FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3181, 418 aa 1>>>pF1KE3181 418 - 418 aa - 418 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3624+/-0.000351; mu= 17.4396+/- 0.022 mean_var=76.6907+/-15.702, 0's: 0 Z-trim(114.7): 23 B-trim: 88 in 1/50 Lambda= 0.146455 statistics sampled from 24602 (24625) to 24602 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.289), width: 16 Scan time: 7.830 The best scores are: opt bits E(85289) XP_011531296 (OMIM: 614797) PREDICTED: E3 ubiquiti ( 418) 2921 626.7 3.3e-179 XP_016860009 (OMIM: 614797) PREDICTED: E3 ubiquiti ( 418) 2921 626.7 3.3e-179 NP_065702 (OMIM: 614797) E3 ubiquitin-protein liga ( 418) 2921 626.7 3.3e-179 NP_067078 (OMIM: 614798) E3 ubiquitin-protein liga ( 420) 2481 533.7 3.2e-151 XP_016860010 (OMIM: 614797) PREDICTED: E3 ubiquiti ( 352) 2461 529.4 5.2e-150 XP_016876967 (OMIM: 614798) PREDICTED: E3 ubiquiti ( 407) 2379 512.2 9.6e-145 XP_005264494 (OMIM: 614797) PREDICTED: E3 ubiquiti ( 320) 2269 488.8 7.9e-138 XP_011531298 (OMIM: 614797) PREDICTED: E3 ubiquiti ( 320) 2269 488.8 7.9e-138 NP_001091980 (OMIM: 609827) E3 ubiquitin-protein l ( 445) 2138 461.3 2.2e-129 NP_659502 (OMIM: 609827) E3 ubiquitin-protein liga ( 469) 2040 440.6 3.9e-123 XP_011543186 (OMIM: 609827) PREDICTED: E3 ubiquiti ( 469) 2040 440.6 3.9e-123 XP_011535294 (OMIM: 614798) PREDICTED: E3 ubiquiti ( 320) 1937 418.7 1e-116 XP_006720274 (OMIM: 614798) PREDICTED: E3 ubiquiti ( 320) 1937 418.7 1e-116 XP_011535292 (OMIM: 614798) PREDICTED: E3 ubiquiti ( 320) 1937 418.7 1e-116 XP_016876968 (OMIM: 614798) PREDICTED: E3 ubiquiti ( 320) 1937 418.7 1e-116 NP_001230065 (OMIM: 609827) E3 ubiquitin-protein l ( 362) 1899 410.7 3e-114 NP_001230064 (OMIM: 609827) E3 ubiquitin-protein l ( 406) 1894 409.7 6.8e-114 XP_011531299 (OMIM: 614797) PREDICTED: E3 ubiquiti ( 239) 1732 375.3 9e-104 XP_016872954 (OMIM: 609827) PREDICTED: E3 ubiquiti ( 320) 1716 372.0 1.2e-102 XP_005267947 (OMIM: 614798) PREDICTED: E3 ubiquiti ( 247) 1305 285.1 1.3e-76 >>XP_011531296 (OMIM: 614797) PREDICTED: E3 ubiquitin-pr (418 aa) initn: 2921 init1: 2921 opt: 2921 Z-score: 3338.3 bits: 626.7 E(85289): 3.3e-179 Smith-Waterman score: 2921; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE3 MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 CTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 CTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 GSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPP 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 THAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 THAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD 370 380 390 400 410 >>XP_016860009 (OMIM: 614797) PREDICTED: E3 ubiquitin-pr (418 aa) initn: 2921 init1: 2921 opt: 2921 Z-score: 3338.3 bits: 626.7 E(85289): 3.3e-179 Smith-Waterman score: 2921; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE3 MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 CTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 CTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 GSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPP 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 THAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 THAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD 370 380 390 400 410 >>NP_065702 (OMIM: 614797) E3 ubiquitin-protein ligase p (418 aa) initn: 2921 init1: 2921 opt: 2921 Z-score: 3338.3 bits: 626.7 E(85289): 3.3e-179 Smith-Waterman score: 2921; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418) 10 20 30 40 50 60 pF1KE3 MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 CTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 CTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPG 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 SQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 SQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 DGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 GSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 GSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 DEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 DEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPP 310 320 330 340 350 360 370 380 390 400 410 pF1KE3 THAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_065 THAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD 370 380 390 400 410 >>NP_067078 (OMIM: 614798) E3 ubiquitin-protein ligase p (420 aa) initn: 2515 init1: 2427 opt: 2481 Z-score: 2835.8 bits: 533.7 E(85289): 3.2e-151 Smith-Waterman score: 2481; 81.4% identity (94.8% similar) in 420 aa overlap (1-418:1-420) 10 20 30 40 50 pF1KE3 MFSPDQENH--PSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVH :::: ::.: :.: :::::::.::::::.:::::::::::::::.:::::::::::::: NP_067 MFSPGQEEHCAPNKEPVKYGELVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVH 10 20 30 40 50 60 60 70 80 90 100 110 pF1KE3 IACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTV . ::::.:::: : :::::::::: ::::::::::..:::::.:::::::::::::::. NP_067 VISTPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTI 70 80 90 100 110 120 120 130 140 150 160 170 pF1KE3 PGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDG :::.....: .:::::::::::.:.:: :.::::.::::::::::::::::::::. :: NP_067 SGSQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDG 130 140 150 160 170 180 180 190 200 210 220 230 pF1KE3 QMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQL .:::::::::::::::.::::.:.::.::::::::.:..::::::::::::.:: ::: : NP_067 HMDGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KE3 QDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKD ::::::::::::::::::.:: :::: ::.:::::::::::::::::.:::::::..::. NP_067 QDGSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKE 250 260 270 280 290 300 300 310 320 330 340 350 pF1KE3 VVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAG ::.:::::.::.:::::::::::.. . ....:::::::.:::::::::::::::::::: NP_067 VVEEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAG 310 320 330 340 350 360 360 370 380 390 400 410 pF1KE3 PPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD ::::::.:::::::::.. ::::::::::::.::::::::: ::.:::. :.::::::.: NP_067 PPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID 370 380 390 400 410 420 >>XP_016860010 (OMIM: 614797) PREDICTED: E3 ubiquitin-pr (352 aa) initn: 2461 init1: 2461 opt: 2461 Z-score: 2814.1 bits: 529.4 E(85289): 5.2e-150 Smith-Waterman score: 2461; 100.0% identity (100.0% similar) in 351 aa overlap (68-418:2-352) 40 50 60 70 80 90 pF1KE3 KSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNT :::::::::::::::::::::::::::::: XP_016 MAISNKDQHSISYTLSRAQTVVVEYTHDSNT 10 20 30 100 110 120 130 140 150 pF1KE3 DMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAG 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 FDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFS 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 LRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINA 160 170 180 190 200 210 280 290 300 310 320 330 pF1KE3 ARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCR 220 230 240 250 260 270 340 350 360 370 380 390 pF1KE3 SVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPF 280 290 300 310 320 330 400 410 pF1KE3 CAHQLAGEQGYIRLIFQGPLD ::::::::::::::::::::: XP_016 CAHQLAGEQGYIRLIFQGPLD 340 350 >>XP_016876967 (OMIM: 614798) PREDICTED: E3 ubiquitin-pr (407 aa) initn: 2425 init1: 2375 opt: 2379 Z-score: 2719.6 bits: 512.2 E(85289): 9.6e-145 Smith-Waterman score: 2379; 81.9% identity (95.5% similar) in 398 aa overlap (21-418:10-407) 10 20 30 40 50 60 pF1KE3 MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIA .::::::.:::::::::::::::.::::::::::::::. XP_016 MLAWPFHSNVVLGYNGALPNGDRGRRKSRFALYKRPKANGVKPSTVHVI 10 20 30 40 70 80 90 100 110 120 pF1KE3 CTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPG ::::.:::: : :::::::::: ::::::::::..:::::.:::::::::::::::. : XP_016 STPQASKAISCKGQHSISYTLSRNQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTISG 50 60 70 80 90 100 130 140 150 160 170 180 pF1KE3 SQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQM ::.....: .:::::::::::.:.:: :.::::.::::::::::::::::::::. ::.: XP_016 SQNTDEAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHM 110 120 130 140 150 160 190 200 210 220 230 240 pF1KE3 DGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQD ::::::::::::::.::::.:.::.::::::::.:..::::::::::::.:: ::: ::: XP_016 DGLTTNGVLVMHPRGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQD 170 180 190 200 210 220 250 260 270 280 290 300 pF1KE3 GSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVV ::::::::::::::::.:: :::: ::.:::::::::::::::::.:::::::..::.:: XP_016 GSLIDLCGATLLWRTADGLFHTPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVV 230 240 250 260 270 280 310 320 330 340 350 360 pF1KE3 DEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPP .:::::.::.:::::::::::.. . ....:::::::.:::::::::::::::::::::: XP_016 EEKQPWAYLSCGHVHGYHNWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPP 290 300 310 320 330 340 370 380 390 400 410 pF1KE3 THAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD ::::.:::::::::.. ::::::::::::.::::::::: ::.:::. :.::::::.: XP_016 THAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPID 350 360 370 380 390 400 >>XP_005264494 (OMIM: 614797) PREDICTED: E3 ubiquitin-pr (320 aa) initn: 2269 init1: 2269 opt: 2269 Z-score: 2595.4 bits: 488.8 E(85289): 7.9e-138 Smith-Waterman score: 2269; 100.0% identity (100.0% similar) in 320 aa overlap (99-418:1-320) 70 80 90 100 110 120 pF1KE3 ISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQ :::::::::::::::::::::::::::::: XP_005 MFQIGRSTESPIDFVVTDTVPGSQSNSDTQ 10 20 30 130 140 150 160 170 180 pF1KE3 SVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 SVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGV 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 LVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCG 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 ATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVY 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 LNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCG 220 230 240 250 260 270 370 380 390 400 410 pF1KE3 HVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD 280 290 300 310 320 >>XP_011531298 (OMIM: 614797) PREDICTED: E3 ubiquitin-pr (320 aa) initn: 2269 init1: 2269 opt: 2269 Z-score: 2595.4 bits: 488.8 E(85289): 7.9e-138 Smith-Waterman score: 2269; 100.0% identity (100.0% similar) in 320 aa overlap (99-418:1-320) 70 80 90 100 110 120 pF1KE3 ISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQ :::::::::::::::::::::::::::::: XP_011 MFQIGRSTESPIDFVVTDTVPGSQSNSDTQ 10 20 30 130 140 150 160 170 180 pF1KE3 SVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGV 40 50 60 70 80 90 190 200 210 220 230 240 pF1KE3 LVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCG 100 110 120 130 140 150 250 260 270 280 290 300 pF1KE3 ATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 ATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVY 160 170 180 190 200 210 310 320 330 340 350 360 pF1KE3 LNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 LNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCG 220 230 240 250 260 270 370 380 390 400 410 pF1KE3 HVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD :::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD 280 290 300 310 320 >>NP_001091980 (OMIM: 609827) E3 ubiquitin-protein ligas (445 aa) initn: 1061 init1: 1061 opt: 2138 Z-score: 2443.8 bits: 461.3 E(85289): 2.2e-129 Smith-Waterman score: 2138; 70.5% identity (88.5% similar) in 417 aa overlap (3-418:30-445) 10 20 30 pF1KE3 MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGD :: .. .:.. :.:::::::::::: : .:: NP_001 MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGYNGCLASGD 10 20 30 40 50 60 40 50 60 70 80 90 pF1KE3 RGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTH .:::.::.:: .: .::::::...: :: ..::.::. ::::::::::...:.::::: NP_001 KGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKALSNRGQHSISYTLSRSHSVIVEYTH 70 80 90 100 110 120 100 110 120 130 140 150 pF1KE3 DSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARI ::.:::::::::::. :::::::: ::. . .. :.::::::.::::.:.: ::.:::: NP_001 DSDTDMFQIGRSTENMIDFVVTDTSPGG-GAAEGPSAQSTISRYACRILCDRRPPYTARI 130 140 150 160 170 160 170 180 190 200 210 pF1KE3 YAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCG ::::::.:.::::::.::::.: :: :::::::::::::: .::.::: ::.:::::::: NP_001 YAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCG 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE3 NVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQ ::..::..::::::::.:: :.: :::::::::::::::::: :: ..::.:.::: :: NP_001 NVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQ 240 250 260 270 280 290 280 290 300 310 320 330 pF1KE3 EINAARPQCPVGFNTLAFPSMKR-KDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRE : ::::::::::..:::::: : . . :..:::::. ::::::::.:: ..:: ..:: NP_001 EANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERE 300 310 320 330 340 350 340 350 360 370 380 390 pF1KE3 CPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFH ::.:: :::::::::: :::. .: :::.:::.::::::::::. ::.: :::::::.:: NP_001 CPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFH 360 370 380 390 400 410 400 410 pF1KE3 AACPFCAHQLAGEQGYIRLIFQGPLD ::::::. :.::.: .::::::::: NP_001 AACPFCGAWLTGEHGCVRLIFQGPLD 420 430 440 >>NP_659502 (OMIM: 609827) E3 ubiquitin-protein ligase p (469 aa) initn: 1047 init1: 963 opt: 2040 Z-score: 2331.6 bits: 440.6 E(85289): 3.9e-123 Smith-Waterman score: 2080; 66.7% identity (83.7% similar) in 441 aa overlap (3-418:30-469) 10 20 pF1KE3 MFSPDQENHPSKAPVKYGELIVLG--------- :: .. .:.. :.::::::::: NP_659 MVLEGNPEVGSPRTSDLQHRGNKGSCVLSSPGEDAQPGEEPIKYGELIVLGCCEEGGEET 10 20 30 40 50 60 30 40 50 60 pF1KE3 ---------------YNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAI ::: : .::.:::.::.:: .: .::::::...: :: ..::. NP_659 EAQRGEVTGPRAHSCYNGCLASGDKGRRRSRLALSRRSHANGVKPDVMHHISTPLVSKAL 70 80 90 100 110 120 70 80 90 100 110 120 pF1KE3 SNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQS ::. ::::::::::...:.:::::::.:::::::::::. :::::::: ::. . .. : NP_659 SNRGQHSISYTLSRSHSVIVEYTHDSDTDMFQIGRSTENMIDFVVTDTSPGG-GAAEGPS 130 140 150 160 170 130 140 150 160 170 180 pF1KE3 VQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVL .::::::.::::.:.: ::.::::::::::.:.::::::.::::.: :: :::::::::: NP_659 AQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVL 180 190 200 210 220 230 190 200 210 220 230 240 pF1KE3 VMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGA :::: .::.::: ::.::::::::::..::..::::::::.:: :.: :::::::::::: NP_659 VMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGA 240 250 260 270 280 290 250 260 270 280 290 300 pF1KE3 TLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKR-KDVVDEKQPWVY :::::: :: ..::.:.::: ::: ::::::::::..:::::: : . . :..::::: NP_659 TLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVY 300 310 320 330 340 350 310 320 330 340 350 360 pF1KE3 LNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCG . ::::::::.:: ..:: ..::::.:: :::::::::: :::. .: :::.:::.::: NP_659 VRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCG 360 370 380 390 400 410 370 380 390 400 410 pF1KE3 HVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD :::::::. ::.: :::::::.::::::::. :.::.: .::::::::: NP_659 HVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGEHGCVRLIFQGPLD 420 430 440 450 460 418 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:58:26 2016 done: Sun Nov 6 01:58:28 2016 Total Scan time: 7.830 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]