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRR
290 300 310 320 330 340
320 330 340 350 360 370
pF1KE2 G-NYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHL
: . :.: ::..::::.:::.::::: ::::.:.:.:..:: :: ::.:::::.:..
NP_878 GRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNS
350 360 370 380 390 400
380 390 400 410 420
pF1KE2 KNSQKASKACCVPTKLEPISILYLDKGV-VTYKFKYEGMAVSECGCR
. : .::::..: ::::::.: . :.:: .:: :.: ::::
NP_878 MAPDAAPASCCVPARLSPISILYIDAANNVVYK-QYEDMVVEACGCR
410 420 430 440 450
>>NP_001191 (OMIM: 112261,112600,235200) bone morphogene (396 aa)
initn: 511 init1: 294 opt: 430 Z-score: 507.3 bits: 102.8 E(85289): 1.6e-21
Smith-Waterman score: 607; 31.7% identity (59.8% similar) in 391 aa overlap (52-424:47-396)
30 40 50 60 70 80
pF1KE2 SPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDP
. .:. .. ..:. ..:.. :: . : :
NP_001 LLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVP
20 30 40 50 60 70
90 100 110 120 130
pF1KE2 PEYMLELYNKF-------ATDRT---SMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFN
: :::.:: . : :. . :: .:::..:. . . .: ..::
NP_001 P-YMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFN
80 90 100 110 120 130
140 150 160 170 180
pF1KE2 VS-IPHHEEVIMAELRLYTLVQRDRMIYDG-VDRKITIFEVLESKGDNEGERNMLVLVSG
.: :: .: . :::... ..: . .. ..:.:.:... : .: .
NP_001 LSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTR
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE2 EIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSA-QNK
. . :.::.:::: :. :: .: ..: . :.. .. .: . .:. ...:. : :..
NP_001 LVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEV-AHLEEKQGVSKRHVRISRSLHQDE
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE2 HN-----PLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMR
:. :::..:. : .. .:.: ... .:.:
NP_001 HSWSQIRPLLVTFGHDGKGHPLHKRE-KRQAKHKQ-------------------------
260 270 280
310 320 330 340 350 360
pF1KE2 SNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEH
:. :.. ::: :::.::...::..::.:::::.:. :.: : .:::.:
NP_001 -----------RKRLKSS-CKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADH
290 300 310 320 330
370 380 390 400 410 420
pF1KE2 LTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC
:. :.:::.:.::. :: : :::::::.: ::.::::.. . .:. :.: :::
NP_001 LNSTNHAIVQTLVNSVNS-KIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGC
340 350 360 370 380 390
pF1KE2 R
:
NP_001 R
>>XP_016877094 (OMIM: 112262,600625,607932) PREDICTED: b (345 aa)
initn: 536 init1: 286 opt: 411 Z-score: 485.9 bits: 98.7 E(85289): 2.5e-20
Smith-Waterman score: 524; 33.5% identity (58.9% similar) in 331 aa overlap (102-424:51-345)
80 90 100 110 120 130
pF1KE2 PTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFN
:: .:::..:. . . . . . .:::
XP_016 RDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFN
30 40 50 60 70 80
140 150 160 170 180
pF1KE2 VS-IPHHEEVIMAELRLYTLVQRDRMIYDGVD-----RKITIFEVLESKGDN-EGERNML
.: ::..: . :::::. :.. . .: : ..:.:.::.. .. :.
XP_016 LSSIPENEVISSAELRLF----REQ-VDQGPDWERGFHRINIYEVMKPPAEVVPGHLITR
90 100 110 120 130
190 200 210 220 230 240
pF1KE2 VLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTS
.: . .. . ..::::::. :. :: . . .. : ... :. .
XP_016 LLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQ------------TRT
140 150 160 170 180
250 260 270 280 290 300
pF1KE2 AQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQL-PELDNLGLDSFSSGPGEEALLQMR
:..: . : : :.: . :: : : ..: : : :. :: . :
XP_016 HQGQH--VRISRSLPQGSG-----------NWAQLRPLLVTFGHD----GRGH-ALTRRR
190 200 210 220
310 320 330 340 350 360
pF1KE2 SNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEH
. : :.. :.: ::.::...::..::.:::::.:. :.: : .:::.:
XP_016 RAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADH
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE2 LTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC
:. :.:::.:.::. ::. :::::::.: ::.::::. . .:. :.: :::
XP_016 LNSTNHAIVQTLVNSVNSS-IPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC
290 300 310 320 330 340
pF1KE2 R
:
XP_016 R
>>XP_016877093 (OMIM: 112262,600625,607932) PREDICTED: b (345 aa)
initn: 536 init1: 286 opt: 411 Z-score: 485.9 bits: 98.7 E(85289): 2.5e-20
Smith-Waterman score: 524; 33.5% identity (58.9% similar) in 331 aa overlap (102-424:51-345)
80 90 100 110 120 130
pF1KE2 PTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFN
:: .:::..:. . . . . . .:::
XP_016 RDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFLFN
30 40 50 60 70 80
140 150 160 170 180
pF1KE2 VS-IPHHEEVIMAELRLYTLVQRDRMIYDGVD-----RKITIFEVLESKGDN-EGERNML
.: ::..: . :::::. :.. . .: : ..:.:.::.. .. :.
