FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE6370, 326 aa 1>>>pF1KE6370 326 - 326 aa - 326 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7603+/-0.000304; mu= 19.7414+/- 0.019 mean_var=69.5904+/-13.971, 0's: 0 Z-trim(117.6): 316 B-trim: 0 in 0/57 Lambda= 0.153744 statistics sampled from 29520 (29839) to 29520 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.35), width: 16 Scan time: 6.220 The best scores are: opt bits E(85289) NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 652 153.2 6.9e-37 XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 652 153.2 6.9e-37 NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 651 152.9 8.1e-37 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 652 153.3 8.4e-37 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 652 153.3 8.9e-37 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 652 153.3 9e-37 XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 639 150.3 5.4e-36 XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 639 150.3 5.4e-36 NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 638 150.3 8.7e-36 NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 638 150.3 9e-36 NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 638 150.3 9.1e-36 XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 636 149.8 1.2e-35 XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 636 149.9 1.3e-35 NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 636 149.9 1.3e-35 XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 636 149.9 1.3e-35 NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 633 149.0 1.4e-35 XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 633 149.1 1.6e-35 NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 633 149.1 1.6e-35 NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 633 149.2 2.1e-35 XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 633 149.2 2.2e-35 XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 633 149.2 2.2e-35 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 625 147.3 5.7e-35 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 626 147.8 7.4e-35 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 626 147.8 7.5e-35 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 614 144.7 2.4e-34 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 614 144.9 3.1e-34 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 613 144.6 3.2e-34 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 613 144.7 3.6e-34 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 613 144.7 3.8e-34 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 613 144.7 3.8e-34 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 613 144.7 4e-34 NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 590 139.4 8.9e-33 NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 590 139.5 1.1e-32 NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 590 139.5 1.2e-32 NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 588 138.9 1.2e-32 NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 590 139.5 1.2e-32 NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 590 139.5 1.2e-32 NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 590 139.5 1.2e-32 NP_000292 (OMIM: 173350,217090) plasminogen isofor ( 810) 586 138.9 3.5e-32 NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 579 136.9 4.7e-32 XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 578 136.9 7.8e-32 XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 578 136.9 7.9e-32 XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 578 136.9 8.3e-32 XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 578 136.9 8.3e-32 XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 578 136.9 8.3e-32 NP_892018 (OMIM: 610477) transmembrane protease se (1059) 560 133.2 2.3e-30 XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 