FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3129, 322 aa 1>>>pF1KE3129 322 - 322 aa - 322 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3060+/-0.000415; mu= 15.1438+/- 0.026 mean_var=53.2175+/-11.283, 0's: 0 Z-trim(109.2): 52 B-trim: 864 in 1/48 Lambda= 0.175811 statistics sampled from 17312 (17360) to 17312 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.581), E-opt: 0.2 (0.204), width: 16 Scan time: 7.560 The best scores are: opt bits E(85289) NP_071411 (OMIM: 611132) ribokinase isoform 1 [Hom ( 322) 2060 530.7 1.6e-150 NP_001274509 (OMIM: 611132) ribokinase isoform 2 [ ( 255) 1611 416.8 2.4e-116 NP_006479 (OMIM: 229800,614058) ketohexokinase iso ( 298) 149 46.0 0.00012 NP_000212 (OMIM: 229800,614058) ketohexokinase iso ( 298) 148 45.7 0.00014 XP_005264353 (OMIM: 229800,614058) PREDICTED: keto ( 299) 148 45.7 0.00014 >>NP_071411 (OMIM: 611132) ribokinase isoform 1 [Homo sa (322 aa) initn: 2060 init1: 2060 opt: 2060 Z-score: 2823.5 bits: 530.7 E(85289): 1.6e-150 Smith-Waterman score: 2060; 100.0% identity (100.0% similar) in 322 aa overlap (1-322:1-322) 10 20 30 40 50 60 pF1KE3 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_071 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV 250 260 270 280 290 300 310 320 pF1KE3 SVQAAGTQSSYPYKKDLPLTLF :::::::::::::::::::::: NP_071 SVQAAGTQSSYPYKKDLPLTLF 310 320 >>NP_001274509 (OMIM: 611132) ribokinase isoform 2 [Homo (255 aa) initn: 1611 init1: 1611 opt: 1611 Z-score: 2209.7 bits: 416.8 E(85289): 2.4e-116 Smith-Waterman score: 1611; 100.0% identity (100.0% similar) in 255 aa overlap (68-322:1-255) 40 50 60 70 80 90 pF1KE3 TGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEF :::::::::::::::::::::::::::::: NP_001 MTSMVCKVGKDSFGNDYIENLKQNDISTEF 10 20 30 100 110 120 130 140 150 pF1KE3 TYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITP 40 50 60 70 80 90 160 170 180 190 200 210 pF1KE3 ATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADA 100 110 120 130 140 150 220 230 240 250 260 270 pF1KE3 GEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAF 160 170 180 190 200 210 280 290 300 310 320 pF1KE3 YLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF ::::::::::::::::::::::::::::::::::::::::::::: NP_001 YLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF 220 230 240 250 >>NP_006479 (OMIM: 229800,614058) ketohexokinase isoform (298 aa) initn: 177 init1: 96 opt: 149 Z-score: 204.5 bits: 46.0 E(85289): 0.00012 Smith-Waterman score: 149; 21.5% identity (54.2% similar) in 284 aa overlap (14-280:2-269) 10 20 30 40 50 60 pF1KE3 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV : .. :: . :..::... :: :. . ::...:.:. NP_006 MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCT 10 20 30 40 70 80 90 100 110 pF1KE3 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDIS-TEFTYQTKDAATGTASIIVNNEGQN . ::: ... ... .. . .... .. .. ..:.: . : .. :.:: . : NP_006 VLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSK-GDTPSSCCIINNSNGN 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 IIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLE---ITPATSLEALTMARRSGVKTLF ... ..: :. :. . :: . :.. : .. : . : .: ... NP_006 RTIVLHDTSL----PDVSAT----DFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTR 110 120 130 140 150 180 190 200 210 220 pF1KE3 NPAP-----AIADLDP-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLK .: .. : :.. .:: ... :. : :. :: .: .. .. NP_006 QPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHL-GFQ--SAEEALRGLYGRVR 160 170 180 190 200 210 230 240 250 260 270 280 pF1KE3 RGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV---KAVDTTGAGDSFVGALAFYLAYYP .: :.. . . :: .:. :. : . .. ..::: ::::.: ... : :. NP_006 KGA-VLVCAWAEEGADALG---PDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGR 220 230 240 250 260 270 290 300 310 320 pF1KE3 NLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF NP_006 SVQEALRFGCQVAGKKCGLQGFDGIV 280 290 >>NP_000212 (OMIM: 229800,614058) ketohexokinase isoform (298 aa) initn: 163 init1: 82 opt: 148 Z-score: 203.1 bits: 45.7 E(85289): 0.00014 Smith-Waterman score: 148; 20.5% identity (53.7% similar) in 283 aa overlap (14-280:2-269) 10 20 30 40 50 60 pF1KE3 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV : .. :: . :..::... :: :. . ::...:.:. NP_000 MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCT 10 20 30 40 70 80 90 100 110 120 pF1KE3 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI . ::: ... ... .. ...:.. ... ..: ... :..:.:. NP_000 VLSLLGAPCAFMGSMAPGHVADFVLDDLRRYSVDLRYTVFQTTGSVPIATVIINE----- 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLE---ITPATSLEALTMARRSGVKTLFN ..:. .: . ... . :: . :.. : .. : . : .: ... . NP_000 ---ASGSRTILYYDRSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQ 110 120 130 140 150 160 180 190 200 210 220 pF1KE3 PAP-----AIADLDP-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKR : .. : :.. .:: ... :. : :. :: .: .. ... NP_000 PPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHL-GFQ--SAEEALRGLYGRVRK 170 180 190 200 210 230 240 250 260 270 280 pF1KE3 GCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV---KAVDTTGAGDSFVGALAFYLAYYPN : :.. . . :: .:. :. : . .. ..::: ::::.: ... : :. NP_000 GA-VLVCAWAEEGADALG---PDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRS 220 230 240 250 260 270 290 300 310 320 pF1KE3 LSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF NP_000 VQEALRFGCQVAGKKCGLQGFDGIV 280 290 >>XP_005264353 (OMIM: 229800,614058) PREDICTED: ketohexo (299 aa) initn: 165 init1: 84 opt: 148 Z-score: 203.1 bits: 45.7 E(85289): 0.00014 Smith-Waterman score: 148; 20.4% identity (54.2% similar) in 284 aa overlap (14-280:2-270) 10 20 30 40 50 60 pF1KE3 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV : .. :: . :..::... :: :. . ::...:.:. XP_005 MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCT 10 20 30 40 70 80 90 100 110 pF1KE3 QAARLGAMTSMVCKVGKDSFGNDYI-ENLKQNDISTEFTYQTKDAATGTASIIVNNEGQN . ::: ... ... ..... ..:.. ... ..: ... :..:.:. XP_005 VLSLLGAPCAFMGSMAPGHVADSFVLDDLRRYSVDLRYTVFQTTGSVPIATVIINE---- 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE3 IIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLE---ITPATSLEALTMARRSGVKTLF ..:. .: . ... . :: . :.. : .. : . : .: ... XP_005 ----ASGSRTILYYDRSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTR 110 120 130 140 150 160 180 190 200 210 220 pF1KE3 NPAP-----AIADLDP-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLK .: .. : :.. .:: ... :. : :. :: .: .. .. XP_005 QPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHL-GFQ--SAEEALRGLYGRVR 170 180 190 200 210 230 240 250 260 270 280 pF1KE3 RGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV---KAVDTTGAGDSFVGALAFYLAYYP .: :.. . . :: .:. :. : . .. ..::: ::::.: ... : :. XP_005 KGA-VLVCAWAEEGADALG---PDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGR 220 230 240 250 260 270 290 300 310 320 pF1KE3 NLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF XP_005 SVQEALRFGCQVAGKKCGLQGFDGIV 280 290 322 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 18:35:00 2016 done: Sun Nov 6 18:35:01 2016 Total Scan time: 7.560 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]