XP_016 LSSIPENEVISSAELRLF----REQ-VDQGPDWERGFHRINIYEVMKPPAEVVPGHLITR
90 100 110 120 130
190 200 210 220 230 240
pF1KE2 VLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTS
.: . .. . ..::::::. :. :: . . .. : ... :. .
XP_016 LLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQ------------TRT
140 150 160 170 180
250 260 270 280 290 300
pF1KE2 AQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQL-PELDNLGLDSFSSGPGEEALLQMR
:..: . : : :.: . :: : : ..: : : :. :: . :
XP_016 HQGQH--VRISRSLPQGSG-----------NWAQLRPLLVTFGHD----GRGH-ALTRRR
190 200 210 220
310 320 330 340 350 360
pF1KE2 SNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEH
. : :.. :.: ::.::...::..::.:::::.:. :.: : .:::.:
XP_016 RAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADH
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE2 LTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGC
:. :.:::.:.::. ::. :::::::.: ::.::::. . .:. :.: :::
XP_016 LNSTNHAIVQTLVNSVNSS-IPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGC
290 300 310 320 330 340
pF1KE2 R
:
XP_016 R
>>XP_016877092 (OMIM: 112262,600625,607932) PREDICTED: b (408 aa)
initn: 536 init1: 286 opt: 411 Z-score: 484.9 bits: 98.7 E(85289): 2.9e-20
Smith-Waterman score: 537; 31.6% identity (57.3% similar) in 393 aa overlap (54-424:53-408)
30 40 50 60 70 80
pF1KE2 IMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPE
::.... .:. ..: : : : .. :.
XP_016 HASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRP-QPSKSAVIPD
30 40 50 60 70 80
90 100 110 120
pF1KE2 YMLELY------------NKFATDRTSMPS--ANIIRSFKNEDLFSQPVSFNGLRKYPLL
:: .:: .. . . :. :: .:::..:. . . . . . .:
XP_016 YMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFL
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE2 FNVS-IPHHEEVIMAELRLYTLVQRDRMIYDGVD-----RKITIFEVLESKGDN-EGERN
::.: ::..: . :::::. :.. . .: : ..:.:.::.. .. :.
XP_016 FNLSSIPENEVISSAELRLF----REQ-VDQGPDWERGFHRINIYEVMKPPAEVVPGHLI
150 160 170 180 190
190 200 210 220 230 240
pF1KE2 MLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEID
.: . .. . ..::::::. :. :: . . .. : ... :.
XP_016 TRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQT------------
200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQL-PELDNLGLDSFSSGPGEEALLQ
. :..: . : : :.: . :: : : ..: : : :. :: .
XP_016 RTHQGQH--VRISRSLPQGSG-----------NWAQLRPLLVTFGHD----GRGH-ALTR
250 260 270 280
310 320 330 340 350 360
pF1KE2 MRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLA
: . : :.. :.: ::.::...::..::.:::::.:. :.: : .:::
XP_016 RRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 EHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSEC
.::. :.:::.:.::. ::. :::::::.: ::.::::. . .:. :.: :
XP_016 DHLNSTNHAIVQTLVNSVNSS-IPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGC
350 360 370 380 390 400
pF1KE2 GCR
:::
XP_016 GCR
>>NP_001193 (OMIM: 112262,600625,607932) bone morphogene (408 aa)
initn: 536 init1: 286 opt: 411 Z-score: 484.9 bits: 98.7 E(85289): 2.9e-20
Smith-Waterman score: 537; 31.6% identity (57.3% similar) in 393 aa overlap (54-424:53-408)
30 40 50 60 70 80
pF1KE2 IMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPE
::.... .:. ..: : : : .. :.
NP_001 HASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRP-QPSKSAVIPD
30 40 50 60 70 80
90 100 110 120
pF1KE2 YMLELY------------NKFATDRTSMPS--ANIIRSFKNEDLFSQPVSFNGLRKYPLL
:: .:: .. . . :. :: .:::..:. . . . . . .:
NP_001 YMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSFHHEEHLENIPGTSENSAFRFL
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE2 FNVS-IPHHEEVIMAELRLYTLVQRDRMIYDGVD-----RKITIFEVLESKGDN-EGERN
::.: ::..: . :::::. :.. . .: : ..:.:.::.. .. :.
NP_001 FNLSSIPENEVISSAELRLF----REQ-VDQGPDWERGFHRINIYEVMKPPAEVVPGHLI
150 160 170 180 190
190 200 210 220 230 240
pF1KE2 MLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEID
.: . .. . ..::::::. :. :: . . .. : ... :.
NP_001 TRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQT------------
200 210 220 230 240
250 260 270 280 290 300
pF1KE2 TSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQL-PELDNLGLDSFSSGPGEEALLQ
. :..: . : : :.: . :: : : ..: : : :. :: .
NP_001 RTHQGQH--VRISRSLPQGSG-----------NWAQLRPLLVTFGHD----GRGH-ALTR
250 260 270 280
310 320 330 340 350 360
pF1KE2 MRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLA
: . : :.. :.: ::.::...::..::.:::::.:. :.: : .:::
NP_001 RRRAKRSPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLA
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE2 EHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSEC
.::. :.:::.:.::. ::. :::::::.: ::.::::. . .:. :.: :
NP_001 DHLNSTNHAIVQTLVNSVNSS-IPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGC
350 360 370 380 390 400
pF1KE2 GCR
:::
NP_001 GCR
424 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:27:01 2016 done: Sun Nov 6 18:27:02 2016
Total Scan time: 8.690 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]