560 133.2 2.4e-30 NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 552 130.9 2.9e-30 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 552 131.4 7.7e-30 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 552 131.4 7.8e-30 >>NP_071402 (OMIM: 609343) brain-specific serine proteas (317 aa) initn: 631 init1: 252 opt: 652 Z-score: 783.2 bits: 153.2 E(85289): 6.9e-37 Smith-Waterman score: 652; 36.1% identity (61.8% similar) in 288 aa overlap (11-288:10-285) 10 20 30 40 50 pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRV--AALVHRQPENQGISLTGSVACGRPSMEG :: . :: . ::..: . :: . : :::.:.. . NP_071 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPP-----------ACGKPQQLN 10 20 30 40 60 70 80 90 100 110 pF1KE6 KILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIK-IYDMYVGL ...:: . . .::: ::.. : : :.::.:. ::..:::::. . : .... .: NP_071 RVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 VNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN .: :...: : : ::.: . .:.:::.:. : ::: :::.:: .. NP_071 WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIH 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 LT-SANCWATGWGLVSKQG---ETSDELQEVQLPLILEPWCHLLY---GHMSYIMPDMLC : ...:: .::: . ..: . ::....:.: : :: . .. : :::: NP_071 LPPNTHCWISGWGSI-QDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLC 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 AGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICD :: . . . .: :::::::.:. . .:: ::.:::.::.. :::: :.: .:. NP_071 AGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEK 230 240 250 260 270 280 300 310 320 pF1KE6 NIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL NP_071 IVQGVQLRGRAQGGGALRAPSQGSGAAARS 290 300 310 >>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific (317 aa) initn: 631 init1: 252 opt: 652 Z-score: 783.2 bits: 153.2 E(85289): 6.9e-37 Smith-Waterman score: 652; 36.1% identity (61.8% similar) in 288 aa overlap (11-288:10-285) 10 20 30 40 50 pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRV--AALVHRQPENQGISLTGSVACGRPSMEG :: . :: . ::..: . :: . : :::.:.. . XP_005 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPP-----------ACGKPQQLN 10 20 30 40 60 70 80 90 100 110 pF1KE6 KILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIK-IYDMYVGL ...:: . . .::: ::.. : : :.::.:. ::..:::::. . : .... .: XP_005 RVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGA 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE6 VNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN .: :...: : : ::.: . .:.:::.:. : ::: :::.:: .. XP_005 WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIH 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE6 LT-SANCWATGWGLVSKQG---ETSDELQEVQLPLILEPWCHLLY---GHMSYIMPDMLC : ...:: .::: . ..: . ::....:.: : :: . .. : :::: XP_005 LPPNTHCWISGWGSI-QDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLC 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE6 AGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICD :: . . . .: :::::::.:. . .:: ::.:::.::.. :::: :.: .:. XP_005 AGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEK 230 240 250 260 270 280 300 310 320 pF1KE6 NIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL XP_005 IVQGVQLRGRAQGGGALRAPSQGSGAAARS 290 300 310 >>NP_036599 (OMIM: 609341) tryptase gamma preproprotein (321 aa) initn: 603 init1: 229 opt: 651 Z-score: 782.0 bits: 152.9 E(85289): 8.1e-37 Smith-Waterman score: 655; 37.9% identity (59.9% similar) in 317 aa overlap (15-320:2-297) 10 20 30 40 50 pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHRQPENQGISLTGSVACGRPSME--- ::: :::..: : :. : :: .::::.. NP_036 MALGACGLLLLLAVPGVS-LRTLQP-----------GCGRPQVSDAG 10 20 30 60 70 80 90 100 110 pF1KE6 GKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYVGL :.:.:: :: ::::.:.. .::::::.:. :::.::::: . : . :....: NP_036 GRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGE 40 50 60 70 80 90 120 130 140 150 160 170 pF1KE6 VNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN ... .. . . : ..::: . .::.:::.:.. ...: .::::: ::.. NP_036 LEITLSPHFST---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCL--PEAS 100 110 120 130 140 150 180 190 200 210 220 pF1KE6 ---LTSANCWATGWGLVSKQGETSDE---LQEVQLPLILEPWCHLLY-GHMSYIM-PDML . ::.:::: ...:: :.::.. .. :. : : . :. :::: NP_036 DDFCPGIRCWVTGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDML 160 170 180 190 200 230 240 250 260 270 280 pF1KE6 CAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWIC :: .: :. ::::::::. : .:.: ::::::.::. : ::::. : . .:: NP_036 CARGPGDA---CQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIR 210 220 230 240 250 260 290 300 310 320 pF1KE6 DNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL .: . . : : : : :. .: NP_036 RHITASGGSESGYPRLPLLAGFFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD 270 280 290 300 310 320 >>NP_001275679 (OMIM: 606751) transmembrane protease ser (413 aa) initn: 578 init1: 313 opt: 652 Z-score: 781.7 bits: 153.3 E(85289): 8.4e-37 Smith-Waterman score: 652; 38.3% identity (65.0% similar) in 277 aa overlap (28-293:136-409) 10 20 30 40 50 pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHR--QPEN-----QGISLTGSVA ::....... ::.: : .:: : NP_001 SLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCS-E 110 120 130 140 150 160 60 70 80 90 100 pF1KE6 CGRPSMEGKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNI :: . ..:.:: . .::::.:: . :.::::.: ::..::::.: : . NP_001 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARL 170 180 190 200 210 220 110 120 130 140 150 160 pF1KE6 KIYDMYVGLVNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLP . . ...:::. . : : :.:.: :: : . ::::..:.: . ::..: NP_001 SSWRVHAGLVSHSAVRPH-QGALVERIIPHPLYSAQNH-DYDVALLRLQTALNFSDTVGA 230 240 250 260 270 280 170 180 190 200 210 220 pF1KE6 VCLATPEVNLTSAN-CWATGWGLVS-KQGETSDELQEVQLPLILEPWCHLLYGHMSYIMP ::: . : .. ... ::..::: . .. .:: ::.. .::. :. . . . : NP_001 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTP 290 300 310 320 330 340 230 240 250 260 270 280 pF1KE6 DMLCAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSK ::::: . . .:.::::::::: . .: .:.:::::::..: .:::::.:. : NP_001 RMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLD 350 360 370 380 390 400 290 300 310 320 pF1KE6 WICDNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL :: :. . NP_001 WIHDTAQDSLL 410 >>NP_001275680 (OMIM: 606751) transmembrane protease ser (448 aa) initn: 578 init1: 313 opt: 652 Z-score: 781.3 bits: 153.3 E(85289): 8.9e-37 Smith-Waterman score: 652; 38.3% identity (65.0% similar) in 277 aa overlap (28-293:171-444) 10 20 30 40 50 pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHR--QPEN-----QGISLTGSVA ::....... ::.: : .:: : NP_001 SLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCS-E 150 160 170 180 190 60 70 80 90 100 pF1KE6 CGRPSMEGKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNI :: . ..:.:: . .::::.:: . :.::::.: ::..::::.: : . NP_001 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARL 200 210 220 230 240 250 110 120 130 140 150 160 pF1KE6 KIYDMYVGLVNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLP . . ...:::. . : : :.:.: :: : . ::::..:.: . ::..: NP_001 SSWRVHAGLVSHSAVRPH-QGALVERIIPHPLYSAQNH-DYDVALLRLQTALNFSDTVGA 260 270 280 290 300 310 170 180 190 200 210 220 pF1KE6 VCLATPEVNLTSAN-CWATGWGLVS-KQGETSDELQEVQLPLILEPWCHLLYGHMSYIMP ::: . : .. ... ::..::: . .. .:: ::.. .::. :. . . . : NP_001 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTP 320 330 340 350 360 370 230 240 250 260 270 280 pF1KE6 DMLCAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSK ::::: . . .:.::::::::: . .: .:.:::::::..: .:::::.:. : NP_001 RMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLD 380 390 400 410 420 430 290 300 310 320 pF1KE6 WICDNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL :: :. . NP_001 WIHDTAQDSLL 440 >>NP_110397 (OMIM: 606751) transmembrane protease serine (457 aa) initn: 578 init1: 313 opt: 652 Z-score: 781.2 bits: 153.3 E(85289): 9e-37 Smith-Waterman score: 652; 38.3% identity (65.0% similar) in 277 aa overlap (28-293:180-453) 10 20 30 40 50 pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHR--QPEN-----QGISLTGSVA ::....... ::.: : .:: : NP_110 SLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCS-E 150 160 170 180 190 200 60 70 80 90 100 pF1KE6 CGRPSMEGKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNI :: . ..:.:: . .::::.:: . :.::::.: ::..::::.: : . NP_110 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARL 210 220 230 240 250 260 110 120 130 140 150 160 pF1KE6 KIYDMYVGLVNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLP . . ...:::. . : : :.:.: :: : . ::::..:.: . ::..: NP_110 SSWRVHAGLVSHSAVRPH-QGALVERIIPHPLYSAQNH-DYDVALLRLQTALNFSDTVGA 270 280 290 300 310 320 170 180 190 200 210 220 pF1KE6 VCLATPEVNLTSAN-CWATGWGLVS-KQGETSDELQEVQLPLILEPWCHLLYGHMSYIMP ::: . : .. ... ::..::: . .. .:: ::.. .::. :. . . . : NP_110 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTP 330 340 350 360 370 380 230 240 250 260 270 280 pF1KE6 DMLCAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSK ::::: . . .:.::::::::: . .: .:.:::::::..: .:::::.:. : NP_110 RMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLD 390 400 410 420 430 440 290 300 310 320 pF1KE6 WICDNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL :: :. . NP_110 WIHDTAQDSLL 450 >>XP_011520749 (OMIM: 609341) PREDICTED: tryptase gamma (346 aa) initn: 547 init1: 223 opt: 639 Z-score: 767.2 bits: 150.3 E(85289): 5.4e-36 Smith-Waterman score: 639; 37.2% identity (61.4% similar) in 290 aa overlap (42-320:42-322) 20 30 40 50 60 pF1KE6 GPSALGLLLLLLVVAPPRVAALVHRQPENQGISLTGSVACGRPSME---GKILGGVPAPE : . ...::::.. :.:.:: :: XP_011 LKSKVPKKAGRCGQGRLHGGSAVGFLGSPPGTPSSFDLGCGRPQVSDAGGRIVGGHAAPA 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE6 RKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYVGLVNLRVDGNHTQ ::::.:.. .::::::.:. :::.::::: . : . :....: ... .. . . XP_011 GAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE6 WYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN---LTSANCWA : ..::: . .::.:::.:.. ...: .::::: ::.. . ::. XP_011 ---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCL--PEASDDFCPGIRCWV 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TGWGLVSKQGETSDE---LQEVQLPLILEPWCHLLY-GHMSYIM-PDMLCAGDILNAKTV :::: ...:: :.::.. .. :. : : . :. :::::: .: XP_011 TGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDA--- 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 CEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPTPAQ :. ::::::::. : .:.: : ::::.::. : ::::. : . .:: .: . . XP_011 CQDDSGGPLVCQVNGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSES 250 260 270 280 290 300 310 320 pF1KE6 PAPALSPALGPTLSVLMAMLAGWSVL : : : : :. .: XP_011 GYPRLPLLAGFFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD 310 320 330 340 >>XP_011520748 (OMIM: 609341) PREDICTED: tryptase gamma (346 aa) initn: 547 init1: 223 opt: 639 Z-score: 767.2 bits: 150.3 E(85289): 5.4e-36 Smith-Waterman score: 639; 37.2% identity (61.4% similar) in 290 aa overlap (42-320:42-322) 20 30 40 50 60 pF1KE6 GPSALGLLLLLLVVAPPRVAALVHRQPENQGISLTGSVACGRPSME---GKILGGVPAPE : . ...::::.. :.:.:: :: XP_011 LKSKVPKKAGRCGQGRLHGGSAVGFLGSPPGTPSSFDLGCGRPQVSDAGGRIVGGHAAPA 20 30 40 50 60 70 70 80 90 100 110 120 pF1KE6 RKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYVGLVNLRVDGNHTQ ::::.:.. .::::::.:. :::.::::: . : . :....: ... .. . . XP_011 GAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST 80 90 100 110 120 130 130 140 150 160 170 180 pF1KE6 WYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN---LTSANCWA : ..::: . .::.:::.:.. ...: .::::: ::.. . ::. XP_011 ---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCL--PEASDDFCPGIRCWV 140 150 160 170 180 190 200 210 220 230 240 pF1KE6 TGWGLVSKQGETSDE---LQEVQLPLILEPWCHLLY-GHMSYIM-PDMLCAGDILNAKTV :::: ...:: :.::.. .. :. : : . :. :::::: .: XP_011 TGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDA--- 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE6 CEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPTPAQ :. ::::::::. : .:.: : ::::.::. : ::::. : . .:: .: . . XP_011 CQDDSGGPLVCQVNGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSES 250 260 270 280 290 300 310 320 pF1KE6 PAPALSPALGPTLSVLMAMLAGWSVL : : : : :. .: XP_011 GYPRLPLLAGFFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD 310 320 330 340 >>NP_001193718 (OMIM: 610050) transmembrane protease ser (532 aa) initn: 476 init1: 441 opt: 638 Z-score: 763.5 bits: 150.3 E(85289): 8.7e-36 Smith-Waterman score: 638; 37.6% identity (65.0% similar) in 266 aa overlap (34-293:264-524) 10 20 30 40 50 60 pF1KE6 PASVMGPLGPSALGLLLLLLVVAPPRVAALVHRQ--PENQGISLTGSVACGRPSMEGKIL .::. : .. ::: : :: .: :.:. NP_001 ESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCS-HCGLRAMTGRIV 240 250 260 270 280 290 70 80 90 100 110 pF1KE6 GGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNIKIYDMYVGLVN ::. : . :::::::.:.. :.:::.... :::.::::: :.: .. . .:.: : NP_001 GGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSN 300 310 320 330 340 350 120 130 140 150 160 170 pF1KE6 LRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVNLT :. . . . ..:.. .: . :.::..:. ...: . :.:: ... NP_001 LH---QLPEAASIAEIIINSNYTDEED-DYDIALMRLSKPLTLSAHIHPACLPMHGQTFS 360 370 380 390 400 180 190 200 210 220 230 pF1KE6 -SANCWATGWGLVSKQGE-TSDELQEVQLPLILEPWCHLLYGHMSYIMPDMLCAGDILNA . .:: ::.: . . . :: :.:::. :: :. . ::. : :.::::. .. NP_001 LNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGG 410 420 430 440 450 460 240 250 260 270 280 290 pF1KE6 KTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPT . :.:::::::::: : : :..::: ::.. ::::..:. :: ...: NP_001 RDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVR 470 480 490 500 510 520 300 310 320 pF1KE6 PAQPAPALSPALGPTLSVLMAMLAGWSVL NP_001 FRKS 530 >>NP_001231924 (OMIM: 610050) transmembrane protease ser (563 aa) initn: 476 init1: 441 opt: 638 Z-score: 763.2 bits: 150.3 E(85289): 9e-36 Smith-Waterman score: 638; 37.6% identity (65.0% similar) in 266 aa overlap (34-293:299-559) 10 20 30 40 50 60 pF1KE6 PASVMGPLGPSALGLLLLLLVVAPPRVAALVHRQ--PENQGISLTGSVACGRPSMEGKIL .::. : .. ::: : :: .: :.:. NP_001 ESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCS-HCGLRAMTGRIV 270 280 290 300 310 320 70 80 90 100 110 pF1KE6 GGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNIKIYDMYVGLVN ::. : . :::::::.:.. :.:::.... :::.::::: :.: .. . .:.: : NP_001 GGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSN 330 340 350 360 370 380 120 130 140 150 160 170 pF1KE6 LRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVNLT :. . . . ..:.. .: . :.::..:. ...: . :.:: ... NP_001 LH---QLPEAASIAEIIINSNYTDEED-DYDIALMRLSKPLTLSAHIHPACLPMHGQTFS 390 400 410 420 430 440 180 190 200 210 220 230 pF1KE6 -SANCWATGWGLVSKQGE-TSDELQEVQLPLILEPWCHLLYGHMSYIMPDMLCAGDILNA . .:: ::.: . . . :: :.:::. :: :. . ::. : :.::::. .. NP_001 LNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGG 450 460 470 480 490 500 240 250 260 270 280 290 pF1KE6 KTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPT . :.:::::::::: : : :..::: ::.. ::::..:. :: ...: NP_001 RDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESSAG 510 520 530 540 550 560 300 310 320 pF1KE6 PAQPAPALSPALGPTLSVLMAMLAGWSVL 326 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Tue Nov 8 12:33:08 2016 done: Tue Nov 8 12:33:09 2016 Total Scan time: 6.220 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]